阅读说明：本技术 一种制备3-羟甲基环戊醇的方法 (Method for preparing 3-hydroxymethyl cyclopentanol ) 是由 李宁 佟国宾 李广亿 王爱琴 王晓东 丛昱 张涛 于 2019-11-19 设计创作，主要内容包括：本发明提供一种制备3-羟甲基环戊醇的方法。该反应体系以水作为溶剂,催化剂采用廉价金属型催化剂,在一定反应温度和氢气压力下实现一步法高收率获得3-羟甲基环戊醇产物。本发明具有反应效率高,产物收率高,催化剂廉价易得且可以多次循环使用等特点,提供了一种从生物质平台化合物出发制备3-羟甲基环戊醇的有效途径。(The invention provides a method for preparing 3-hydroxymethyl cyclopentanol. The reaction system takes water as a solvent, adopts a cheap metal catalyst, and realizes a one-step method to obtain a 3-hydroxymethyl cyclopentanol product with high yield under a certain reaction temperature and hydrogen pressure. The method has the characteristics of high reaction efficiency, high product yield, cheap and easily-obtained catalyst, capability of being recycled for multiple times and the like, and provides an effective way for preparing the 3-hydroxymethyl cyclopentanol from a biomass platform compound.)

1. A method for preparing 3-hydroxymethyl cyclopentanol is characterized in that: converting 5-hydroxymethylfurfural serving as a raw material into 3-hydroxymethylcyclopentanol by using a cheap metal catalyst and water as a solvent in the presence of hydrogen;

the cheap metal catalyst is an A/X supported catalyst and comprises an active metal A and a carrier X, wherein the active metal A is loaded on the carrier, and the carrier X is SiO₂、TiO₂、ZnO、Al₂O₃And MgO, and the active metal A is at least one of Fe, Co, Ni, Cu and Zn.

2. The method of claim 1, wherein: the preparation method of the A/X type supported catalyst comprises the following steps: dissolving metal precursor salt in water, stirring, adding sodium carbonate solution to adjust the pH value to 7-10, aging at 50-90 ℃ for 15h, then carrying out suction filtration, washing to neutrality, drying, grinding, calcining at 300-700 ℃ for 1-12 h, cooling, and then reducing at 500 ℃ for 1-12 h in hydrogen atmosphere.

3. The method of claim 2, wherein: the mass loading of the active metal A in the cheap metal A/X type catalyst is 1-60%.

4. The method of claim 2, wherein the metal precursor salt is at least one of a nitrate, sulfate, carbonate, oxalate, chloride salt of the corresponding metal.

5. The method of claim 1, wherein: the mass concentration of the raw material 5-hydroxymethylfurfural in water is 0.1-10%.

6. The method of claim 1, wherein: the mass ratio of the A/X supported catalyst to the raw material 5-hydroxymethylfurfural is 1:500-1: 5.

7. The method of claim 1, wherein: the reaction is carried out in an intermittent closed high-pressure reaction kettle, and the reaction temperature is 120-220 ℃; the reaction time is 0.5h-24 h; the hydrogen pressure is 1MPa-9 MPa.

Technical Field

The invention belongs to the field of fine chemical synthesis, and particularly relates to a method for preparing 3-hydroxymethyl cyclopentanol.

Background

Environmental energy problems caused by the continuous consumption of fossil resources promote the development of the sustainable biomass resources to produce fuels and value-added chemicals worldwide. Lignocellulose is the most abundant organic carbon source and renewable resource in nature, and is an indispensable raw material in the biorefinery process. Furfural and 5-hydroxymethylfurfural can be obtained through acid-catalyzed hydrolysis and dehydration, and both furan derivatives are considered to be biomass-based platform compounds with good prospects.

