阅读说明：本技术 诺丽果赛洛宁原提取液在制备治疗疾病的药物中的应用 (Application of noni fruit siloronin extract in preparation of medicines for treating diseases ) 是由 李季民 于 2020-07-07 设计创作，主要内容包括：本发明公开了诺丽果赛洛宁原提取液在制备治疗疾病的药物中的应用,属于药物技术领域,是从诺丽果中提取赛洛宁原提取液,然后将此赛洛宁原提取液与普通常规的药剂填充剂配合,经常规方法制成所需要的药物。本应用方法能够充分的实现诺丽果的药用和保健价值,提升了原料的利用率,配制出的药物具有很好的抗菌抑菌作用,并能够明显提高人体的免疫能力。(The invention discloses an application of noni fruit siloronin extract in preparing a medicament for treating diseases, which belongs to the technical field of medicaments. The application method can fully realize the medicinal and health-care values of the noni fruits, improves the utilization rate of the raw materials, and the prepared medicine has good antibacterial and bacteriostatic effects and can obviously improve the immunity of human bodies.)

1. The application of noni fruit siloronin extract in preparing medicines for treating diseases is characterized in that the siloronin extract is extracted from noni fruits, and then the siloronin extract is matched with a common conventional medicine filler to prepare the required medicines by a conventional method.

2. The use of the noni fruit siloronin extract as claimed in claim 1 in the preparation of a medicament for the treatment of a disease, wherein the pharmaceutical bulking agent is a pharmaceutically acceptable acid, base, salt, hydrate or other excipient.

3. The use of the noni fruit siloronin extract according to claim 1 in the manufacture of a medicament for the treatment of a disease, wherein the medicament is in the form of at least one of a tablet, a capsule, an oral liquid, an emulsion and an injection.

4. The use of the noni fruit siloronin extract solution in the preparation of a medicament for treating a disease according to claim 1, wherein the extraction method of the siloronin extract solution comprises the steps of:

1) firstly, cleaning noni fruits, then mixing the noni fruits with water, putting the noni fruits and the water into a juicer, and obtaining fruit pulp for later use after juicing is completed;

2) adding a complex enzyme into the fruit pulp obtained in the step 1), and performing heat preservation enzymolysis for 1-2 hours for later use;

3) putting the fruit pulp processed in the step 2) into a centrifuge for centrifugal processing, and collecting a centrifugal liquid for later use;

4) standing the centrifugate obtained in the step 3), and then taking the upper layer liquid for later use;

5) filtering the supernatant liquid obtained in the step 4) by using a filter membrane, and obtaining a filtrate which is the sironine extracting solution.

5. The use of the noni fruit siloronin extract in the preparation of a medicament for treating a disease according to claim 4, wherein the noni fruit and water in step 1) are mixed at a weight ratio of 1: 5-6.

6. The application of the noni fruit siloronin extract in preparing the medicines for treating the diseases as claimed in claim 4, wherein the addition amount of the complex enzyme in the step 2) is 0.4-0.6% of the total mass of the fruit pulp; the complex enzyme contains cellulase, hemicellulase, beta-glucanase and pectinase; and controlling the enzymolysis temperature to be 40-45 ℃ during heat preservation enzymolysis treatment.

7. The use of the noni fruit siloronin extract according to claim 4 in the preparation of a medicament for treating a disease, wherein the rotation speed of centrifugation in the step 3) is controlled to be 2500 to 2800 rpm.

8. The application of the noni fruit siloronin extract in preparing the medicines for treating diseases according to claim 4, characterized in that the standing treatment in the step 4) is controlled to be 2-3 h, and ultrasonic treatment is carried out for 20min at the beginning of standing; the frequency of the ultrasonic wave during ultrasonic treatment is 300-350 kHz.

9. The use of the noni fruit siloronin extract solution in the preparation of a medicament for treating diseases according to claim 4, wherein the pore size of the filter membrane is controlled to be 5 to 10 μm during the filtration treatment in the step 5).

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to application of a noni fruit siloronin extracting solution in preparation of a medicine for treating diseases.

