阅读说明：本技术 一种制备鸟氨酸的生产工艺 (Production process for preparing ornithine ) 是由 王健 周旭波 方培新 王华萱 何亚章 王威 于 2020-12-28 设计创作，主要内容包括：一种制备鸟氨酸的生产工艺,包括通过管道连接的发酵罐、发酵液储罐、陶瓷膜装置、纳滤装置、脱色罐、活性炭过滤装置、蒸发浓缩结晶器、冷却结晶罐、离心装置、双锥真空干燥设备、板框过滤机、蒸发浓缩装置、配制罐和造粒干燥装置。本发明用纯物理的提取方法提取精制鸟氨酸,具有操作方便的优点。(A production process for preparing ornithine comprises a fermentation tank, a fermentation liquor storage tank, a ceramic membrane device, a nanofiltration device, a decoloration tank, an active carbon filtering device, an evaporation concentration crystallizer, a cooling crystallization tank, a centrifugal device, a double-cone vacuum drying device, a plate-frame filter, an evaporation concentration device, a preparation tank and a granulation drying device which are connected through pipelines. The invention uses a pure physical extraction method to extract and refine the ornithine, and has the advantage of convenient operation.)

1. A production process for preparing ornithine is characterized by comprising the following steps: the production system for preparing the ornithine comprises a fermentation tank, a fermentation liquor storage tank, a ceramic membrane device, a nanofiltration device, a decoloration tank, an activated carbon filtering device, an evaporation concentration crystallizer, a cooling crystallization tank, a centrifugal device, a double-cone vacuum drying device, a plate-and-frame filter, an evaporation concentration device, a preparation tank and a granulation drying device; the outlet of the fermentation tank is communicated with the feed inlet of the fermentation liquor storage tank through a pipeline, and the outlet of the fermentation liquor storage tank is respectively communicated with the ceramic membrane device and the evaporation concentration device through pipelines; a clear liquid outlet of the ceramic membrane device is connected with the nanofiltration device, and a concentrated bacterial pulp outlet of the ceramic membrane device is communicated with the plate-and-frame filter through a pipeline; a clear liquid outlet of the nanofiltration device is communicated with a decoloring tank through a pipeline, a concentrated liquid outlet of the nanofiltration device is communicated with a preparation tank through a pipeline, an outlet of the decoloring tank is communicated with an activated carbon filtering device through a pipeline, a clear liquid outlet of the activated carbon filtering device is communicated with an evaporation concentration crystallizer through a pipeline, an outlet of the evaporation concentration crystallizer is communicated with a cooling crystallization tank through a pipeline, an outlet of the cooling crystallization tank is communicated with a centrifugal device through a pipeline, a solid material outlet of the centrifugal device is communicated with a double-cone vacuum drying device through a pipeline, a mother liquor outlet of the centrifugal device is communicated with a fermentation liquor storage tank through a pipeline, a clear liquid outlet of a plate and frame filter is communicated with the fermentation liquor storage tank through a pipeline, an outlet of the evaporation concentration device is communicated with the preparation tank through a pipeline, and an outlet of the;

the production process comprises the following steps:

injecting a sterile culture medium into the fermentation tank, inoculating ornithine producing bacteria, performing fermentation culture, and inactivating the ornithine producing bacteria after the culture is finished to obtain inactivated ornithine fermentation liquor;

conveying the inactivated ornithine fermentation liquor to a fermentation liquor storage tank, uniformly mixing the inactivated ornithine fermentation liquor with clear liquor filtered by a plate and frame filter and centrifugal mother liquor of a centrifugal device in the fermentation liquor storage tank, conveying a part of fermentation liquor to a ceramic membrane device, and conveying a part of fermentation liquor to an evaporation concentration device;

filtering the fermentation liquor conveyed to the ceramic membrane device by the ceramic membrane device, conveying filtered clear liquor to the nanofiltration device, conveying concentrated bacterial pulp to the plate-and-frame filter, refluxing the clear liquor filtered by the plate-and-frame filter to a fermentation liquor storage tank, and taking filtered bacterial residues as mycoprotein feed;

