阅读说明：本技术 桂花花提取物在制备防治口唇疱疹药物中的应用 (Application of osmanthus flower extract in preparation of medicine for preventing and treating herpes labialis ) 是由 黄静 黄慧勤 徐一丹 于 2020-05-11 设计创作，主要内容包括：本发明公开桂花(Osmanthus fragrans(Thunb.)Lour.)花提取物在制备防治口唇疱疹药物中的应用,所述药物中的活性成分为桂花花提取物,所述桂花花提取物为申请号为CN201710420375.7的中国发明专利申请中的公开的桂花净油。本发明将桂花花提取物作为活性物质用于防治由1型单纯疱疹病毒(HSV-1)感染,主要在口唇、唇缘及鼻孔附近等皮肤黏膜交界处反复发作的口唇疱疹病症(又称复发性唇疱疹)。桂花花提取物作为活性成分经皮肤吸收,提高了患者的免疫力,可治疗口唇疱疹,尤其是可将口唇疱疹的病程阻断在发生期(水泡没有破裂之前),使病程不再进入发展期。(The invention discloses application of a sweet Osmanthus flower extract (Osmanthus fragrans flower (Thunb.) L our.) in preparing a medicament for preventing and treating herpes labialis, wherein an active ingredient in the medicament is the sweet Osmanthus flower extract which is disclosed in Chinese invention patent application with the application number of CN 201710420375.7.)

1. The application of the osmanthus flower extract in preparing the medicament for preventing and treating herpes labialis is characterized in that the active component of the medicament is the osmanthus flower extract.

2. The application of the osmanthus flower extract in preparing the medicine for preventing and treating herpes labialis according to claim 1, wherein the herpes labialis is mainly a disease (also called recurrent herpes labialis) which is caused by the infection of herpes simplex virus type 1 (HSV-1) and is activated when the immunity of a body is low and is repeatedly attacked at skin mucosa junctions such as lips, lips and nearby nostrils.

3. The application of the osmanthus flower extract in preparing the medicine for preventing and treating herpes labialis according to claim 1, wherein the medicine can treat the herpes labialis, and particularly can block the course of the herpes labialis at the development stage (before the blister is not broken), so that the course of the herpes labialis does not enter the development stage any more.

4. The application of the osmanthus flower extract in preparing the medicine for preventing and treating herpes labialis according to claim 1, wherein the medicine is a medicine, a medical apparatus or a cosmetic.

5. The application of the osmanthus flower extract in preparing the medicine for preventing and treating herpes labialis according to claim 1, wherein the mass percentage concentration range of the osmanthus flower extract is 0.01-2%.

6. The application of the osmanthus flower extract in preparing the medicine for preventing and treating herpes labialis according to claim 1, wherein the administration mode of the medicine is external administration.

7. The application of the osmanthus flower extract in preparing the medicine for preventing and treating herpes labialis according to claim 4, wherein the dosage form of the medicine is ointment, cream, gel, condensation, emulsion or water aqua.

8. The application of the osmanthus flower extract in preparing the medicine for preventing and treating herpes labialis according to any one of claims 1 to 7, wherein the medicine further comprises an auxiliary material, and the auxiliary material is an auxiliary material of a corresponding dosage form allowed to be used for preparing medicines, medical instruments or cosmetics.

Technical Field

The invention belongs to the field of medicine preparation, and particularly relates to application of an Osmanthus fragrans (Thunb.) fragrans (Osmanthus fragrans) L our) flower extract in preparation of a medicine for preventing and treating herpes labialis.

Background

Herpes labialis (also known as "upper fire") is one of the most common types of herpes simplex, a skin and mucosal disease caused primarily by herpes simplex virus type 1 (HSV-1) infection. Humans are the only natural host for herpes simplex viruses. The virus is infectious. The virus is present in the blister fluid, saliva and feces of patients, convalescent persons or healthy carriers, and is transmitted by direct contact or by indirect transmission through objects contaminated with saliva. After a human body is infected by the herpes simplex virus, the virus can be latent in normal mucous membrane, blood, saliva and sensory ganglion cells of the human body for a long time, and can be activated to cause repeated outbreak of pathogenic conditions when the immunity of the human body is low, such as cold, fever, fatigue, mood depression, high pressure, stress, anxiety, menstrual period and the like, and the outbreak part is mainly at the skin-mucous membrane junction of lips, nostrils and the like, so the herpes labialis is also called as recurrent herpes labialis.

