阅读说明：本技术 一种纳米硒复合材料及制备方法 (Nano-selenium composite material and preparation method thereof ) 是由 林兴发 徐苏 许美兰 严滨 童昕 叶茜 曾孟祥 于 2020-08-18 设计创作，主要内容包括：本发明属于纳米材料技术领域,具体是一种纳米硒复合材料及制备方法。本发明的纳米硒复合材料原料包括以下的组分,0.005～0.5mol/L第一还原剂、0.003～0.1mol/L聚乙二醇二丙烯酸酯、0.001～0.1mol/L硒酸盐或亚硒酸盐、0.01～0.1mol/L水溶性光引发剂,余量为水；所述第一还原剂为丙烯酰氨基葡萄糖。本发明采用新型还原剂以聚乙二醇二丙烯酸酯作为模板获得纳米硒后,通过紫外光照射使得聚乙二醇二丙烯酸酯和第一还原剂发生反应获得三维网络结构或者高分子量聚合物包覆纳米硒,获得的纳米硒较为稳定,延长纳米硒的储存时间,而且可以实现纳米硒的缓释。(The invention belongs to the technical field of nano materials, and particularly relates to a nano selenium composite material and a preparation method thereof. The nano-selenium composite material comprises the following components, 0.005-0.5 mol/L of first reducing agent, 0.003-0.1 mol/L of polyethylene glycol diacrylate, 0.001-0.1 mol/L of selenate or selenite, 0.01-0.1 mol/L of water-soluble photoinitiator and the balance of water; the first reducing agent is acrylamido glucose. According to the invention, after the novel reducing agent is adopted to obtain the nano-selenium by taking the polyethylene glycol diacrylate as a template, the polyethylene glycol diacrylate reacts with the first reducing agent through ultraviolet irradiation to obtain the three-dimensional network structure or the high molecular weight polymer coated nano-selenium, so that the obtained nano-selenium is relatively stable, the storage time of the nano-selenium is prolonged, and the slow release of the nano-selenium can be realized.)

1. The nano-selenium composite material is characterized in that raw materials comprise 0.005-0.5 mol/L of first reducing agent, 0.003-0.1 mol/L of polyethylene glycol diacrylate, 0.001-0.1 mol/L of selenate or selenite, 0.01-0.1 mol/L of water-soluble photoinitiator and the balance of water; the first reducing agent is acrylamido glucose.

2. The nano-selenium composite of claim 1, further comprising 0.002 to 0.1mol/L of a second reducing agent.

3. The nano-selenium composite material of claim 2, wherein the second reducing agent is selected from one or more of vitamin C, glucose and glutathione.

4. The nano-selenium composite material of claim 2, wherein the concentration ratio of the first reducing agent to the second reducing agent is 1-4: 1.

5. The nano-selenium composite of claim 1, wherein the polyethylene glycol diacrylate has a number average molecular weight of 250 to 2000.

6. The nano-selenium composite material of claim 1, wherein the selenate is selected from one or more of sodium selenate, potassium selenate, magnesium selenate and ammonium selenate.

7. The nano-selenium composite material of claim 1, wherein the selenite is selected from one or more of sodium selenite, potassium selenite and magnesium selenite.

8. A preparation method of the nano-selenium composite material as claimed in any one of claims 1 to 7, characterized in that, the raw material components are accurately weighed according to the formulation requirements, the polyethylene glycol diacrylate, the selenate or the selenite are added into water, stirred uniformly at 10-30 ℃, the first reducing agent and the second reducing agent are added and stirred continuously until the color of the solution is not changed after being changed into red, the water-soluble photoinitiator is added, stirred uniformly, and irradiated by ultraviolet light to form gel, so as to obtain the nano-selenium composite material.

9. The preparation method according to claim 8, wherein the intensity of the ultraviolet light is 1-10 mW/cm²The dominant wavelength is 365 nm.

10. The method according to claim 8, wherein the gel is formed and then vacuum freeze-dried.

Technical Field

The invention belongs to the technical field of nano materials, and relates to a nano selenium composite material and a preparation method thereof.

