阅读说明：本技术 一种方便显微镜下操作的微管夹持器 (Microtubule holder convenient for operation under microscope ) 是由 孙晶 汤勇 于 2021-10-20 设计创作，主要内容包括：本申请公开了一种方便显微镜下操作的微管夹持器,涉及夹持器技术领域。在能够可靠夹持微管或微丝的前提下,不仅精巧灵活,而且不会遮挡微管或微丝,从而在显微镜下能够看到微管或微丝的下端在操作界面上的所有运动轨迹,进而能够追踪微管或微丝下端的实时位置。该微管夹持器包括第一夹片、第二夹片和多个限位销；第一夹片和第二夹片相对设置；第一夹片的前端设有第一夹持部,后端设有第一连接部,顶部设有连接杆；第二夹片的前端设有第二夹持部,后端设有第二连接部；第一连接部和第二连接部均滑动连接在限位销上；第一连接部内设有第一永磁体,第二连接部内设有第二永磁体,第一永磁体和第二永磁体相互吸引。本申请用于提升微管夹持器的性能。(The application discloses make things convenient for microtube holder of operation under microscope relates to holder technical field. On the premise of reliably clamping the micro-tube or the micro-wire, the micro-tube or the micro-wire is not only exquisite and flexible, but also cannot be shielded, so that all movement tracks of the lower end of the micro-tube or the micro-wire on an operation interface can be seen under a microscope, and the real-time position of the lower end of the micro-tube or the micro-wire can be tracked. The micro-tube clamp holder comprises a first clamping piece, a second clamping piece and a plurality of limiting pins; the first clamping piece and the second clamping piece are oppositely arranged; the front end of the first clamping piece is provided with a first clamping part, the rear end of the first clamping piece is provided with a first connecting part, and the top of the first clamping piece is provided with a connecting rod; the front end of the second clamping piece is provided with a second clamping part, and the rear end of the second clamping piece is provided with a second connecting part; the first connecting part and the second connecting part are both connected to the limit pin in a sliding manner; a first permanent magnet is arranged in the first connecting portion, a second permanent magnet is arranged in the second connecting portion, and the first permanent magnet and the second permanent magnet attract each other. The micro-tube clamp is used for improving the performance of the micro-tube clamp.)

1. A microtubule holder convenient for operation under a microscope is characterized by comprising a first clamping piece, a second clamping piece and a plurality of limiting pins; the first clamping piece and the second clamping piece are arranged oppositely;

the front end of the first clamping piece is provided with a first clamping part, the rear end of the first clamping piece is provided with a first connecting part, and the top of the first clamping piece is provided with a connecting rod;

the front end of the second clamping piece is provided with a second clamping part, and the rear end of the second clamping piece is provided with a second connecting part;

the first connecting part and the second connecting part are both connected to the limit pin in a sliding mode; the first permanent magnet is arranged in the first connecting portion, the second permanent magnet is arranged in the second connecting portion, and the first permanent magnet and the second permanent magnet attract each other.

2. The microtube holder for facilitating microscopical manipulation of claim 1,

the top surfaces of the first connecting parts are respectively provided with a first mounting cavity with an upward opening, the lower part of the first permanent magnet is embedded into the first mounting cavity, and the upper part of the first permanent magnet extends out of the first mounting cavity;

the top surface of the second connecting portion is provided with a second mounting cavity with an upward opening, the lower portion of the second permanent magnet is embedded into the second mounting cavity, and the upper portion of the second permanent magnet extends out of the second mounting cavity.

3. The microtube holder for facilitating microscopical operation according to claim 1, wherein the clamping surface of the first clamping part is provided with a groove extending in a vertical direction, and the groove width of the groove is 0.8 times the diameter of the microtube or the microwire.

4. The microtube holder for facilitating microscopical manipulation of claim 1, wherein the first clamping portion has a thickness less than a thickness of the first connection portion; the thickness of the second clamping part is smaller than that of the second connecting part.

5. The microtube holder for facilitating microscopical manipulation according to claim 4, wherein the first and second holding portions are each 6mm in length, 0.4mm in thickness and 1.5mm in width.

