阅读说明：本技术 一种用于一次性医药耗材的抗菌塑料及其制备方法 (Antibacterial plastic for disposable medical consumables and preparation method thereof ) 是由 黄苗苗 张贵霖 于 2019-09-19 设计创作，主要内容包括：本发明涉及抗菌塑料的技术领域,特别是涉及一种用于一次性医药耗材的抗菌塑料,包括重量份数的如下原料：90～110份的高分子聚合物材料,1～3份的抗菌剂,3～5份的偶联剂,1～5份的抗氧剂,1～3份的增塑剂；抗菌剂包括重量份数的如下原料：5～10份的氯化银,2～5份的白云母粉,3～6份的碱性氨基酸,0.2～0.5份的保护剂。制备方法包括将高分子聚合物材料和抗菌剂搅拌混合,再加入偶联剂、抗氧剂和增塑剂搅拌混合,高速捏合,微波交联,挤出造粒即得。本发明解决现有技术中生物医用高分子材料与生物体的相容性较差的问题,通过将银离子引入高分子聚合物材料中用于提高生物医用高分子材料的抗菌性能。(The invention relates to the technical field of antibacterial plastics, in particular to an antibacterial plastic for disposable medical consumables, which comprises the following raw materials in parts by weight: 90-110 parts of a high polymer material, 1-3 parts of an antibacterial agent, 3-5 parts of a coupling agent, 1-5 parts of an antioxidant and 1-3 parts of a plasticizer; the antibacterial agent comprises the following raw materials in parts by weight: 5-10 parts of silver chloride, 2-5 parts of muscovite powder, 3-6 parts of basic amino acid and 0.2-0.5 part of protective agent. The preparation method comprises the steps of stirring and mixing the high molecular polymer material and the antibacterial agent, adding the coupling agent, the antioxidant and the plasticizer, stirring and mixing, kneading at a high speed, performing microwave crosslinking, and performing extrusion granulation to obtain the antibacterial agent. The invention solves the problem of poor compatibility between biomedical polymer materials and organisms in the prior art, and silver ions are introduced into the polymer materials to improve the antibacterial performance of the biomedical polymer materials.)

1. An antibacterial plastic for disposable medical consumables is characterized by comprising the following raw materials in parts by weight: 90-110 parts of a high polymer material, 1-3 parts of an antibacterial agent, 3-5 parts of a coupling agent, 1-5 parts of an antioxidant and 1-3 parts of a plasticizer;

the antibacterial agent comprises the following raw materials in parts by weight: 5-10 parts of silver chloride, 2-5 parts of muscovite powder, 3-6 parts of basic amino acid and 0.2-0.5 part of protective agent.

2. An antimicrobial plastic for disposable medical consumables according to claim 1 wherein: the antibacterial plastic comprises the following raw materials in parts by weight: 100 parts of high molecular polymer material, 2.0-2.5 parts of antibacterial agent, 4 parts of coupling agent, 3 parts of antioxidant and 2 parts of plasticizer;

the antibacterial agent comprises the following raw materials in parts by weight: 8 parts of silver chloride, 4 parts of muscovite powder, 5 parts of basic amino acid and 0.4 part of protective agent.

3. An antimicrobial plastic for disposable medical consumables according to claim 1 or 2, wherein: the high molecular polymer material is at least one of polyethylene, medical polyvinyl chloride, polypropylene, polycarbonate and polyisoprene;

the coupling agent is at least one of a silane coupling agent KH550, a silane coupling agent KH560 and a silane coupling agent KH 570;

the antioxidant is at least one of antioxidant 1010, antioxidant DLTP and antioxidant CA;

the plasticizer is at least one of dihydroxy polyoxyethylene ether, oxypropylene ether, allyl polyvinyl ether, polyethylene glycol monomethyl ether, methoxy polyethylene glycol and methacrylate ether.

4. An antimicrobial plastic for disposable medical consumables according to claim 3, wherein: the high molecular polymer material is polycarbonate; the antioxidant is 1010; the plasticizer is dihydroxy polyoxyethylene ether.

5. An antimicrobial plastic for disposable medical consumables according to claim 1 or 2, wherein: the basic amino acid is at least one of arginine, lysine and histidine; the protective agent is citric acid or phenyl o-hydroxybenzoate.