The development and utilization of the downstream products of the 5-hydroxymethylfurfural can effectively reduce the dependence of some important chemicals on petroleum resources. 3-hydroxymethyl cyclopentanol as one of the downstream products of 5-hydroxymethyl furfural is a high value-added chemical, and can be used for preparing spices, medicaments and polymers, such as methyl jasmonate, carbocyclic nucleoside and the like. 5-hydroxymethylfurfural is the product of acid-catalyzed dehydration of hexoses in the aqueous phase. The process of separating 5-hydroxymethylfurfural from the resulting aqueous solution increases the production cost thereof, while the direct use of the aqueous solution of 5-hydroxymethylfurfural as a raw material for the preparation of 3-hydroxymethylcyclopentanol significantly reduces the production cost.

The preparation of 3-hydroxymethylcyclopentanol by hydrogenation rearrangement in aqueous phase of 5-hydroxymethylfurfural has been reported at present, [ Catal. Sci.Technol.,2017,7, 2947-]In which Pt/SiO is used₂The catalyst system is co-catalyzed with lanthanide metal oxide, so that the yield of the 3-hydroxymethyl cyclopentanol reaches 88 percent. The reaction system uses a noble metal catalyst to increase the reaction cost, and the catalyst system is complex, the concentration of reactants is low, the reaction time is long, and the large-scale industrial production is not facilitated. [ Green chem.,2017,19, 1701-1713-]Dissolving 0.23g of 5-hydroxymethylfurfural in 45ml of water, and adding 0.02g of Co-Al₂O₃The catalyst is reacted for 48 hours in a kettle type stirring reactor under the conditions of 180 ℃ and 20bar to obtain the yield of the 3-hydroxymethyl cyclopentanol with 94 percent. The methodThe method has the advantages of low reactant concentration, long reaction time, direct inactivation of the catalyst after one-time use, incapability of recycling and reduction of economic benefit.

Therefore, the industrialized cheap metal catalyst is developed, the process method for preparing the 3-hydroxymethyl cyclopentanol by selectively hydrogenating and rearranging the 5-hydroxymethyl furfural is realized with high efficiency and high yield, the catalyst can be recycled, the production cost of the 3-hydroxymethyl cyclopentanol can be obviously reduced, and the industrial application prospect is good.

Disclosure of Invention

The invention aims to provide a method for preparing 3-hydroxymethyl cyclopentanol. In particular to a method for preparing 3-hydroxymethyl cyclopentanol with high yield in one step by taking a lignocellulose platform compound 5-hydroxymethyl furfural as a raw material and adopting a supported cheap metal catalyst in a water phase, wherein the catalyst can still be recycled for multiple times after being recovered, washed and dried

The invention is realized by the following technical scheme:

a method for preparing 3-hydroxymethyl cyclopentanol uses cheap metal catalyst, uses water as solvent, and converts 5-hydroxymethyl furfural into 3-hydroxymethyl cyclopentanol directly and selectively in one step in a kettle type reactor;

the cheap metal catalyst is an A/X supported catalyst and comprises an active metal A and a carrier X which are supported on a carrier, wherein the carrier X is SiO₂、TiO₂、ZnO、Al₂O₃And MgO, and the active metal A is at least one of Fe, Co, Ni, Cu and Zn.

Based on the technical scheme, preferably, the preparation method of the cheap metal A/X type catalyst comprises the following steps: dissolving a certain amount of metal precursor salt (precursor salt of active metal A and precursor salt of carrier X) used by the catalyst in a certain amount of water, stirring, adding a sodium carbonate solution to adjust the pH value to a certain range, aging at a certain temperature for 15h, then carrying out suction filtration and washing to neutrality, drying, grinding, calcining at a certain temperature, cooling, introducing hydrogen, and reducing at about 500 ℃ for 1-12 h;

the pH value is 7-10;

the aging temperature is 50-90 ℃;

the calcination temperature is 300-700 ℃, and the calcination time is 1-12 h.

Based on the technical scheme, the mass loading of the active metal A in the cheap metal A/X type catalyst is preferably 1-60%.

Based on the above technical scheme, preferably, the metal precursor salt is at least one of nitrate, sulfate, carbonate, oxalate and chloride of the corresponding metal.

