阅读说明：本技术 丁氟螨酯和二嗪磷的农药组合物 (Pesticide composition of cyflumetofen and diazinon ) 是由 厉建燕 吴春林 于 2021-01-15 设计创作，主要内容包括：本发明公开了一种用于农业害虫的杀虫杀螨组合物,该组合物含有两种活性成分,第一种活性成分为丁氟螨酯,第二种活性成分为二嗪磷,所述第一种活性成分与第二种活性成分的重量比为1～30∶30～1以及其他助剂复配而成。本发明所述的杀虫杀螨组合物适合用于防治果树、蔬菜、水稻等作物上的螨类、蝇类、食叶害虫、二化螟及稻飞虱等害虫。速效性和持效性方面均优于单剂,弥补单剂农药的自身不足,延缓害虫抗药性的产生,提高药剂效果扩大防治谱,降低农药的使用剂量和用药成本,并能减轻对环境的污染,有益于环境保护和农业害虫的综合治理。(The invention discloses an insecticidal and acaricidal composition for agricultural pests, which comprises two active ingredients, wherein the first active ingredient is cyflumetofen, the second active ingredient is diazinon, the weight ratio of the first active ingredient to the second active ingredient is 1-30: 30-1, and the composition is compounded by other additives. The insecticidal and acaricidal composition is suitable for preventing and controlling mites, flies, leaf eating pests, chilo suppressalis, rice planthoppers and other pests on crops such as fruit trees, vegetables, rice and the like. The quick-acting property and the lasting effect are both superior to those of a single pesticide, the self-deficiency of the single pesticide is made up, the generation of the drug resistance of pests is delayed, the control spectrum is expanded by improving the pesticide effect, the using dose and the application cost of the pesticide are reduced, the pollution to the environment can be reduced, and the environment protection and the comprehensive control of agricultural pests are facilitated.)

1. An insecticidal and acaricidal composition for agricultural pests, characterized by: the insecticidal and acaricidal composition contains two active ingredients, wherein the first active ingredient is cyflumetofen, the second active ingredient is diazinon, and the weight ratio of the first active ingredient to the second active ingredient is 1-30: 30-1.

2. A pesticidal and acaricidal composition for agricultural pests according to claim 1, characterized in that: the weight ratio of the first active ingredient to the second active ingredient is 1-10: 10-1.

3. A pesticidal and acaricidal composition for agricultural pests according to claim 1, characterized in that: the weight ratio of the first active ingredient to the second active ingredient is 1-5: 10-1.

4. An insecticidal and acaricidal composition for agricultural pests, characterized by: the insecticidal and acaricidal composition according to claim 1, which comprises 5-80% by weight, and the balance of agriculturally acceptable carriers and adjuvants.

5. A pesticidal-acaricidal composition for agricultural pests according to claim 4, characterized in that: an insecticidal and acaricidal composition according to claim 1, which comprises 5 to 60% by weight of the composition.

6. A pesticidal-acaricidal composition for agricultural pests according to claim 5, characterized in that: the insecticidal and acaricidal agent can be prepared into conventional dosage forms such as aqueous emulsion, microemulsion, suspending agent, oil suspending agent, wettable powder or water dispersible granule.

7. A pesticidal-acaricidal composition for agricultural pests according to claim 1 or 6, characterized in that: the insecticidal and acaricidal agent is used for preventing and controlling agricultural pests, and is particularly suitable for preventing and controlling pests such as mites, flies, leaf eating pests, chilo suppressalis, rice planthoppers and the like on crops such as fruit trees, vegetables, rice and the like.

Technical Field

The invention belongs to the field of pesticides, and particularly relates to a pesticide composition compounded by cyflumetofen and diazinon and a preparation method thereof.

