阅读说明：本技术 一种用于治疗慢性荨麻疹的药物及制备方法 (Medicine for treating chronic urticaria and preparation method thereof ) 是由 李危胜 于 2021-09-13 设计创作，主要内容包括：本发明涉及中药技术领域,具体而言,涉及一种用于治疗慢性荨麻疹的药物及制备方法,该药物按质量分数计包括70-90％的薄荷提取物和10-30％的溶剂。其制备方法为：S1自然晾干薄荷；S2在薄荷表面喷洒甘油磷酸钠溶液,加入纤维素酶溶液,粉碎；S3冷冻干燥处理,提取,分离过滤、浓缩；S4向薄荷渣中加入研磨剂和纤维素酶溶液,研磨,加入乙醇水溶液浸提,减压过滤、浓缩滤液；S5二氧化碳超临界萃取提取液,得到薄荷提取物；S6加入溶剂,即得到上述药物。薄荷脑对慢性荨麻疹具有优异的止痒效果,可快速止痒,缓解患者的不适,并且薄荷提取物天然刺激性物质,可长期使用,无不良副作用。(The invention relates to the technical field of traditional Chinese medicines, in particular to a medicine for treating chronic urticaria and a preparation method thereof, wherein the medicine comprises 70-90% of mint extract and 10-30% of solvent by mass. The preparation method comprises the following steps: s1 naturally airing the mint; s2 spraying sodium glycerophosphate solution on the surface of mint, adding cellulase solution, and pulverizing; s3 freeze drying, extracting, separating, filtering, and concentrating; s4 adding grinding agent and cellulase solution into the mint residue, grinding, adding ethanol water solution for leaching, filtering under reduced pressure, and concentrating the filtrate; s5 extracting the extractive solution with supercritical carbon dioxide to obtain herba Menthae extract; s6 adding solvent to obtain the medicine. The menthol has excellent itching relieving effect on chronic urticaria, can quickly relieve itching and relieve discomfort of a patient, and the mint extract is a natural irritant substance and can be used for a long time without adverse side effects.)

1. A medicine for treating chronic urticaria is characterized by comprising 70-90% of mint extract and 10-30% of solvent by mass.

2. The medicament for treating chronic urticaria according to claim 1, wherein the mass fraction of said mint extract is 80-90%.

3. The medicament for treating chronic urticaria according to claim 1, wherein said mint extract is menthol.

4. A medicament as claimed in claim 3, for the treatment of chronic urticaria, wherein said mint extract is l-menthol.

5. The agent for the treatment of chronic urticaria as claimed in claim 1, wherein said solvent is water or ethanol.

6. A process for the preparation of a medicament as claimed in any one of claims 1 to 5 for the treatment of chronic urticaria, comprising the steps of:

s1, selecting fresh mint, cleaning, and naturally airing the surface moisture;

s2, selecting the mint naturally dried in the step S1, spraying a sodium glycerophosphate solution on the surface of the mint, naturally drying for 1-2h, adding a cellulase solution, and simultaneously crushing the mint;

s3, freeze-drying the crushed mint, adding an extractant for extraction, separating, filtering and concentrating to obtain an extracting solution A and mint residues;

s4, adding an abrasive and a cellulase solution into the mint residue, grinding the mint residue until the volume of the mint residue is reduced to 20-50% of the original volume, adding an ethanol water solution for extraction, filtering under reduced pressure, and concentrating the filtrate to obtain an extracting solution B;

s5, mixing the extract A and the extract B, and performing carbon dioxide supercritical extraction to obtain a mint extract;

s6, adding a solvent into the mint extract, and adjusting the ratio of the mint extract to the solvent to obtain the medicine.

7. The method for preparing a medicament for treating chronic urticaria as claimed in claim 6, wherein in said step S2, the volume fraction of said sodium glycerophosphate solution is 0.1-1%, and the mass ratio of said sodium glycerophosphate solution to said mint is (0.5-1): 1.

8. the method for preparing a medicament for treating chronic urticaria as claimed in claim 6, wherein in said step S2, the mass fraction of said cellulase solution is 1-5%, and the mass ratio of said cellulase solution to said mint is 1: (15-20).

