阅读说明：本技术 康艾注射液在制备治疗或预防艾滋病药物中的应用 (Application of kang' ai injection in preparing medicine for treating or preventing AIDS ) 是由 睢大筼 翁红 于晓风 李建英 蔡利剑 铁芳 于 2019-12-06 设计创作，主要内容包括：本发明公开了康艾注射液在制备治疗或预防艾滋病药物中的应用。本发明经研究发现,康艾注射液可以显著提高HIV/AIDS模型小鼠的脾脏和胸腺的脏器系数,显著提高迟发型超敏反应的水平,明显提高NK细胞的杀伤作用和血清溶血素水平,提高巨噬细胞的吞噬能力,还能提高T淋巴细胞的转化率,提高HIV/AIDS模型小鼠的TNF-α、IL-6的细胞因子水平,增强固有免疫,适应性免疫,提高细胞免疫水平,可作为治疗或预防艾滋病的候选药物。(The invention discloses an application of kang ai injection in preparing a medicament for treating or preventing AIDS, which is found by research that the kang ai injection can obviously improve the organ coefficient of spleen and thymus of an HIV/AIDS model mouse, obviously improve the level of delayed type hypersensitivity, obviously improve the killing function of NK cells and the level of serum hemolysin, improve the phagocytic capacity of macrophages, improve the conversion rate of T lymphocytes, improve the cytokine levels of TNF- α and IL-6 of the HIV/AIDS model mouse, enhance innate immunity, adaptive immunity and improve the level of cellular immunity, and can be used as a candidate medicament for treating or preventing AIDS.)

1. Application of KANGAI injection in preparing medicine for treating or preventing AIDS is provided.

2. The use of claim 1, wherein the composition of the raw materials of the kang' ai injection comprises ginseng, astragalus and kurarinone.

3. The use of claim 2, wherein the kang' ai injection comprises the following components in a mass ratio of (10-50): (6-18): (0.5-3).

4. The use of claim 2 or 3, wherein the conai injection comprises the following components in a mass ratio of ginseng, astragalus and oxymatrine (25-35): (8-12): (0.5-1.5).

5. The use of any one of claims 1-4, wherein said AIDS comprises acute HIV infection and/or asymptomatic HIV infection.

6. The use of any one of claims 1-5, wherein said AIDS is caused by infection with CXCR4 tropic AIDS virus.

7. The use as claimed in any one of claims 1 to 6, wherein the KANGAI injection is prepared from Ginseng radix, radix astragali and oxymatrine as active ingredients, and conventional adjuvants by conventional method.

8. The use according to any one of claims 1 to 7, wherein said kang' ai injection is prepared by a process comprising the steps of:

extracting Ginseng radix with ethanol solution to obtain ethanol extractive solution, and concentrating to obtain Ginseng radix fluid extract; extracting radix astragali with water to obtain water extractive solution, and concentrating to obtain radix astragali fluid extract; mixing the Ginseng radix fluid extract and radix astragali fluid extract, adding water, adding active carbon to remove impurities, and filtering to obtain Ginseng radix and radix astragali filtrate;

dissolving kurarinone in water, filtering, adding the filtrate of Ginseng radix and radix astragali, mixing, and diluting with water for injection.

Technical Field

The invention relates to a new application of kang 'ai injection, in particular to an application of kang' ai injection in preparing a medicine for treating or preventing AIDS.

Background

Acquired Immune Deficiency Syndrome (AIDS), collectively known as acquired immunodeficiency syndrome, is a serious immunodeficiency infectious disease caused by infection with Human Immunodeficiency Virus (HIV). Data of the United nations AIDS planning administration in 2019 show that 3790 thousands of people are infected with HIV all over the world, 170 thousands of newly infected people in 2018 and 77 thousands of people dying from AIDS in 2018. Currently clinically used drugs against HIV/AIDS are mainly second generation HIV inhibitors: diaryl pyrimidines, rilpivirine and etravirine. However, with the wide use of these drugs, cross-resistance and serious toxic side effects are easily generated, so that the clinical application of these drugs is greatly limited. Moreover, the currently used anti-HIV infection drugs have various other disadvantages, such as high price, inconvenient use, complicated medicine taking, incapability of clearing viruses in vivo and the like.

