阅读说明：本技术 一种用于治疗产后风的中药制剂 (Traditional Chinese medicine preparation for treating postpartum wind ) 是由 黄大帅 于 2020-07-31 设计创作，主要内容包括：本发明属于中药技术领域,尤其是一种用治疗产后风的中药制剂。所述中药制剂,由复方活性提取物与载体材料制成。所述复方活性提取物由以下重量份的原料制成：22-25份苍耳、10-15份沙棘、15-18份螺旋藻、12-16份山茱萸、16-18份远志、6-10份泽兰叶、10-15份艾叶、15-18份桂枝、12-16份狗脊制成。本发明提供的中药制剂,具有散寒、祛风除湿、活血止痛、宁心安神、促进损伤组织修复的的功效,而且稳定好、透皮吸收率高,对于妇女产后风具有良好的疗效。(The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine preparation for treating postpartum wind. The traditional Chinese medicine preparation is prepared from a compound active extract and a carrier material. The compound active extract is prepared from the following raw materials in parts by weight: 22-25 parts of cocklebur, 10-15 parts of sea-buckthorn, 15-18 parts of spirulina, 12-16 parts of dogwood, 16-18 parts of polygala tenuifolia, 6-10 parts of eupatorium japonicum leaves, 10-15 parts of folium artemisiae argyi, 15-18 parts of cassia twig and 12-16 parts of rhizoma cibotii. The traditional Chinese medicine preparation provided by the invention has the effects of dispelling cold, dispelling wind and removing dampness, promoting blood circulation to arrest pain, calming the heart and soothing the nerves and promoting the repair of damaged tissues, is good in stability and high in transdermal absorption rate, and has a good curative effect on postpartum wind of women.)

1. A Chinese medicinal preparation for treating puerperal fever is characterized in that the Chinese medicinal preparation is prepared from a compound active extract and a carrier material; the compound active extract is prepared from the following raw materials in parts by weight: 22-25 parts of cocklebur, 10-15 parts of sea-buckthorn, 15-18 parts of spirulina, 12-16 parts of dogwood, 16-18 parts of polygala tenuifolia, 6-10 parts of eupatorium japonicum leaves, 10-15 parts of folium artemisiae argyi, 15-18 parts of cassia twig and 12-16 parts of rhizoma cibotii.

2. The traditional Chinese medicine preparation for treating postpartum wind as claimed in claim 1, wherein the traditional Chinese medicine preparation for treating postpartum wind is prepared from a compound active extract and a carrier material according to a mass ratio of 2: 3-5.

3. The traditional Chinese medicine preparation for treating postpartum wind as claimed in claim 1 or 2, wherein the carrier material is polylactic acid-chitosan graft copolymer.

4. The traditional Chinese medicine preparation for treating postpartum wind as claimed in claim 1 or 2, wherein the preparation method of the compound active extract comprises the following steps: weighing the raw materials according to the weight parts, mixing and crushing the raw materials to 60-80 meshes to prepare medicinal powder for later use; submerging the medicinal powder in warm water of 40-45 deg.C, soaking for 2-3 hr, and filtering; and then adding a compound organic solvent into the filtrate, extracting under ultrahigh pressure, filtering, recovering the organic solvent in the filtrate, and freeze-drying to obtain the compound active extract.

5. The traditional Chinese medicine preparation for treating postpartum wind as claimed in claim 4, wherein the compound organic solvent is prepared from ionic liquid, surfactant and water according to the weight ratio of 3-5: 2: 1, in terms of mass ratio.

6. The traditional Chinese medicine preparation for treating postpartum wind as claimed in claim 5, wherein the ionic liquid is 1-methyl-3-hexylimidazole hexafluorophosphate; the surfactant is an N-acyl amino acid type surfactant.

7. The traditional Chinese medicine preparation for treating postpartum wind as claimed in claim 5, wherein the conditions of the ultrahigh pressure extraction are as follows: the pressure is 200-300MPa, the feed-liquid ratio is 1:10(g/ml), and the extraction time is 15-20 min.

8. The method for preparing a traditional Chinese medicine preparation for treating postpartum wind as claimed in claim 1 or 2, wherein the method for preparing the traditional Chinese medicine preparation for treating postpartum wind comprises the following steps: taking the compound active extract and a carrier material in a mass ratio of 2: 3-5; dissolving carrier material in anhydrous ethanol, heating to 40 deg.C, adding compound live extract, stirring, and mixing to obtain mixed solution; and (3) the mixed solution is flushed with distilled water, then is kept stand, ethanol is removed, and the traditional Chinese medicine preparation is prepared after freeze drying.