9. The method for preparing a medicament for treating chronic urticaria as claimed in claim 6, wherein in said step S3, said freeze-drying process comprises the steps of:

s31, freezing the mint at-10-0 ℃ for 2-3h, and heating to room temperature at a heating rate of 1-5 ℃/min;

s32, freezing the mint processed in the step S31 at the temperature of-20 to-10 ℃ for 2 to 3 hours, heating to 1 to 5 ℃ at the heating rate of 1 to 5 ℃/min, refrigerating for 0.5 to 1 hour, and heating to room temperature at the heating rate of 0.5 to 1 ℃/min.

10. The method for preparing a medicament for treating chronic urticaria as claimed in claim 6, wherein in said step S3, the extracting step includes: adding ethanol water solution and dilute hydrochloric acid into herba Menthae, adjusting pH of the solution system to 3-4, and reflux extracting for 1-2 hr;

wherein the reflux extraction temperature is 40-50 deg.C, and the volume fraction of ethanol water solution is 75%.

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a medicine for treating chronic urticaria and a preparation method thereof.

Background

Chronic urticaria is caused by various factors, such as temporary inflammatory congestion and tissue edema of skin, mucous membrane and blood vessels, and the disease course is more than 6 weeks, so that the chronic urticaria is called. The clinical manifestations of chronic urticaria are that the patients are subjected to wind mass and plaque in trunk, face or limbs irregularly, and the attack times are different. In the acute attack period of the chronic urticaria, skin pruritus is intolerable, so that the patients are subjected to emotional dysphoria and the like.

At present, most of the medicines for treating urticaria and relieving itching are chemical preparations, contain certain hormones, are easy to generate drug effect dependence after long-term use, and are easy to cause certain damage to skin. The traditional Chinese medicine preparation has small side effect, but has poor itching relieving effect and slow effect.

Disclosure of Invention

The invention aims to provide a medicine for treating chronic urticaria, which comprises a mint extract and a solvent, wherein the mint extract contains menthol, has an excellent itching relieving effect on chronic urticaria, can quickly relieve itching and relieve discomfort of a patient, and is a natural irritant substance of the mint extract, can be used for a long time and has no adverse side effect.

The invention also aims to provide a preparation method of the medicine for treating chronic urticaria, and the mint extract prepared by the method has high menthol content, high purity, less impurities and good treatment effect on chronic urticaria.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

In one aspect, the embodiment of the invention provides a medicament for treating chronic urticaria, which comprises 70-90% of mint extract and 10-30% of solvent by mass.

The menthol in the mint extract has an excellent itching relieving effect on chronic urticaria, can quickly relieve itching after use, relieves discomfort of a patient and improves the comfort level of the patient, and the mint extract has the advantages of simple medicinal components, small irritation to the skin of the patient, less side effect, high concentration of the mint extract, quick itching relieving effect and better treatment effect compared with a compound itching relieving medicament in the prior art.

In another aspect, the present invention provides a method for preparing a medicine for treating chronic urticaria, including the following steps:

s1, selecting fresh mint, cleaning, and naturally airing the surface moisture;

s2, spraying a sodium glycerophosphate solution on the surfaces of the mints after the mints are naturally dried in the step S1, naturally drying for 1-2 hours, adding a cellulase solution, and simultaneously crushing the mints;

s3, freeze-drying the crushed mint, adding an extractant for extraction, separating, filtering and concentrating to obtain an extracting solution A and mint residues;

s4, adding an abrasive and a cellulase solution into the mint residue, grinding the mint residue until the volume of the mint residue is reduced to 20-50% of the original volume, adding an ethanol water solution for extraction, filtering under reduced pressure, and concentrating the filtrate to obtain an extracting solution B;

s5, mixing the extract A and the extract B, and performing carbon dioxide supercritical extraction to obtain a mint extract;

s6, adding a solvent into the mint extract, and adjusting the ratio of the mint extract to the solvent to obtain the medicine.

In the invention, the cellulose solution is added to decompose the mint fiber, promote the rupture of the mint fiber and improve the release rate of the effective components; by freezing treatment, cell sap in mint cell tissues is promoted to freeze and enlarge the volume, and cell walls are punctured, so that the cell rupture is further improved, and the release of mint active ingredients is improved.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

1. in the invention, the mint extract and the solvent are mixed, the content of the extract is controlled to be 70-90%, the itching relieving component is single and has high concentration, the itching relieving effect on chronic urticaria is good, the irritation to the skin is small, and the medicine does not contain hormone components and can be used for a long time.