6. A method for preparing an antimicrobial plastic for disposable medical consumables according to any one of claims 1 to 5, comprising the steps of:

adding silver chloride, muscovite powder and a protective agent into a reactor according to the weight part ratio, adding sterilized water to form a suspension, stirring at a constant temperature of 40-60 ℃ for 1-2 h, standing for 4-5 h, performing suction filtration, adding alkaline amino acid according to the weight part ratio into filter residues, uniformly mixing, performing freeze drying for at least 30min, grinding in a grinder for 20-30 min, and sieving with a 200-mesh sieve after grinding to obtain the antibacterial agent;

and secondly, adding the high-molecular polymer material and the antibacterial agent into a stirrer according to the weight part ratio, stirring and mixing for at least 30min, adding the coupling agent, the antioxidant and the plasticizer according to the weight part ratio, stirring and mixing for at least 30min, kneading the materials in a high-speed kneader, performing microwave crosslinking after the kneading is finished, crushing, and adding the materials into an extruder for granulation to obtain the antibacterial plastic.

7. A method of preparing an antimicrobial plastic for disposable medical consumables according to claim 6, wherein: the addition amount of the sterilizing water is 3.0-5.0 times of the weight of the silver chloride.

8. A method of preparing an antimicrobial plastic for disposable medical consumables according to claim 6, wherein: the kneading temperature is 80-100 ℃, the kneading time is 10-15 min, and the rotation speed of the kneading machine is 500-800 r/min.

9. A method of preparing an antimicrobial plastic for disposable medical consumables according to claim 6, wherein: the microwave power of the microwave crosslinking is 600-1000W, and the microwave crosslinking time is 3-5 min.

Technical Field

The invention relates to the technical field of antibacterial plastics, in particular to an antibacterial plastic for disposable medical consumables and a preparation method thereof.

Background

Along with improvement of living standard and acceleration of aging speed, the frequency of using medical consumables by residents is continuously increased, and rapid development of medical consumable industry is driven. In the aspect of high-end medical consumable products, except for the support type partial products, most high-value consumables in the high-value consumable market are monopolized by imported products.

The disposable medical consumables can be roughly divided into biomedical metal materials, medical inorganic nonmetal materials, biomedical polymer materials, biological composite materials, nano biomedical materials, bionic materials and biological derivative materials according to the materials. The biomedical polymer material has the longest development history, the most extensive application and the largest consumption. In the prior art, the biomedical polymer material has poor compatibility with organisms and poor antibacterial performance.

Disclosure of Invention

In view of the above disadvantages of the prior art, the present invention provides an antibacterial plastic for disposable medical consumables, which is used to solve the problems of poor compatibility between biomedical polymer materials and organisms and poor antibacterial performance in the prior art, and also provides a preparation method of the antibacterial plastic for disposable medical consumables. The invention introduces silver ions into the high molecular polymer material to improve the antibacterial property of the biomedical high molecular material, and then introduces basic amino acid into the high molecular polymer material to improve the compatibility of the biomedical high molecular material and organisms.

In order to attain the above and other related objects,

the invention provides an antibacterial plastic for disposable medical consumables, which comprises the following raw materials in parts by weight: 90-110 parts of a high polymer material, 1-3 parts of an antibacterial agent, 3-5 parts of a coupling agent, 1-5 parts of an antioxidant and 1-3 parts of a plasticizer;

the antibacterial agent comprises the following raw materials in parts by weight: 5-10 parts of silver chloride, 2-5 parts of muscovite powder, 3-6 parts of basic amino acid and 0.2-0.5 part of protective agent.

Silver ions are introduced into the high molecular polymer material to improve the antibacterial property of the biomedical high molecular material, and basic amino acid is introduced into the high molecular polymer material to improve the compatibility of the biomedical high molecular material and organisms. The antibacterial agent is added into the antibacterial plastic to improve the antibacterial performance, and the muscovite powder is added into the antibacterial agent to effectively improve the dispersion performance of the antibacterial agent, so that the antibacterial agent is added into the polymer material to be dispersed more uniformly, and the performance of the polymer material is more uniform; the compatibility of the antibacterial agent and the basic amino acid can be effectively improved by adding the basic amino acid into the antibacterial agent.

