用于递送核酸的新型脂质和脂质纳米颗粒制剂
阅读说明:本技术 用于递送核酸的新型脂质和脂质纳米颗粒制剂 (Novel lipid and lipid nanoparticle formulations for delivery of nucleic acids ) 是由 史蒂文·M·安塞尔 杜新曜 于 2016-10-28 设计创作,主要内容包括:提供了具有以下结构(I)的化合物或其药物可接受的盐、互变异构体或立体异构体其中R~(1)、R~(2)、R~(3)、L~(1)、L~(2)、G~(1)、G~(2)和G~(3)如本文所定义。还提供了所述化合物作为用于递送治疗剂的脂质纳米颗粒制剂的组分的用途,包含所述化合物的组合物,及它们的使用方法和制备方法。(There is provided a compound having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof Wherein R is 1 、R 2 、R 3 、L 1 、L 2 、G 1 、G 2 And G 3 As defined herein. Also provided are uses of the compounds as components of lipid nanoparticle formulations for the delivery of therapeutic agents, compositions comprising the compounds, and methods of their use and preparation.)