2. In the invention, when the effective components in the mint are extracted, the sodium glycerophosphate solution with a certain concentration is sprayed on the surface of the mint, so that the menthol can be prevented from being oxidized in the crushing process, the impurities in the extract can be further reduced, the content of the menthol in the extract is improved, and the purity of the menthol is improved.

3. The cellulase solution is added in the extraction process, and the cellulase decomposes the fiber in the mint, so that the cell wall of the mint is broken, the cell sap is released, the release of the effective components is improved, good conditions are provided for subsequent extraction, and the extraction rate of the effective components of the mint is improved.

4. During the extraction process, the crushed mint is frozen, the cell sap is frozen in the freezing process, the cell wall is punctured, the cell sap is promoted to be released, and the release rate of the mint active ingredients is improved by the combined action of the cell sap and cellulase in the early stage. And the mint residues are extracted for the second time, and the residual menthol in the mint residues can be extracted out under the action of the grinding agent and the cellulase solution, so that the utilization rate of mint is improved.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

The embodiment of the invention provides a medicine for treating chronic urticaria, which comprises 70-90% of mint extract and 10-30% of solvent by mass.

Menthol has excellent effect of relieving itching of chronic urticaria, and can relieve itching quickly after a patient uses the spray of the invention during acute attack, relieve discomfort of the patient to a certain extent and improve the comfort of the patient. The medicinal components of the medicinal composition are simple, the medicinal composition is sprayed on the affected skin of a patient, the irritation to the skin of the patient is small, the side effect is less, the concentration of the mint extract is high, the itching relieving effect is quick, and compared with a compound itching relieving medicament in the prior art, the medicinal composition has a better treatment effect.

In some embodiments of the invention, the mass fraction of the mint extract is 80-90%, when the concentration of the mint extract is lower than 70%, the mint extract is sprayed on affected skin, and is difficult to stimulate nerve endings of the skin to generate cold feeling and poor in itching relieving effect, and when the concentration is higher than 90%, the mint extract has high stimulation to the skin, is not beneficial to treatment in the later stage of urticaria, and also aggravates urticaria in severe cases. The concentration of the mint extract is controlled to be between 80 and 90, and the treatment effect on chronic urticaria is good.

In some embodiments of the invention, the mint extract is menthol, further l-menthol. The menthol has excellent effect of relieving itching of urticaria, is mixed with a solvent, is sprayed on the surface of skin, volatilizes the solvent, reduces the temperature of the surface of the skin, and simultaneously stimulates nerve endings of the skin to generate cold feeling, thereby playing a role in relieving itching.

In some embodiments of the invention, the solvent is water or ethanol. The ethanol is volatile and is mixed with the mint extract to be sprayed on the skin, and along with the volatilization of the ethanol, on one hand, the heat on the surface of the skin can be taken away to generate cold feeling, on the other hand, the pores of the skin are enlarged, the absorption efficiency of the menthol is improved, and then the itching relieving effect of the medicine is improved.

In another aspect, the present invention provides a method for preparing a medicine for treating chronic urticaria, including the following steps:

s1, selecting fresh mint, cleaning, and naturally airing the surface moisture;

s2, spraying a sodium glycerophosphate solution on the surfaces of the mints after the mints are naturally dried in the step S1, naturally drying for 1-2 hours, adding a cellulase solution, and simultaneously crushing the mints;

s3, freeze-drying the crushed mint, adding an extractant for extraction, separating, filtering and concentrating to obtain an extracting solution A and mint residues;

s4, adding an abrasive and a cellulase solution into the mint residue, grinding the mint residue until the volume of the mint residue is reduced to 20-50% of the original volume, adding an ethanol water solution for extraction, filtering under reduced pressure, and concentrating the filtrate to obtain an extracting solution B;

s5, mixing the extract A and the extract B, and performing carbon dioxide supercritical extraction to obtain a mint extract;

s6, adding a solvent into the mint extract, and adjusting the ratio of the mint extract to the solvent to obtain the medicine.

