阅读说明：本技术 一种治疗血管内皮炎症损伤的黄精组合物的应用 (Application of rhizoma polygonati composition for treating vascular endophthalmitis injury ) 是由 封芬 周斌 李勇杰 魏海谅 欧阳恩鸿 于 2021-06-17 设计创作，主要内容包括：本发明公开了中药制药领域的一种治疗血管内皮炎症损伤的黄精组合物的应用,包括黄精、枸杞子、生地黄、红景天、三七粉、川芎、干地龙和葛根,还包括胶囊壳体,所述胶囊壳体的轴向固定连接有莫比乌斯环,所述莫比乌斯环将胶囊壳体分割为若干个腔室,任意腔室内填装有不同药物,相对于采用胶囊类的缓释药物,本技术方案中利用分割的独立腔室进行药物的储藏,此时独立腔室可以进行药物储藏,以实现药物的分量溶解,以减少胃部负担,实现进一步的缓释作用,减少剂量和服用次数,从而起到更佳的治疗效果。(The invention discloses an application of a polygonatum composition for treating vascular dermatitis injury in the field of traditional Chinese medicine preparation, which comprises polygonatum, wolfberry fruit, radix rehmanniae recen, rhodiola rosea, pseudo-ginseng powder, ligusticum wallichii, dried earthworm and radix puerariae, and further comprises a capsule shell, wherein the capsule shell is axially and fixedly connected with a Mobius ring, the capsule shell is divided into a plurality of cavities by the Mobius ring, different medicines are filled in any cavity, and compared with capsule slow-release medicines, the separated independent cavities are used for storing the medicines in the technical scheme, and the independent cavities can store the medicines so as to realize component dissolution of the medicines, reduce stomach burden, realize further slow-release effect, reduce dosage and administration times and further play a better treatment effect.)

1. The application of a sealwort composition for treating vascular dermatitis injury comprises sealwort, medlar, dried rehmannia root, rhodiola root, notoginseng powder, hemlock parsley, dried earthworm and kudzu root, and is characterized in that: the capsule shell is axially and fixedly connected with a Mobius ring, the Mobius ring divides the capsule shell into a plurality of cavities, and different medicines are filled in any cavity.

2. The use of the composition of polygonatum sibiricum for the treatment of injury due to vascular dermatitis as claimed in claim 1, wherein: the ratio of the plurality of chambers is 3: 2: 2: 2: 1: 2: 2, wherein the ratio of the sealwort, the medlar, the dried rehmannia root, the rhodiola root, the pseudo-ginseng powder, the hemlock parsley, the dry earthworm and the kudzu root is 3: 2: 2: 2: 1: 2: 2.

3. the use of the composition of polygonatum sibiricum for the treatment of injury due to vascular dermatitis as claimed in claim 2, wherein: the capsule shell is made of transparent materials, the Mobius rings are connected to two axial ends of the capsule shell in a sliding mode, cavities which are located on the same side and are adjacent to each other are filled with rhizoma polygonati and pseudo-ginseng powder, and the rhizoma polygonati and the pseudo-ginseng powder are not located in the lowest cavity.

4. The use of the composition of polygonatum sibiricum for the treatment of injury due to vascular dermatitis as claimed in claim 3, wherein: the radial side of the capsule shell is provided with a mark for distinguishing the upper part and the lower part of the capsule shell.

5. The use of the composition of polygonatum sibiricum for the treatment of injury due to vascular dermatitis as claimed in claim 1, wherein: the composition is applied to the medicines for treating the vascular dermatitis injury diseases.

6. The use of the composition of polygonatum sibiricum for the treatment of injury due to vascular dermatitis as claimed in claim 5, wherein: the injury diseases of the vascular dermatitis comprise hypertension, hyperlipidemia, type 2 diabetes mellitus or metabolic syndrome cardiovascular and cerebrovascular complications.

Technical Field

The invention belongs to the field of traditional Chinese medicine pharmacy, and particularly relates to an application of a polygonatum sibiricum composition for treating vascular endothelial inflammation injury.

Background

Vasculitis is the infiltration of inflammatory cells in and around the blood vessel wall with associated vascular damage, including cellulose deposition, collagen fibrosis, endothelial cell and myocyte necrosis, also known as vasculitis. The pathogenic factor directly acts on the vascular wall and is primary vasculitis, and patients with certain clinical symptoms and physical signs on the basis of the vasculitis are vasculitis diseases; secondary vasculitis is caused by inflammatory lesions of adjacent tissues and vessel walls.

Rhizoma polygonati is a traditional Chinese medicine in China, and can tonify middle-jiao and Qi, remove wind and dampness, calm five internal organs, lighten the body, prolong life and avoid hunger after being taken for a long time. Rhizome of Polygonatum sibiricum contains polysaccharide, saponin, flavone, lignan, amino acid, quinone compounds, vitamins, alkaloids, various trace elements and other components, wherein Polygonatum sibiricum polysaccharide is one of the most important active components of Polygonatum sibiricum. Rhizoma Polygonati has antioxidant, antiinflammatory, blood sugar lowering, blood lipid regulating, cardiovascular system protecting, antiaging, and antibacterial effects. Aiming at the pathogenesis of vasculitis, rhizoma polygonati can obviously inhibit the activity of hydroxymethyl glutaryl coenzyme A reductase (HMGR) which is a rate-limiting enzyme of cholesterol biosynthesis, thereby reducing the generation of endogenous cholesterol and having the functions of preventing and treating Atherosclerosis (AS) and liver fat infiltration.