6. The microtube holder for facilitating microscopical procedures of claim 1, wherein the clamping surface of the second clamping portion is provided with a resilient protective pad.

7. The microtube holder for facilitating microscopical procedures of claim 6, wherein the resilient protective pad is a rubber pad affixed to the second clamping portion.

8. The microtube holder according to claim 1, wherein the number of the three limiting pins is three, and the connecting line of the central points of the end faces of the three limiting pins is a regular triangle.

9. The microtube holder for facilitating microscopic procedures of claim 1, wherein the connecting rod is a cylinder having a length of 200mm and a diameter of 6 mm.

Technical Field

The application relates to the technical field of holders, in particular to a microtube holder convenient for operation under a microscope.

Background

In a fine stereotaxic apparatus (space coordinate error 100 μm) in a narrow area (the narrowest width is only 3 cm), microtubes (the diameter of the microtubes is 100 μm to 400 μm) or microwires (the diameter of the microwires is 70 μm to 400 μm) are placed, and the minimum horizontal spacing between the required microtubes or microwires is up to 1000 μm. Such operations require a high level of operator skill, and usually such fine operations are performed with the aid of a stereomicroscope and a stereotaxic apparatus and by means of a gripper. For example, referring to fig. 1, the conventional holder 01 includes a fixed clamping plate 02, a movable clamping plate 03, an adjusting screw 04, and a connecting rod 05, and although it can firmly clamp a micro-tube or a micro-wire, since it realizes a clamping function by the adjusting screw 04, it occupies a large operation interface, easily blocks a view from a microscope, and only observes the operation interface from a limited angle and a working distance, so that it is very disadvantageous to accurately positioning a three-dimensional coordinate of the micro-tube or the micro-wire under the limited interface and the operation is complicated. For example, when a plurality of 100 μm electrode microtubules are implanted into the brain of a mouse on a stereotaxic apparatus, the space occupied by the conventional holder 01 is large and significantly conflicts with the components on the stereotaxic apparatus, so that the expected positioning implantation operation cannot be completed. Meanwhile, the space occupied by the two clamping pieces is more than 2mm, so that a second micro-tube cannot be continuously placed in the vicinity of 2mm in the horizontal direction after the first micro-tube is embedded.

The operation of this kind requires fine and delicate, so there is a need for a device for holding the micro-tube or micro-wire, which is compact and flexible while being stably held, and is easy to operate, so that all the movement tracks of the lower end of the micro-tube or micro-wire on the operation interface can be seen under a microscope.

Disclosure of Invention

The embodiment of the application provides a microtube holder convenient for operation under a microscope, which is not only exquisite and flexible and convenient for operation but also can not shield the microtube or the microwire on the premise of reliably holding the microtube or the microwire, so that all movement tracks of the lower end of the microtube or the microwire on an operation interface can be seen under the microscope, and the real-time position of the lower end of the microtube or the microwire can be tracked.

In order to achieve the above object, embodiments of the present application provide a microtube holder for facilitating microscope operations, including a first clamping piece, a second clamping piece, and a plurality of limit pins; the first clamping piece and the second clamping piece are arranged oppositely; the front end of the first clamping piece is provided with a first clamping part, the rear end of the first clamping piece is provided with a first connecting part, and the top of the first clamping piece is provided with a connecting rod; the front end of the second clamping piece is provided with a second clamping part, and the rear end of the second clamping piece is provided with a second connecting part; the first connecting part and the second connecting part are both connected to the limit pin in a sliding mode; the first permanent magnet is arranged in the first connecting portion, the second permanent magnet is arranged in the second connecting portion, and the first permanent magnet and the second permanent magnet attract each other.

Furthermore, the top surfaces of the first connecting parts are respectively provided with a first mounting cavity with an upward opening, the lower part of the first permanent magnet is embedded into the first mounting cavity, and the upper part of the first permanent magnet extends out of the first mounting cavity; the top surface of the second connecting portion is provided with a second mounting cavity with an upward opening, the lower portion of the second permanent magnet is embedded into the second mounting cavity, and the upper portion of the second permanent magnet extends out of the second mounting cavity.

Furthermore, a groove extending in the vertical direction is formed in the clamping surface of the first clamping part, and the groove width of the groove is 0.8 times of the diameter of the micro-tube or the micro-wire.