Background

Noni (Morinda citrifolia Linn), a tropical evergreen perennial broadleaf shrub or small arbor originating from islands of the south pacific ocean, is a plant of the Morinda genus of the rubiaceae family. Noni fruit is called 'super fruit', is rich in 227 nutrient components, comprises 13 vitamins (A, B, C, E and the like), 16 minerals (potassium, sodium, zinc, calcium, iron, magnesium, phosphorus, copper, selenium and the like), 8 trace elements, more than 20 amino acids including 9 amino acids essential to human body (the total content of the amino acids is the first content in 16 tropical fruits, and the super combination containing the most amino acids in plants) and a plurality of substances with antioxidant effect. Also contains medicinal components such as belladonna, various compounds, various green onion wakening compounds, various alkaloids, sitosterol, various flavone glycosides, alizarin, rutin and the like, and has various effects of resisting aging, bacteria, viruses, tumors and parasites, relieving pain, reducing blood pressure, diminishing inflammation, improving immunity and the like. In 6 months and 1 day 2010, noni pulp is approved as new resource food by No. 9 notice of Ministry of health of China, the safety of noni pulp is fully demonstrated, and no toxic or side effect is caused after long-term use.

Noni contains a proxeronine component which can construct the celecoxib, and the celecoxib is proved to have good treatment and health care effects by people. At present, most of methods for extracting the siloenine component from noni are solvent methods, and the solvent residues are easily caused by the solvent methods, so that the quality of the siloenine component in the noni is influenced, and the potential safety hazard of the siloenine component in use is increased. And the prior art has less application modes of the proxeronine component in the medicine.

Disclosure of Invention

The invention aims to provide application of noni fruit siloronin extracting solution in preparing a medicament for treating diseases.

The technical purpose of the invention is realized by the following technical scheme:

the application of noni fruit siloronin extract in preparing medicines for treating diseases is to extract siloronin extract from noni fruit, then mix the siloronin extract with common conventional medicinal filler, and make into required medicines by conventional method.

Further, the medicament filler is medically acceptable acid, alkali, salt, hydrate or other auxiliary materials.

Further, the drug may be formulated into at least one of tablets, capsules, oral liquid preparations, emulsions, and injections.

Further, the extraction method of the homocline extracting solution comprises the following steps:

1) firstly, cleaning noni fruits, then mixing the noni fruits with water, putting the noni fruits and the water into a juicer, and obtaining fruit pulp for later use after juicing is completed;

2) adding a complex enzyme into the fruit pulp obtained in the step 1), and performing heat preservation enzymolysis for 1-2 hours for later use;

3) putting the fruit pulp processed in the step 2) into a centrifuge for centrifugal processing, and collecting a centrifugal liquid for later use;

4) standing the centrifugate obtained in the step 3), and then taking the upper layer liquid for later use;

5) filtering the supernatant liquid obtained in the step 4) by using a filter membrane, and obtaining a filtrate which is the sironine extracting solution.

Further, the corresponding weight ratio of the noni fruits and water in the step 1) is 1: 5-6.

Further, the adding amount of the complex enzyme in the step 2) is 0.4-0.6% of the total mass of the fruit pulp; the complex enzyme contains cellulase, hemicellulase, beta-glucanase and pectinase; and controlling the enzymolysis temperature to be 40-45 ℃ during heat preservation enzymolysis treatment.

Further, the rotation speed of the centrifugation in the step 3) is controlled to be 2500-2800 rpm.

Further, the standing treatment time in the step 4) is controlled to be 2-3 h, and ultrasonic treatment is carried out for 20min at the beginning of standing; the frequency of the ultrasonic wave during ultrasonic treatment is 300-350 kHz.

Further, the aperture of the filter membrane is controlled to be 5-10 μm during the filtration treatment in the step 5).

Compared with the prior art, the invention has the following advantages:

the invention provides an application of noni fruit siloronin extract in preparing a medicament for treating diseases, wherein the noni fruit siloronin extract is extracted from noni fruits, then the siloronin extract is directly or indirectly matched to prepare the medicament, during the extraction process of the siloronin extract, the fruit pulp is subjected to enzymolysis treatment by using complex enzyme, so that channels for releasing effective components are opened, the full release of the effective components is promoted, then the centrifugal standing treatment is carried out, the extract full of the siloronin is separated, and finally the extract is filtered by using a filter membrane, so that larger impurity components are removed, the extraction purity of the siloronin is improved. The application method can fully realize the medicinal and health-care values of the noni fruits, improves the utilization rate of the raw materials, ensures that the prepared medicine has good antibacterial and bacteriostatic effects, can obviously improve the immunity of human bodies, and has high market competitiveness and popularization and application values.

Detailed Description

The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.