In the invention, the cellulose solution is added to decompose fiber and cell wall of mint, promote the rupture of mint fiber and cell, release cell sap after rupture, and further improve the release rate of effective components; and moreover, the freezing treatment is adopted to promote the cell sap in the mint cell tissues to be frozen, the volume of the frozen cell sap is increased, the cell walls are punctured, the cell rupture rate is further improved, the cell rupture quantity is increased, and the release of the mint active ingredients is improved. In the invention, the cellulase treatment is matched with the freezing treatment, so that the dosage of the extractant can be reduced, the separation difficulty of the later effective components and the extractant is reduced, and the purity of the effective components is improved.

In some embodiments of the present invention, the volume fraction of the sodium glycerophosphate solution is 0.1-1%, and the ratio of the spraying amount of the sodium glycerophosphate solution to the mass of the mint is (0.5-1): 1. selecting the raw materials with the volume fraction of 0.1-1 percent and controlling the mass ratio of (0.5-1): 1, a proper amount of sodium glycerophosphate is loaded on the surfaces of the stems and leaves of the mint, so that the menthol in the effective components can be prevented from being oxidized in the crushing and extracting processes, and the purity of the menthol is improved. When the content of the loaded sodium glycerophosphate is too large, the decomposition effect of the cellulase is affected, and when the content of the sodium glycerophosphate is too small, the antioxidation effect is poor.

In some embodiments of the invention, in the step S2, the mass fraction of the cellulase solution is 1-5%, and the mass ratio of the cellulase solution to the mint is 1: (15-20). In the invention, a proper amount of cellulase is added for decomposing mint fibers, promoting mint cell wall rupture and improving the release efficiency of cell sap.

In some embodiments of the present invention, in the step S3, the freeze-drying process includes the steps of: s31, freezing the mint at-10-0 ℃ for 2-3h, and heating to room temperature at a heating rate of 1-5 ℃/min;

s32, freezing the mint processed in the step S31 at the temperature of-20 to-10 ℃ for 2 to 3 hours, heating to 1 to 5 ℃ at the heating rate of 1 to 5 ℃/min, refrigerating for 0.5 to 1 hour, and heating to room temperature at the heating rate of 0.5 to 1 ℃/min.

In the invention, the mint cell sap is frozen through two freezing treatments, the volume of the frozen cell sap is increased, the cell wall is punctured, and the thawed cell sap is released in the subsequent temperature rise process; in the second freezing process, the cell sap is frozen at a lower freezing temperature and then heated to a temperature higher than 0 ℃, the cell wall is further broken with the increase of the temperature, and more cell sap is released.

In some embodiments of the present invention, in the step S3, the extracting step includes: adding ethanol water solution and dilute hydrochloric acid into herba Menthae, adjusting pH of the solution system to 3-4, and reflux extracting for 1-2 hr; wherein the reflux extraction temperature is 40-50 deg.C, and the volume fraction of ethanol water solution is 75%.

In the extraction process, dilute hydrochloric acid is added to adjust the pH value of the solution system, so that the solution system is acidic, and the decomposition activity of the cellulase is improved. The ethanol is used as the reflux extracting solution, so that the menthol can be effectively extracted, the decomposition and volatilization of the menthol are reduced, and the extraction efficiency and the purity are improved.

In some embodiments of the present invention, in step S4, the abrasive includes, in parts by weight, 1-5 parts talc, 10-20 parts absolute ethanol, and 10-20 parts water. The talcum powder is added into the grinding agent, and the anti-adhesion effect of the talcum powder is utilized to prevent the mint residues from being bonded together in the grinding process, so that the crushing efficiency of the mint residues is improved, and the extraction efficiency of effective components is further improved.

The features and properties of the present invention are described in further detail below with reference to examples.

Examples

As shown in Table 1, according to the proportion in Table 1, levo-menthol and absolute ethyl alcohol are mixed to obtain a uniform solution, namely the medicine for treating chronic urticaria, and the medicine is filled into a spray bottle for standby. Among them, the extract levomenthol used in examples 1 to 5 was commercially available. The extracts of examples 6-10 were prepared as follows. In table 1, ethanol is absolute ethanol.

