阅读说明：本技术 一种卡巴拉汀中间体的纯化方法 (Purification method of rivastigmine intermediate ) 是由 李小新 余晓磊 杨日芳 李文明 马淑贤 张宇 于 2020-03-30 设计创作，主要内容包括：本发明公开了一种卡巴拉汀中间体的纯化方法,本发明以3-羟基苯乙酮为原料,通过与二甲胺反应生成中间体3-[1-(二甲氨基)乙基]苯酚,采用特定的拆分体系对该中间体进行拆分纯化,得到S-3-[1-(二甲氨基)乙基]苯酚,然后进一步制备获得卡巴拉汀。采用本申请方法制备的中间体制备的卡巴拉汀与其他卡巴拉汀的制备方法相比,成本低,收率高,效果好,对环境污染少,减少了无机盐的残留,有利于大规模工业化生产。(The invention discloses a purification method of a rivastigmine intermediate, which comprises the steps of taking 3-hydroxyacetophenone as a raw material, reacting with dimethylamine to generate an intermediate 3- [1- (dimethylamino) ethyl ] phenol, adopting a specific resolution system to perform resolution and purification on the intermediate to obtain S-3- [1- (dimethylamino) ethyl ] phenol, and then further preparing to obtain the rivastigmine. Compared with other rivastigmine preparation methods, the rivastigmine prepared by the intermediate prepared by the method has the advantages of low cost, high yield, good effect, less environmental pollution, reduction of inorganic salt residue and contribution to large-scale industrial production.)