after the filtered clear liquid conveyed into the nanofiltration device is filtered by the nanofiltration device, the nanofiltration clear liquid is conveyed to a decoloring tank, and the nanofiltration concentrated liquid is conveyed to a preparation tank;

after the nanofiltration clear liquid is conveyed to a decoloring tank, adding activated carbon into the decoloring tank according to 1-5% of the volume of the feed liquid, heating to 50-80 ℃, maintaining for 1-3 hours for decoloring, and after the decoloring, conveying the decolored liquid to an activated carbon filtering device;

filtering the decolorized solution by an active carbon filtering device, removing waste active carbon, conveying clear liquid to an evaporation concentration crystallizer, and regenerating the waste active carbon;

carrying out evaporative concentration and pre-crystallization on the feed liquid through an evaporative concentration crystallizer, and conveying the crystal slurry to a cooling crystallization tank after the solid content of the feed liquid reaches 30-50%;

cooling and crystallizing the crystal mush in a cooling crystallizing tank, controlling the cooling temperature gradient to be reduced to 5-10 ℃, maintaining for 10-30 hours, and then conveying the crystal mush to a centrifugal device;

centrifuging the crystal mush in a centrifugal device, leaching by using cooling water in the centrifuging process, refluxing centrifugal mother liquor obtained by centrifuging to a fermentation liquor storage tank, and conveying wet crystals obtained by centrifuging to a double-cone vacuum drying device for drying;

drying for 5-20 hours by using a double-cone vacuum drying device to obtain a finished product of the ornithine crystals;

and (3) carrying out evaporation concentration on the ornithine fermentation liquor conveyed to the evaporation concentration device through the evaporation concentration device, concentrating until the solid content is 30-60%, conveying the concentrated solution to a preparation tank, uniformly mixing with the nanofiltration concentrated solution, and conveying the material liquid to a granulation drying device for drying after preparation to obtain the granular ornithine product.

2. The process according to claim 1 for producing ornithine, wherein: a stirring device and a cooling tube are arranged in the fermentation tank; a stirring device is arranged in the fermentation liquor storage tank; the membrane aperture of the ceramic membrane device is 8-200 nm; the molecular weight cut-off of the nanofiltration device is 800-; a stirring device is arranged in the decoloring tank, and an interlayer heating device is arranged outside the tank body of the decoloring tank; the activated carbon filtering device is a plate frame filter or a sand core filter; the evaporation concentration crystallizer is a multi-effect evaporation concentration crystallizer; a stirring device is arranged in the cooling crystallization tank; the centrifugal device is a centrifugal machine; the evaporation concentration device is a double-effect evaporation concentrator or a multi-effect evaporation concentrator; a stirring system is arranged in the preparation tank; the granulation drying device is a guniting granulation dryer.

3. The process according to claim 1 for producing ornithine, wherein: and a valve is arranged on the pipeline.

Technical Field

The invention belongs to the technical field of amino acid production equipment, and particularly relates to a production process for preparing ornithine.

Background

Ornithine (Orn) is a basic amino acid that does not participate in protein biosynthesis. In 1877 jeffer gained its name because ornithine was found in the hydrolysis product liquid of bird urine fed with benzoic acid. The product development of ornithine in the fields of medicine and food health products mainly focuses on: (1) can reduce abnormal ammonia nitrogen concentration, participate in liver detoxification process, and effectively protect liver and treat liver diseases, such as ornithine aspartate complex salt and ornithine phenylacetate. The aspartic acid and ornithine injection prepared by adopting ornithine as a raw material in the German Mayer pharmaceutical factory and the aspartic acid and ornithine granules prepared by adopting the ornithine as a raw material in Wuhan Kerui pharmaceutical industry Limited are clinically determined in liver cirrhosis, hyperammonemia and hepatic encephalopathy. (2) Ornithine is a good clinical nutrient and can be used for recovery from trauma and burn, such as ornithine alpha-ketoglutarate. (3) Promoting synthesis of growth hormone and insulin-like growth factor, promoting energy metabolism, reducing fat accumulation in vivo, enhancing muscle and physical strength, and promoting weight loss and health, such as ornithine health tablet series of Jianan Happy sports of popular nutrition company in USA. (4) Is a precursor of polyamine synthesis of cell growth factor, and is effective in caring skin, such as ornithine hydrochloride. (5) Can inhibit polyamine synthesis and delay tumor cell growth, and is a novel anticancer drug with good prospect, such as eflornithine prepared from ornithine as raw material, which is mainly used for treating brain tumor, and can be used with nitrosoureas and interferon to enhance curative effect. In europe, ornithine solution is sold as a dietary drug, and japan treats ornithine with carnitine, glutamic acid, and the like as food seasonings. Therefore, ornithine is a raw material and an intermediate of medicines, and has a multifunctional health-care effect, thereby causing special attention of people. With the increasing use of ornithine in the food and pharmaceutical industries, the yield is far from meeting the market demand. Mass production and application are impossible, and ornithine is present in a small amount in nature, so that market competition is increasingly intense, and therefore, how to reduce cost and improve yield becomes a focus of attention of many researchers and producers.

