阅读说明：本技术 一种含***根提取物的止血、祛瘀软膏及其制备方法 (An ointment containing radix Cannabis extract for stopping bleeding and removing blood stasis, and its preparation method ) 是由 刘胜贵 王钲霖 蒋永昌 薛红芬 李智高 付彬彬 孔令羽 马海悦 于 2020-07-23 设计创作，主要内容包括：本发明公开了一种含大麻根提取物的止血、祛瘀软膏及其制备方法,属于止血药物制备技术领域。它是由以下重量份的原辅料组成：纯化水15～50份、羊毛脂15～30份、凡士林5～20份、蜂蜡20～40份、大麻根提取物10～30份、透皮吸收促进剂0.5～5份、乳化剂1～10份、保湿剂5～15份。该止血软膏中的有效活性成份大麻酮类、萜醇类、大麻碱等,对软组织划伤、擦伤、跌打损伤具有明显的止血、祛瘀作用。同时具有很好的消炎、抗过敏、抗菌、抗病毒等功效。该软膏安全、绿色、无副作用,工艺简单,适合工业化生产。(The invention discloses an ointment containing a cannabis sativa root extract for stopping bleeding and removing blood stasis and a preparation method thereof, belonging to the technical field of preparation of hemostatic medicaments. The composition comprises the following raw and auxiliary materials in parts by weight: 15-50 parts of purified water, 15-30 parts of lanolin, 5-20 parts of vaseline, 20-40 parts of beeswax, 10-30 parts of hemp root extract, 0.5-5 parts of transdermal absorption enhancer, 1-10 parts of emulsifier and 5-15 parts of humectant. The effective active components of the hemostatic ointment, such as cannabinoids, terpene alcohols, cannabinoids, etc., have obvious hemostatic and blood stasis dispelling effects on soft tissue scratch, bruise and traumatic injury. Meanwhile, the composition has good effects of diminishing inflammation, resisting allergy, resisting bacteria, resisting viruses and the like. The ointment is safe, green, has no side effect, simple process, and is suitable for industrial production.)

1. An ointment containing a cannabis sativa root extract for stopping bleeding and removing blood stasis and a preparation method thereof are characterized in that the ointment is prepared from the following raw materials in parts by weight:

15-50 parts of purified water, 15-30 parts of lanolin, 5-20 parts of vaseline, 20-40 parts of beeswax, 10-30 parts of hemp root extract, 0.5-5 parts of transdermal absorption enhancer, 1-10 parts of emulsifier and 5-15 parts of humectant.

2. The hemostatic ointment containing cannabis sativa root extract and the preparation method thereof as claimed in claim 1, wherein the preparation method comprises the steps of:

(1) putting lanolin, vaseline and beeswax into a beaker according to a proportion, and heating and melting on a water bath;

(2) sequentially adding a humectant, a transdermal absorption enhancer and an emulsifier in a certain proportion into the oily liquid melted in the step (1), stirring for dissolving, and uniformly mixing to obtain an oily phase liquid;

(3) preheating purified water to the temperature consistent with that of the oil phase, adding a certain proportion of cannabis sativa root extract, completely dissolving, slowly adding the water phase into the oil phase in the step (2), and continuously stirring clockwise while adding until the solution is in cream yellow semisolid state.

3. The ointment for stopping bleeding and removing blood stasis as claimed in claim 1 and claim 2, wherein the transdermal absorption enhancer comprises one or more of azone, menthol, borneol and octyldodecanol.

4. The ointment of claim 1 and claim 2, wherein the emulsifier comprises one or more of glyceryl monostearate, aluminum distearate, sodium lauryl sulfate, tween-20, tween-80, span-20, span-80, triethanolamine stearate, and potassium stearate.

5. The ointment for hemostasis and stasis removal containing cannabis sativa root extract and the preparation method thereof as claimed in claim 1 and claim 2, wherein the moisturizer comprises one or more of glycerin, propylene glycol, butylene glycol, sorbitol, glyceryl polyether-26, and sodium hyaluronate.

6. The ointment for hemostasis and stasis removal and the preparation method thereof as claimed in claim 1 and claim 2, wherein the cannabis root extract mainly comprises cannabinoids, terpene alcohols and cannabinoids, and has obvious effects of hemostasis and stasis removal on soft tissue scratch, bruise and traumatic injury; meanwhile, the composition has good effects of diminishing inflammation, resisting allergy, resisting bacteria, resisting viruses and the like.