Based on the technical scheme, preferably, the mass concentration of the raw material 5-hydroxymethylfurfural in water is 0.1-10%.

Based on the technical scheme, the preferred mass ratio of the A/X type catalyst to the raw material 5-hydroxymethylfurfural is 1:500-1: 5.

Based on the technical scheme, the reaction is preferably carried out in an intermittent closed high-pressure reaction kettle, the reaction temperature is 120-220 ℃, the hydrogen pressure is 1-9 MPa, and the reaction time is 0.5-24 h.

The cheap metal catalyst recovered after the reaction is washed for 3 to 8 times by one or two or more of acetone, methanol, ethanol, water, dichloromethane or cyclohexane, and then dried in an oven at the temperature of between 40 and 100 ℃ for 8 to 24 hours for recycling.

Advantageous effects

The method utilizes a cheap metal catalyst to catalyze and convert 5-hydroxymethylfurfural to prepare 3-hydroxymethylcyclopentanol, wherein the cheap metal catalyst has proper weak acidity, is beneficial to rearrangement of an intermediate product and further obtains a target product; meanwhile, the cheap metal catalyst is simple and easy to prepare, and has the advantages of high specific surface area, high surface active metal content, good active metal dispersibility and the like, so that the high catalytic performance, high heat resistance and high cycle stability of the catalyst are ensured, and the catalyst has a good industrial application prospect.

Detailed Description

The following further details the practice of the invention:

<1> general preparation of catalyst for the synthesis of 3-hydroxymethylcyclopentanol as follows:

dissolving a certain amount of metal precursor salt used by the catalyst in a certain amount of water, stirring, adding a sodium carbonate solution to adjust the pH value to 7-10, aging at 50-90 ℃ for 15h, then performing suction filtration and washing to neutrality, drying, grinding, calcining at 300-700 ℃, cooling, introducing hydrogen, and reducing at about 500 ℃.

<2> evaluation of reaction for preparing 3-hydroxymethylcyclopentanol by catalytic conversion of 5-hydroxymethylfurfural

The method comprises the steps of putting a 5-hydroxymethylfurfural raw material into a high-pressure intermittent stirring reaction kettle with a proper volume, pouring water, stirring and dissolving, adding a certain amount of supported catalyst, and sealing the reaction kettle. Filling nitrogen with the pressure of about 1MPa to replace air in the kettle for more than 3 times, then filling hydrogen with the pressure of about 1MPa to replace the nitrogen in the kettle for more than 3 times, carrying out hydrogenation rearrangement reaction on 5-hydroxymethylfurfural in a water phase at a certain hydrogen pressure and a certain reaction temperature, stirring at the rotating speed of 600-800 rpm, stopping the reaction after reacting for a certain time, cooling to room temperature, separating the catalyst from the obtained liquid mixture, drying the catalyst for reuse, detecting and analyzing the liquid mixture by using high performance liquid chromatography, and analyzing the conversion rate of raw materials and the yield of target products by using an external standard method.

The present invention will be further described with reference to examples, but it is not limited to any one of these examples or the like.

Preparation of cheap metal catalyst:

example 1

10％Co-ZnO-Al₂O₃The preparation of (1):

1.46g of Co (NO)₃)₂·6H₂O、5.95g Zn(NO₃)₂·6H₂O、9.38g Al(NO₃)₃·9H₂Dissolving O in 150ml water, stirring, and dropwise adding Na₂CO₃Adjusting pH of the mixed solution to 7, aging at 80 deg.C for 15 hr, cooling the obtained mixture to room temperature, vacuum filtering, washing with a large amount of water to neutrality, drying in 105 deg.C oven for 30 hr, grinding, and calcining in muffle furnace at 500 deg.C for 6 hrThen, the mixture is reduced for 3 hours in a tube furnace at 500 ℃ and passivated for standby.

