阅读说明：本技术 一种有机膜在***提取中的应用 (Application of organic membrane in hemp extraction ) 是由 宋云飞 李义军 赵军 于 2020-05-26 设计创作，主要内容包括：本发明属于膜分离领域,具体涉及一种有机膜在大麻提取中的应用。一种有机膜在大麻提取中的应用,是将大麻原料经过有机溶剂提取之后依次进行微孔滤膜过滤、非孔有机膜过滤,收集滤液、回收溶剂即得大麻提取物。本发明采用特种有机膜为非孔膜,其分离主要由分子溶解性主导,而非扩散性,对提取液进行膜过滤分离,一次性可以解决低温冷冻提取/冬化处理带来的一系列问题。(The invention belongs to the field of membrane separation, and particularly relates to application of an organic membrane in hemp extraction. An application of organic membrane in extracting Cannabis sativa comprises extracting Cannabis sativa with organic solvent, sequentially filtering with microporous membrane and non-porous organic membrane, collecting filtrate, and recovering solvent to obtain Cannabis sativa extract. The invention adopts a special organic membrane as a non-porous membrane, the separation of the non-porous membrane is mainly dominated by molecular solubility, but not diffusibility, and the membrane filtration separation is carried out on the extracting solution, so that a series of problems caused by low-temperature freezing extraction/winterization treatment can be solved at one time.)

1. Use of an organic film in hemp extraction, characterized in that it comprises the following steps:

extracting the hemp raw material by using an organic solvent, sequentially carrying out microfiltration membrane filtration and non-porous organic membrane filtration, collecting filtrate, and recovering the solvent to obtain the hemp extract.

2. The use of the organic film according to claim 1 for hemp extraction, wherein the organic solvent is any one of methanol, ethanol, acetone, n-hexane, n-heptane, ethyl acetate.

3. Use of an organic membrane according to claim 1 for hemp extraction, characterized in that the pore size of the microfiltration membrane is 0.1-50 μm.

4. Use of an organic membrane according to claim 1 in hemp extraction, characterized in that the non-porous organic membrane is a polyimide composite membrane.

5. Use of an organic film according to claim 1 in hemp extraction, characterized in that the non-porous organic film is a silicon coated polyimide composite film.

6. Use of an organic membrane according to any one of claims 1 to 5 for hemp extraction, wherein the non-porous organic membrane filtration has a membrane pressure difference of 0.5 to 2.0 MPa.

7. Use of an organic membrane according to any one of claims 1 to 5 for the extraction of cannabis, characterised in that during the filtration of the non-porous organic membrane the temperature of the liquid to be filtered is between 20 ℃ and 55 ℃.

8. Use of an organic membrane according to any one of claims 1 to 5 in hemp extraction, characterized in that during non-porous organic membrane filtration, when the ratio of the volume of membrane-permeated solution to the volume of membrane-non-permeated solution is greater than 5, an organic solvent is added for rinsing.

9. Use of an organic membrane according to claim 8 for hemp extraction, wherein an organic solvent is added for a diafiltration process at a membrane permeate to membrane non-permeate volume ratio of greater than 10 during non-porous organic membrane filtration.

10. Use of an organic membrane for hemp extraction according to claim 8, characterized in that the organic solvent is added in an amount of 1-5 times the volume of the membrane-impermeable solution.

Technical Field

The invention belongs to the field of membrane separation, and particularly relates to application of an organic membrane in hemp extraction.

Background

Cannabidiol (CBD) is the main chemical component in medicinal plant marijuana, is extracted from female marijuana plant, is a non-addictive component in marijuana, and has pharmacological effects of resisting spasm, anxiety and inflammation.

