阅读说明：本技术 一种具有可预防口臭功能的岩藻多糖含片及其制备方法 (Fucoidin buccal tablet with function of preventing halitosis and preparation method thereof ) 是由 于大洋 于 2019-11-15 设计创作，主要内容包括：本发明公开了一种具有可预防口臭功能的岩藻多糖含片,包括以下重量份的原料：巨藻5～15份、蒸馏水50～75份、乙醇水溶液15～45份、薄荷20～40份、佩兰20～40份、金银花20～40份、甘草20～40份、蔗糖15～30份、葡萄糖15～30份、淀粉50～75份。本发明配方科学,配比严谨,所得岩藻多糖含片不仅具有神经传导、免疫调节、抑制癌症之生长及转移、呼吸道感染之预防与治疗、胶原蛋白之调节,且能够有效的杀死肠胃内部的幽门螺杆菌,治疗患者口臭,同时能够保证服用者口气清新,具有降火清毒功效,适宜推广。(The invention discloses a fucoidin buccal tablet with a function of preventing halitosis, which comprises the following raw materials in parts by weight: 5-15 parts of kelp, 50-75 parts of distilled water, 15-45 parts of ethanol aqueous solution, 20-40 parts of mint, 20-40 parts of eupatorium, 20-40 parts of honeysuckle, 20-40 parts of liquorice, 15-30 parts of cane sugar, 15-30 parts of glucose and 50-75 parts of starch. The fucoidin buccal tablet has scientific formula and strict proportioning, not only has nerve conduction, immunoregulation, inhibition of cancer growth and metastasis, prevention and treatment of respiratory tract infection and regulation of collagen, but also can effectively kill helicobacter pylori in intestines and stomach and treat halitosis of patients, can ensure fresh breath of users, has the efficacy of reducing pathogenic fire and clearing away toxic materials, and is suitable for popularization.)

1. A fucoidin buccal tablet with function of preventing halitosis is characterized by comprising the following raw materials in parts by weight: 5-15 parts of kelp, 50-75 parts of distilled water, 15-45 parts of ethanol aqueous solution, 20-40 parts of mint, 20-40 parts of eupatorium, 20-40 parts of honeysuckle, 20-40 parts of liquorice, 15-30 parts of cane sugar, 15-30 parts of glucose and 50-75 parts of starch.

2. The fucoidin buccal tablet with the function of preventing halitosis according to claim 1, is characterized by comprising the following raw materials in parts by weight: 8-12 parts of kelp, 57-68 parts of distilled water, 25-35 parts of an ethanol water solution, 25-35 parts of mint, 25-35 parts of eupatorium, 25-35 parts of honeysuckle, 25-35 parts of liquorice, 20-25 parts of cane sugar, 20-25 parts of glucose and 55-70 parts of starch.

3. The fucoidin buccal tablet with the function of preventing halitosis according to claim 1, is characterized by comprising the following raw materials in parts by weight: 10 parts of kelp, 62.5 parts of distilled water, 30 parts of ethanol water solution, 30 parts of mint, 30 parts of eupatorium, 30 parts of honeysuckle, 30 parts of liquorice, 22.5 parts of cane sugar, 22.5 parts of glucose and 62.5 parts of starch.

4. A preparation method of a fucoidin buccal tablet with the function of preventing halitosis is characterized by comprising the following steps:

s1, soaking the kelp in distilled water for 1-48 hours, carrying out water extraction for 1-24 hours, carrying out coarse filtration to obtain filtrate and kelp residues, carrying out ultrafiltration on the filtrate through a membrane with a molecular weight cutoff of 3600-500000 Da to obtain permeate and concentrated solution, wherein the permeate can be used as a raw material for extracting iodine and mannitol;

s2, adding the concentrated solution into an ethanol aqueous solution after conventional concentration, standing at a controlled temperature for 10-20 hours, and then centrifuging, precipitating and drying to obtain fucose;

s3, pulverizing herba Menthae, herba Eupatorii, flos Lonicerae, and radix Glycyrrhizae, and extracting with water at a ratio of 1: 12;

s4, combining the extracting solutions in the S3, concentrating to a proper amount, and mixing with a glucose solution, a sucrose solution and starch with a proper amount of water;

s5, granulating the mixed substance in the S4, and then drying and tabletting;

s6, carrying out various detections on the granulated buccal tablets and packaging.