Meanwhile, because the concentration degree of the traditional Chinese medicine is not high, the traditional Chinese medicine is often required to be taken in large dose and many times.

Disclosure of Invention

In order to solve the problems, the invention aims to apply the polygonatum composition to vascular endophthalmitis injury, improve the slow release efficiency of the composition and reduce the administration dosage and frequency.

In order to achieve the purpose, the technical scheme of the invention is as follows: the application of a sealwort composition for treating vascular dermatitis injury comprises sealwort, medlar, dried rehmannia root, rhodiola root, pseudo-ginseng powder, szechuan lovage rhizome, dried earthworm and kudzuvine root, and further comprises a capsule shell, wherein the capsule shell is axially and fixedly connected with a Mobius ring, the capsule shell is divided into a plurality of chambers by the Mobius ring, and different medicines are filled in any chamber.

After the scheme is adopted, the following beneficial effects are realized: 1. compared with the capsule slow-release medicine, the separated independent cavity is used for storing the medicine in the technical scheme, and the independent cavity can be used for storing the medicine so as to realize the component dissolution of the medicine, reduce the burden of the stomach, realize the further slow-release effect and reduce the dosage and the taking times, thereby achieving better treatment effect.

2. Compared with the prior art of further sustained-release effect, the technical scheme can divide the medicine with slight side effect by utilizing the independent cavity, thereby reducing the side effect of the medicine and reducing the loss in the human body healing process.

3. Compared with the prior art adopting an independent chamber, the Mobius ring is utilized to carry out segmentation and bearing in the technical scheme, and due to the characteristics of the Mobius ring, the maximization of a bearing surface is realized, so that the maximum medicinal material capacity in the segmentation chamber with the same volume is realized.

Further, the ratio of the plurality of chambers is 3: 2: 2: 2: 1: 2: 2, wherein the ratio of the sealwort, the medlar, the dried rehmannia root, the rhodiola root, the pseudo-ginseng powder, the hemlock parsley, the dry earthworm and the kudzu root is 3: 2: 2: 2: 1: 2: 2.

has the advantages that: 1. the technical scheme has the effects of tonifying qi and yin, removing blood stasis and descending turbidity, clearing heat and removing collaterals when the symptoms and the root causes are treated together, and is suitable for pathological mechanisms of related diseases, namely vasculitis, pathogenic qi and yin deficiency, phlegm and blood stasis internal resistance and collaterals invasion of chronic diseases.

2. Rhizoma Polygonati rhizome contains rhizoma Polygonati polysaccharide, rhizoma Polygonati oligosaccharide, nicotinic acid, quinones, mucus, amino acids and zinc, copper, ferrum and other essential microelements. The rhizoma Polygonati alcohol extract can enhance heart contractility, increase coronary blood flow, and improve blood rheological parameters and atherosclerotic focus. Has pharmacological effects of lowering blood pressure, inhibiting hyperglycemia, and preventing and treating atherosclerosis and liver fat infiltration; it also has antibacterial and antiviral effects, and can improve immunity, increase activity of superoxide dismutase in vivo, and delay aging.

Further, the capsule shell is made of transparent materials, the Mobius rings are connected to two axial ends of the capsule shell in a sliding mode, cavities which are located on the same side and adjacent to the capsule shell are filled with rhizoma polygonati and pseudo-ginseng powder, and neither the rhizoma polygonati nor the pseudo-ginseng powder is located in the lowest cavity.

Has the advantages that: compared with the prior art of direct loading, this technical scheme will load the medicine and carry out mass balance to keep the relative level in capsule both ends, avoid capsule shell perk when the bottling, reduce the transportation volume, also reduce simultaneously and swallow the in-process because capsule shell is partial to one side all the time and the bite that leads to feels.

Further, one side of the capsule housing in the radial direction is provided with a mark for distinguishing the upper part and the lower part of the capsule housing.

Has the advantages that: utilize the sign in this technical scheme in order to distinguish the top and the below of capsule shell, at this moment in capsule shell production process, operating personnel can see through transparent capsule shell and observe the medicine quality condition, because inside left side of capsule is equal with right side quality, consequently can observe the bending deflection condition of mobius ring in order to confirm whether qualified quality (because the neighbouring cavity is filled with sealwort and pseudo-ginseng powder, and sealwort and pseudo-ginseng powder are not located the minimum cavity, if lead to wrong packing or few packing, mobius ring can be because one side is heavy and the perk).

Further, the composition is applied to the medicine for treating the vascular dermatitis injury diseases.