Example 2

10％Ni-ZnO-Al₂O₃The preparation of (1):

the procedure was similar to example 1 except that 1.46g of Co (NO) from example 1 was used₃)₂·6H₂Changing O to 1.45g Ni (NO)₃)₂·6H₂O, other steps are the same as example 1, and 10% Ni-ZnO-Al is obtained₂O₃。

Example 3

10％Cu-ZnO-Al₂O₃The preparation of (1):

the procedure was similar to example 1 except that 1.46g of Co (NO) from example 1 was used₃)₂·6H₂Changing O to 1.21g Cu (NO)₃)₂·3H₂O, other steps are the same as example 1, and 10% Cu-ZnO-Al is prepared₂O₃。

Example 4

10％Ni-TiO₂-Al₂O₃The preparation of (1):

the procedure is analogous to example 2, except that 5.95g of Zn (NO) from example 2 are used₃)₂·6H₂Changing O to 3.79g TiCl₄Other steps are the same as example 2, and 10% Ni-TiO is prepared₂-Al₂O₃。

Example 5

10％Ni-SiO₂-Al₂O₃The preparation of (1):

the procedure is analogous to example 2, except that 5.95g of Zn (NO) from example 2 are used₃)₂·6H₂Changing O to 5.68g Na₂SiO₃·9H₂O, other steps are the same as example 2, and 10% Ni-SiO is prepared₂-Al₂O₃。

Example 6

10％Ni-MgO-Al₂O₃The preparation of (1):

the procedure is analogous to example 2, except that 5.95g of Zn (NO) from example 2 are used₃)₂·6H₂O was changed to 2.41g MgSO₄Other steps are the same as example 2, and 10% Ni-MgO-Al is prepared₂O₃。

Example 7

60％Ni-ZnO-Al₂O₃The preparation of (1):

the procedure is similar to example 2, except that Ni (NO) in example 2 is used₃)₂·6H₂The mass of O was changed from 1.45g to 21.46g, and the other steps were carried out in the same manner as in example 2 to prepare 60% Ni-ZnO-Al₂O₃。

Example 8

50％Ni-ZnO-Al₂O₃The preparation of (1):

the procedure is similar to example 2, except that Ni (NO) in example 2 is used₃)₂·6H₂The mass of O was changed from 1.45g to 14.38g, and the other steps were the same as in example 2 to prepare 50% Ni-ZnO-Al₂O₃。

Example 9

30％Ni-ZnO-Al₂O₃The preparation of (1):

the procedure is similar to example 2, except that Ni (NO) in example 2 is used₃)₂·6H₂The mass of O was changed from 1.45g to 6.16g, and other steps were carried out in the same manner as in example 2 to prepare 30% Ni-ZnO-Al₂O₃。

Example 10

1％Ni-ZnO-Al₂O₃The preparation of (1):

the procedure is similar to example 2, except that Ni (NO) in example 2 is used₃)₂·6H₂The mass of O was changed from 1.45g to 0.15g, and the other steps were carried out in the same manner as in example 2 to prepare 1% Ni-ZnO-Al₂O₃。

Preparation of 3-hydroxymethylcyclopentanol:

example 11

1.0g of raw material 5-hydroxymethylfurfural is dissolved in 50ml of water, then 100mg of cheap metal catalyst is added, 4MPa of hydrogen is filled into a 100ml closed high-pressure reaction kettle, and the reaction is carried out for 4 hours by heating and stirring at 160 ℃.

TABLE 1 Effect of different catalysts on feedstock conversion and yield of target product

As can be seen from table 1, catalysts with different contents, different carriers and different metal loadings all have excellent catalytic activity for the reaction, wherein the activity with Ni is the best among all the supported active metals; in all carriers, with ZnO-Al₂O₃The activity is best; the highest yield of 3-hydroxymethylcyclopentanol was obtained when the Ni loading was 60%.