TABLE 1 pharmaceutical compounding ratios of examples 1-10

Example 6

The mint extract was prepared according to the following procedure:

s1, selecting fresh mint leaves and mint stalks, cleaning, and naturally airing the moisture on the surface;

s2, selecting the mint naturally dried in the step S1, flatly spreading the mint in a container, spraying a sodium glycerophosphate solution with the volume fraction of 1% on the surface of the mint, naturally drying the mint for 2 hours, adding a cellulose solution with the mass fraction of 5% into the mint, and crushing the mint by using a crusher; wherein the mass ratio of the spraying amount of the sodium glycerophosphate solution to the mint is 0.5: 1;

s3, freezing the crushed mint for 3h at-5 ℃, then heating to 25 ℃ at the heating rate of 2 ℃/min, freezing for 3h at-10 ℃ after 1h, then heating to 5 ℃ at the heating rate of 2 ℃/min, refrigerating for 1h, and heating to room temperature at the heating rate of 1 ℃/min;

then adding 75% by volume of ethanol and 50% by mass of dilute hydrochloric acid, reflux-extracting at 45 + -1 deg.C for 2 hr, separating, filtering, and concentrating to obtain extractive solution A and herba Menthae residue; wherein the mass ratio of the cellulase solution to the mint is 1: 15.

s4, adding an abrasive and a cellulase solution with the mass fraction of 5% into the mint residues, grinding the mint residues until the volume of the mint residues is reduced to 50% of the original volume, adding an ethanol water solution with the volume fraction of 75% for repeatedly leaching for 3-5 times, and then filtering under reduced pressure and concentrating the filtrate to obtain an extracting solution B; wherein the mass ratio of the grinding agent to the mint residue is 0.5: 1.

S5, mixing the extract A and the extract B, and performing carbon dioxide supercritical extraction to obtain a mint extract;

s6, adding a certain amount of absolute ethyl alcohol into the mint extract, and adjusting the ratio of the mint extract to the solvent to obtain the medicine.

Example 7

The difference from example 6 is that, in this example, the ratio of the spraying amount of the sodium glycerophosphate solution in step S2 to the mass of the mint is 1: 1, the mass ratio of the cellulase solution to the mint in the step S3 is 1: 20, the mass fraction of the cellulase solution is 1 percent, and the rest steps and the mixture ratio are the same as those of the embodiment 6.

Example 8

The difference from example 6 is that in example 8, the ratio of the spraying amount of the sodium glycerophosphate solution to the mass of the mint in step S2 is 0.8: 1, the mass ratio of the cellulase solution to the mint in the step S3 is 1: 18, the mass fraction of the cellulase solution is 3%, and the rest steps and the mixture ratio are the same as those of the embodiment 6.

Example 9

The difference from example 6 is that in example 9, the freeze-drying treatment step was: freezing herba Menthae at 0 deg.C for 2h, and heating to 25 deg.C at a rate of 1 deg.C/min; and then the mint is frozen at the temperature of minus 20 ℃ for 2h, the temperature is raised to 1 ℃ at the temperature raising rate of 5 ℃/min, the mint is refrigerated for 0.5h, the temperature is raised to the room temperature at the temperature raising rate of 0.5 ℃/min, and the rest steps and the mixture ratio are the same as those of the embodiment 6.

Example 10

The difference from example 6 is that in example 10, the freeze-drying treatment step was: freezing herba Menthae at-15 deg.C for 2h, and heating to 25 deg.C at a rate of 1 deg.C/min; and then the mint is frozen at the temperature of 15 ℃ below zero for 2h, the temperature is raised to 0.5 ℃ at the temperature raising rate of 5 ℃/min, the mint is refrigerated for 1h, the temperature is raised to the room temperature at the temperature raising rate of 1 ℃/min, and the rest steps and the mixture ratio are the same as those of the embodiment 6.

The drugs prepared according to the above-described preparation methods of examples 6 to 10 are the drugs of examples 6 to 10, respectively. The composition ratios of the respective components of the polishing slurry used in examples 6 to 10 are shown in Table 2.

TABLE 2 formulation of abrasives for examples 6-10

	Example 6	Example 7	Example 8	Example 9	Example 10
						Talcum powder (g)	10	20	15	20	10
Absolute ethyl alcohol (g)	20	10	10	15	15
						Water (g)	10	20	20	15	10

Comparative example

Comparative example 1: the difference from example 1 is that the mass fraction of the extract is 60%, and the rest is the same as that of example 1.