Methods for producing ornithine include chemical synthesis, enzymatic (including bacterial) method, and microbial fermentation. Both of the former are produced from expensive ornithine and the latter from an inexpensive carbon source (glucose).

Disclosure of Invention

In order to overcome the defects in the prior art, the invention aims to provide a production process for preparing ornithine.

In order to achieve the above objects and other related objects, the present invention provides the following technical solutions: a production process for preparing ornithine is characterized by comprising the following steps: the production system for preparing the ornithine comprises a fermentation tank, a fermentation liquor storage tank, a ceramic membrane device, a nanofiltration device, a decoloration tank, an activated carbon filtering device, an evaporation concentration crystallizer, a cooling crystallization tank, a centrifugal device, a double-cone vacuum drying device, a plate-and-frame filter, an evaporation concentration device, a preparation tank and a granulation drying device; the outlet of the fermentation tank is communicated with the feed inlet of the fermentation liquor storage tank through a pipeline, and the outlet of the fermentation liquor storage tank is respectively communicated with the ceramic membrane device and the evaporation concentration device through pipelines; a clear liquid outlet of the ceramic membrane device is connected with the nanofiltration device, and a concentrated bacterial pulp outlet of the ceramic membrane device is communicated with the plate-and-frame filter through a pipeline; a clear liquid outlet of the nanofiltration device is communicated with a decoloring tank through a pipeline, a concentrated liquid outlet of the nanofiltration device is communicated with a preparation tank through a pipeline, an outlet of the decoloring tank is communicated with an activated carbon filtering device through a pipeline, a clear liquid outlet of the activated carbon filtering device is communicated with an evaporation concentration crystallizer through a pipeline, an outlet of the evaporation concentration crystallizer is communicated with a cooling crystallization tank through a pipeline, an outlet of the cooling crystallization tank is communicated with a centrifugal device through a pipeline, a solid material outlet of the centrifugal device is communicated with a double-cone vacuum drying device through a pipeline, a mother liquor outlet of the centrifugal device is communicated with a fermentation liquor storage tank through a pipeline, a clear liquid outlet of a plate and frame filter is communicated with the fermentation liquor storage tank through a pipeline, an outlet of the evaporation concentration device is communicated with the preparation tank through a pipeline, and an outlet of the;

the production process comprises the following steps:

injecting a sterile culture medium into the fermentation tank, inoculating ornithine producing bacteria, performing fermentation culture, and inactivating the ornithine producing bacteria after the culture is finished to obtain inactivated ornithine fermentation liquor;

conveying the inactivated ornithine fermentation liquor to a fermentation liquor storage tank, uniformly mixing the inactivated ornithine fermentation liquor with clear liquor filtered by a plate and frame filter and centrifugal mother liquor of a centrifugal device in the fermentation liquor storage tank, conveying a part of fermentation liquor to a ceramic membrane device, and conveying a part of fermentation liquor to an evaporation concentration device;

filtering the fermentation liquor conveyed to the ceramic membrane device by the ceramic membrane device, conveying filtered clear liquor to the nanofiltration device, conveying concentrated bacterial pulp to the plate-and-frame filter, refluxing the clear liquor filtered by the plate-and-frame filter to a fermentation liquor storage tank, and taking filtered bacterial residues as mycoprotein feed;

