阅读说明：本技术 一种d-泛酸钙全合成环保工艺 (Full-synthesis environment-friendly process of D-calcium pantothenate ) 是由 吴江 于 2020-05-14 设计创作，主要内容包括：本发明涉及一种合成D-泛酸钙的成套新工艺。本发明由β-氨基丙酸与氧化钙在水和/或甲醇中合成β-氨基丙酸钙,过滤后,负压蒸干β-氨基丙酸钙溶液中的水和/或甲醇,或过滤后,保持20℃-65℃搅拌结晶8-40小时,再过滤,再过滤的滤饼用甲醇置换滤饼中的母液三次以上,使滤饼中的水份含量小于1%,滤液去掉70%以上溶剂后可套用再过滤步骤。用甲醇浸润β-氨基丙酸钙后,加入D-泛解酸内酯的甲醇溶液,先较低温度反应再回流反应合成D-泛酸钙,再完全蒸去或部分蒸去甲醇,加水溶解过滤,转入喷雾干燥机喷雾干燥出产品D-泛酸钙。产品质量符合行业标准,产品收率比现行工艺水平提高15%-20%。(The invention relates to a complete set of new process for synthesizing D-calcium pantothenate, which comprises the steps of synthesizing β -calcium aminopropionate from β -aminopropionic acid and calcium oxide in water and/or methanol, carrying out negative pressure evaporation on water and/or methanol in β -calcium aminopropionate solution after filtration, keeping the temperature of 20-65 ℃ for stirring and crystallizing for 8-40 hours, carrying out filtration, replacing mother liquor in a filter cake with methanol for more than three times by using a filtered filter cake, ensuring that the water content in the filter cake is less than 1%, removing more than 70% of solvent from the filtrate, then carrying out filtration, infiltrating β -calcium aminopropionate with methanol, adding a methanol solution of D-pantoic acid lactone, carrying out low-temperature reaction and reflux reaction to synthesize the D-calcium pantothenate, completely or partially evaporating the methanol, adding water to dissolve and filter, and transferring to a spray dryer for spray drying to obtain the product D-calcium pantothenate, wherein the product quality meets the industrial standard, and the product yield is improved by 15-20% compared with the existing process level.)

一种D-泛酸钙全合成环保工艺

技术领域

本发明涉及一种D-泛酸钙全合成环保工艺，具体涉及一种产品收率达到100%的合成D-泛酸钙的成套新工艺。

背景技术

D-泛酸钙是维生素B5，化学名称为（R）-（+）-N-(2,4-二羟基-3，3-二甲基-1-氧代丁基)-β-丙氨酸钙盐，英文名：D-（+）-Pantothenic acid calcium salt，作为重要的营养成分，广泛用于饲料添加剂、食品添加剂、医药等领域；

D-泛酸钙合成路线，目前行业内使用的都是β-氨基丙酸与氧化钙在甲醇中反应合成β-氨基丙酸钙，过滤后再加入D-泛解酸内酯合成D-泛酸钙，通过低温结晶析出D-泛酸钙，其母液再回收甲醇、钙、D-泛解酸内酯、β-氨基丙酸等原料返回套用，回收不了或变质的物料做为废液交由环保系统处理，回收过程中利用到硫酸和大量的有机溶剂，增加了损耗而且作业环境差，这种工艺主原料综合利用率在工业生产中只能达到80-85%。