阅读说明：本技术 用于制备核苷前体药物的方法 (Process for preparing nucleoside prodrugs ) 是由 克里斯多佛·麦圭根 法布里齐奥·佩尔图萨蒂 于 2013-11-15 设计创作，主要内容包括：本申请涉及用于制备核苷前体药物的方法。用于制备核苷的氨基磷酸酯的方法,其中关于磷原子P的不对称手性中心的期望的对映体以富集的量被提供。所述方法包括将核苷与氯磷酸酯在包括金属盐的催化剂的存在下混合,所述金属盐选自由Cu盐、Fe盐、La盐及Yb盐组成的组。(The present application relates to processes for preparing nucleoside prodrugs. A process for preparing phosphoramidates of nucleosides wherein a desired enantiomer of an asymmetric chiral center for a phosphorus atom P is provided in enriched amounts. The method comprises mixing the nucleoside with a chlorophosphate in the presence of a catalyst comprising a metal salt selected from the group consisting of a Cu salt, a Fe salt, a La salt and a Yb salt.)