阅读说明：本技术 一种预防和治疗心脑血管疾病的组合物及其制备方法 (A composition for preventing and treating cardiovascular and cerebrovascular diseases, and its preparation method ) 是由 贺砥砥 林波 于 2019-12-20 设计创作，主要内容包括：本发明提供一种预防和治疗心脑血管疾病的组合物,所述组合物从心脑血管疾病的发病原因-高血压、高血脂、高血糖入手,通过各组分协同作用,达到有效预防和治疗心脑血管疾病的目的。本发明提供的组合物首先通过葛根粉中的黄酮类物质与大豆磷脂中的有效物质协同发挥促进氧代谢、促进新陈代谢,改善人体微循环的作用,活化脑细胞,促进心脑血管受损部分的修复,促进脂类、糖类代谢,促进血脂、血糖和血压的正常化；其次通过纳豆冻干粉中的纳豆激酶和红曲米粉中的有效物质莫纳可林协同作用,限制胆固醇合成速度,促进血栓溶解；最后通过决明子提取物中的有效物质,提升人体的免疫力,进一步提升对心脑血管疾病的预防和治疗效果。(The invention provides a composition for preventing and treating cardiovascular and cerebrovascular diseases, which starts from the pathogenesis of the cardiovascular and cerebrovascular diseases, namely hypertension, hyperlipidemia and hyperglycemia, and achieves the aim of effectively preventing and treating the cardiovascular and cerebrovascular diseases through the synergistic effect of the components. The composition provided by the invention firstly has the effects of promoting oxygen metabolism, promoting metabolism and improving human body microcirculation through the synergistic effect of flavonoid substances in the radix puerariae powder and effective substances in soybean lecithin, activating brain cells, promoting the repair of damaged parts of heart and cerebral vessels, promoting the metabolism of lipids and saccharides, and promoting the normalization of blood fat, blood sugar and blood pressure; secondly, the synergistic effect of the nattokinase in the natto freeze-dried powder and the monacolin in the red yeast rice powder is utilized to limit the synthesis speed of cholesterol and promote thrombolysis; and finally, the immunity of the human body is improved through the effective substances in the cassia seed extract, and the prevention and treatment effects on the cardiovascular and cerebrovascular diseases are further improved.)

1. The composition for preventing and treating cardiovascular and cerebrovascular diseases is characterized by comprising the following components in parts by weight:

5-30 parts of kudzu root powder, 2-20 parts of natto freeze-dried powder, 5-30 parts of red yeast rice powder, 5-40 parts of cassia seed extract and 5-40 parts of soybean lecithin.

2. The composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 1, wherein the preparation method of pueraria lobata powder comprises the steps of: taking clean radix puerariae, drying, granulating, adding water, heating and refluxing, concentrating, spray drying and crushing to obtain the radix puerariae powder.

3. The composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 1, wherein the preparation method of the natto freeze-dried powder comprises the following steps: soaking soybeans, cooking until the soybeans are well cooked, cooling to 20-40 ℃, inoculating natto bacterial liquid, fermenting for 18-30h at 35-45 ℃ and the relative humidity of 50-90% to obtain natto, refrigerating the obtained natto for more than 24h at 0-10 ℃, freeze-drying, crushing, and sieving with a 40-80-mesh sieve to obtain the natto freeze-dried powder.

4. The composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 1, wherein the preparation method of red yeast rice flour comprises the following steps: soaking rice in water, cooking to be cooked thoroughly, cooling to 20-40 deg.C, inoculating Monascus ruber, adding additional culture medium, performing solid culture to obtain red rice, oven drying, and pulverizing to obtain the red rice powder.

5. The composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 1, wherein the method for preparing the cassia seed extract comprises the following steps: adding dried semen Cassiae into 8-12 times of water, heating and reflux extracting, concentrating, spray drying, pulverizing, and sieving to obtain semen Cassiae extract.

6. The composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 1, wherein said composition further comprises: sorbitol and magnesium stearate.

7. The composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 6, wherein said components comprise sorbitol 22-80 parts by weight and magnesium stearate 0.1-2.4 parts by weight.