In an embodiment of the present invention, the antibacterial plastic comprises the following raw materials in parts by weight: 100 parts of high molecular polymer material, 2.0-2.5 parts of antibacterial agent, 4 parts of coupling agent, 3 parts of antioxidant and 2 parts of plasticizer;

the antibacterial agent comprises the following raw materials in parts by weight: 8 parts of silver chloride, 4 parts of muscovite powder, 5 parts of basic amino acid and 0.4 part of protective agent.

In an embodiment of the present invention, the polymer material is at least one of polyethylene, medical polyvinyl chloride, polypropylene, polycarbonate, and polyisoprene;

the coupling agent is at least one of a silane coupling agent KH550, a silane coupling agent KH560 and a silane coupling agent KH 570;

the antioxidant is at least one of antioxidant 1010, antioxidant DLTP and antioxidant CA;

the plasticizer is at least one of dihydroxy polyoxyethylene ether, oxypropylene ether, allyl polyvinyl ether, polyethylene glycol monomethyl ether, methoxy polyethylene glycol and methacrylate ether.

The high molecular polymer material can be selected from conventional high molecular polymer materials, and is generally applicable.

In an embodiment of the present invention, the polymer material is polycarbonate; the antioxidant is 1010; the plasticizer is dihydroxy polyoxyethylene ether.

In one embodiment of the present invention, the basic amino acid is at least one of arginine, lysine, and histidine; the protective agent is citric acid or phenyl o-hydroxybenzoate.

In a second aspect of the present invention, there is provided a method of preparing the above-mentioned antibacterial plastic for disposable medical consumables, comprising the steps of:

adding silver chloride, muscovite powder and a protective agent into a reactor according to the weight part ratio, adding sterilized water to form a suspension, stirring at a constant temperature of 40-60 ℃ for 1-2 h, standing for 4-5 h, performing suction filtration, adding alkaline amino acid according to the weight part ratio into filter residues, uniformly mixing, performing freeze drying for at least 30min, grinding in a grinder for 20-30 min, and sieving with a 200-mesh sieve after grinding to obtain the antibacterial agent;

and secondly, adding the high-molecular polymer material and the antibacterial agent into a stirrer according to the weight part ratio, stirring and mixing for at least 30min, adding the coupling agent, the antioxidant and the plasticizer according to the weight part ratio, stirring and mixing for at least 30min, kneading the materials in a high-speed kneader, performing microwave crosslinking after the kneading is finished, crushing, and adding the materials into an extruder for granulation to obtain the antibacterial plastic.

During the preparation process of the antibacterial plastic, the antibacterial agent is prepared firstly, the basic amino acid is added in the preparation process of the antibacterial agent, the phenomenon that the performance of the antibacterial agent is affected due to the fact that the basic amino acid is dissolved in water is avoided, the basic amino acid is uniformly mixed, redundant water is removed through freeze drying, a large amount of sterilizing water is removed in the early stage, only a small part of residual water needs to be removed through freeze drying in the later stage, and energy consumption can be effectively reduced. The mixing effect of the basic amino acid is better under the condition that part of water remains in filter residue. The powder with smaller grain diameter is obtained by grinding, the ductility and the dispersity of the powder can be mainly improved, and then the materials are dispersed more uniformly and the crosslinking degree is higher by kneading and microwave crosslinking. The antibacterial plastic can be generally used for preparing sterilized centrifuge tubes (15ml and 50ml), PCR8 calandria (including a cover) and the like.

In an embodiment of the invention, the addition amount of the sterilizing water is 3.0-5.0 times of the weight of the silver chloride.

In an embodiment of the invention, the kneading temperature is 80-100 ℃, the kneading time is 10-15 min, and the rotation speed of the kneader is 500-800 r/min.

In an embodiment of the invention, the microwave power of the microwave crosslinking is 600-1000W, and the microwave crosslinking time is 3-5 min.

As mentioned above, the antibacterial plastic for disposable medical consumables and the preparation method thereof of the invention have the following beneficial effects: silver ions are introduced into the high molecular polymer material to improve the antibacterial property of the biomedical high molecular material, and basic amino acid is introduced into the high molecular polymer material to improve the compatibility of the biomedical high molecular material and organisms. The antibacterial agent is added into the antibacterial plastic to improve the antibacterial performance, and the muscovite powder is added into the antibacterial agent to effectively improve the dispersion performance of the antibacterial agent, so that the antibacterial agent is added into the polymer material to be dispersed more uniformly, and the performance of the polymer material is more uniform; the compatibility of the antibacterial agent and the basic amino acid can be effectively improved by adding the basic amino acid into the antibacterial agent.