Background

The problems of pesticide residue, environmental toxicology, pest resistance and the like caused by long-term unscientific use of the insecticidal acaricide developed and marketed in the nineties of the twentieth century are increasingly serious, some medicaments even generate cross resistance among pests, and the 3R (resistance, rampant and residue) problem of chemical control of pesticides is a global problem. In recent years, with the increasing demands and importance of people on environmental ecology, food safety and the like, some traditional insecticidal and acaricidal agents are banned and restricted in many countries and regions due to the limitation and influence of toxicity, residue, environmental factors, resistance and the like. The continuous, large-amount and single-use of chemical pesticides is a main reason for rapid drug resistance of pests, and simultaneously causes a series of problems of pest rampant, pesticide residue exceeding standard, environmental pollution, increase of pesticide cost for farmers and the like. Therefore, compounding the pesticide to prepare a compound preparation is an effective and quick way for solving the problem, and has positive significance for agricultural sustainable development.

Cyflumetofen, which has the common name of cyflumetofen, is a novel acyl acetonitrile acaricide developed by tsukamur chemical company of Japan, and has the chemical name of 2-methoxyethyl- (R, S) -2- (4-tert-butylphenyl) -2-cyano-3-oxo-3- (2-trifluoro-o-methylphenyl) propionate, and the molecular formula is as follows: c₂₄H₂₄F₃NO₄Relative molecular mass: 447.4. pure product is white solid, no odor, boiling point: 269.2 ℃ (2.2kPa), melting point: 77.9-81.7 ℃. The vapor pressure (25 ℃) is less than 5.9X 10-6Pa (25 ℃). Water solubility: 0.028mg/L (20 ℃, g/L) (pH7), n-hexane 5.23, methanol 99.9, acetone, dichloromethane, ethyl acetate, toluene > 500; density (20 ℃): 1.229, respectively; kow logP (pH7, 20 ℃), 4.3; stability, stable in a weakly acidic medium, unstable in an alkaline medium; hydrolysis of DT at 25 ℃₅₀Is 9d (pH 4), 5h (pH7), 12min (pH 9); the temperature can be kept stable up to 293 ℃. Toxicity: rat (female) acute oral LD₅₀More than 2000mg/kg, acute percutaneous LD of rat₅₀More than 5000mg/kg, acute inhalation of LC in rats₅₀(4h) 2.65mg/L, has no irritation to rabbit eyes and skin, and is allergic to guinea pig skin.

The cyflumetofen is a novel benzoylacetonitrile acaricide, has novel action mechanism, no cross resistance with the existing insecticide, is effective on mites which have resistance, has high selectivity, belongs to a contact non-systemic acaricide, has high activity on all growth stages of harmful mites, has higher activity on nymphs, and has LC (liquid chromatography) on eggs, adult mites, young mites, nymphs in the first stage and nymphs in the second stage₅₀Values of 30mg/L, 4.8mg/L, 0.9mg/L, 1.0mg/L, 1.9mg/L, LC to young mites before and after hatching of eggs₅₀Has a value of 2.5mg/L, and can be used in outdoor and protected gardensThe technical crops control mites in all growing periods and can be used in cooperation with biological control technology; and the pesticide composition has the advantages of quick action, longer lasting period, small harm to the environment, quick metabolism and decomposition in soil and water, safety to crops, safety to mammals and aquatic organisms, beneficial organisms, natural enemies and other non-target organisms, environmental friendliness, good resistance management tool and no phytotoxicity to various plants.

The cyflumetofen is mainly used for preventing and controlling main parasitic mites of crops such as fruit trees, vegetables, tea trees and the like and ornamental crops such as flowers and the like, and particularly has more remarkable effect on pest mites with resistance, such as citrus red spiders, cotton red spiders, physodes phymatosus red spiders, red leaf mites and panonychus ulmi, and can be used for controlling pests such as diamond back moths, prodenia litura, striped rice borers, rice planthoppers, peach aphids and the like in a multi-dose manner, so that the cost is saved. The cyflumetofen has short application time in China, has no cross resistance with the existing pesticide, and is recommended to be mixed or used alternately with other medicaments with different action mechanisms in order to delay and avoid the generation of drug resistance. The cyflumetofen is expected to have long-term development value and outstanding prospect as a brand-new acaricide.