Herpes labialis is a self-healing disease, and the natural course of disease from onset to recovery is about 10-15 days, and can be generally divided into three stages: the first stage is the development period (2-3 days), namely, irritation pain, burning pain, itching, tension increase and the like appear at the skin mucosa junction such as the lips, nostrils and the like, then dense groups or groups of needle head-size blisters appear, mild erythema exists around the blisters, and intolerable itching and pain feeling is accompanied; the second stage is the development period (3-4 days), i.e. the blister is broken, and the affected part has seepage to form superficial erosion; the third stage is a healing period (5-8 days), in which the affected part gradually dries, scabs and falls off. After the healing, the local part can remain with temporary pigmentation. Although the disease has good prognosis, the disease course is long, the focus is at the mouth and the lip, the pain and the itch are uncomfortable, the mouth is dare to open after scabbing, and the eating, the language and the beauty of a patient are influenced.

At present, the treatment method of herpes labialis is daily care, namely adjusting mental state, avoiding fatigue, fully resting and assisting oral administration to supplement vitamin C and vitamin B complex. If necessary, acyclovir, ribavirin and other antiviral drugs are externally or orally taken. However, the clinical therapeutic effect of antiviral drugs is not good and the course of disease cannot be effectively shortened.

Sweet Osmanthus is a commonly known name of Osmanthus fragrans (Osmanthus fragrans) of Olea (Oleaceae) L our, also called as Cinnamomum japonicum, Murraya paniculata and the like, evergreen arbor or shrub, corolla tetrandra and small in shape, and has wide application and long history as an additive component in the field of food processing due to the remarkable sweet and fragrant smell and taste of sweet Osmanthus.

The Osmanthus fragrans (Osmanthus fragrans (Thunb.) L our.) flower contains a certain amount of absolute oil components, is a kind of oily substance with non-volatile fat-soluble components as the main components, and is an important secondary metabolite.

The Chinese invention patent application with the application number of CN201710420375.7 discloses an osmanthus flower extract, namely osmanthus flower absolute, and at present, the osmanthus flower extract is mainly used as a spice or common skin care, and the application of the osmanthus flower extract in the preparation of a medicament for preventing and treating herpes labialis is not reported.

Disclosure of Invention

In order to solve the problems, the invention provides a new application of an osmanthus flower extract, namely an application of the osmanthus flower extract in preparing a medicament for preventing and treating herpes labialis. Based on the application, the osmanthus flower extract can be used as an active ingredient for treating herpes labialis dermatosis.

In order to achieve the purpose, the invention adopts the following technical scheme:

the application of the osmanthus flower extract in preparing the medicine for preventing and treating herpes labialis is characterized in that the active component of the medicine is the osmanthus flower extract, and the osmanthus flower extract is the osmanthus flower absolute disclosed in the Chinese invention patent application with the application number of CN 201710420375.7.

The medicine is medicinal product, medical apparatus or cosmetic.

The mass percentage concentration range of the osmanthus flower extract is 0.01-2%.

The administration mode of the medicine is external administration.

The dosage forms of the medicine are cream, application, cream, gel, condensation, emulsion and aqua.

The medicine also comprises other auxiliary materials, and the auxiliary materials are auxiliary materials of corresponding formulations allowed to be used for preparing medicines, medical instruments or cosmetics.

Compared with the prior art, the invention has the beneficial effects that:

the osmanthus flower extract is used as an active substance for preventing and treating the herpes labialis skin disease, and after the osmanthus flower extract is absorbed through skin as an active ingredient, the immunity of a patient is improved, the herpes labialis can be treated, and particularly, the disease course of the herpes labialis can be blocked in a development period (before blisters are not broken), so that the disease course does not enter the development period any more. The osmanthus flower extract has a good immunoregulation effect, and the osmanthus flower extract is used as an active ingredient of a medicament for treating herpes labialis, and the aim of treating the herpes labialis is achieved by utilizing the immunoregulation effect of the osmanthus flower extract after the osmanthus flower extract is absorbed by skin.

Detailed Description

The present invention will be further described with reference to the following examples, which are intended to illustrate only some, but not all, of the embodiments of the present invention. All other embodiments that can be obtained by a person skilled in the art based on the embodiments of the present invention without any creative effort belong to the protection scope of the present invention.