Example 12

Dissolving 1.0g of 5-hydroxymethylfurfural in 50ml of water, and adding 100mg of 60% Ni-ZnO-Al prepared under different conditions₂O₃The supported catalyst is prepared through charging hydrogen in 4MPa into 100ml sealed high pressure reactor, heating and stirring at 160 deg.c for 4 hr. Changing 60% of Ni-ZnO-Al₂O₃The pH value, aging temperature and calcining temperature in the catalyst preparation process obtain different performance data, and the result chart 2

TABLE 260% Ni-ZnO-Al₂O₃Influence of catalyst preparation method on raw material conversion rate and yield of target product

As can be seen from Table 2, Ni-ZnO-Al was prepared at different pH values, different aging temperatures and different calcination temperatures₂O₃All have catalytic activity to the reaction, and obtain 3-hydroxymethyl cyclopentanol with a certain yield. Wherein the pH has less effect on the reaction, the product yield is relatively low at pH 7, when pH is high>The product yield was higher at 7, but there was no significant effect. When the catalyst is aged at a temperature ofThe best yield of 3-hydroxymethyl cyclopentanol is 76.5% when the temperature is 80 ℃ and the calcining temperature is 600 ℃.

Example 13

A certain mass of 5-hydroxymethylfurfural was dissolved in 50ml of water, and 0.1g of 60% Ni-ZnO-Al prepared in example 7 was added₂O₃The catalyst is prepared by charging hydrogen gas with a certain pressure into a 100ml closed high-pressure reaction kettle, and heating and stirring the mixture at a certain reaction temperature for reaction for a certain hour. The conditions of the reaction were varied, specifically as shown in Table 3, and the results are shown in Table 2,

TABLE 3 Effect of different reaction conditions on the conversion of starting materials and yield of the desired product

As can be seen from Table 3, different reaction temperatures, different hydrogen pressures, different reaction times and different catalyst loadings all have catalytic activity for the reaction, and the conversion of the raw material reaches 100%. When the temperature is lower than 140 ℃, although the conversion rate of the raw material reaches 100%, the yield of the target product is low, and the reaction stays in the process of the intermediate product. When the temperature is increased, the yield of the 3-hydroxymethyl cyclopentanol is gradually increased, which shows that the temperature has a great influence on the yield of the target product. When the hydrogen pressure is 5MPa, the higher yield of the 3-hydroxymethyl cyclopentanol is 85.9 percent, and when the hydrogen pressure is continuously increased, the product yield is gradually reduced, which indicates that byproducts are generated. The reaction time also has certain influence on the product yield, and the yield of the 3-hydroxymethyl cyclopentanol is up to 92.7 percent when the reaction time is 24 hours. The mass concentration of the raw material also has certain influence on the yield of the target product, when the mass concentration of the raw material reaches 0.6 percent, the yield of the 3-hydroxymethyl cyclopentanol is as high as 94.4 percent, even if the mass concentration of the raw material is improved to 5 percent, the yield of the 3-hydroxymethyl cyclopentanol is also as high as 87.0 percent.

Example 14

1.0g of 5-hydroxymethylfurfural was dissolved in 50ml of water and a certain amount of 60% Ni-ZnO-Al prepared in example 7 was added₂O₃Catalyst, reaction under 100ml of closed high pressure5MPa of hydrogen is filled into the reactor, and the reaction is carried out for 12 hours by heating and stirring at 180 ℃. The catalyst recovered after the reaction was washed three times with acetone, dried in an oven at 60 ℃ for 12h, and then recycled under the same reaction conditions, and the specific cycle number and the corresponding conversion rate and yield are shown in table 4.

TABLE 460% Ni-ZnO-Al₂O₃Influence of catalyst recycling times on raw material conversion rate and target product yield

As can be seen from Table 4, Ni-ZnO-Al₂O₃The yield of the 3-hydroxymethyl cyclopentanol is not obviously reduced and can still reach more than 90 percent after the catalyst is recycled for four times, which shows that the catalyst has good stability in the reaction and lays a solid foundation for future large-scale production.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or modifications of the invention described in the foregoing embodiments, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made without departing from the spirit and principle of the present invention shall fall within the protection scope of the present invention.