Further, the vascular dermatitis injury disease comprises hypertension, hyperlipidemia, type 2 diabetes or metabolic syndrome cardiovascular and cerebrovascular complications.

Drawings

FIG. 1 is a schematic diagram of an embodiment of the present invention.

Detailed Description

The following is further detailed by way of specific embodiments:

reference numerals in the drawings of the specification include: capsule housing 1, mobius ring 2, chamber 3, logo 4.

The embodiment is basically as shown in the attached figure 1: the sealwort composition for treating vascular endothelial inflammation injury comprises sealwort, medlar, radix rehmanniae, rhodiola rosea, notoginseng powder, ligusticum wallichii, dried earthworm and kudzu root, and is applied to medicaments for treating vascular endothelial inflammation injury diseases, wherein the vascular endothelial inflammation injury diseases comprise hypertension, hyperlipidemia, diabetes or metabolic syndrome cardiovascular and cerebrovascular complications.

Still include capsule shell 1, capsule shell 1's axial fixedly connected with Mobius ring 2, Mobius ring 2 is divided into a plurality of cavity 3 with capsule shell 1, and different medicines are packed into in arbitrary cavity 3, and the proportion of accounting for 3 of a plurality of cavity 3 is 3: 2: 2: 2: 1: 2: 2, wherein the ratio of the sealwort, the medlar, the dried rehmannia root, the rhodiola root, the pseudo-ginseng powder, the hemlock parsley, the dry earthworm and the kudzu root is 3: 2: 2: 2: 1: 2: 2.

the capsule shell 1 is made of transparent materials, one radial side of the capsule shell 1 is provided with marks 4 for distinguishing the upper part and the lower part of the capsule shell 1, the Mobius rings 2 are connected to the two axial ends of the capsule shell 1 in a sliding mode, cavities 3 which are located on the same side and adjacent to each other are filled with rhizoma polygonati and pseudo-ginseng powder, and the rhizoma polygonati and the pseudo-ginseng powder are not located in the lowest cavity 3.

The specific implementation process is as follows: the technical scheme has the effects of tonifying qi and yin, removing blood stasis and descending the turbid, clearing heat and removing collaterals by treating both symptoms and root causes, and is suitable for the pathological mechanisms of vascular inflammatory diseases, qi and yin deficiency, phlegm and blood stasis internal resistance and collaterals invasion of chronic diseases, wherein rhizome of rhizoma polygonati contains rhizoma polygonati polysaccharide, rhizoma polygonati oligosaccharide, nicotinic acid, quinones, mucus, amino acid, zinc, copper, iron and other trace elements necessary for a human body. The rhizoma Polygonati alcohol extract can enhance heart contractility, increase coronary blood flow, and improve blood rheological parameters and atherosclerotic focus. Has pharmacological effects of lowering blood pressure, inhibiting hyperglycemia, and preventing and treating atherosclerosis and liver fat infiltration; it also has antibacterial and antiviral effects, and can improve immunity, increase activity of superoxide dismutase in vivo, and delay aging.

Utilize the independent cavity 3 of cutting apart to carry out the storage of medicine among this technical scheme, independent cavity 3 can carry out the medicine storage this moment to realize that the weight of medicine dissolves, in order to reduce stomach burden, realize further slow release effect, thereby play better treatment, utilize independent cavity 3 to cut apart the medicine that has slight side effect afterwards, thereby reduce the side effect of medicine, reduce the loss of human healing in-process.

Meanwhile, due to the characteristics of the mobius ring 2, the maximization of the bearing surface is realized, so that the maximum medicinal material capacity in the partition chambers 3 with the same volume is realized, and as the marks 4 are adopted in the technical scheme to distinguish the upper surface from the lower surface, at the moment, in the production process of the capsule shell 1, an operator can observe the quality condition of the medicament through the transparent capsule shell 1, and as the quality of the left side and the right side in the capsule is equal, the bending deflection condition of the mobius ring 2 can be observed to determine whether the quality is qualified or not (as the adjacent chambers 3 are filled with rhizoma polygonati and pseudo-ginseng powder, and the rhizoma polygonati and the pseudo-ginseng powder are not positioned in the lowest chamber 3, if the wrong filling or the few filling is caused, the mobius ring 2 tilts due to the weight of one side).

Subsequently, the quality balance is carried out by keeping the filled medicine, so that the two ends of the capsule are kept to be relatively horizontal, the tilting of the capsule shell 1 in bottling is avoided, the transportation volume is reduced, and the jamming feeling caused by the fact that the capsule shell 1 is always deviated to one side in the swallowing process is also reduced.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

The foregoing is merely an example of the present invention, and common general knowledge in the field of known specific structures and characteristics is not described herein in any greater extent than that known in the art at the filing date or prior to the priority date of the application, so that those skilled in the art can now appreciate that all of the above-described techniques in this field and have the ability to apply routine experimentation before this date can be combined with one or more of the present teachings to complete and implement the present invention, and that certain typical known structures or known methods do not pose any impediments to the implementation of the present invention by those skilled in the art. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.