从生物流体中除去细菌毒素的方法
阅读说明:本技术 从生物流体中除去细菌毒素的方法 (Method for removing bacterial toxins from biological fluids ) 是由 A·皮尼 C·法尔恰尼 L·布拉奇 J·布鲁内提 L·奎尔希尼 于 2018-04-19 设计创作,主要内容包括:本发明涉及从生物流体中除去细菌毒素如脂多糖和脂磷壁酸的方法。在所述方法中,将选自KKIRVRLSA、RRIRVRLSA、KRIRVRLSA和RKIRVRLSA的肽通过其C末端、任选地通过插入的连接体与固体载体共价连接,并用于捕获毒素。本发明还涉及这种衍生化的固体载体,以及涉及包含这种衍生化的固体载体的筒、柱和医疗装置。(The present invention relates to a method for removing bacterial toxins such as lipopolysaccharides and lipoteichoic acids from biological fluids. In the method, a peptide selected from the group consisting of KKIRVRLSA, RRIRVRLSA, KRIRVRLSA and RKIRVRLSA is covalently linked via its C-terminus, optionally via an intervening linker, to a solid support and used to capture the toxin. The invention also relates to such derivatized solid supports, and to cartridges, columns, and medical devices comprising such derivatized solid supports.)
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