阅读说明：本技术 一种具有ros响应的两亲性聚合物自组装胶束的制备方法 (Preparation method of amphiphilic polymer self-assembled micelle with ROS response ) 是由 代凤英 李新坡 胡浩东 张博 王少腾 于 2021-10-09 设计创作，主要内容包括：本发明提供了一种具有ROS响应的两亲性聚合物自组装胶束的制备方法。本发明提供的聚合物首先通过丙烯酰氯对分子量为2000的葡聚糖进行改性得到AC-Dex,再通过开环反应(ROP)制备一定分子量的聚乳酸大分子链转移剂(PLLA-CTA),并将其与AC-Dex进行可逆加成-断裂链转移聚合(RAFT)形成两亲性聚合物。该聚合物在水中可分别自组装成包载柠檬酸、维生素c、没食子酸的胶束,除具有良好的生物相容性和生物可降解性外,聚乳酸还具有良好的氧化应激敏感性,遇到H-(2)O-(2)会发生断裂,聚合物裂解后释放出柠檬酸、维生素c、没食子酸。所以该纳米载体具有很好的氧化应激响应药物释放的特性及潜在的阿尔茨海默症治疗应用前景。(The inventionProvides a preparation method of an amphiphilic polymer self-assembled micelle with ROS response. The polymer provided by the invention is prepared by modifying glucan with the molecular weight of 2000 by acryloyl chloride to obtain AC-Dex, preparing a polylactic acid macromolecular chain transfer agent (PLLA-CTA) with a certain molecular weight by a ring opening Reaction (ROP), and performing reversible addition-fragmentation chain transfer polymerization (RAFT) on the polylactic acid macromolecular chain transfer agent and the AC-Dex to form an amphiphilic polymer. The polymer can be respectively self-assembled into micelles for encapsulating citric acid, vitamin c and gallic acid in water, besides good biocompatibility and biodegradability, the polylactic acid also has good oxidative stress sensitivity, and when encountering H 2 O 2 Can be broken, and the polymer is cracked to release citric acid, vitamin c and gallic acid. Therefore, the nano-carrier has good oxidative stress response drug release characteristics and potential application prospects in Alzheimer disease treatment.)