Background

The nano selenium has better effect of eliminating free radicals and has attracted great interest. However, nano-selenium is nano-scale particles, and is easy to aggregate, so that the storage time is insufficient, and the use of the product is influenced.

In addition, the industry is also continuously searching for novel reducing agents prepared by reducing nano-selenium.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide a nano selenium composite material.

The invention also aims to provide a preparation method of the nano selenium composite material.

The technical scheme of the invention is as follows:

a nano-selenium composite material comprises the following raw materials, 0.005-0.5 mol/L of first reducing agent, 0.003-0.1 mol/L of polyethylene glycol diacrylate (PEGDA), 0.001-0.1 mol/L of selenate or selenite, 0.01-0.1 mol/L of water-soluble photoinitiator and the balance of water; the first reducing agent is acrylamido glucose.

The water-soluble photoinitiator is not particularly limited, and may be one or more selected from the group consisting of a photoinitiator Irgacure 2959, a photoinitiator APi180, and a photoinitiator APi220, which can be dissolved in water and can generate radicals under the irradiation of ultraviolet light.

Preferably, the catalyst also comprises 0.002-0.1 mol/L of a second reducing agent.

More preferably, the second reducing agent is one or more selected from vitamin C, glucose and glutathione. More preferably, the second reducing agent is selected from one or a combination of vitamin C and glucose.

More preferably, the concentration ratio of the first reducing agent to the second reducing agent is 1-4: 1.

Preferably, the number average molecular weight of the polyethylene glycol diacrylate is 250-2000. Specifically, the polyethylene glycol diacrylate may be selected from PEGDA-300 (wherein 300 represents the number average molecular weight, and so on), PEGDA-1000, PEGDA-2200, PEGDA-3000, and PEGDA-4500.

Preferably, the selenate is one or more selected from sodium selenate, potassium selenate, magnesium selenate and ammonium selenate.

Preferably, the selenite is one or more selected from sodium selenite, potassium selenite and magnesium selenite.

According to the preparation method of the nano-selenium composite material, the raw material components are accurately weighed according to the formula requirement, the polyethylene glycol diacrylate, the selenate or the selenite are added into water, the mixture is uniformly stirred at 10-30 ℃, the first reducing agent and the second reducing agent are added and continuously stirred until the color of the solution is changed into red, the solution is not changed, the water-soluble photoinitiator is added, the mixture is uniformly stirred, and ultraviolet light irradiates to form gel, so that the nano-selenium composite material is obtained.

Preferably, the intensity of the ultraviolet light is 1-10 mW/cm²The dominant wavelength is 365 nm.

Preferably, the nano selenium composite material in a solid state is obtained by vacuum freeze drying after the gel is formed.

The invention has the beneficial effects that:

(1) the invention adopts a novel reducing agent to reduce selenate or selenite, and the obtained nano-selenium has uniform particle size dispersion.

(2) The invention adopts the polyethylene glycol diacrylate which is not only used as a template for reducing the nano-selenium to obtain the nano-selenium, but also participates in the subsequent ultraviolet illumination reaction. The novel reducing agent-acrylamido glucose also participates in the subsequent ultraviolet irradiation reaction, and the polyethylene glycol diacrylate and the acrylamido glucose react under the irradiation of ultraviolet light to form a crosslinked three-dimensional network structure-a gel state or a high molecular weight polymer state, so that the wrapping and dispersing effects on the nano-selenium are improved, and the storage time of the nano-selenium is prolonged.

(3) The new reducing agent, acrylamide glucosamine, has biological activity, so the obtained nano selenium composite material can be applied to biological materials, not only plays the role of nano selenium, but also plays the role of acrylamide glucosamine, such as antibacterial property.

(4) The polyethylene glycol adopted in the invention has good biocompatibility and biodegradability, so that the nano selenium can be gradually released in the degradation process, and the problem of contradiction between the nano selenium concentration and the use frequency is solved, namely if the nano selenium is added at one time, the nano selenium concentration is high, the harm to a human body is possible, and if the nano selenium is added at one time, the nano selenium concentration is low, the nano selenium needs to be added for multiple times.

Detailed Description

The technical solution of the present invention is further illustrated and described by the following detailed description.