At present, the cannabidiol extraction process comprises a freezing extraction step or a winterization step, the freezing extraction at (-50 ℃) has high requirements on equipment, the requirements on equipment heat preservation, sealing and related accessories are high, and the consumption of vulnerable parts is increased. The equipment needs to be insulated when winterization treatment is carried out at (-40 ℃), the winterization time is generally 48 hours, and a large amount of solvent storage tank equipment needs to be occupied. Centrifugation or filtration is needed after winterization, and the operation of the treatment process is complicated. The removal rate of the product pigment and wax after freezing extraction or winterization treatment is about 70-80%, and a large amount of impurities exist in the product, so that the subsequent further separation and purification are influenced.

The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.

Disclosure of Invention

In order to solve the defects of the prior art, the invention provides the application of the organic membrane in the extraction of the hemp, and the specific organic membrane is used as a separation medium, so that the prepared product has good and stable quality, the extraction operation is simple and convenient, the cost is low, and the production process is clean and environment-friendly.

The purpose of the invention is realized by the following technical scheme:

the application of an organic membrane in hemp extraction comprises the following steps:

extracting the hemp raw material by using an organic solvent, sequentially carrying out microfiltration membrane filtration and non-porous organic membrane filtration, collecting filtrate, and recovering the solvent to obtain the hemp extract.

Preferably, in the above technical solution, the organic solvent is any one of methanol, ethanol, acetone, n-hexane, n-heptane and ethyl acetate.

Preferably, in the above technical solution, the pore size of the microporous filter membrane is 0.1-50 μm.

Preferably, in the above technical solution, the non-porous organic film is a polyimide composite film.

Preferably, in the above technical solution, the non-porous organic film is a silicon-coated polyimide composite film.

Preferably, in the above technical solution, the membrane pressure difference of the non-porous organic membrane is 0.5-2.0 Mpa.

Preferably, in the above technical scheme, in the non-porous organic membrane filtration process, the temperature of the liquid to be filtered is 20 ℃ to 55 ℃.

Preferably, in the above technical solution, in the non-porous organic membrane filtration process, when the volume ratio of the membrane permeated solution to the membrane non-permeated solution is greater than 5, an organic solvent is added for thorough washing.

Preferably, in the above technical solution, in the non-porous organic membrane filtration process, when the volume ratio of the membrane permeated solution to the membrane non-permeated solution is greater than 10, an organic solvent is added for thorough washing.

Preferably, in the above technical solution, the amount of the organic solvent added is 1-5 times of the volume of the solution that does not permeate the membrane.

The invention adopts a special organic membrane as a non-porous membrane, the separation of the non-porous membrane is mainly dominated by molecular solubility, but not diffusibility, and the membrane filtration separation is carried out on the extracting solution, so that a series of problems caused by low-temperature freezing extraction/winterization treatment can be solved at one time.

The method can be used for extracting the cannabidiol at room temperature, only common extraction equipment is used, the membrane occupies less equipment, the equipment investment is reduced, and meanwhile, the energy consumption is saved by more than 60%. The winterization process is eliminated, the process time is greatly shortened from the original 48 hours to 12 hours. The organic membrane separation replaces the steps of freezing, winterization and centrifugation, the obtained product has lighter color, the removal rate of pigment and wax reaches more than 95%, fewer impurities and higher purity, the product quality is improved, the subsequent further separation and purification steps are simplified, the production efficiency is improved, and the production cost of the product is reduced by 40% in total.

The method for separating the cannabidiol by using the organic membrane has the characteristics of high speed and high recovery rate. The method has the advantages of reasonable design, safe and reliable process, simple operation and good popularization and use values.

Drawings

FIG. 1 is a color schematic of the hemp extract of the present invention and winterization/freezing extraction, wherein the left flask contains membrane-treated hemp extract and the right flask contains winterization/freezing extract.

Detailed Description

The present invention will be described in further detail with reference to specific examples, but the embodiments of the present invention are not limited to the scope of the examples. These examples are intended to illustrate the invention only and are not intended to limit the scope of the invention. In addition, various modifications may occur to those skilled in the art upon reading the present disclosure, and such equivalent variations are within the scope of the present invention as defined in the appended claims.