7. The ointment for stopping bleeding and removing blood stasis as claimed in claim 2, wherein the ointment is melted by heating in water bath at 60-80 ℃ in step (1).

8. The hemostatic and stasis-removing ointment containing cannabis sativa root extract and the preparation method thereof as claimed in claim 1 and claim 2, wherein the hemostatic ointment has significant curative effects on soft tissue scratches, abrasions, traumatic injuries and the like.

Technical Field

The invention belongs to the technical field of preparation of external medicines, and particularly relates to an ointment containing a cannabis sativa root extract and having the effects of stopping bleeding and removing blood stasis and a preparation method thereof.

Background

Industrial hemp is also called hemp, which is an annual herb of Cannabis (Cannabis sativa L.) of Cannabis of the order Urticales (Rosales) of the family Cannabaceae of the Magnoliaceae (Magnolia), and is also called hemp, etc. The hemp can be planted in hills, mud flats and other wastelands, does not compete with grains, cotton and oil for land, has strong natural disaster resistance, and can realize stable yield in various climates. China hemp is a treasure and mainly has three functions of weaving, eating and medicine. The hemp skin is rich in fiber and can be used for processing clothes and various ornaments, the hemp stem core is an excellent wood substitute and can also be used for producing superfine powder, and the hemp seeds are rich in high-quality protein and fatty acid necessary for human bodies and can be applied to the fields of food, health care products and the like. The hemp leaves are rich in various active substances, such as cannabinol, choline, oleanolic acid, oleanoline, flavonoids and the like.

There are several tens of known compounds isolated from the root of cannabis sativa, including cannabine (canabisavine), anhydrocannabine (anhydrocannabine), choline (choline), neurone (neurone), friedelin (friedelin), epifriedelinol (epifriedelinol), carvone (cannaberrylene root-rotanone of caja sativa), dihydrocarvone (dihydrocarvone), beta-sitosterol (beta-sitosterol), cannabicycloether terpene phenol (cannabigrol), and further including various fatty acids and 5 alpha-ergosta-3-one, 5 alpha-stigmast-3-one (5 alpha-stigmast-3-one), campesterol (campesteol), stigmasterol (stigmasterol), 5 beta-stigmast-22-en-3-one (5 alpha-stigmast-22-3-one), and stigmasterol-4-3-one (5 alpha-stigmast-4-3-one), campest-4-en-3-one (campest-4-en-3-one), stigmast-4, 22-diene-3-one (stigmast-4,22-dien-3-one), stigmast-5-en-3 beta-ol-7-one, campest-5-en-3 beta-ol-7-one (campest-5-en-3 beta-ol-7-one), stigmast-5, 22-en-3 beta-ol-7-one (stigmast-5, 22-dien-3 beta-ol-7-one), etc., wherein the contained flavone and polyphenol substances belong to non-cannabis phenolic compounds with immune activation, Has antioxidant, antitumor, antibacterial, antiviral, cardiovascular and cerebrovascular disease resisting, and blood pressure lowering effects, and can be used for removing blood stasis, stopping bleeding, and promoting urination. At present, the local hemostatic materials which are clinically applied mostly comprise powders, porous sponges, oxidized regenerated cellulose, fibrin glue, hemostatic gauze and the like. They have certain disadvantages: the gelatin raw material is mostly from cow leather, allergic reaction is easy to occur due to species difference, the infection rate of wounds is increased, particularly for polluted wounds, the tissue adhesion of the gelatin and the collagen is poor and the gelatin and the collagen are easy to fall off, and the hemostatic functions of the gelatin and the collagen both depend on sufficient platelets and blood coagulation factors, so the application is limited; fibrin glue, which is derived from blood, may cause viral infections; the oxidized regenerated cellulose has loose structure, poor adhesion to bleeding points, possibility of causing re-bleeding, longer hemostasis time and poorer effect on bleeding sufferers, is not suitable for being used as a wound hemostasis material independently, so the application is limited; porous zeolite and potato starch give off a large amount of heat after absorbing moisture in blood, resulting in local necrosis of wounds, inflammatory reaction, etc.