after the filtered clear liquid conveyed into the nanofiltration device is filtered by the nanofiltration device, the nanofiltration clear liquid is conveyed to a decoloring tank, and the nanofiltration concentrated liquid is conveyed to a preparation tank;

after the nanofiltration clear liquid is conveyed to a decoloring tank, adding activated carbon into the decoloring tank according to 1-5% of the volume of the feed liquid, heating to 50-80 ℃, maintaining for 1-3 hours for decoloring, and after the decoloring, conveying the decolored liquid to an activated carbon filtering device;

filtering the decolorized solution by an active carbon filtering device, removing waste active carbon, conveying clear liquid to an evaporation concentration crystallizer, and regenerating the waste active carbon;

carrying out evaporative concentration and pre-crystallization on the feed liquid through an evaporative concentration crystallizer, and conveying the crystal slurry to a cooling crystallization tank after the solid content of the feed liquid reaches 30-50%;

cooling and crystallizing the crystal mush in a cooling crystallizing tank, controlling the cooling temperature gradient to be reduced to 5-10 ℃, maintaining for 10-30 hours, and then conveying the crystal mush to a centrifugal device;

centrifuging the crystal mush in a centrifugal device, leaching by using cooling water in the centrifuging process, refluxing centrifugal mother liquor obtained by centrifuging to a fermentation liquor storage tank, and conveying wet crystals obtained by centrifuging to a double-cone vacuum drying device for drying;

drying for 5-20 hours by using a double-cone vacuum drying device to obtain a finished product of the ornithine crystals;

and (3) carrying out evaporation concentration on the ornithine fermentation liquor conveyed to the evaporation concentration device through the evaporation concentration device, concentrating until the solid content is 30-60%, conveying the concentrated solution to a preparation tank, uniformly mixing with the nanofiltration concentrated solution, and conveying the material liquid to a granulation drying device for drying after preparation to obtain the granular ornithine product.

The preferable technical scheme is as follows: a stirring device and a cooling tube are arranged in the fermentation tank; a stirring device is arranged in the fermentation liquor storage tank; the membrane aperture of the ceramic membrane device is 8-200 nm; the molecular weight cut-off of the nanofiltration device is 800-; a stirring device is arranged in the decoloring tank, and an interlayer heating device is arranged outside the tank body of the decoloring tank; the activated carbon filtering device is a plate frame filter or a sand core filter; the evaporation concentration crystallizer is a multi-effect evaporation concentration crystallizer; a stirring device is arranged in the cooling crystallization tank; the centrifugal device is a centrifugal machine; the evaporation concentration device is a double-effect evaporation concentrator or a multi-effect evaporation concentrator; a stirring system is arranged in the preparation tank; the granulation drying device is a guniting granulation dryer. .

The preferable technical scheme is as follows: the pipeline is provided with a valve.

Due to the application of the technical scheme, the invention has the beneficial effects that:

the invention adopts a biological fermentation method to produce ornithine, adopts the ingenious arrangement and matching of the processes of a ceramic membrane, a nanofiltration membrane, a decoloring device, a filtering device, a concentration device, a crystallization device, a drying device and the like, adopts a pure physical extraction method to extract and refine ornithine, and fully and reasonably recycles waste liquid in the extraction processes of ceramic membrane concentrated bacterial pulp, nanofiltration concentrated liquid, centrifugal mother liquid and the like, so that no waste liquid is discharged in the whole production process flow. The method removes the ion exchange process commonly adopted in the ornithine extraction process, reduces a large amount of acid-base wastewater, greatly lightens the pressure of environmental protection treatment of production enterprises, and reduces the environmental protection expenditure of enterprises. The crystal ornithine product produced by the invention has higher purity, can be further processed into food-grade or pharmaceutical-grade products, and the produced low-content granular ornithine product can be further processed to be used as a feed additive and the produced byproduct mycoprotein, so that the economic benefit of ornithine production enterprises can be greatly increased, and the core competitiveness of the enterprises can be improved.

Drawings

FIG. 1 is a schematic view of the structure of the present invention.