Comparative example 2: the difference from example 1 is that levo-menthol with a purity of 98% was used directly as the drug.

Examples of the experiments

1. The content of menthol in the mint extracts of examples 6 to 10 was measured by gas chromatography, and the results are shown in Table 3.

TABLE 3 percentage of menthol and extraction rate in mint extracts of examples 6-10

	Example 6	Example 7	Example 8	Example 9	Example 10
						Menthol content (%)	98.20％	97.30％	95.40％	89.50％	92.50％
Extraction ratio (%)	3.5％	3.3％	3.3％	3.6％	3.8％

Wherein, the extraction ratio in table 3 refers to the mass ratio of menthol to mint in the extract. As can be seen from table 3, the mint extracts prepared by the preparation methods of examples 6 to 10 of the present invention have high menthol content, and the extraction rate of menthol is 70% or more, which is high. The method is characterized in that when the effective components in the mint are extracted, the sodium glycerophosphate solution with a certain concentration is sprayed on the surface of the mint, so that the menthol can be prevented from being oxidized in the crushing process, the impurities in the extract can be further reduced, the cellulose solution is added, the cell wall of the mint is broken, the cell sap is released, the release of the effective components is further improved, good conditions are provided for subsequent extraction, and the purity of the menthol is improved. And freezing the pulverized mint to promote the release of cell sap, and combining with cellulase in the previous stage to improve the release rate of the effective components of mint. And the mint residues are extracted for the second time, and the residual menthol in the mint residues can be extracted out under the action of the grinding agent and the cellulase solution, so that the utilization rate of mint is improved.

2. Clinical trial

120 patients with chronic urtica are randomly selected, and the clinical diagnosis of 120 patients shows that the skin itch and eruption appear in a hidden time, the eruption appears as small numb spots, the large numb spots are flat and hard knots and are higher than the skin, and once the skin is scratched, the eruption is connected into a sheet shape, becomes red, is scorched and is itchy.

The 120 patients were randomly divided into 12 groups, and during the period of onset of disease, the drugs of examples 1 to 10 and comparative examples 1 to 2 were sprayed, respectively, and the treatment of each patient was evaluated by the following scoring criteria, and the results are shown in Table 4.

TABLE 4 statistics of drug treatment for examples 1-10 and comparative examples 1-2

And (4) invalidation: the patient still can not relieve the pruritus after spraying the medicine for 1-2 times in the acute attack period.

And (3) relieving: the patient relieves the pruritus after spraying the medicine for 1 time in the acute attack period, but begins to itch within 10-20 min; or after 20min, the itching begins again, and the itching can not be immediately relieved after the spraying;

the method has the following advantages: during acute attack, after the medicine is sprayed for 1 time, the patient can relieve the pruritus, the pruritus does not recur within 1 hour, or the pruritus starts again after 30min, and the itching can be immediately relieved after the spraying.

As can be seen from the above Table 4, the drugs of examples 1 to 10 showed an effective number of cases of 7 or more, an effective rate of 70 or more, and a good antipruritic effect for a long period of time. Compared with comparative examples 1-2, the number of ineffective cases is large (3-4 cases), the number of effective cases is small (3-4 cases), the number of remission cases is 3-4 cases, while in examples 1-10, the number of ineffective cases is small (0-1 case), and the number of remission liquid is small, which shows that comparative examples 1-2 have a certain remission effect on pruritus caused by chronic urtica, but can relieve itching only in a short time and have a poor long-term itching-relieving effect.

By comparing the treatment effects of examples 1 to 10 and comparative examples 1 to 2, it can be shown that the antipruritic effect of the drugs of examples 1 to 10 of the present invention on chronic urticaria is excellent, when a patient with chronic urticaria has an acute attack, the application of the drug of the present invention can immediately relieve itching, and after the application of the spray of the present invention, the itching can be quickly relieved, the discomfort of the patient can be relieved to a certain extent, and the comfort of the patient can be improved. The medicinal components of the medicinal composition are simple, the medicinal composition is sprayed on the affected skin of a patient, the irritation to the skin of the patient is small, the side effect is less, the concentration of the mint extract is high, the itching relieving effect is quick, and compared with a compound itching relieving medicament in the prior art, the medicinal composition has a better treatment effect.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.