9. The traditional Chinese medicine preparation for treating postpartum wind as claimed in claim 1 or 2, wherein the traditional Chinese medicine preparation is used as a medicated bath agent for treating postpartum wind; the using method comprises the following steps: dissolving 30g of the Chinese medicinal preparation in 30-40kg of warm water, and soaking at 39-45 deg.C.

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine preparation for treating postpartum wind.

Background

The puerperal fever, also called as puerperal fever, is that the exterior and interior tissues of muscles and bones of the puerperal women are greatly opened, a large amount of active substances are discharged, warm substances are reduced, the tissue space is enlarged, a cold object can enter while being deficient, if the cold object is wrapped in the body, the cold object can occupy the tissue space and is difficult to discharge, the life of the body is reduced after the cold object is wrapped in the body, and all parts of the body, the channels and collaterals, the viscera and the bone can be directly eroded. If the emotion of the postpartum woman is too changed, a disease condition can be caused, and the disease condition can form various symptoms of postpartum wind after long-term development. Postpartum wind manifests itself clinically as systemic symptoms, such as: cold and wind are feared, the condition aggravates when meeting cold and wind, and the self-induction machine body feels empty and blows; due to large tissue space and poor heat preservation capability, the patient shows sweating due to deficiency, is cold after sweating, and wears cotton clothes on severe patients in summer; the limbs feel cold without temperature, the self-warming and unhealthy in the bed, the cold sensation of the limbs, the weakness of the limbs, the laziness to exercise and weighing, and the like, and the muscles are sour, sleepy, numb and painful; soreness and pain of joints of limbs, aggravated by cold or wind.

At present, western medicine has no specific therapy for the disease, and traditional Chinese medicine is effective in a treatment mode of aiming at internal causes and regulating the whole body state of a human body. Therefore, in recent years, more and more traditional Chinese medicine researches on postpartum wind are carried out, but at present, most of the diseases are clinically treated by medicines for resolving dampness, dispelling cold, dredging collaterals and relieving pain, the curative effect is poor, the pain relieving effect can be achieved generally, and the diseases are difficult to be cured radically. At present, there are also many researches on traditional Chinese medicine preparations for treating postpartum wind.

Patent publication No. CN102961633A discloses an external preparation for postpartum rheumatism, which is prepared from herba Lycopodii, caulis Kadsurae Longipedunculatae, Eucommiae cortex, caulis Lonicerae, herba Selaginellae, herba Cymbopogonis Citrari, radix Pini, herba Menthae, and Camphora. Publication No. CN108498718A discloses a Chinese medicinal preparation for treating puerperal fever, which is prepared from radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Gentianae Marcrophyllae, herba Schizonepetae charcoal, ramulus Uncariae cum uncis, rhizoma Gastrodiae, radix et rhizoma Rhei, periostracum Cicadae, Scorpio, Saviae Miltiorrhizae radix, herba asari, radix Aconiti Preparata, and radix astragali. Patent publication No. CN105853815A discloses a Chinese medicinal composition for treating puerperal rheumatism, which is prepared from radix Angelicae sinensis, caulis Spatholobi, rhizoma Polygoni Cuspidati, cortex Daphne Giraldii Nitsche, radix Aconiti Szechenyiani, concretio silicea Bambusae seu Schizostachyi, radix Clematidis, herba Speranskiae Tuberculatae, and herba Saussureae Involueratae. Also, for example, patent publication No. CN104257917A discloses a Yao medicine external preparation for preventing and treating puerperal rheumatism, which is prepared from radix seu folium Gaultheriae Yunnanensis, herba Pileae Scriptae, caulis Aristolochiae Manshuriensis, herba Lycopodii, herba Commelinae, radix Angelicae sinensis, caulis et folium Gaultheriae Yunnanensis, radix Toddaliae Asiaticae, caulis Spatholobi, XIAOTANGUFENG, semen Sojae Preparatum rhizoma Zingiberis recens, and rhizoma Ardisiae Gigantifoliae. Also, for example, patent publication No. CN107469044A discloses a foot bath traditional Chinese medicine composition with effects of warming spleen, activating collaterals and dispelling cold, which is prepared from the following raw materials: safflower, polygala root, angelica, hemlock parsley, ginger, eupatorium japonicum, suberect spatholobus stem, folium artemisiae argyi, folium cortex eucommiae, cassia twig, rhizoma cibotii, selfheal and wild chrysanthemum. The traditional Chinese medicine preparation disclosed in the patent treats postpartum wind-stroke, slow recovery of tissue injury caused by postpartum, poor absorption effect of active ingredients and poor curative effect by the effects of dispelling wind and removing dampness, promoting blood circulation to remove meridian obstruction, dispelling cold and relieving pain and the like.