5. The method for preparing the fucoidan buccal tablet having the function of preventing halitosis according to claim 4, wherein the control temperature in S2 is 4 ℃.

6. The method for preparing the fucoidan buccal tablet having the function of preventing halitosis according to claim 4, wherein the weight percentage of the ethanol aqueous solution is 95%.

7. The method for preparing the fucoidin buccal tablet with the function of preventing halitosis as claimed in claim 4, wherein the extraction times of each kind of Chinese herbal medicine in S3 are 3 times, and each extraction time is 1 h.

8. The method for preparing the fucoidan buccal tablet having the function of preventing halitosis according to claim 4, wherein the moisture content of the granules in S5 is controlled to be 5-8%, and the moisture content after drying is lower than 5%.

9. The method for preparing fucoidan buccal tablet having halitosis preventing function according to claim 4, wherein the buccal tablet detection procedures packaged in S6 include sensory, physicochemical and microbial detection.

Technical Field

The invention relates to the technical field of fucoidin buccal tablets, in particular to a fucoidin buccal tablet with a function of preventing halitosis and a preparation method thereof.

Background

Fucose is a six-carbon sugar, also known as 6-deoxy-L-galactose, and can be considered as a methyl pentose. The majority of fucose present in nature is L-fucose, and fucose in the D configuration is found in some glycoglycerols as a rare sugar only. L-fucose is present in greater amounts in seaweed and gums, and is also found in polysaccharides of certain bacteria. Fucose, which is a constituent of sugar chains in glycoproteins, is widely present on plasma membranes on the surfaces of various types of cells. Fucose has one less hydroxyl group on the sixth carbon atom than general six-carbon sugars, so fucose is less hydrophilic than other monosaccharides, and more hydrophobic. Fucose in certain blood group substance molecules is a marker for certain blood groups. The traditional fucose buccal tablet has the functions of nerve conduction, immunoregulation, cancer growth and metastasis inhibition, respiratory tract infection prevention and treatment and collagen regulation, but after the fucose buccal tablet is taken, a heavy medicinal smell can be remained in the oral cavity, and the traditional fucose buccal tablet does not have the function of preventing halitosis, so that a fucoidin buccal tablet with the function of preventing halitosis is designed to solve the problems.

Disclosure of Invention

The invention aims to solve the defects in the prior art, and provides a fucoidin buccal tablet with a function of preventing halitosis and a preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

a fucoidin buccal tablet with function of preventing halitosis comprises the following raw materials in parts by weight: 5-15 parts of kelp, 50-75 parts of distilled water, 15-45 parts of ethanol aqueous solution, 20-40 parts of mint, 20-40 parts of eupatorium, 20-40 parts of honeysuckle, 20-40 parts of liquorice, 15-30 parts of cane sugar, 15-30 parts of glucose and 50-75 parts of starch.

Preferably, the fucoidin buccal tablet with the function of preventing halitosis comprises the following raw materials in parts by weight: 8-12 parts of kelp, 57-68 parts of distilled water, 25-35 parts of an ethanol water solution, 25-35 parts of mint, 25-35 parts of eupatorium, 25-35 parts of honeysuckle, 25-35 parts of liquorice, 20-25 parts of cane sugar, 20-25 parts of glucose and 55-70 parts of starch.

Preferably, the fucoidin buccal tablet with the function of preventing halitosis comprises the following raw materials in parts by weight: 10 parts of kelp, 62.5 parts of distilled water, 30 parts of ethanol water solution, 30 parts of mint, 30 parts of eupatorium, 30 parts of honeysuckle, 30 parts of liquorice, 22.5 parts of cane sugar, 22.5 parts of glucose and 62.5 parts of starch.