The diazinon is also called diazinon, diosmetin and dipirophos and is an organophosphorus pesticide, and the pure product of diazinon is colorless oily liquid with light ester fragrance and boiling point of 83-84 ℃ (266.6 multiplied by 10)^-4Pa), density of 1.116-1.118, vapor pressure of 186.7 × 10^-4Pa. Unstable at 50 deg.C or higher, and decompose at 120 deg.C or higher. Stable to light and easy to be oxidized. The water solubility is 40mg/kg at normal temperature, can be mixed with ethanol, acetone and xylene, can be gradually decomposed in water or dilute acid, is stable in dilute alkali, can be quickly decomposed in strong acid or strong alkali, and has strong volatility.

Diazinon is a broad-spectrum organic phosphorus insecticide and acaricide, has an action mechanism that the diazinon is combined with a nicotine acetylcholine receptor to interfere normal conduction of a pest nervous system, so that the pest is paralyzed and killed, has strong contact poisoning and stomach poisoning effects on pests and mites, better fumigating effect and weaker systemic action, has ovicidal effect on some pests, has good killing effect on various mites, flies, lice and ticks, and can be sprayed on skin and back hairThe adhesive force is strong, the insecticidal action can be maintained for a long time, and the effective period of one-time application can reach 6-8 weeks. Except cats, birds and bees, diazinon can be used for killing all scabies, itch mites, ticks, lice and the like which are parasitic on the body surfaces of livestock. The pesticide has strong osmosis, quick action and short pesticide effect period of leaf surface spraying, but has long pesticide effect period in soil, and can be applied to rice, sugarcane, corn, cotton, vegetables, fruit trees, tobacco, flowers and the like to control leaf eating pests, boring pests, piercing-sucking mouthpart pests and underground pests. The diazinon belongs to a medium-toxicity pesticide, has low toxicity to fishes and higher animals, is slightly toxic to earthworms, has no mutagenic, teratogenic and carcinogenic effects on animals below a test dose, and is used as an active drug for rats through acute oral LD₅₀1250mg/kg, acute oral LD of mice₅₀80-135 mg/kg, 250-355 mg/kg. Rat acute percutaneous LD50 is 2150mg/kg, rabbit acute percutaneous LD₅₀540-650 mg/kg, has slight stimulation to the skin and eyes of female white rabbits, is easy to degrade and excrete in the test animal body, and absorbed medicines are discharged out of the body from urine within 3 days.

The compounding of different kinds of agricultural chemicals is a main method for enlarging the prevention and cure range and preventing and curing resistant pests. Through formula screening, reasonable proportion is screened out, the actual prevention and control effect is effectively improved, the pesticide use amount is reduced, and the cost is reduced.

In recent years, due to changes in a farmland farming system and climate conditions and selection of medicines throughout the year, "tiny pests" such as mites, which are originally secondary targets of control, are also turned into primary targets of control on some crops in some areas, and the damage is on the rise. Since mites are extremely resistant pests, they need to be replaced or used alternately by insecticidal and acaricidal agents with a new action mechanism. In order to overcome and make up for the above deficiencies, research departments at home and abroad mostly mix a pesticide with other pesticides to improve the pesticide effect, avoid the generation of resistance, prolong the lasting period, expand the insecticidal spectrum and reduce the cost. After being consulted, no new pesticide of the combination of the cyflumetofen and the diazinon and the patent report of the composition exist at home and abroad at present.

Disclosure of Invention

The invention aims to provide an agricultural insecticidal and acaricidal composition prepared by compounding cyflumetofen and diazinon according to the situation.

The invention also aims to provide a preparation method of the insecticidal and acaricidal composition.

