阅读说明：本技术 一种用于婴幼儿鹅口疮的药物组合物及其应用 (Medicine composition for infantile thrush and application thereof ) 是由 贾炳晖 于 2019-12-04 设计创作，主要内容包括：本发明涉及一组药物组合滴剂,具体涉及一种治疗婴幼儿鹅口疮的口腔外用滴剂及制备方法。本发明由氟康唑、5%碳酸氢钠注射液、鱼肝油、葡糖糖酸锌口服液按照一定的组分配制而成。本发明组合物中的碳酸氢钠使口腔保持碱性环境,有助于抑制口腔白色念珠菌的正长,提高氟康唑的药效；组合物中的鱼肝油易粘附在口腔黏膜上,使氟康唑在口腔保持持久的疗效；组合物中的葡糖糖酸锌口服液有利于口腔黏膜的修复,改善药物不良口感的问题。本发明解决了患儿家长因分割药物不精确、调配药物过程中浪费药物、涂抹药物困难、患儿依从性差等问题。本发明具有极大的商业开发前景。(The invention relates to a group of medicinal combined drops, in particular to an oral externally-applied drop for treating infantile thrush and a preparation method thereof. The invention is prepared from fluconazole, 5 percent sodium bicarbonate injection, cod liver oil and zinc gluconate oral liquid according to a certain component. The sodium bicarbonate in the composition keeps the alkaline environment of the oral cavity, is beneficial to inhibiting the growth of candida albicans in the oral cavity and improving the drug effect of the fluconazole; the cod liver oil in the composition is easy to adhere to the oral mucosa, so that the fluconazole can keep a lasting curative effect in the oral cavity; the zinc gluconate oral liquid in the composition is beneficial to the repair of oral mucosa and solves the problem of poor taste of the medicament. The invention solves the problems that parents of children patients do not accurately cut medicines, the medicines are wasted in the process of preparing the medicines, the medicines are difficult to coat, the compliance of the children patients is poor and the like. The invention has great commercial development prospect.)

1. A pharmaceutical composition oral external drop for treating infantile thrush is characterized by being prepared from 100mg of fluconazole, 5ml of 5% sodium bicarbonate injection, 2ml of cod liver oil and 3ml of zinc gluconate oral liquid according to the weight ratio.

2. The use of the oral external drop for treating thrush of an infant as claimed in claim 1, wherein 2 to 3 drops are orally administered each time, 3 to 5 times a day, and 7 to 10 days are a treatment course.

Technical Field

The invention relates to a group of medicinal composition drops, in particular to an oral externally-applied drop for treating thrush of infants.

Background

Thrush is commonly known as acute pseudomembranous type candida stomatitis, is also called as a snowdrop disease, is an acute or subacute mycosis caused by candida albicans infection and can appear on any part of oral mucosa. It is common to newborn infants, malnutrition, hypoimmunity, chronic diarrhea, and infants who have long-term use of broad-spectrum antibiotics or hormones. Mainly characterized in that the mucous membrane of the oral cavity has milky velvet membrane which is not easy to peel off and wipes off the white membrane, and the bottom layer is a red wound surface which is accompanied with pain and taste decline. Thrush can be transmitted contactlessly by hands, milk, nipples, toys, maternal secretions, and the like. The infant suffers from crying, refusal to eat, dysphoria and even low fever. In severe cases, fungal infection of the lower respiratory tract and the digestive tract and even fungal septicemia can be caused, and the patients have life worry.

At present, the main therapeutic drugs for thrush include nystatin, fluconazole, sodium bicarbonate and the like. The nystatin belongs to polyene antifungal drugs, has broad-spectrum antifungal effect, but is not absorbed by skin mucosa, has extremely low blood concentration after oral administration, is clinically limited to local application and has undesirable curative effect. Fluconazole is a medicament for treating fungal infection, is a broad-spectrum antifungal medicament, has a treatment effect on fungal infection of human and animals, is one of common medicaments for treating thrush at present, and has the advantages of quick response and obvious effect. The sodium bicarbonate is a medicine for adjuvant therapy of thrush, destroys the living environment of fungi and inhibits the growth of the fungi by adjusting the pH environment of the oral cavity, but cannot be used for a long time and is not beneficial to the establishment of normal flora of the oral cavity of the infant.

At present, no preparation special for infant thrush is clinically used, and the recurrent thrush is converted into chronic recurrent thrush due to the factors of inaccurate medicine segmentation, difficult control of dosage, improper oral cavity smearing and medication method, non-standard medication course, rejection of the infant and the like in treatment.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition suitable for treating infantile thrush, namely oral drops, which can remarkably improve the treatment effect of infantile thrush by selecting proper components and proportion and is safe and free from toxic and side effects. In order to achieve the purpose, the invention adopts the following technical scheme: a medicinal composition oral external drop for treating thrush of infants is characterized by being prepared from the following components in parts by weight: 100mg of fluconazole, 5ml of 5% sodium bicarbonate injection, 2ml of cod liver oil and 3ml of zinc gluconate oral liquid.

The innovation of the invention is that the sodium bicarbonate in the composition keeps the alkaline environment of the oral cavity, is beneficial to inhibiting the growth of candida albicans in the oral cavity and improving the drug effect of fluconazole; the cod liver oil in the composition is easy to adhere to oral mucosa to maintain lasting curative effect; the zinc gluconate oral liquid in the composition is beneficial to the repair of oral mucosa and can also improve the problem of poor mouthfeel. The invention has the advantages of simple use, long action time, quick effect and high bioavailability, can be pasted on the affected part for a long time, solves the problems of unprofessional medicine division, medicine waste in the medicine preparation process, difficult medicine application and the like of children family members, is better applied to the pediatric clinical medicinal preparation, and has great commercial development prospect in the development of drops.

Example 1.

The fluconazole aqueous solution is prepared by the following components in parts by weight, 100mg of fluconazole is crushed, 100 meshes of the fluconazole are sieved, 5ml of 5% sodium bicarbonate injection is added, the mixture is shaken and stirred evenly, 2ml of cod liver oil and 3ml of zinc gluconate oral liquid are added, the mixture is shaken and stirred evenly, and the mixture is filled into a 10ml PE light-shading bottle and stored at low temperature.

The beneficial effects of the invention are illustrated below in combination with clinical experimental data:

92 patients with thrush of infants are treated clinically, and the oral externally-applied drop prepared according to the example 1 is used for 3 times a day, 3 to 5 drops at a time and is continuously used for 5 to 7 days.

And (3) evaluating the curative effect:

and (3) curing: the symptoms of white spots and red wound surfaces in the oral cavity disappear;

the effect is shown: the symptoms of leukoplakia and red wound surfaces in the oral cavity are relieved but not completely disappeared;

and (4) invalidation: the symptoms of leukoplakia and red wound surface in the oral cavity are not disappeared and are not obviously changed.

The treatment results are as follows: 89 cases are cured, 3 cases are obviously effective, 0 case is ineffective, the effective rate reaches 99.9 percent, and the follow-up visit is carried out after 3 months without relapse.

It should be understood that the above-described examples of the present invention are illustrative for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. Not all embodiments are exhaustive. All obvious changes and modifications which are obvious to the technical scheme of the invention are covered by the protection scope of the invention.