8. The method for preparing a composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 6 or 7, comprising the steps of:

(1) uniformly mixing kudzu root powder, natto freeze-dried powder, red yeast rice powder and semen cassiae extract to obtain mixed powder A;

(2) adding the alcohol water solution into the mixed powder A, mixing, shaking, and sieving to obtain wet granules; drying and sieving the wet granules to obtain mixed powder B;

(3) mixing part of sorbitol and soybean lecithin in a weight ratio of 1-2:1, uniformly mixing, sieving, adding magnesium stearate, uniformly mixing, adding the rest of sorbitol, uniformly mixing to obtain mixed powder C, uniformly mixing the mixed powder B and the mixed powder C, and tabletting to obtain the composition for preventing and treating cardiovascular and cerebrovascular diseases.

9. Use of the composition for preventing and treating cardiovascular and cerebrovascular diseases according to any one of claims 1 to 7 for preparing health food or medicament for protecting liver.

10. Use of the composition for preventing and treating cardiovascular and cerebrovascular diseases according to any one of claims 1 to 7 in the preparation of health food or medicament for treating and regulating sleep.

Technical Field

The invention belongs to the technical field of food, and particularly relates to a composition for preventing and treating cardiovascular and cerebrovascular diseases and a preparation method thereof.

Background

Cardiovascular and cerebrovascular diseases are always called as the first killers threatening human health, and according to related survey reports, more than 300 million people die of the cardiovascular and cerebrovascular diseases every year in China, while 75% of survivors with diseases lose labor capacity to different degrees, wherein 4% of the survivors are heavy. More worried about, 80% of adults over 30 years old in China suffer from cardiovascular and cerebrovascular diseases such as hyperlipidemia, hypertension, coronary heart disease, cerebral apoplexy and the like more or less, but 95% of adults suffer from cardiovascular and cerebrovascular diseases such as hyperlipidemia, hypertension, coronary heart disease, cerebral apoplexy and the like, the health condition of the cardiovascular and cerebrovascular systems is not clear enough, 90% of adults suffer from unknown blood pressure levels, and 60% of adults suffer from lack of regular examination and maintenance.

At present, 90% of medical institutions in China focus on treatment after diseases occur, and 90% of primary medical workers know the cardiovascular and cerebrovascular diseases only 5 to 10 years ago.

Cardiovascular and cerebrovascular disease risk factors hypertension is the root cause of major cardiovascular and cerebrovascular diseases, 50-60% of cerebrovascular accidents and 40-50% of myocardial infarction are associated with elevated blood pressure. Hypertension, hyperglycemia and hyperlipidemia are the sources of cardiovascular and cerebrovascular diseases.

Disclosure of Invention

In order to radically control the disability rate and the fatality rate of cardiovascular and cerebrovascular diseases in China and reduce the morbidity of the cardiovascular and cerebrovascular diseases so as to meet the requirements of times development and increasing medical care of people, the invention provides a composition which is prepared from medicinal and edible kudzu root, cassia seed, natto freeze-dried powder obtained by biological fermentation or extraction technology, red yeast rice powder and soybean lecithin.

The invention aims to provide a composition for preventing and treating cardiovascular and cerebrovascular diseases.

Another object of the present invention is to provide a method for preparing the above composition for preventing and treating cardiovascular and cerebrovascular diseases.

According to the purpose of the invention, the invention provides a composition for preventing and treating cardiovascular and cerebrovascular diseases, which comprises the following components in parts by weight:

5-30 parts of kudzu root powder, 2-20 parts of natto freeze-dried powder, 5-30 parts of red yeast rice powder, 5-40 parts of cassia seed extract and 5-40 parts of soybean lecithin.

The invention starts from the pathogenesis of cardiovascular and cerebrovascular diseases, and provides a composition for preventing and treating cardiovascular and cerebrovascular diseases, wherein the components of the composition are matched with each other and have synergistic effect, the composition firstly improves the microcirculation in a human body, reduces the blood fat, the blood sugar and the blood pressure, then limits the synthesis speed of cholesterol, reduces the generation amount of cholesterol, dissolves thrombus, reduces the blood viscosity and removes redundant blood fat in blood by a method of promoting oxygen metabolism and metabolism, and simultaneously, the composition provided by the invention can improve the immunity of the human body while preventing and treating cardiovascular and cerebrovascular diseases, thereby achieving the effects of improving eyesight, resisting bacteria, protecting liver and protecting liver.