Detailed Description

The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.

Example 1

An antibacterial plastic for disposable medical consumables comprises the following raw materials in parts by weight: 90 parts of high polymer material (medical polyvinyl chloride), 1 part of antibacterial agent, 3 parts of coupling agent (silane coupling agent KH550), 1 part of antioxidant (antioxidant 1010) and 1 part of plasticizer (dihydroxy polyoxyethylene ether);

the antibacterial agent comprises the following raw materials in parts by weight: 5 parts of silver chloride, 2 parts of muscovite powder, 3 parts of basic amino acid (arginine) and 0.2 part of protective agent (citric acid).

A method for preparing the antibacterial plastic for disposable medical consumables comprises the following steps:

step one, adding silver chloride, muscovite powder and a protective agent into a reactor according to the weight part ratio, adding sterilized water to form a suspension, wherein the addition amount of the sterilized water is 3.0 times of the weight of the silver chloride, stirring at a constant temperature of 40 ℃ for 2 hours, standing for 4 hours, performing suction filtration, adding alkaline amino acid according to the weight part ratio into filter residues, uniformly mixing, performing freeze drying for at least 30min, grinding in a grinder for 20min, and sieving with a 200-mesh sieve after grinding is finished to obtain the antibacterial agent;

and secondly, adding the high-molecular polymer material and the antibacterial agent into a stirrer according to the weight part ratio, stirring and mixing for at least 30min, adding the coupling agent, the antioxidant and the plasticizer according to the weight part ratio, stirring and mixing for at least 30min, kneading the materials in a high-speed kneader at the kneading temperature of 80 ℃ for 15min at the kneading speed of 500r/min, performing microwave crosslinking after finishing kneading, wherein the microwave power is 600W, the microwave crosslinking time is 5min, crushing, and adding the materials into an extruder for granulation to obtain the antibacterial plastic.

Example 2

An antibacterial plastic for disposable medical consumables comprises the following raw materials in parts by weight: 110 parts of a high molecular polymer material (polycarbonate), 3 parts of an antibacterial agent, 5 parts of a coupling agent (a silane coupling agent KH560), 5 parts of an antioxidant (an antioxidant DLTP), and 3 parts of a plasticizer (polyethylene glycol monomethyl ether);

the antibacterial agent comprises the following raw materials in parts by weight: 10 parts of silver chloride, 5 parts of muscovite powder, 6 parts of basic amino acid (lysine) and 0.5 part of protective agent (phenyl o-hydroxybenzoate).

A method for preparing the antibacterial plastic for disposable medical consumables comprises the following steps:

step one, adding silver chloride, muscovite powder and a protective agent into a reactor according to the weight part ratio, adding sterilized water to form a suspension, wherein the addition amount of the sterilized water is 5.0 times of the weight of the silver chloride, stirring at a constant temperature of 60 ℃ for 1 hour, standing for 5 hours, performing suction filtration, adding alkaline amino acid according to the weight part ratio into filter residues, uniformly mixing, performing freeze drying for at least 30min, grinding in a grinder for 30min, and sieving with a 200-mesh sieve after grinding is finished to obtain the antibacterial agent;

and secondly, adding the high-molecular polymer material and the antibacterial agent into a stirrer according to the weight part ratio, stirring and mixing for at least 30min, adding the coupling agent, the antioxidant and the plasticizer according to the weight part ratio, stirring and mixing for at least 30min, kneading the materials in a high-speed kneader at the kneading temperature of 100 ℃ for 10min at the kneading speed of 800r/min, performing microwave crosslinking after finishing kneading, wherein the microwave power is 1000W, the microwave crosslinking time is 3min, crushing, and adding the materials into an extruder for granulation to obtain the antibacterial plastic.

Example 3

An antibacterial plastic for disposable medical consumables comprises the following raw materials in parts by weight: 100 parts of high polymer material (polycarbonate), 2.0 parts of antibacterial agent, 4 parts of coupling agent (silane coupling agent KH570), 3 parts of antioxidant (antioxidant CA) and 2 parts of plasticizer (polyethylene glycol monomethyl ether);

the antibacterial agent comprises the following raw materials in parts by weight: 8 parts of silver chloride, 4 parts of muscovite powder, 5 parts of basic amino acid (histidine) and 0.4 part of protective agent (phenyl o-hydroxybenzoate).