The technical scheme adopted by the invention for achieving the aim of the invention is as follows:

the insecticidal and acaricidal composition for agricultural pests comprises two active ingredients, wherein the first active ingredient is cyflumetofen, the second active ingredient is diazinon, and the weight ratio of the first active ingredient to the second active ingredient is 1-30: 30-1, more preferably 1-10: 10-1, and particularly preferably 1-5: 10-1.

The invention also provides an insecticidal and acaricidal composition for agricultural pests, which comprises 5-80% of the insecticidal and acaricidal composition by weight, and the balance of agriculturally acceptable carriers and auxiliaries.

The insecticidal and acaricidal composition is particularly preferably 5-60% by weight.

The carrier of the present invention may be a solid or a liquid, and any carrier conventionally used for formulating insecticidal and acaricidal compositions can be used.

Suitable solid carriers include minerals, plants, synthetic fillers and inorganic salts. The liquid carrier includes water and an organic solvent. Suitable organic solvents include: aromatic hydrocarbons, alcohols, ethers, ketones, and the like; the special solvent can be dimethylformamide, dimethyl sulfoxide, polyethylene glycol, etc.; vegetable oil, etc. The organic solvents mentioned above may be used alone, or may be used in combination with other solvents.

The auxiliary agent can comprise one or more of a surfactant, an antifoaming agent, a thickening agent, a suspending agent and an antifreezing agent according to needs, and can also comprise other auxiliary agents commonly used in the industry according to needs.

The insecticidal and acaricidal agent can be prepared into suspending agents, missible oil, wettable powder, water dispersible granules and the like according to a general method in the field.

The insecticidal and acaricidal composition for agricultural pests is suitable for preventing and controlling agricultural pests, and is particularly suitable for preventing and controlling pests such as mites, flies, leaf eating pests, striped rice borers, rice planthoppers and the like on crops such as fruit trees, vegetables, rice and the like.

Compared with the prior art, the insecticidal and acaricidal composition has the following advantages: the quick-acting property and the lasting effect are both better than those of a single pesticide, and the self deficiency of the single pesticide is made up; the two active ingredients are reasonably mixed according to different action modes and different action mechanisms of pests, so that the generation of drug resistance of the pests is delayed, the effect of the pesticide is improved, the prevention and treatment spectrum is enlarged, the use dosage and the application cost of the pesticide are reduced, the service life of the pesticide is prolonged, the pollution to the environment can be reduced, and the environment protection and the comprehensive control of agricultural pests are facilitated.

Detailed Description

In order to better understand the nature of the present invention, the present invention is further illustrated below with reference to examples, but the present invention is by no means limited to the following examples. It will be appreciated by those skilled in the art that the present invention encompasses all alternatives, modifications and equivalents as may be included within the scope of the claims.

The material formulation selection in the following examples can be made according to local conditions, without substantial effect on the results. In these examples, all percentages are by weight unless otherwise indicated.

The invention carries out indoor and outdoor toxicity test on the mixture of the insecticidal and acaricidal composition.

Based on the survey data, the data is processed by DPS software to calculate the EC for each drug₅₀R value, etc., and the co-toxicity coefficient (CTC value) of the blend was calculated according to the grandsinope and Johuson (1960) method. The co-toxicity coefficient (CTC value) of the compound combination is more than or equal to 120, which shows a synergistic effect; CTC is less than or equal to 80 and shows antagonism; 80 < CTC < 120 showed additive effects.

Example 1: insecticidal and acaricidal composition compounded by cyflumetofen and diazinon

TABLE 1 indoor determination of Tetranychus cinnabarinus by combination of cyflumetofen and diazinon

The test results in table 1 show that the insecticidal and acaricidal composition compounded by the cyflumetofen and the diazinon has the co-toxicity coefficient of more than 120 in the range of 1-30: 30-1 (by weight ratio), and shows a synergistic effect on the tetrandrine. The mixing of the two has rationality and feasibility.