The effective substance monacolin in the red yeast rice powder can not be used together with the lipstatin in lipid-lowering medicines, but the lipstatin in the lipid-lowering medicines in the prior art is a main lipstatin, so the application of the red yeast rice powder in cardiovascular and cerebrovascular diseases is greatly limited, and the red yeast rice powder can be used alone even if the red yeast rice powder can be used, and can not achieve good effect.

The composition for preventing and treating cardiovascular and cerebrovascular diseases provided by the invention firstly has the combined action of the radix puerariae powder and the soybean phospholipids, and flavonoids in the radix puerariae powder and effective substances in the soybean phospholipids play a role in promoting oxygen metabolism, promoting metabolism and improving human body microcirculation in a synergistic manner, so that brain cells are activated, the repair of damaged parts of cardiovascular and cerebrovascular vessels is promoted, lipid and carbohydrate metabolism is promoted, and the normalization of blood fat, blood sugar and blood pressure is promoted; secondly, through the interaction between the natto freeze-dried powder and the red yeast rice powder, the natto kinase in the natto freeze-dried powder and the monacolin in the red yeast rice powder have synergistic effect, thereby limiting the synthesis speed of cholesterol, promoting thrombolysis and simultaneously generating no toxic or side effect; according to the invention, the immunity of a human body is improved through the effective substances in the cassia seed extract, and the prevention and treatment effects on cardiovascular and cerebrovascular diseases are further improved.

The composition for preventing and treating cardiovascular and cerebrovascular diseases provided by the invention has the advantages of outstanding efficacy, safe components, no toxic or side effect and capability of being eaten for a long time.

In order to illustrate the effects of the compositions provided by the present invention, the present invention provides the following description of the components.

Kudzuvine root, sweet and pungent in flavor and neutral in nature. Enter spleen and stomach meridians. The functions are as follows: relieving exterior syndrome, expelling pathogenic factors from muscles and skin, invigorating yang, promoting eruption, relieving fever, promoting salivation, relieving restlessness, quenching thirst, and relieving diarrhea. The main treatment is as follows: typhoid fever, tepidity, headache, stiff neck, dysphoria with smothery sensation, diabetes, diarrhea, dysentery, macula impetigo, hypertension, angina pectoris, and deafness. The kudzu root mainly comprises: isoflavone compounds, triterpenes, alkaloids, etc., wherein the isoflavone compounds include daidzein, daidzin, and puerarin; triterpenes include various saponins. Puerarin has obvious effect of stabilizing blood sugar, isoflavone compound in radix Puerariae has effect of stabilizing blood lipid, total flavone and puerarin in radix Puerariae can improve myocardial oxygen metabolism, dilate blood vessel, and improve microcirculation, thereby preventing myocardial infarction, myocardial ischemia, arrhythmia, etc. The daidzin in radix Puerariae is effective in decomposing alcohol, reducing irritation to brain and intestine and stomach, promoting metabolism, and accelerating elimination of alcohol and residual toxin in liver, thereby protecting liver.

The natto freeze-dried powder contains nattokinase with complete activity. Nattokinase (NK) is a subtilisin produced by Bacillus natto. As one kind of alkaline serine proteinase, NK is in single chain polypeptide structure, no disulfide bond, easy to dissolve in water and light yellow or white. The nattokinase reduces blood fat, does not cause adverse reaction of a human body, does not cause damage to the human body, and can also reduce blood viscosity and improve blood rheology indexes. The nattokinase is prepared by fermenting soybeans, wherein the soybeans are rich in nutrient substances and contain various amino acids, and a large number of viscous substances such as polypeptides and polysaccharides, wherein isoflavone, saponin, crude polysaccharide, phospholipid and the like are common functional factors in health care varieties for assisting in reducing blood fat, most of the functional factors are antioxidant substances, can effectively reduce blood fat and cholesterol, can remove lipid peroxide pigments in brain tissues, and can also play a role in assisting in reducing blood fat. In addition, nattokinase is also known to have good thrombolytic effect, and fibrinolytic activity is also proved by a fibrin plate experiment; the viscous substance in natto contains angiotensin converting enzyme inhibitor, and has effect in lowering blood pressure. The nattokinase can also dissolve coronary artery thrombus, obviously reduce thrombus, promote blood vessel recanalization and obviously reduce myocardial ischemia degree. The natto contains angiotensin converting enzyme inhibitor, which can convert angiotensin into active form in inactive state, and not only can exert its function, but also can reduce blood pressure caused by blood vessel tension.