A method for preparing the antibacterial plastic for disposable medical consumables comprises the following steps:

step one, adding silver chloride, muscovite powder and a protective agent into a reactor according to the weight part ratio, adding sterilized water to form a suspension, wherein the addition amount of the sterilized water is 4.0 times of the weight of the silver chloride, stirring at a constant temperature of 50 ℃ for 1.5h, standing for 4.5h, performing suction filtration, adding alkaline amino acid into filter residue according to the weight part ratio, uniformly mixing, performing freeze drying for at least 30min, then grinding in a grinder for 25min, and sieving with a 200-mesh sieve after grinding is finished to obtain the antibacterial agent;

and secondly, adding the high-molecular polymer material and the antibacterial agent into a stirrer according to the weight part ratio, stirring and mixing for at least 30min, adding the coupling agent, the antioxidant and the plasticizer according to the weight part ratio, stirring and mixing for at least 30min, kneading the materials in a high-speed kneader at the kneading temperature of 90 ℃ for 12min at the kneading speed of 700r/min, performing microwave crosslinking after finishing kneading, wherein the microwave power is 800W, the microwave crosslinking time is 4min, crushing, and adding the materials into an extruder for granulation to obtain the antibacterial plastic.

Example 4

An antibacterial plastic for disposable medical consumables comprises the following raw materials in parts by weight: 100 parts of high polymer material (polycarbonate), 2.5 parts of antibacterial agent, 4 parts of coupling agent (silane coupling agent KH550), 3 parts of antioxidant (antioxidant 1010) and 2 parts of plasticizer (dihydroxypolyethenoxy ether);

the antibacterial agent comprises the following raw materials in parts by weight: 8 parts of silver chloride, 4 parts of muscovite powder, 5 parts of basic amino acid (lysine) and 0.4 part of protective agent (citric acid).

A method for preparing the antibacterial plastic for disposable medical consumables comprises the following steps:

step one, adding silver chloride, muscovite powder and a protective agent into a reactor according to the weight part ratio, adding sterilized water to form a suspension, wherein the addition amount of the sterilized water is 5.0 times of the weight of the silver chloride, stirring at a constant temperature of 60 ℃ for 1 hour, standing for 5 hours, performing suction filtration, adding alkaline amino acid according to the weight part ratio into filter residues, uniformly mixing, performing freeze drying for at least 30min, grinding in a grinder for 30min, and sieving with a 200-mesh sieve after grinding is finished to obtain the antibacterial agent;

and secondly, adding the high-molecular polymer material and the antibacterial agent into a stirrer according to the weight part ratio, stirring and mixing for at least 30min, adding the coupling agent, the antioxidant and the plasticizer according to the weight part ratio, stirring and mixing for at least 30min, kneading the materials in a high-speed kneader at the kneading temperature of 100 ℃ for 10min at the kneading speed of 800r/min, performing microwave crosslinking after finishing kneading, wherein the microwave power is 1000W, the microwave crosslinking time is 3min, crushing, and adding the materials into an extruder for granulation to obtain the antibacterial plastic.

Example 5

An antibacterial plastic for disposable medical consumables comprises the following raw materials in parts by weight: 100 parts of high polymer material (polycarbonate), 2.2 parts of antibacterial agent, 4 parts of coupling agent (silane coupling agent KH550), 3 parts of antioxidant (antioxidant 1010) and 2 parts of plasticizer (dihydroxypolyethenoxy ether);

the antibacterial agent comprises the following raw materials in parts by weight: 8 parts of silver chloride, 4 parts of muscovite powder, 5 parts of basic amino acid (lysine) and 0.4 part of protective agent (citric acid).

A method for preparing the antibacterial plastic for disposable medical consumables comprises the following steps:

step one, adding silver chloride, muscovite powder and a protective agent into a reactor according to the weight part ratio, adding sterilized water to form a suspension, wherein the addition amount of the sterilized water is 5.0 times of the weight of the silver chloride, stirring at a constant temperature of 60 ℃ for 1 hour, standing for 5 hours, performing suction filtration, adding alkaline amino acid according to the weight part ratio into filter residues, uniformly mixing, performing freeze drying for at least 30min, grinding in a grinder for 30min, and sieving with a 200-mesh sieve after grinding is finished to obtain the antibacterial agent;

and secondly, adding the high-molecular polymer material and the antibacterial agent into a stirrer according to the weight part ratio, stirring and mixing for at least 30min, adding the coupling agent, the antioxidant and the plasticizer according to the weight part ratio, stirring and mixing for at least 30min, kneading the materials in a high-speed kneader at the kneading temperature of 100 ℃ for 10min at the kneading speed of 800r/min, performing microwave crosslinking after finishing kneading, wherein the microwave power is 1000W, the microwave crosslinking time is 3min, crushing, and adding the materials into an extruder for granulation to obtain the antibacterial plastic.

