阅读说明：本技术 来自癌症相关蛋白的免疫原性异变肽及其使用方法 (Immunogenic variant peptides from cancer-associated proteins and methods of use thereof ) 是由 R·珀蒂 麦可·F·宾矽欧塔 B·科德 D·巴里 于 2018-11-08 设计创作，主要内容包括：本文提供了包括异变突变(heteroclitic mutation)的肿瘤相关抗原性肽和包含此类异变肽(heteroclitic peptide)的融合多肽。还提供了编码此类肽和融合多肽的核酸,包括此类肽、融合多肽或核酸的重组的细菌或李斯特菌属(Listeria)菌株,以及包括此类重组的细菌或李斯特菌属菌株的细胞库。本文还提供了产生此类肽、融合多肽、核酸以及重组的细菌或李斯特菌属菌株的方法。还提供了包括此类肽、融合多肽、核酸或重组的细菌或李斯特菌属菌株的免疫原性组合物、药物组合物和疫苗。还提供了在受试者中诱导抗肿瘤相关抗原的免疫应答的方法,在受试者中诱导抗肿瘤或抗癌免疫应答的方法,在受试者中治疗肿瘤或癌症的方法,在受试者中预防肿瘤或癌症的方法,以及使用此类肽、重组融合多肽、核酸、重组的细菌或李斯特菌属菌株、免疫原性组合物、药物组合物或疫苗来保护受试者免于肿瘤或癌症的方法。(Provided herein are tumor-associated antigenic peptides comprising a heteromutation (heterolytic mutation) and fusion polypeptides comprising such heterolytic peptides. Also provided are nucleic acids encoding such peptides and fusion polypeptides, recombinant bacterial or Listeria (Listeria) strains comprising such peptides, fusion polypeptides, or nucleic acids, and cell banks comprising such recombinant bacterial or Listeria strains. Also provided herein are methods of producing such peptides, fusion polypeptides, nucleic acids, and recombinant bacterial or listeria strains. Immunogenic compositions, pharmaceutical compositions and vaccines comprising such peptides, fusion polypeptides, nucleic acids or recombinant bacteria or listeria strains are also provided. Also provided are methods of inducing an immune response against a tumor-associated antigen in a subject, methods of inducing an anti-tumor or anti-cancer immune response in a subject, methods of treating a tumor or cancer in a subject, methods of preventing a tumor or cancer in a subject, and methods of protecting a subject from a tumor or cancer using such peptides, recombinant fusion polypeptides, nucleic acids, recombinant bacteria or listeria strains, immunogenic compositions, pharmaceutical compositions, or vaccines.)