Further, the thickness of the first clamping part is smaller than that of the first connecting part; the thickness of the second clamping part is smaller than that of the second connecting part.

Further, the length of first clamping part and second clamping part is 6mm, and thickness is 0.4mm, and the width is 1.5 mm.

Furthermore, an elastic protection pad is arranged on the clamping surface of the second clamping part.

Further, the elastic protection pad is a rubber pad adhered to the second clamping part.

Furthermore, the number of the limiting pins is three, and the connecting lines of the central points of the end faces of the three limiting pins are regular triangles.

Further, the connecting rod is the cylinder, the length of connecting rod is 200mm, and the diameter is 6 mm.

Compared with the prior art, the application has the following beneficial effects:

1. according to the micro-tube clamp holder, the first permanent magnet and the second permanent magnet which are mutually attracted are respectively arranged in the first clamping piece and the second clamping piece, compared with the technical scheme that the micro-tube or the micro-wire is clamped through the adjusting screw in the prior art, the micro-tube clamp holder has the advantages that the structure is simplified while reliable clamping force is provided for the micro-tube or the micro-wire, the size is reduced, all movement tracks of the lower end of the micro-tube or the micro-wire on an operation interface can be seen under a microscope, and the purpose of tracking the real-time position of the lower end of the micro-tube or the micro-wire is achieved.

2. When the micro-tube clamp holder is used for loading the micro-tube or the micro-wire, only the two clamping pieces are manually separated, the micro-tube or the micro-wire is loaded and then loosened, the micro-tube or the micro-wire can be automatically clamped by the magnetic force of the permanent magnets in the two clamping pieces, the clamping is reliable, and the operation is very convenient.

3. The micro-tube holder is small in structure, expected micro-tube or micro-wire positioning operation can be completed smoothly in a narrow area which is 30mm at the narrowest, the lower end of the micro-tube or micro-wire can be well exposed, and the real-time position of the micro-tube or micro-wire can be determined under a microscope.

4. The thickness of the clamping part of the micro-tube clamp holder is 0.4mm, and two micro-tubes or micro-wires which are adjacent to each other in the horizontal direction and have the thickness of 0.8mm can be successively positioned to be successfully completed.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a perspective view of a prior art gripper;

FIG. 2 is a schematic perspective view of a microtube holder for facilitating microscopic manipulation according to an embodiment of the present application;

FIG. 3 is an exploded view of a microtube holder for facilitating microscopic manipulation according to an embodiment of the present application.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

In the description of the present application, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the referred device or element must have a particular orientation, be constructed in a particular orientation, and be operated, and thus should not be construed as limiting the present application.

In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; the specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.

The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless otherwise specified.

Embodiments of the present application provide a microtube holder that facilitates operation under a microscope. The micro-tube holder is compact and small, the length, the width and the height of the occupied interface space are only 20mm multiplied by 8mm multiplied by 5mm, and the expected micro-tube or micro-wire positioning operation can be completed smoothly in the narrow area of 30mm at the narrowest.

Referring to fig. 2 and 3, the microtube holder for facilitating the operation under a microscope in the embodiment of the present application comprises a first clamping piece 1, a second clamping piece 2 and a plurality of limiting pins 3. Wherein, the first clamping piece 1 and the second clamping piece 2 are arranged oppositely. The front end of the first clamping piece 1 is provided with a first clamping part 11, the rear end is provided with a first connecting part 12, and the top is provided with a connecting rod 4 for connecting a stereotaxic instrument. The second clip 2 has a second clamping portion 21 at the front end and a second connecting portion 22 at the rear end. The first connecting portion 12 and the second connecting portion 22 are slidably connected to the stopper pin 3. A first permanent magnet 13 is arranged in the first connecting part 12, a second permanent magnet 23 is arranged in the second connecting part 22, and the first permanent magnet 13 and the second permanent magnet 23 attract each other. The magnetic force between the first permanent magnet 13 and the second permanent magnet 23 can clamp the micro-tube or the micro-wire, and the first clamping piece 1 and the second clamping piece 2 can be separated manually.