Red rice powder is red or purple rice prepared by inoculating Monascus fungus (Monascus) to rice and fermenting. The red yeast rice powder has sweet taste and warm nature, and has effects of promoting blood circulation, removing blood stasis, invigorating spleen and resolving food stagnation. It can be used for treating puerperal lochiorrhea, abdominal pain due to blood stasis, dysentery, and traumatic injury. The main functional components of the red yeast rice comprise monascus pigment, ergosterol and enzyme active substances, such as: amylase, saccharifying enzyme, maltase, protease, pectinase, esterifying enzyme, gamma-aminobutyric acid, and monacolin. HMC-CoA reductase is the rate-limiting enzyme of cholesterol synthesis system, and the activity of HMC-CoA reductase determines the synthesis rate of cholesterol. The monacolin in red yeast rice powder can specifically resist and inhibit the activity of HMC-CoA reductase, reduce the plasma lipoprotein concentration containing low-density lipoprotein (LDL), medium-density lipoprotein (IDL) and very-low-density lipoprotein (VLDL) by increasing the activity of apolipoprotein receptor, increase the activity of LDL receptor complementally and promote the removal of LDL in plasma, thereby achieving the purpose of reducing the concentration of cholesterol in blood. Meanwhile, the enzyme active substances in the red yeast rice powder also have the function of assisting in reducing blood fat. In addition, the gamma-aminobutyric acid in the red yeast rice powder has double control effects on blood pressure and has the effect of reducing blood sugar.

Semen Cassiae has sweet, bitter and salty taste, and good for entering liver, kidney and large intestine channels, and has effects of loosening bowel to relieve constipation, removing liver fire and improving eyesight. The effective components of the cassia seed are as follows: anthraquinones, naphtho-pyrones, proteins, amino acids, saccharides, trace elements, and the like. Anthraquinone aglycone and protein in semen Cassiae can reduce triacylglycerol content, total cholesterol content, and low density lipoprotein content; the cassia seed extract has obvious inhibiting effect on staphylococcus, diphtheria bacillus, typhoid bacillus and the like; the cassia seed has the functions of diminishing inflammation and purging the lower-jiao energy, so the cassia seed can dispel wind-heat, improve eyesight and relax bowels, and has a certain inhibiting effect on obesity.

Phospholipid is one of important components of human tissue composition, can be used as a source of daily polyphosphoric acid cholesterol, and is related to fat in a body, a cholesterol metabolic enzyme system, conversion of fat in a liver and the like. Soybean lecithin is the precursor of active substances such as acetylcholine and prostate in brain and nervous system, and can dissolve and remove certain lipid peroxides, activate brain cells, and regulate endocrine system. Therefore, the soybean lecithin is used for the anti-aging health care product, can prolong the service life, and has different relieving and treating effects on various senile diseases, senile dementia and cerebrovascular system diseases. Soybean phospholipids can also regulate cholesterol and lipid metabolism in vivo, reduce and partially eliminate cholesterol deposition in blood vessel wall, and can be used for preventing and treating cardiovascular diseases. The soybean phospholipids can increase and improve blood coagulation, and can be used for production of blood-tonifying product. In addition, the soybean lecithin also has the effects of protecting the liver, preventing fatty liver and liver cirrhosis, partially dissolving gallstone and preventing generation of the gallstone, and can eliminate the harm of toxic substances such as smoke, wine, benzene glue and the like to human bodies, thereby having a certain detoxification effect. The research also finds that the soybean phospholipid product can be used for treating various chronic diseases such as diabetes, arthritis, hypotension, gastric dilatation, neurosis and the like.

Preferably, the preparation method of the kudzu root powder comprises the following steps: taking clean radix puerariae, drying, granulating, adding water, heating and refluxing, concentrating, spray drying and crushing to obtain the radix puerariae powder.

Preferably, the preparation method of the natto freeze-dried powder comprises the following steps: soaking soybeans, cooking until the soybeans are well cooked, cooling to 20-40 ℃, inoculating natto bacterial liquid, fermenting for 18-30h at 35-45 ℃ and the relative humidity of 50-90% to obtain natto, refrigerating the obtained natto for more than 24h at 0-10 ℃, freeze-drying, crushing, and sieving with a 40-80-mesh sieve to obtain the natto freeze-dried powder.

