哒嗪酮衍生物

文档序号:722776 发布日期:2021-04-16 浏览:31次 >En<

阅读说明:本技术 哒嗪酮衍生物 (Pyridazinone derivatives ) 是由 西田友明 上町昊 岩田昌门 柴田一 西卷拓也 清重沙织 于 2019-07-18 设计创作,主要内容包括:提供了:哒嗪酮衍生物和/或其药学上可接受的盐,其可用作在其中涉及Nav1.1的疾病和多种中枢神经系统疾病的治疗剂和/或预防剂;和药物,其含有所述哒嗪酮衍生物和/或其药学上可接受的盐作为活性成分。由式(1)表示的化合物或其药学上可接受的盐。[在式中,M~1代表饱和的或部分不饱和的C-(4-12)碳环基团等;R~1和R~2独立地代表氢原子等;M~2代表由式(2a)表示的基团等;X~(1a)、X~(1b)和X~(1c)独立地代表N等;X~2、X~3和X~4独立地代表CR~3等;A~1和A~2独立地代表N等;且R~3代表氢原子等。](Provided is a method for producing: a pyridazinone derivative and/or a pharmaceutically acceptable salt thereof, which is useful as a therapeutic and/or prophylactic agent for diseases in which nav1.1 is involved and various central nervous system diseases; and a medicament containing the pyridazinone derivativeAs an active ingredient, a compound and/or a pharmaceutically acceptable salt thereof. A compound represented by formula (1) or a pharmaceutically acceptable salt thereof. [ in the formula, M 1 Represents saturated or partially unsaturated C 4‑12 Carbocyclic groups, and the like; r 1 And R 2 Independently represent a hydrogen atom or the like; m 2 Represents a group represented by the formula (2a), etc.; x 1a 、X 1b And X 1c Independently represent N, etc.; x 2 、X 3 And X 4 Independently represent CR 3 Etc.; a. the 1 And A 2 Independently represent N, etc.; and R is 3 Represents a hydrogen atom or the like.])

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