In the above drawings, 1, a fermentation tank; 2. a fermentation liquor storage tank; 3. a ceramic membrane device; 4. a nanofiltration device; 5. a decolorizing tank; 6. an activated carbon filtration device; 7. an evaporation concentration crystallizer; 8. cooling the crystallizing tank; 9. a centrifugal device; 10. a double cone vacuum drying apparatus; 11. a plate frame filter; 12. an evaporation concentration device; 13. preparing a tank; 14. a granulation drying device.

Detailed Description

The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.

Please refer to fig. 1. It should be understood that in the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship which the product of the present invention is usually placed in when used, which is only for the convenience of describing the present invention and simplifying the description, but does not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and therefore, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance. The terms "horizontal", "vertical", "overhang" and the like do not imply that the components are required to be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present invention, it should be further noted that, unless otherwise specifically stated or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may include, for example, a fixed connection, a detachable connection, an integral connection, a mechanical connection, an electrical connection, a direct connection, an indirect connection via an intermediate medium, and a communication between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Example 1: production process for preparing ornithine

As shown in fig. 1, a production process and a system for preparing ornithine, which comprises a fermentation tank 1, a fermentation liquor storage tank 2, a ceramic membrane device 3, a nanofiltration device 4, a decoloration tank 5, an active carbon filtration device 6, an evaporation concentration crystallizer 7, a cooling crystallization tank 8, a centrifugal device 9, a double-cone vacuum drying device 10, a plate-and-frame filter 11, an evaporation concentration device 12, a preparation tank 13 and a granulation drying device 14; the outlet of the fermentation tank 1 is connected with a fermentation liquor storage tank 2, the outlet of the fermentation liquor storage tank 2 is respectively connected with a ceramic membrane device 3 and an evaporation concentration device 12, the clear liquid outlet of the ceramic membrane device 3 is connected with a nanofiltration device 4, the concentrated bacterial pulp outlet of the ceramic membrane device 3 is connected with a plate frame filter 11, the clear liquid outlet of the nanofiltration device 4 is connected with a decoloration tank 5, the concentrated liquid outlet of the nanofiltration device 4 is connected with a preparation tank 13, the outlet of the decoloration tank 5 is connected with an active carbon filtration device 6, the clear liquid outlet of the active carbon filtration device 6 is connected with an evaporation concentration crystallizer 7, the outlet of the evaporation concentration crystallizer 7 is connected with a cooling crystallization tank 8, the outlet of the cooling crystallization tank 8 is connected with a centrifugal device 9, the solid material outlet of the centrifugal device 9 is connected with a double-cone vacuum drying device 10, the mother liquid outlet of, the outlet of the evaporation concentration device 12 is connected with a preparation tank 13, and the outlet of the preparation tank 13 is connected with a granulation drying device 14.

The fermentation tank 1 is provided with a stirring device and a cooling tube; the fermentation liquid storage tank 2 is provided with a stirring device; the membrane aperture of the ceramic membrane device 3 is 100 nm; the molecular weight cut-off of the nanofiltration device 4 is 900 Dalton; the decoloring tank 5 is provided with a stirring device and a heating device; the activated carbon filtering device 6 is a plate-frame filter or a sand core filter; the evaporation concentration crystallizer 7 is a multi-effect evaporation concentration crystallizer; the cooling crystallization tank 8 is provided with a stirring device and a cooling device; the centrifugal device 9 is a centrifuge; the evaporation concentration device 12 is a double-effect or multi-effect evaporation concentrator; the preparation tank 13 is provided with a stirring system; the granulation drying device 14 is a guniting granulation dryer.

The devices are connected through pipelines, and valves are installed on the pipelines for control.

The production process comprises the following steps:

(1) injecting a sterile culture medium into the fermentation tank 1, adding ornithine producing bacteria, controlling appropriate conditions for fermentation culture, and inactivating the ornithine producing bacteria in the fermentation tank after culture; the ornithine producing bacteria, the fermentation medium and the culture conditions may adopt the technical scheme with the authorization bulletin number of 102433288.