Formulation example 2:

the formulation is mixed, sheared and airflow crushed according to the proportion to prepare the 10 percent cyflumetofen and diazinon wettable powder.

The control effect of the embodiment 2 applied to controlling citrus red mites is 84.87% and 90.97% respectively 3 days and 7 days after the pesticide is applied. The control single dose of cyflumetofen SC is applied according to the same method, and the control effect is 78.23 percent and 82.68 percent respectively after 3 days and 7 days of application. After the cyflumetofen and the diazinon are compounded, the synergistic effect is obvious, and the control effect is better than that of a single agent.

Formulation example 3:

the formulation is prepared into the 15 percent cyflumetofen and diazinon water dispersible granules by dry grinding, granulation, drying and screening according to the proportion.

The application of the embodiment 3 in controlling tetranychus pomonensis has control effects of 85.16% and 92.66% respectively in 3 days and 7 days after application. The control single dose of cyflumetofen SC is applied according to the same method, and the control effect is 73.25 percent and 80.64 percent respectively 3 days and 7 days after the application. After the cyflumetofen and the diazinon are compounded, the synergistic effect is obvious, and the control effect is better than that of a single agent.

Formulation example 4:

the formulation is pre-crushed according to a proportion, then is added into a sand mill for grinding, and is prepared into 20 percent of cyflumetofen and diazinon suspending agent after high shear mixing.

The control effect of the example 4 applied to chilo suppressalis in 7 days and 15 days after drug administration is 82.76% and 89.46% respectively. The control single-dose diazinon missible oil is applied by the same method, and the control effect is 72.65% and 80.64% 7 days and 15 days after the application respectively. After the cyflumetofen and the diazinon are compounded, the synergistic effect is obvious, and the control effect is better than that of a single agent.

The above description has been given only for the specific embodiments of the present invention, and it is obvious that the present invention is not limited to the above embodiments. All modifications which can be derived or suggested directly from the disclosure of the present invention by a person skilled in the art are intended to fall within the scope of the present invention.

The compound pesticide can be processed into conventional formulations such as water emulsion, microemulsion, suspending agent, oil suspending agent, wettable powder or water dispersible granules. The formulations are prepared in a known manner, usually by intimately mixing or grinding the active ingredient with surfactants, solvents or solid carriers.

In order to enhance the dispersibility, emulsibility, wettability, stability, permeability and the like of the composition, the invention adds solvents or cosolvents, emulsifiers, dispersants, coemulsifiers, antifreezes, defoamers, thickeners, stabilizers or binders with different weights, and processes the mixture into different dosage forms according to the processing method known by the technical personnel in the technical field. The preparation can be diluted by water into water dispersible solution, and applied to different crops and occasions by spraying, atomizing, dusting, broadcasting or irrigating.

The cyflumetofen and the diazinon are adopted as effective components, the compound pesticide is compounded according to a specific proportion and content, the cyflumetofen and the diazinon are subjected to indoor toxicity measurement according to different proportions, the result co-toxicity coefficients are obviously greater than 120, and the fact that the two agents are compounded has a remarkable synergistic effect is shown.

The field pesticide effect test shows that the two pesticides have good control effect on pests on fruit trees and vegetables, the comprehensive control effect reaches more than 80%, the pesticide composition has good quick-acting property and long lasting period, the defects of two single pesticides of cyflumetofen and diazinon are overcome, the cost can be reduced by compounding the two pesticides, the generation of drug resistance of the pests is delayed, and no phytotoxicity or adverse effect is generated during the test period.

The results fully show that the cyflumetofen and the diazinon are compounded by a scientific method, so that the control effect is improved, the duration is prolonged, the generation of drug resistance of pests can be delayed, the drug cost is reduced, and the cyflumetofen and the diazinon are safe to crops and have practical application value.