Disclosure of Invention

In order to solve the technical problems in the prior art, the invention provides the traditional Chinese medicine preparation for treating postpartum wind, which is good in absorption and high in curative effect. The method is realized by the following technical scheme:

a Chinese medicinal preparation for the treatment of puerperal rheumatism is prepared from compound active extract and carrier material; the compound active extract is prepared from the following raw materials in parts by weight: 22-25 parts of cocklebur, 10-15 parts of sea-buckthorn, 15-18 parts of spirulina, 12-16 parts of dogwood, 16-18 parts of polygala tenuifolia, 6-10 parts of eupatorium japonicum leaves, 10-15 parts of folium artemisiae argyi, 15-18 parts of cassia twig and 12-16 parts of rhizoma cibotii.

Preferably, the traditional Chinese medicine preparation for treating postpartum wind is prepared from the compound active extract and a carrier material according to the mass ratio of 2: 3-5.

Preferably, the carrier material is a polylactic acid-chitosan graft copolymer.

Preferably, the preparation method of the compound active extract comprises the following steps: weighing the raw materials according to the weight parts, mixing and crushing the raw materials to 60-80 meshes to prepare medicinal powder for later use; submerging the medicinal powder in warm water of 40-45 deg.C, soaking for 2-3 hr, and filtering; and then adding a compound organic solvent into the filtrate, extracting under ultrahigh pressure, filtering, recovering the organic solvent in the filtrate, and freeze-drying to obtain the compound active extract.

Preferably, the composite organic solvent is prepared from ionic liquid, surfactant and water in a weight ratio of 3-5: 2: 1, in terms of mass ratio.

Preferably, the ionic liquid is 1-methyl-3-hexylimidazole hexafluorophosphate; the surfactant is an N-acyl amino acid type surfactant.

Preferably, the conditions of the ultrahigh pressure extraction are as follows: the pressure is 200-300MPa, the feed-liquid ratio is 1:10(g/ml), and the extraction time is 15-20 min.

Preferably, the preparation method of the traditional Chinese medicine preparation for treating postpartum wind comprises the following steps: taking the compound active extract and a carrier material in a mass ratio of 2: 3-5; dissolving carrier material in anhydrous ethanol, heating to 40 deg.C, adding compound live extract, stirring, and mixing to obtain mixed solution; and (3) the mixed solution is flushed with distilled water, then is kept stand, ethanol is removed, and the traditional Chinese medicine preparation is prepared after freeze drying.

Preferably, the traditional Chinese medicine preparation is used as a medicated bath agent for treating postpartum wind; the using method comprises the following steps: dissolving 30g of the Chinese medicinal preparation in 30-40kg of warm water, and soaking at 39-45 deg.C.

The invention adopts the following components and effects:

and (3) cocklebur: bitter and pungent taste, slightly cold nature; it enters lung, spleen and liver meridians. The efficacy is as follows: dispel wind and heat, remove dampness and remove toxicity. The main treatment is as follows: common cold, wind-head, dizziness, nasosinusitis, conjunctival congestion, nebula, rheumatism, numbness, rheumatism, furuncle, scabies, skin pruritus, hemorrhoids and dysentery.

Sea-buckthorn: sweet and sour in flavor and warm in nature. It enters spleen, stomach, lung and heart meridians. Has the functions of invigorating spleen, promoting digestion, relieving cough, eliminating phlegm, promoting blood circulation, removing blood stasis and promoting tissue repair. The main treatment is as follows: cough with excessive phlegm, dyspepsia, abdominal pain due to dyspepsia, traumatic injury, blood stasis and swelling, and amenorrhea due to blood stasis.

Spirulina: spirulina platensis (Notdst.) Geitl, which is a kind of Spirulina body. Has effects in repairing damaged cells and promoting cell growth.

Dogwood fruit: sour and astringent taste, slightly warm in nature. It enters liver and kidney meridians. The efficacy is as follows: tonify liver and kidney, astringe and induce astringency. The main treatment is as follows: soreness and weakness of waist and knees, dizziness, tinnitus, impotence, spermatorrhea, enuresis, frequent urination, metrorrhagia, menorrhagia, profuse sweating, and loss of health due to asthenia.

Polygala root: bitter and pungent in flavor and warm in nature. It enters heart, kidney and lung meridians. The efficacy is as follows: induce tranquilization and promote intelligence, dispel phlegm and induce resuscitation, resolve carbuncle and swelling. The main treatment is as follows: insomnia, dreaminess, palpitation, severe palpitation, amnesia, epilepsy, mania, cough, excessive phlegm, carbuncle, sore, breast swelling and pain, and pharyngitis.