(2) Conveying the inactivated ornithine fermentation liquor to a fermentation liquor storage tank 2, uniformly mixing the inactivated ornithine fermentation liquor with clear liquor filtered by a plate and frame filter 11 and centrifugal mother liquor of a centrifugal device 9 in the fermentation liquor storage tank 2, conveying a part of fermentation liquor to a ceramic membrane device 3, and conveying a part of fermentation liquor to an evaporation concentration device 12;

(3) the fermentation liquor conveyed to the ceramic membrane device 3 is filtered by the ceramic membrane device 3, the filtered clear liquid is conveyed to the nanofiltration device 4, the concentrated bacterial pulp is conveyed to the plate-and-frame filter 11, the clear liquid filtered by the plate-and-frame filter 11 flows back to the fermentation liquor storage tank 2, and the filtered bacterial residues can be used as mycoprotein feed;

(4) after the filtered clear liquid conveyed to the nanofiltration device 4 is filtered by the nanofiltration device 4, the nanofiltration clear liquid is conveyed to the decolorization tank 5, and the nanofiltration concentrated liquid is conveyed to the preparation tank 13;

(5) after the nanofiltration clear liquid is conveyed to a decoloring tank 5, adding activated carbon according to 1-5% of the volume of the feed liquid, heating to 50-80 ℃, maintaining for 1-3 hours, decoloring, and after the decoloring, conveying the decolored liquid to an activated carbon filtering device 6;

(6) filtering the decolorized solution by an active carbon filtering device 6, removing waste active carbon, conveying clear liquid to an evaporation concentration crystallizer 7, and regenerating the waste active carbon;

(7) carrying out evaporation concentration and pre-crystallization on the feed liquid through an evaporation concentration crystallizer 7, and conveying the crystal mush to a cooling crystallization tank 8 after the solid content of the feed liquid reaches 30-50%;

(8) cooling and crystallizing the crystal mush in a cooling and crystallizing tank 8, controlling the cooling temperature gradient to be reduced to 5-10 ℃, maintaining for 10-30 hours, and then conveying the crystal mush to a centrifugal device 9;

(9) centrifuging the crystal mush in a centrifugal device 9, leaching by using cooling water in the centrifuging process, refluxing the centrifugal mother liquor to a fermentation liquor storage tank 2, and conveying wet crystals obtained by centrifuging to a double-cone vacuum drying device 10 for drying;

(10) controlling the temperature and the vacuum degree of the bipyramid vacuum drying equipment 10, and drying for 5-20 hours to obtain a finished product of the ornithine crystals;

(11) the ornithine fermentation liquor conveyed to the evaporation concentration device 12 is evaporated and concentrated through the evaporation concentration device 12 until the solid content is 30-60%, the concentrated liquor is conveyed to a preparation tank 13, is uniformly mixed with the nanofiltration concentrated liquor, is added with auxiliary materials for preparation, and is conveyed to a granulation drying device 14 for drying to obtain granular ornithine products.

Example 2: production process for preparing ornithine

A production process for preparing ornithine comprises a production system for preparing ornithine, wherein the production system for preparing ornithine comprises a fermentation tank, a fermentation liquor storage tank, a ceramic membrane device, a nanofiltration device, a decoloration tank, an active carbon filtering device, an evaporation concentration crystallizer, a cooling crystallization tank, a centrifugal device, a double-cone vacuum drying device, a plate-and-frame filter, an evaporation concentration device, a preparation tank and a granulation drying device; the outlet of the fermentation tank is communicated with the feed inlet of the fermentation liquor storage tank through a pipeline, and the outlet of the fermentation liquor storage tank is respectively communicated with the ceramic membrane device and the evaporation concentration device through pipelines; a clear liquid outlet of the ceramic membrane device is connected with the nanofiltration device, and a concentrated bacterial pulp outlet of the ceramic membrane device is communicated with the plate-and-frame filter through a pipeline; a clear liquid outlet of the nanofiltration device is communicated with a decoloring tank through a pipeline, a concentrated liquid outlet of the nanofiltration device is communicated with a preparation tank through a pipeline, an outlet of the decoloring tank is communicated with an activated carbon filtering device through a pipeline, a clear liquid outlet of the activated carbon filtering device is communicated with an evaporation concentration crystallizer through a pipeline, an outlet of the evaporation concentration crystallizer is communicated with a cooling crystallization tank through a pipeline, an outlet of the cooling crystallization tank is communicated with a centrifugal device through a pipeline, a solid material outlet of the centrifugal device is communicated with a double-cone vacuum drying device through a pipeline, a mother liquor outlet of the centrifugal device is communicated with a fermentation liquor storage tank through a pipeline, a clear liquid outlet of a plate and frame filter is communicated with the fermentation liquor storage tank through a pipeline, an outlet of the evaporation concentration device is communicated with the preparation tank through a pipeline, and an outlet of the;