Therefore, as the first permanent magnet 13 and the second permanent magnet 23 which attract each other are respectively arranged in the first clamping piece 1 and the second clamping piece 2, compared with the technical scheme of clamping the micro-tube or the micro-wire through the adjusting screw in the prior art, the micro-tube holder in the embodiment of the application has the advantages that the structure is simplified while the reliable clamping force is provided for the micro-tube or the micro-wire, the volume is reduced, the micro-tube or the micro-wire is not shielded, all movement tracks of the lower end of the micro-tube or the micro-wire on the operation interface can be seen under a microscope, and the purpose of tracking the real-time position of the lower end of the micro-tube or the micro-wire is further realized.

Meanwhile, when the micro-tube or the micro-wire is loaded into the micro-tube or the micro-wire clamp holder in the embodiment of the application, only the two clamping pieces are manually separated, the micro-tube or the micro-wire is loaded and then loosened, the micro-tube or the micro-wire can be automatically clamped by the magnetic force of the permanent magnets in the two clamping pieces, the clamping is reliable, and the operation is very convenient.

Referring to fig. 2, in some embodiments, the top surfaces of the first connecting portions 12 are each provided with a first mounting cavity 14 with an upward opening, the lower portion of the first permanent magnet 13 is embedded in the first mounting cavity 14, and the upper portion of the first permanent magnet 13 extends out of the first mounting cavity 14. The top surface of the second connecting portion 22 is provided with a second mounting cavity 24 with an upward opening, the lower portion of the second permanent magnet 23 is embedded into the second mounting cavity 24, and the upper portion of the second permanent magnet 23 extends out of the second mounting cavity 24. Thereby, the first permanent magnet 13 and the second permanent magnet 23 are easily attached and detached.

With continued reference to fig. 2 and 3, in some embodiments, the stop pins 3 are cylindrical pins, and the number of the stop pins 3 is three, and the connecting lines of the center points of the end surfaces of the three stop pins 3 are regular triangles. Thereby, the first clip piece 1 and the second clip piece 2 are firmly hung in a three-point surface-forming manner. It should be noted that the number of the limit pins 3 may also be two or four, and is not limited herein.

With continued reference to fig. 3, in order to ensure a fixed vertical direction for preventing the micro-tube or the micro-wire from being damaged when the micro-tube or the micro-wire is clamped, in some embodiments, the clamping surface of the first clamping portion 11 is provided with a groove 25 extending in the vertical direction, the groove width of the groove 25 is 0.8 times the diameter of the micro-tube or the micro-wire, and the clamping surface of the second clamping portion 21 is provided with an elastic protection pad 5. Specifically, the elastic protection pad 5 is a rubber pad adhered or bound to the second clamping portion 21. Therefore, the micro-tube or the micro-wire can be ensured to have a definite direction when being clamped, and the micro-tube or the micro-wire can be prevented from being damaged due to too large clamping force.

In some embodiments, the connecting rod 4 is a cylinder made of stainless steel, and the length of the connecting rod 4 is 200mm and the diameter is 6 mm. Therefore, the space is saved and the connection with the stereotaxic instrument is reliable.

Referring to fig. 2 and 3, in order to make the first clip piece 1 and the second clip piece 2 as small as possible while ensuring a sufficient clamping force, in some embodiments, the length × width × height of the first clip piece 1 is 20mm × 5mm × 4mm, and the second clip piece 2 has the same size as the first clip piece 1. The first clamping piece 1 and the second clamping piece 2 are both single-piece clamping mouths, that is, the thickness of the first clamping portion 11 is smaller than that of the first connecting portion 12, and the thickness of the second clamping portion 21 is smaller than that of the second connecting portion 22. Specifically, the length of each of the first clamping portion 11 and the second clamping portion 21 is 6mm, the thickness thereof is 0.4mm, and the width thereof is 1.5 mm. Therefore, on the premise of reliably clamping the microtubes or the microwires, the microtubes or the microwires adjacent to each other in the horizontal direction can be successively and successfully positioned in daily work, the lower ends of the microtubes or the microwires can be well exposed, and the real-time position can be determined under a microscope.

The above is only an embodiment of the present application, but the scope of the present application is not limited thereto, and any changes or substitutions within the technical scope of the present disclosure should be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.