The invention also provides a preparation method of the fucoidin buccal tablet with the function of preventing halitosis, which comprises the following steps:

s1, soaking the kelp in distilled water for 1-48 hours, carrying out water extraction for 1-24 hours, carrying out coarse filtration to obtain filtrate and kelp residues, carrying out ultrafiltration on the filtrate through a membrane with a molecular weight cutoff of 3600-500000 Da to obtain permeate and concentrated solution, wherein the permeate can be used as a raw material for extracting iodine and mannitol;

s2, adding the concentrated solution into an ethanol aqueous solution after conventional concentration, standing at a controlled temperature for 10-20 hours, and then centrifuging, precipitating and drying to obtain fucose;

s3, pulverizing herba Menthae, herba Eupatorii, flos Lonicerae, and radix Glycyrrhizae, and extracting with water at a ratio of 1: 12;

s4, combining the extracting solutions in the S3, concentrating to a proper amount, and mixing with a glucose solution, a sucrose solution and starch with a proper amount of water;

s5, granulating the mixed substance in the S4, and then drying and tabletting;

s6, carrying out various detections on the granulated buccal tablets and packaging.

Preferably, the control temperature in S2 is 4 ℃.

Preferably, the weight percentage of the ethanol water solution is 95%.

Preferably, the extraction times of the various Chinese herbal medicines in the S3 are 3 times, and each extraction time is 1 h.

Preferably, the granulating moisture in the S5 is controlled to be 5-8%, and the moisture after drying is lower than 5%.

Preferably, the buccal tablet detection program packaged in S6 includes sensory, physicochemical and microbial detection.

The fucoidin buccal tablet with the function of preventing halitosis, which is provided by the invention, has the advantages of scientific formula and strict proportion, not only has the functions of nerve conduction, immunoregulation, inhibition of growth and metastasis of cancers, prevention and treatment of respiratory tract infection and regulation of collagen, but also can effectively kill helicobacter pylori in intestines and stomach to treat halitosis of patients, can ensure fresh breath of the users, has the efficacy of reducing pathogenic fire and clearing away toxic materials, and is suitable for popularization.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.

Example one

The invention provides a fucoidin buccal tablet with function of preventing halitosis, which is characterized by comprising the following raw materials in parts by weight: 5 parts of kelp, 50 parts of distilled water, 15 parts of ethanol aqueous solution, 20 parts of mint, 20 parts of eupatorium, 20 parts of honeysuckle, 20 parts of liquorice, 15 parts of cane sugar, 15 parts of glucose and 50 parts of starch,

the invention provides a preparation method of a fucoidin buccal tablet with a function of preventing halitosis, which comprises the following steps:

s1, soaking the giant kelp in distilled water for 1 hour, carrying out water extraction for 1 hour, carrying out coarse filtration to obtain filtrate and giant kelp residues, carrying out ultrafiltration on the filtrate through a membrane with molecular weight cutoff of 3600Da to obtain permeate and concentrated solution, wherein the permeate can be used as a raw material for extracting iodine and mannitol;

s2, adding the concentrated solution into an ethanol aqueous solution after conventional concentration, standing for 10 hours at controlled temperature, and then obtaining fucose after centrifugation, precipitation and drying;

s3, pulverizing herba Menthae, herba Eupatorii, flos Lonicerae, and radix Glycyrrhizae, and extracting with water at a ratio of 1: 12;

s4, combining the extracting solutions in the S3, concentrating to a proper amount, and mixing with a glucose solution, a sucrose solution and starch with a proper amount of water;

s5, granulating the mixed substance in the S4, and then drying and tabletting;

s6, carrying out various detections on the granulated buccal tablets and packaging.

The temperature in S2 is controlled to be 4 ℃, the weight percentage of the ethanol water solution is 95%, the extraction times of various Chinese herbal medicines in S3 are 3 times, the extraction time is 1h each time, the granulation water content in S5 is controlled to be 5, the water content after drying is lower than 5%, and the detection procedures of the buccal tablets packaged in S6 comprise sensory, physicochemical and microbial detection.

Example two

The invention provides a fucoidin buccal tablet with function of preventing halitosis, which is characterized by comprising the following raw materials in parts by weight: 10 portions of kelp, 62.5 portions of distilled water, 30 portions of ethanol water solution, 30 portions of mint, 30 portions of eupatorium, 30 portions of honeysuckle, 30 portions of liquorice, 22.5 portions of cane sugar, 22.5 portions of glucose and 62.5 portions of starch,

the invention provides a preparation method of a fucoidin buccal tablet with a function of preventing halitosis, which comprises the following steps:

s1, soaking the kelp in distilled water for 24.5 hours, carrying out water extraction for 12.5 hours, carrying out coarse filtration to obtain filtrate and kelp residues, carrying out ultrafiltration on the filtrate through a membrane with the molecular weight cut-off of 251800Da to obtain permeate and concentrated solution, wherein the permeate can be used as a raw material for extracting iodine and mannitol;

s2, adding the concentrated solution into an ethanol aqueous solution after conventional concentration, standing for 15 hours at controlled temperature, and then obtaining fucose after centrifugation, precipitation and drying;

s3, pulverizing herba Menthae, herba Eupatorii, flos Lonicerae, and radix Glycyrrhizae, and extracting with water at a ratio of 1: 12;

s4, combining the extracting solutions in the S3, concentrating to a proper amount, and mixing with a glucose solution, a sucrose solution and starch with a proper amount of water;

s5, granulating the mixed substance in the S4, and then drying and tabletting;

s6, carrying out various detections on the granulated buccal tablets and packaging.

The temperature in S2 is controlled to be 4 ℃, the weight percentage of the ethanol water solution is 95%, the extraction times of various Chinese herbal medicines in S3 are 3 times, the extraction time is 1h each time, the granulation water content in S5 is controlled to be 6.5%, the water content after drying is lower than 5%, and the detection procedures of the packaged buccal tablets in S6 comprise sensory, physicochemical and microbial detection.

EXAMPLE III

The invention provides a fucoidin buccal tablet with function of preventing halitosis, which is characterized by comprising the following raw materials in parts by weight: 15 parts of kelp, 75 parts of distilled water, 45 parts of ethanol aqueous solution, 40 parts of mint, 40 parts of eupatorium, 40 parts of honeysuckle, 40 parts of liquorice, 30 parts of cane sugar, 30 parts of glucose and 75 parts of starch,

the invention provides a preparation method of a fucoidin buccal tablet with a function of preventing halitosis, which comprises the following steps:

s1, soaking the kelp in distilled water for 48 hours, carrying out water extraction for 24 hours, carrying out coarse filtration to obtain filtrate and kelp residues, carrying out ultrafiltration on the filtrate by a 500000Da molecular weight cutoff membrane to obtain permeate and concentrated solution, wherein the permeate can be used as a raw material for extracting iodine and mannitol;

s2, adding the concentrated solution into an ethanol water solution after conventional concentration, standing for 20 hours at controlled temperature, and then obtaining fucose after centrifugation, precipitation and drying;

s3, pulverizing herba Menthae, herba Eupatorii, flos Lonicerae, and radix Glycyrrhizae, and extracting with water at a ratio of 1: 12;

s4, combining the extracting solutions in the S3, concentrating to a proper amount, and mixing with a glucose solution, a sucrose solution and starch with a proper amount of water;

s5, granulating the mixed substance in the S4, and then drying and tabletting;

s6, carrying out various detections on the granulated buccal tablets and packaging.

The temperature in S2 is controlled to be 4 ℃, the weight percentage of the ethanol water solution is 95%, the extraction times of various Chinese herbal medicines in S3 are 3 times, the extraction time is 1h each time, the granulation water content in S5 is controlled to be 8%, the water content after drying is lower than 5%, and the detection procedures of the buccal tablets packaged in S6 comprise sensory, physicochemical and microbial detection.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.