The preparation method of the natto freeze-dried powder provided by the invention is used for fermenting under the conditions of proper temperature and humidity, and then the natto freeze-dried powder is obtained by utilizing a freeze-drying technology, and the obtained natto freeze-dried powder has high natto kinase content and high activity.

Preferably, the preparation method of the red yeast rice powder comprises the following steps: soaking rice in water, cooking to be cooked thoroughly, cooling to 20-40 deg.C, inoculating Monascus ruber, adding additional culture medium, performing solid culture to obtain red rice, oven drying, and pulverizing to obtain the red rice powder.

Preferably, the preparation method of the cassia seed extract comprises the following steps: adding dried semen Cassiae into 8-12 times of water, heating and reflux extracting, concentrating, spray drying, pulverizing, and sieving to obtain semen Cassiae extract. The cassia seed extract provided by the invention adopts a heating reflux extraction method to extract effective substances in the cassia seed, so that water-soluble active ingredients in the cassia seed are kept as much as possible, the yield of the effective ingredients in the cassia seed is improved, and the efficacy of the finally obtained composition is improved.

Preferably, the composition further comprises: sorbitol and magnesium stearate.

Preferably, the components comprise 22-80 parts of sorbitol and 0.1-2.4 parts of magnesium stearate in parts by weight.

The invention provides a preparation method of the composition for preventing and treating cardiovascular and cerebrovascular diseases, which comprises the following steps:

(1) uniformly mixing kudzu root powder, natto freeze-dried powder, red yeast rice powder and semen cassiae extract to obtain mixed powder A;

(2) adding the alcohol water solution into the mixed powder A, mixing, shaking, and sieving to obtain wet granules; drying and sieving the wet granules to obtain mixed powder B;

(3) mixing part of sorbitol and soybean lecithin in a weight ratio of 1-2:1, uniformly mixing, sieving, adding magnesium stearate, uniformly mixing, adding the rest of sorbitol, uniformly mixing to obtain mixed powder C, uniformly mixing the mixed powder B and the mixed powder C, and tabletting to obtain the composition for preventing and treating cardiovascular and cerebrovascular diseases.

The composition for preventing and treating cardiovascular and cerebrovascular diseases provided by the invention can be applied to preparation of health-care food or drugs for protecting liver.

The composition for preventing and treating cardiovascular and cerebrovascular diseases provided by the invention can be applied to preparation of health-care food or medicines for treating and regulating sleep.

The composition for preventing and treating cardiovascular and cerebrovascular diseases provided by the invention can effectively reduce blood pressure, blood sugar and blood fat, can effectively protect liver, regulate sleep, relax bowel, improve immunity of human body and improve physique of sub-health people.

The invention has the beneficial effects that:

1. the composition for preventing and treating cardiovascular and cerebrovascular diseases provided by the invention starts from the pathogenesis of cardiovascular and cerebrovascular diseases, and achieves the purpose of effectively preventing and treating cardiovascular and cerebrovascular diseases through the same matching and synergistic effect of all components which are homologous in medicine and food. The composition for preventing and treating cardiovascular and cerebrovascular diseases provided by the invention firstly has the combined action of the radix puerariae powder and the soybean phospholipids, and flavonoids in the radix puerariae powder and effective substances in the soybean phospholipids play a role in promoting oxygen metabolism, promoting metabolism and improving human body microcirculation in a synergistic manner, so that brain cells are activated, the repair of damaged parts of cardiovascular and cerebrovascular vessels is promoted, lipid and carbohydrate metabolism is promoted, and the normalization of blood fat, blood sugar and blood pressure is promoted; secondly, through the interaction between the natto freeze-dried powder and the red yeast rice powder, the natto kinase in the natto freeze-dried powder and the monacolin in the red yeast rice powder have synergistic effect, thereby limiting the synthesis speed of cholesterol, promoting thrombolysis and simultaneously generating no toxic or side effect; according to the invention, the immunity of a human body is improved through the effective substances in the cassia seed extract, and the prevention and treatment effects on cardiovascular and cerebrovascular diseases are further improved.

2. The composition for preventing and treating cardiovascular and cerebrovascular diseases provided by the invention has the advantages of outstanding efficacy, safe components and no toxic or side effect through mutual matching and synergistic effect of the components, and can be eaten for a long time.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

In the examples of the present invention, 100g is used per 1 part by weight.