阅读说明：本技术 一种降尿酸药物及其制作方法 (Uric acid reducing medicine and preparation method thereof ) 是由 蒋勇 于 2021-07-14 设计创作，主要内容包括：一种降尿酸药物,包括黄豆发酵提取物、车前子提取物和东革阿里提取物。制作方法的具体步骤为,一：将黄豆粉碎后,发酵完成后提取分离纯化,提取分离纯化后的液体减压浓缩,剩余浆状物冻干得到黄豆发酵提取物；二：将车前子粉碎,加去离子水,超声波提取分离纯化,剩余液体减压浓缩后喷雾干燥得到车前子提取物；三：将东革阿里粉碎,加去离子水,超声波提取分离纯化,剩余液体减压浓缩后喷雾干燥得到东革阿里提取物；四：车前子提取物和东革阿里提取物按照1:10比例混合,得到车前子东革阿里混合提取物；五：将黄豆发酵提取物与车前子东革阿里混合提取物按照质量比1-2：2-3的比例混合。(A medicine for reducing uric acid comprises fermented semen glycines extract, semen plantaginis extract and Eurycoma longifolia extract. The manufacturing method comprises the following specific steps: crushing soybeans, extracting, separating and purifying after fermentation is finished, concentrating the liquid after extraction, separation and purification under reduced pressure, and freeze-drying the residual pulp to obtain a soybean fermented extract; II, secondly: pulverizing semen plantaginis, adding deionized water, ultrasonic extracting, separating and purifying, concentrating the rest liquid under reduced pressure, and spray drying to obtain semen plantaginis extract; thirdly, the method comprises the following steps: crushing Eurycoma longifolia, adding deionized water, performing ultrasonic extraction, separation and purification, concentrating the residual liquid under reduced pressure, and performing spray drying to obtain Eurycoma longifolia extract; fourthly, the method comprises the following steps: mixing semen plantaginis extract and Eurycoma longifolia extract at a ratio of 1:10 to obtain semen plantaginis and Eurycoma longifolia mixed extract; fifthly: mixing a soybean fermented extract and a plantain seed eurycoma longifolia mixed extract according to a mass ratio of 1-2: 2-3.)

1. The uric acid reducing medicine is characterized in that: comprises fermented soybean extract, semen plantaginis extract and Eurycoma longifolia extract.

2. The uric acid lowering drug according to claim 1, characterized in that: wherein the ratio of semen plantaginis extract to Eurycoma longifolia extract is 1: 10.

3. The uric acid lowering drug according to claim 2, characterized in that: the mixture of the plantain seed extract and the eurycoma longifolia extract and the fermented soybean extract are mixed according to the mass ratio of 1-2: 2-3.

4. A preparation method of a medicine for reducing uric acid is characterized by comprising the following steps: the method comprises the specific steps of carrying out,

the method comprises the following steps: crushing soybeans, adding water, heating to boil and sterilize, adding bacillus subtilis, fermenting at 25 ℃, extracting, separating and purifying after fermentation, concentrating the extracted, separated and purified liquid under reduced pressure, and freeze-drying the residual pulp to obtain a soybean fermentation extract;

step two: pulverizing semen plantaginis, adding deionized water, ultrasonic extracting, separating and purifying, concentrating the rest liquid under reduced pressure, and spray drying to obtain semen plantaginis extract;

step three: crushing Eurycoma longifolia, adding deionized water, performing ultrasonic extraction, separation and purification, concentrating the residual liquid under reduced pressure, and performing spray drying to obtain Eurycoma longifolia extract;

step four: mixing the plantain seed extract obtained in the second step and the third step with the eurycoma longifolia extract according to the proportion of 1:10 to obtain a plantain seed and eurycoma longifolia mixed extract;

step five: mixing a soybean fermented extract and a plantain seed eurycoma longifolia mixed extract according to a mass ratio of 1-2: 2-3.

Technical Field

The invention relates to the technical field of medicines, in particular to a uric acid reducing medicine and a preparation method thereof.

Background

Uric acid is the terminal metabolite of human purine compounds. Disorders of purine metabolism lead to hyperuricemia. The prevalence of the disease is influenced by various factors, and is related to heredity, sex, age, life style, dietary habits, drug treatment, economic development degree and the like. Hyperuricemia is the basis of gout. Gout is a recurrent inflammatory disease caused by increased purine biosynthesis, excessive uric acid production or elevated blood uric acid due to inadequate uric acid excretion, and deposit of urate crystals in joint synovium, bursa, cartilage and other tissues. It is a group of heterogeneous diseases caused by the deposition of mono-natriuretic urate (MSU) crystals or uric acid in the extracellular fluid in a supersaturated state. The disease is characterized in that the monohydrate sodium urate crystal with double refraction can be found in synovial fluid and tophus. The clinical characteristics are as follows: hyperuricemia, characteristic acute arthritis caused by crystallization and deposition of urate, tophus and interstitial nephritis, and severe cases of joint deformity and dysfunction are often accompanied with uric acid urinary calculus.