the production process comprises the following steps:

injecting a sterile culture medium into the fermentation tank, inoculating ornithine producing bacteria, performing fermentation culture, and inactivating the ornithine producing bacteria after the culture is finished to obtain inactivated ornithine fermentation liquor;

conveying the inactivated ornithine fermentation liquor to a fermentation liquor storage tank, uniformly mixing the inactivated ornithine fermentation liquor with clear liquor filtered by a plate and frame filter and centrifugal mother liquor of a centrifugal device in the fermentation liquor storage tank, conveying a part of fermentation liquor to a ceramic membrane device, and conveying a part of fermentation liquor to an evaporation concentration device;

filtering the fermentation liquor conveyed to the ceramic membrane device by the ceramic membrane device, conveying filtered clear liquor to the nanofiltration device, conveying concentrated bacterial pulp to the plate-and-frame filter, refluxing the clear liquor filtered by the plate-and-frame filter to a fermentation liquor storage tank, and taking filtered bacterial residues as mycoprotein feed;

after the filtered clear liquid conveyed into the nanofiltration device is filtered by the nanofiltration device, the nanofiltration clear liquid is conveyed to a decoloring tank, and the nanofiltration concentrated liquid is conveyed to a preparation tank;

after the nanofiltration clear liquid is conveyed to a decoloring tank, adding active carbon into the decoloring tank according to 3% of the volume of the feed liquid, heating to 60 ℃, maintaining for 2 hours for decoloring, and after the decoloring, conveying the decoloring liquid to an active carbon filtering device;

filtering the decolorized solution by an active carbon filtering device, removing waste active carbon, conveying clear liquid to an evaporation concentration crystallizer, and regenerating the waste active carbon;

carrying out evaporative concentration and pre-crystallization on the feed liquid through an evaporative concentration crystallizer, and conveying the crystal slurry to a cooling crystallization tank after the solid content of the feed liquid reaches 30-50%;

cooling and crystallizing the crystal mush in a cooling crystallizing tank, controlling the cooling temperature gradient to be reduced to 8 ℃, and conveying the crystal mush to a centrifugal device after maintaining for 20 hours;

centrifuging the crystal mush in a centrifugal device, leaching by using cooling water in the centrifuging process, refluxing centrifugal mother liquor obtained by centrifuging to a fermentation liquor storage tank, and conveying wet crystals obtained by centrifuging to a double-cone vacuum drying device for drying;

drying for 15 hours by using a bipyramid vacuum drying device to obtain a finished product of the ornithine crystals;

and (3) carrying out evaporation concentration on the ornithine fermentation liquor conveyed to the evaporation concentration device through the evaporation concentration device, concentrating until the solid content is 40%, conveying the concentrated solution to a preparation tank, uniformly mixing with the nanofiltration concentrated solution, and conveying the material liquid to a granulation drying device for drying after preparation to obtain the granular ornithine product.

The preferred embodiment is: a stirring device and a cooling tube are arranged in the fermentation tank; a stirring device is arranged in the fermentation liquor storage tank; the membrane aperture of the ceramic membrane device is 100 nm; the molecular weight cut-off of the nanofiltration device is 2500 daltons; a stirring device is arranged in the decoloring tank, and an interlayer heating device is arranged outside the tank body of the decoloring tank; the activated carbon filtering device is a plate frame filter or a sand core filter; the evaporation concentration crystallizer is a multi-effect evaporation concentration crystallizer; a stirring device is arranged in the cooling crystallization tank; the centrifugal device is a centrifugal machine; the evaporation concentration device is a double-effect evaporation concentrator or a multi-effect evaporation concentrator; a stirring system is arranged in the preparation tank; the granulation drying device is a guniting granulation dryer. .

The preferred embodiment is: the pipeline is provided with a valve.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.