Oral care product and whitening composition thereof
阅读说明：本技术 口腔护理产品及其美白组合物 (Oral care product and whitening composition thereof ) 是由 卡耶坦·多戈-伊索纳吉 帕洛马·皮门塔 黄春 于 2018-06-19 设计创作，主要内容包括：本发明公开了一种口腔护理产品、其美白组合物及其使用方法。所述口腔护理产品包含口腔可接受的载体和所述美白组合物。所述美白组合物包含美白增效剂和过氧化。(The invention discloses an oral care product, a whitening composition thereof and a using method thereof. The oral care product comprises an orally acceptable carrier and the whitening composition. The whitening composition includes a whitening synergist and peroxide.)
1. A whitening composition comprising a whitening synergist and a hydrogen peroxide source, wherein the whitening synergist comprises a monopersulfate salt.
2. The whitening composition of any preceding claim, wherein said monopersulfate is an alkali metal monopersulfate.
3. The whitening composition of any preceding claim, wherein the whitening potentiator comprises potassium monopersulfate.
4. The whitening composition of any preceding claim, wherein said whitening potentiator consists of a monopersulfate.
5. The whitening composition of any preceding claim, further comprising an orally acceptable carrier, wherein said whitening potentiator is stored separately from said orally acceptable carrier and said source of hydrogen peroxide until the point of use.
6. The whitening composition of any preceding claim, wherein the whitening composition is substantially free of water.
7. The whitening composition of any preceding claim, further comprising a buffering agent.
8. The whitening composition of claim 7, wherein the buffer comprises at least one of sodium bicarbonate and sodium carbonate.
9. An oral care product comprising an orally acceptable carrier and a whitening composition comprising a whitening synergist and a hydrogen peroxide source, wherein the whitening synergist comprises a monopersulfate salt.
10. The oral care product of claim 9, wherein the oral care product is a mouthwash.
11. The oral care product of claim 9 or claim 10, wherein the whitening potentiator is packaged separately from the orally acceptable carrier.
12. A method for whitening teeth in a subject, comprising contacting a whitening composition comprising a whitening booster and a hydrogen peroxide source with the surfaces of the teeth of a subject in need thereof, wherein the whitening booster comprises a monopersulfate.
13. The method of claim 12, further comprising contacting the whitening potentiator with hydrogen peroxide from the hydrogen peroxide source prior to contacting the surface of the tooth.
14. The method of claim 12 or claim 13, further comprising contacting the hydrogen peroxide source with water to produce the hydrogen peroxide.
15. The method of claims 12-14, further comprising contacting the whitening composition to the surface of the tooth at least twice a day.
Background
Conventional oral care products (e.g., mouthwashes, toothpastes, gels, etc.) containing whitening agents are commonly employed to whiten teeth. For example, conventional mouthwashes containing hydrogen peroxide are typically employed to oxidize surface and/or dentin bound chromophores in teeth, thereby whitening the teeth. While mouthwashes comprising hydrogen peroxide have proven effective for whitening teeth, different chromophores on the surface typically oxidize in different ratios and/or via different mechanisms. Thus, a mouthwash containing a single whitening agent (e.g., hydrogen peroxide) may require a relatively long treatment time to significantly whiten teeth.
In view of the foregoing, oral care products incorporating hydrogen peroxide typically contain additional whitening agents that facilitate the oxidation of different chromophores, thereby reducing treatment time. Although oral care products incorporating a variety of whitening agents have been shown to have enhanced efficacy in whitening teeth, it is desirable to employ a relatively more reactive whitening agent to further reduce treatment time. However, whitening agents with relatively enhanced reactivity are often unstable and/or susceptible to degradation. For example, whitening agents that have relatively increased reactivity typically react with and/or degrade other components of the dentifrice (e.g., water), thereby reducing their effectiveness.
Accordingly, there is a need for improved whitening compositions and methods for whitening teeth.
Disclosure of Invention
This summary is intended only to introduce a simplified summary of some aspects of one or more embodiments of the disclosure. Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview, is not intended to identify key or critical elements of the teachings or to delineate the scope of the disclosure. Rather, its sole purpose is to present one or more concepts in a simplified form as a prelude to the more detailed description that is presented later.
The foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing a whitening composition comprising a whitening potentiator and a hydrogen peroxide source, wherein the whitening potentiator comprises a monopersulfate.
In at least one embodiment, the monopersulfate is an alkali metal salt of monopersulfate.
In another embodiment, the whitening potentiator comprises potassium monopersulfate.
In another embodiment, the whitening potentiator comprises only a monopersulfate.
In another embodiment, the whitening composition consists of or consists essentially of a whitening synergist and a hydrogen peroxide source. As used herein, consisting essentially of a whitening synergist and a hydrogen peroxide source may refer to any substance, compound, material, etc. that comprises a whitening synergist and a hydrogen peroxide source, and that does not substantially affect the combination of the whitening synergist and the hydrogen peroxide source and/or does not synergistically interact with the whitening synergist and/or the hydrogen peroxide source to increase the whitening efficacy of the whitening composition. Thus, consisting essentially of a whitening synergist and a hydrogen peroxide source means that the composition may comprise any additional substances, compounds, materials, etc. that do not substantially interact and/or synergistically interact with the whitening synergist and/or the hydrogen peroxide source, thereby increasing the whitening efficacy of the whitening composition.
In another embodiment, the whitening composition further comprises an orally acceptable carrier, and the whitening potentiator is stored separately from the orally acceptable carrier and the source of hydrogen peroxide until the point of use.
In another embodiment, the whitening composition is substantially free of water.
In another embodiment, the whitening composition further comprises a buffering agent.
In another embodiment, the buffer comprises at least one of sodium bicarbonate and sodium carbonate.
The foregoing and/or other aspects and uses embodied in the present disclosure may also be achieved by providing an oral care product comprising an orally acceptable carrier and any of the whitening compositions disclosed herein.
In at least one embodiment, the oral care product is a mouthwash.
In another embodiment, the whitening potentiator of an oral care product is packaged separately from an orally acceptable carrier.
The foregoing and/or other aspects and uses embodied in the present disclosure may also be achieved by providing a method for whitening teeth of a subject, the method comprising contacting a tooth surface of a subject in need thereof with any of the whitening compositions disclosed herein.
In at least one embodiment, the method comprises contacting the whitening potentiator with hydrogen peroxide from a hydrogen peroxide source prior to contacting the surface of the teeth.
In another embodiment, the hydrogen peroxide source is contacted with water to produce hydrogen peroxide.
In another embodiment, the whitening composition is contacted with the surface of the teeth at least twice daily.
Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. It should be understood that the detailed description and specific examples, while indicating exemplary aspects of the disclosure, are intended for purposes of illustration only and are not intended to limit the scope of the disclosure.
Detailed Description
The following description of the various aspects is merely exemplary in nature and is in no way intended to limit the disclosure, its application, or uses.
Ranges are used throughout as a shorthand way of describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. In addition, all references cited herein are hereby incorporated by reference in their entirety. In the event of a conflict in a definition in the present disclosure and a definition in a cited reference, the present disclosure controls.
Unless otherwise indicated, all percentages and amounts expressed herein and elsewhere in this specification are to be understood as referring to weight percentages. The amounts given are based on the effective weight of the material.
Moreover, all numerical values are "about" or "approximately" the stated value, and take into account experimental error and deviation as would be expected by one of ordinary skill in the art. It should be understood that all numbers and ranges disclosed herein are approximations and approximate ranges, regardless of whether "about" is used in connection therewith. It is also to be understood that the term "about" in connection with a numerical value, as used herein, refers to a value that can be ± 0.01% (inclusive), 0.1% (inclusive), 0.5% (inclusive), 1% (inclusive), 2% (inclusive), 3% (inclusive), 5% (inclusive), 10% (inclusive), or 15% (inclusive) of the numerical value. It should also be understood that when numerical ranges are disclosed herein, any number falling within the range is also expressly disclosed.