Herba lycopi: the nature, flavor and meridian tropism are bitter and pungent, and the nature is slightly warm; it enters liver and spleen meridians. The efficacy is as follows: has the functions of promoting blood circulation to restore menstrual flow, removing blood stasis and resolving carbuncle, inducing diuresis and relieving swelling. The main treatment is as follows: menoxenia, amenorrhea, dysmenorrhea, postpartum abdominal pain due to blood stasis, sore, carbuncle, toxic swelling, edema and ascites.

Folium artemisiae argyi: pungent and bitter taste, warm nature; it enters liver, spleen and kidney meridians. The efficacy is as follows: warming channels to stop bleeding, dispelling cold to relieve pain, eliminating dampness to relieve itching. The main treatment is as follows: bleeding due to deficiency-cold, abdominal pain due to deficiency-cold, diarrhea, dysentery, cholera, and leukorrhagia.

Cassia twig: pungent and sweet with warm nature. It enters bladder, heart and lung meridians. The efficacy is as follows: induce sweating to relieve exterior syndrome, dispel cold to alleviate pain, activate yang to regulate qi. The main treatment is as follows: common cold due to wind-cold, pain due to congealing cold with blood stasis, phlegm-fluid retention, water retention syndrome, and palpitation.

Rhizoma cibotii: bitter and sweet in taste and warm in nature. It enters liver and kidney meridians. The efficacy is as follows: dispel wind-damp, tonify liver and kidney, strengthen waist and knees. The main treatment is as follows: wind-damp arthralgia, soreness and weakness of the waist and knees, and weakness of the lower limbs.

The invention has the beneficial effects that:

the invention provides the traditional Chinese medicine preparation for treating the postpartum wind, which is prepared by taking xanthium sibiricum, sea buckthorn, spirulina, dogwood, polygala tenuifolia, eupatorium japonicum leaves, folium artemisiae argyi, cassia twig and rhizoma cibotii as prescription medicines through multiple prescription screening according to etiology and pathogenesis dialectical treatment of the postpartum wind. In the formula, the xanthium sibiricum is taken as a monarch drug to play the roles of dispelling wind cold and activating blood circulation. Herba Lycopi and folium Artemisiae Argyi for dispelling pathogenic wind, removing dampness, and relieving pain; polygala root, radix Polygalae for tranquilizing mind; the three public assistant drugs can dispel wind, remove dampness and calm the nerves, and are ministerial drugs. Sea buckthorn and spirulina to promote the repair and growth of histiocyte; dogwood and cibotium rhizome have the effects of tonifying liver and kidney and strengthening bones and muscles; the four drugs assist the monarch drug to promote the repair of injured bones and muscles and tissues, are adjuvant drugs, can prevent the invasion of wind-cold-dampness pathogen again, and achieve the effect of radical treatment. Cassia twig, ramulus Cinnamomi, warm in nature and fragrant in smell, enters bladder, heart and lung channels, dispels cold to stop pain, activates yang to regulate qi, warms and activates meridians and collaterals, harmonizes yingfen and weifen, carries various medicines to float upwards, and is guided to joints of four limbs as a guiding medicine. In a word, the six medicines in the formula are assistant and guide, have strict structure and mild medicine, and have the effects of dispelling cold, dispelling wind, removing dampness, promoting blood circulation, relieving pain, calming heart, soothing nerves and promoting the repair of damaged tissues.

According to the invention, the active ingredients in the traditional Chinese medicine compound are extracted by adopting the ultrahigh pressure auxiliary ionic liquid under the normal temperature condition, so that the active ingredients can be prevented from being damaged in the extraction process, and the natural active ingredients in the traditional Chinese medicine can be extracted to the maximum extent; and the extraction time is short, and the energy consumption is low.

The invention adopts the carrier material and the active extract of the Chinese herbal compound to prepare the Chinese herbal preparation, the carrier material can improve the stability of the active ingredients of the Chinese herbal compound and enhance the transdermal absorption of the active ingredients; thereby improving the absorption capacity of the body to the traditional Chinese medicine preparation. Moreover, the traditional Chinese medicine preparation is used by medicated bath, and the active ingredients of the medicine act on the surface, local parts and affected parts of the muscles of the whole body, are absorbed by the channels, travel along the blood vessels of the channels and collaterals, internally reach the viscera, and generate the down effect from the surface to the inside; is beneficial to dredging channels and collaterals, expelling wind and removing cold.

In conclusion, the traditional Chinese medicine preparation provided by the invention has the effects of dispelling cold, dispelling wind and removing dampness, promoting blood circulation and relieving pain, calming the heart and soothing the nerves and promoting the repair of damaged tissues, is good in stability and high in transdermal absorption rate, and has a good curative effect on postpartum wind of women.

Detailed Description

The technical solution of the present invention is further defined below with reference to the specific embodiments, but the scope of the claims is not limited to the description.