阅读说明：本技术 抗FXI/FXIa抗体及其用途 (anti-FXI/FXIa antibodies and uses thereof ) 是由 田海军 刘登念 邓俗俊 马克·P·崔西 王成 郑勇 肖亮 薛彤彤 王晶翼 于 2020-04-06 设计创作，主要内容包括：本发明属于治疗性单克隆抗体领域,具体而言提供了抗FXI/FXIa的抗体或其抗原结合片段,编码它们的核酸分子,制备它们的方法。本发明的抗FXI/FXIa抗体或其抗原结合片段对FXI/FXIa具有特异性和高亲和力,能够有效抑制FXI/FXIa的活性。因此,本发明进一步提供了包含所述抗体或其抗原结合片段的药物组合物,以及其在制备药物中的用途,所述药物用于预防和/或治疗与凝血或血栓栓塞相关的疾病或病症。(The present invention is in the field of therapeutic monoclonal antibodies, and specifically provides antibodies or antigen-binding fragments thereof against FXI/FXIa, nucleic acid molecules encoding them, and methods for preparing them. The anti-FXI/FXIa antibody or the antigen-binding fragment thereof has specificity and high affinity to FXI/FXIa and can effectively inhibit the activity of FXI/FXIa. Accordingly, the invention further provides a pharmaceutical composition comprising the antibody or antigen-binding fragment thereof, and the use thereof in the manufacture of a medicament for the prevention and/or treatment of a disease or disorder associated with coagulation or thromboembolism.)