The invention prepares the cannabine, the cannabinoides, the total polyphenols and the like extracted from the hemp roots into the hemostatic ointment, and aims to provide guidance for fully utilizing the bioactive components in the hemp roots, improving the added value of hemp processed products, perfecting the hemp industrial chain and realizing the comprehensive utilization of hemp resources and the maximization of benefits.

Disclosure of Invention

The invention aims to provide an ointment containing a cannabis root extract for stopping bleeding and removing blood stasis and a preparation method thereof. The effective active ingredients in the ointment have the effects of stopping bleeding, removing blood stasis, resisting oxidation and inhibiting bacteria, can effectively astringe wounds, relieve pain, and inhibit the breeding of various drug-resistant bacteria such as aerobic gram-positive coccus, staphylococcus aureus, staphylococcus suppurativa and beta-hemolytic streptococcus, and can also be used for treating secondary skin infections such as eczema combined infection, ulcer combined infection, dermatitis combined infection, wound combined infection and the like. The ointment is safe, green, has no side effect, simple process, and is suitable for industrial production.

In order to achieve the purpose, the invention adopts the following technical scheme:

an ointment containing cannabis sativa root extract for stopping bleeding and removing blood stasis and a preparation method thereof, which is prepared from the following raw materials in parts by weight:

15-50 parts of purified water, 15-30 parts of lanolin, 5-20 parts of vaseline, 20-40 parts of beeswax, 10-30 parts of hemp root extract, 0.5-5 parts of transdermal absorption enhancer, 1-10 parts of emulsifier and 5-15 parts of humectant.

The transdermal absorption enhancer is a medicine for promoting the medicine to rapidly permeate into the skin and reach the affected part. Comprises one or more of azone, menthol, borneol and octyldodecanol.

The emulsifier is used for promoting oil-water mixing to form uniform and stable emulsion. Comprises one or more of glyceryl monostearate, aluminum distearate, sodium dodecyl sulfate, tween-20, tween-80, span-20, span-80, triethanolamine stearate, and potassium stearate.

The moisturizers function to bind water in the lower humidity range, moisturize the skin, and they can maintain the skin in a more than normal equilibrium state of water content by controlling the exchange of moisture between the product and the surrounding air, thus acting to reduce skin dryness. Comprises one or more of glycerol, propylene glycol, butanediol, sorbitol, glyceryl polyether-26 and sodium hyaluronate.

The antiseptic is one or more of ethylparaben, sodium benzoate, benzalkonium chloride, DMDMH (dimethylol dimethyl hydantoin), and diazolidinyl urea.

The cannabis root extract mainly contains cannabinoids, terpene alcohols and cannabinoids as effective components, and has obvious effects of stopping bleeding and removing blood stasis on soft tissue scratches, bruises and traumatic injuries; meanwhile, the composition has good effects of diminishing inflammation, resisting allergy, resisting bacteria, resisting viruses and the like. The ointment is safe, green, has no side effect, simple process, and is suitable for industrial production.

An ointment containing cannabis sativa root extract for stopping bleeding and removing blood stasis and a preparation method thereof, which comprises the following steps:

(1) putting lanolin, vaseline and beeswax into a beaker according to a proportion, and heating and melting on a water bath.

(2) And (2) sequentially adding a humectant, a transdermal absorption enhancer and an emulsifier in a certain proportion into the melted oily liquid in the step (1), stirring for dissolving, and uniformly mixing. Obtaining oil phase liquid.

(3) Preheating purified water to the temperature consistent with the oil phase, and adding a certain proportion of cannabis sativa root extract. And (3) after complete dissolution, slowly adding the water phase into the oil phase in the step (2), and continuously stirring clockwise while adding until the solution is in an emulsion yellow semisolid state, thus obtaining the emulsion yellow semisolid.

In the step (1), the water bath is heated and melted, and the temperature of the water bath is 60-80 ℃.

The beneficial effects of the invention are as follows:

1) the effective active ingredients in the ointment have obvious functions of stopping bleeding and removing blood stasis, and have obvious curative effects on soft tissue scratches, bruises, traumatic injuries and the like.

2) The ointment has good antiinflammatory, antiallergic, antibacterial, and antiviral effects.

3) The invention has simple preparation process, simple usage, definite curative effect and low cost, is suitable for large-scale production, and is a product with great popularization and application value.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments.