阅读说明：本技术 用于制备(s)-1-(3-乙氧基-4-甲氧基苯基)-2-甲烷磺酰基乙胺的工艺 (Process for the preparation of (S) -1- (3-ethoxy-4-methoxyphenyl) -2-methanesulfonylethylamine ) 是由 贾斯提·文卡特斯瓦拉鲁 奇恩纳皮莱·拉詹迪兰 纳尔拉马迪·拉维库马·雷迪 泰伦斯·约瑟夫·康诺 于 2013-02-20 设计创作，主要内容包括：本发明提供的是用于制备2-[1-(3-乙氧基-4-甲氧基苯基)-2-甲基磺酰基乙基]-4-乙酰基氨基异吲哚啉-1,3-二酮合成中的氨基砜中间体的新工艺,2-[1-(3-乙氧基-4-甲氧基苯基)-2-甲基磺酰基乙基]-4-乙酰基氨基异吲哚啉-1,3-二酮可用于预防或治疗与异常高水平或活性的TNF-α有关的疾病或病症。本发明进一步提供的是用于商业生产(S)-1-(3-乙氧基-4-甲氧基苯基)-2-甲烷磺酰基乙胺的工艺。(The present invention provides a novel process for the preparation of an aminosulfone intermediate in the synthesis of 2- [1- (3-ethoxy-4-methoxyphenyl) -2-methylsulfonylethyl ] -4-acetylaminoisoindoline-1, 3-dione, which 2- [1- (3-ethoxy-4-methoxyphenyl) -2-methylsulfonylethyl ] -4-acetylaminoisoindoline-1, 3-dione is useful in the prevention or treatment of diseases or disorders associated with abnormally high levels or activity of TNF-alpha. Further provided by the present invention is a process for the commercial production of (S) -1- (3-ethoxy-4-methoxyphenyl) -2-methanesulfonylethylamine.)