Comparative example 1

An antibacterial plastic for disposable medical consumables comprises the following raw materials in parts by weight: 100 parts of high polymer material (polycarbonate), 4 parts of coupling agent (silane coupling agent KH550), 3 parts of antioxidant (antioxidant 1010) and 2 parts of plasticizer (dihydroxy polyoxyethylene ether).

A method of preparing the above antimicrobial plastic for disposable medical consumables, comprising: stirring and mixing the high-molecular polymer material, the coupling agent, the antioxidant and the plasticizer for at least 30min according to the weight part ratio, then kneading the materials in a high-speed kneader at the kneading temperature of 100 ℃ for 10min at the kneading speed of 800r/min, performing microwave crosslinking after the kneading is finished, wherein the microwave power is 1000W and the microwave crosslinking time is 3min, crushing, and then adding into an extruder for granulation to obtain the antibacterial plastic.

Comparative example 2

An antibacterial plastic for disposable medical consumables comprises the following raw materials in parts by weight: 100 parts of high polymer material (polycarbonate), 2.2 parts of antibacterial agent, 4 parts of coupling agent (silane coupling agent KH550), 3 parts of antioxidant (antioxidant 1010) and 2 parts of plasticizer (dihydroxypolyethenoxy ether);

the antibacterial agent comprises the following raw materials in parts by weight: 8 parts of silver chloride and 4 parts of muscovite powder.

A method for preparing the antibacterial plastic for disposable medical consumables comprises the following steps:

step one, adding silver chloride and muscovite powder into a reactor according to the weight part ratio, adding sterilized water to form a suspension, wherein the addition amount of the sterilized water is 5.0 times of the weight of the silver chloride, stirring at the constant temperature of 60 ℃ for 1h, standing for 5h, performing suction filtration, drying strong filter residue, then putting the strong filter residue into a grinder to grind for 30min, and sieving by a 200-mesh sieve after grinding to obtain the antibacterial agent;

and secondly, adding the high-molecular polymer material and the antibacterial agent into a stirrer according to the weight part ratio, stirring and mixing for at least 30min, adding the coupling agent, the antioxidant and the plasticizer according to the weight part ratio, stirring and mixing for at least 30min, kneading the materials in a high-speed kneader at the kneading temperature of 100 ℃ for 10min at the kneading speed of 800r/min, performing microwave crosslinking after finishing kneading, wherein the microwave power is 1000W, the microwave crosslinking time is 3min, crushing, and adding the materials into an extruder for granulation to obtain the antibacterial plastic.

The properties of the antibacterial plastics prepared in examples 1 to 6 and the antibacterial plastics prepared in comparative examples 1 to 2 are shown in table 1:

table 1

Detecting items	Antibacterial ratio of Escherichia coli/%)	Antibacterial ratio of Staphylococcus aureus/%)	Antibacterial activity of Pseudomonas aeruginosa/%)
				Example 1	97	95	88
Example 2	98	96	89
				Example 3	99	97	90
Example 4	99	97	90
				Example 5	99	97	90
Comparative example 1	52	43	35
				Comparative example 2	91	89	81
Detection standard	QB/T2591-2003	QB/T2591-2003	QB/T2591-2003

As can be seen from Table 1, the antibacterial plastics prepared in examples 1 to 6 have better antibacterial effect. In comparative example 1, no antibacterial agent was added, and the difference between the antibacterial effect of the antibacterial plastic prepared in examples 1 to 6 was large.

In summary, the invention introduces silver ions into the high molecular polymer material to improve the antibacterial property of the biomedical high molecular material, and then introduces basic amino acid into the high molecular polymer material to improve the compatibility of the biomedical high molecular material and organisms. Therefore, the invention effectively overcomes various defects in the prior art and has high industrial utilization value.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.