At present, the uric acid reducing products at home and abroad mainly take western medicines as main medicines, and the main medicines for treating hyperuricemia on the market comprise: febuxostat, propanesultam, benzbromarone, allopurinol and colchicine. Wherein febuxostat and allopurinol are xanthine oxidase inhibitors, the production of uric acid in a body is reduced, so that the purpose of reducing uric acid is achieved, and the side effect is that cardiovascular and cerebrovascular diseases are caused by obvious damage to the heart and the brain; the benzbromarone has the action principle that the concentration of uric acid in blood is reduced by expanding glomeruli to excrete uric acid, has great side effect and is easy to cause uremia; the propane sultone and the colchicine are used for treating gout in the acute stage, and have obvious side effects.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides a uric acid reducing medicine which uses natural products for both food and medicine as raw materials, obtains active ingredients through operations of fermentation, extraction, separation and purification and the like, is combined in a scientific formula and has the function of reducing the concentration of blood uric acid, and a preparation method thereof, and the specific technical scheme is as follows:

a medicine for reducing uric acid comprises fermented semen glycines extract, semen plantaginis extract and Eurycoma longifolia extract.

As an optimization: wherein the ratio of semen plantaginis extract to Eurycoma longifolia extract is 1: 10.

As an optimization: the mixture of the plantain seed extract and the eurycoma longifolia extract and the fermented soybean extract are mixed according to the mass ratio of 1-2: 2-3.

From the viewpoint of traditional Chinese medicine, hyperuricemia, namely gout symptom, is damp-heat arthralgia under general conditions. Hyperuricemia has obvious damage to the kidney, liver and spleen of human viscera. The formula of the combination is as follows: the soybean extract contains nattokinase as active component, and has effects of protecting viscera and organs of human body, dissolving thrombi, and regulating metabolism balance of human body; the semen plantaginis extract has effects of clearing heat, eliminating dampness, eliminating phlegm, removing liver heat, improving eyesight, promoting diuresis and treating stranguria; the Eurycoma longifolia Jack extract has effects of invigorating kidney, strengthening body constitution, promoting diuresis, eliminating jaundice, relieving fatigue, and enhancing immunity. The combination of the natural product extracts for both food and medicine can effectively accelerate the excretion of uric acid and balance the metabolism.

A preparation method of a medicine for reducing uric acid comprises the following steps,

the method comprises the following steps: crushing soybeans, adding water, heating to boil and sterilize, adding bacillus subtilis, fermenting at 25 ℃, extracting, separating and purifying after fermentation, concentrating the extracted, separated and purified liquid under reduced pressure, and freeze-drying the residual pulp to obtain a soybean fermentation extract;

step two: pulverizing semen plantaginis, adding deionized water, ultrasonic extracting, separating and purifying, concentrating the rest liquid under reduced pressure, and spray drying to obtain semen plantaginis extract;

step three: crushing Eurycoma longifolia, adding deionized water, performing ultrasonic extraction, separation and purification, concentrating the residual liquid under reduced pressure, and performing spray drying to obtain Eurycoma longifolia extract;

step four: mixing the plantain seed extract obtained in the second step and the third step with the eurycoma longifolia extract according to the proportion of 1:10 to obtain a plantain seed and eurycoma longifolia mixed extract;

step five: mixing a soybean fermented extract and a plantain seed eurycoma longifolia mixed extract according to a mass ratio of 1-2: 2-3.

The invention has the beneficial effects that: 1. the blood uric acid concentration is quickly and safely reduced, gout is prevented, and uncomfortable symptoms in the gout attack stage are relieved; 2. protecting kidney function, and preventing uremia caused by high uric acid and reversal of uremia prophase symptoms (creatinine value < 600).

Detailed Description

Preferred embodiments of the present invention are described in detail so that the advantages and features of the present invention may be more readily understood and appreciated by those skilled in the art, thereby providing a clear and concise definition of the scope of the invention.

A medicine for reducing uric acid comprises fermented semen glycines extract, semen plantaginis extract and Eurycoma longifolia extract. The ratio of the plantain seed extract to the eurycoma longifolia extract is 1:10, and the mass ratio of the mixture of the plantain seed extract and the eurycoma longifolia extract to the fermented soybean extract is 1-2: 2-3.

The preparation method of the medicine for reducing uric acid comprises the following specific steps,

the method comprises the following steps: crushing soybeans, adding water, heating to boil and sterilize, adding bacillus subtilis, fermenting at 25 ℃, extracting, separating and purifying after fermentation, concentrating the extracted, separated and purified liquid under reduced pressure, and freeze-drying the residual pulp to obtain a soybean fermentation extract;

step two: pulverizing semen plantaginis, adding deionized water, ultrasonic extracting, separating and purifying, concentrating the rest liquid under reduced pressure, and spray drying to obtain semen plantaginis extract;

step three: crushing Eurycoma longifolia, adding deionized water, performing ultrasonic extraction, separation and purification, concentrating the residual liquid under reduced pressure, and performing spray drying to obtain Eurycoma longifolia extract;

step four: mixing the plantain seed extract obtained in the second step and the third step with the eurycoma longifolia extract according to the proportion of 1:10 to obtain a plantain seed and eurycoma longifolia mixed extract;

step five: mixing a soybean fermented extract and a plantain seed eurycoma longifolia mixed extract according to a mass ratio of 1-2: 2-3.

Case 1: the frequency of gout attack is 1 time/month, the taking of the food and medicine dual-purpose composition for one month shows that the blood uric acid is less than 330, the body feeling is comfortable, no rebound exists and the effect is satisfactory.

Case 2: yang Jie, male, 43 years old, about 720 blood uric acid, creatinine 580. After the composition is taken for 1 month, the hospital test result shows that the blood uric acid is less than 390 and the creatinine is 95. The general edema completely disappears, the mental state is good, and the easy lassitude symptom completely disappears.