In view of the above problems, the use of traditional Chinese medicine for improving the symptoms of patients, improving the quality of life, alleviating the toxic and side effects of antiviral drugs, improving the immune function of the organism, and reducing the incidence of opportunistic infection is a promising research direction, and thus, chinese patent document CN108815494A discloses a traditional Chinese medicine composition for treating aids, which is prepared from the following raw materials in percentage by weight: 5-10% of cistanche, 8-15% of polygonum multiflorum, 6-8% of eucommia ulmoides, 8-15% of fructus psoraleae, 6-10% of rehmannia glutinosa, 10-15% of astragalus membranaceus, 3-8% of liquorice, 3-8% of phellodendron amurense, 6-10% of dried ginger, 3-8% of clove and 10-15% of epimedium. The preparation method comprises the following steps: cutting the raw materials, decocting with water twice, mixing decoctions, filtering, concentrating the filtrate to obtain soft extract with relative density of 1.28-1.32, drying to obtain dry extract, pulverizing into 80 mesh powder, or making into tablet or pill. However, the above-mentioned traditional Chinese medicine composition has the disadvantages of complex composition and the like, thereby limiting the application thereof.

The KANGAI injection has effects in invigorating qi, strengthening body resistance, and enhancing immunity. Can be used for treating primary liver cancer, lung cancer, rectal cancer, malignant lymphoma, gynecological malignant tumor, leucopenia and chronic hepatitis B caused by various reasons, is a variety accepted in the national Chinese patent medicine standard, and comprises three medicines of radix astragali, ginseng and kurarinone.

At present, there is no report of using Kangai injection for treating AIDS.

Disclosure of Invention

The invention aims to solve the technical problem of providing a new application of a kang ai injection, namely the application of the kang ai injection in preparing a medicament for treating or preventing AIDS.

The invention provides an application of kang' ai injection in preparing a medicament for treating or preventing AIDS.

Furthermore, the raw material medicines of the kang' ai injection comprise ginseng, astragalus and kurarinone.

Further, in the kang ai injection, the mass ratio of the ginseng, the astragalus and the kurarinone is (10-50): (6-18): (0.5-3).

Further, in the kang ai injection, the mass ratio of the ginseng, the astragalus and the kurarinone is (25-35): (8-12): (0.5-1.5).

Further, the aids includes acute HIV infection and/or asymptomatic HIV infection.

Further, aids is caused by CXCR4 tropic aids virus infection.

Furthermore, the kang' ai injection is prepared by taking ginseng, astragalus and kurarinone as active ingredients and adding conventional auxiliary materials according to a conventional process to prepare a clinically acceptable injection.

Further, the preparation method of the kang' ai injection comprises the following steps:

extracting Ginseng radix with ethanol solution to obtain ethanol extractive solution, and concentrating to obtain Ginseng radix fluid extract; extracting radix astragali with water to obtain water extractive solution, and concentrating to obtain radix astragali fluid extract; mixing the Ginseng radix fluid extract and radix astragali fluid extract, adding water, adding active carbon to remove impurities, and filtering to obtain Ginseng radix and radix astragali filtrate;

dissolving kurarinone in water, filtering, adding the filtrate of Ginseng radix and radix astragali, mixing, and diluting with water for injection.

(1) The kang' ai injection can obviously improve the organ coefficient of spleen and thymus of an HIV/AIDS model mouse, obviously improve the level of delayed hypersensitivity, obviously improve the killing effect of NK cells and the level of serum hemolysin, improve the phagocytic capacity of macrophages, improve the conversion rate of T lymphocytes, improve the cytokine levels of TNF- α and IL-6 of the HIV/AIDS model mouse, and can be used as a candidate medicament for treating or preventing AIDS.

(2) The composition of the invention fully considers the composition of the raw materials and the proportion of the raw materials to each other, so that the raw materials are mutually matched and act together under the specific proportion, thereby playing the role of resisting AIDS, having less toxic and side effects and higher safety;

(3) the composition provided by the invention only comprises three raw materials, and is simple in composition and low in cost.

Detailed Description

The kang' ai injection of the present invention can be prepared by the following preparation method, and can also be commercially available.