The present inventors have surprisingly and unexpectedly found that inclusion of a whitening potentiator, such as a Monopersulfate (MPS), in an oral care product or whitening composition thereof provides an unexpected and statistically significant increase in whitening efficacy compared to conventional hydrogen peroxide oral care products. The present inventors have also surprisingly and unexpectedly found that the combination of MPS and hydrogen peroxide exhibits a synergistic effect (e.g., an effect beyond additive) that provides an unexpected and statistically significant enhancement or increase in whitening efficacy for an oral care composition or a whitening composition thereof. In particular, the oral care composition or whitening composition thereof combining MPS and hydrogen peroxide provides a tooth whitening effect at a faster rate.
Composition comprising a metal oxide and a metal oxide
The compositions disclosed herein may be or include an oral care product or oral care composition and/or whitening compositions thereof. For example, the composition may be an oral care product comprising a whitening composition, or a whitening composition thereof. In typical embodiments, the composition may be a mouthwash comprising a whitening composition, or a whitening composition thereof. The whitening composition may comprise one or more whitening synergists or enhancers, one or more sources of hydrogen peroxide, one or more buffers, and combinations and mixtures thereof. For example, the whitening composition may comprise one or more whitening boosters and one or more sources of hydrogen peroxide. In another example, the whitening composition may comprise one or more whitening potentiators, one or more sources of hydrogen peroxide, and one or more buffering agents. As further described herein, the whitening potentiator can be or include one or more non-peroxide bleaching agents capable of or configured to synergistically interact to enhance the whitening efficacy of the oral care product or whitening composition thereof.
Any one or more of the whitening potentiator, hydrogen peroxide source, and/or buffer can be stored separately from each other up to the point of use where the whitening potentiator, hydrogen peroxide source, and/or buffer can be combined, mixed, or contacted with each other to form an oral care product or whitening composition thereof. For example, the whitening potentiator may be stored separately from the source of hydrogen peroxide and/or the buffering agent. In another example, the hydrogen peroxide source may be kept separate from the whitening potentiator and/or the buffer. In yet another example, the buffering agent may be stored separately from the whitening potentiator and/or the source of hydrogen peroxide.
In at least one embodiment, any one or more of the whitening synergist, the hydrogen peroxide source, and/or the buffer of the whitening composition may be stored in a separate container until the point of use. For example, any one or more of the whitening potentiator, hydrogen peroxide source, and/or buffer may be stored in a first vessel or container, and the remaining one or more of the whitening potentiator, hydrogen peroxide source, and/or buffer may be stored in a second vessel or container. Each of the first vessel or container and the second vessel or container may be stored separately from each other up to the point of use. The respective contents of the first vessel or container and the second vessel or container may be mixed, stirred, dispersed, dissolved, combined, or contacted with each other prior to use or at the point of use to produce a whitening composition.
In at least one embodiment, any one or more of the whitening synergist, the hydrogen peroxide source, and/or the buffer of the whitening composition may be maintained in a separate phase up to the point of use. For example, an oral care product or whitening composition thereof may comprise at least two separate phases, which may be combined with each other to produce a whitening composition. For example, any one or more of the whitening potentiator, hydrogen peroxide source, and/or buffer can be stored in a first phase (e.g., a hydrophilic phase) and the remaining one or more of the whitening potentiator, hydrogen peroxide source, and/or buffer can be stored in a second phase (e.g., a hydrophobic phase). In one exemplary embodiment, at least the whitening synergist and the hydrogen peroxide source may be stored in separate phases. In another exemplary embodiment, the hydrogen peroxide source may be stored in a separate phase from the carrier (such as water). The first or hydrophilic phase may be combined, mixed or otherwise contacted with the second or hydrophobic phase prior to or at the point of use. The surfactant or surfactant system may aid or assist in the mixing of the hydrophilic and hydrophobic phases.
The whitening composition or components thereof may be anhydrous prior to use. For example, the whitening composition or components thereof may be free or substantially free of water. As used herein, "free" or "substantially free" may refer to a composition that contains less than 5.0 wt.%, less than 3.0 wt.%, less than 1.0 wt.%, less than 0.1 wt.%, less than 0.05 wt.%, less than 0.01 wt.%, less than 0.005 wt.%, or less than 0.0001 wt.%, based on the total weight of the composition.
In one embodiment, contacting the whitening composition or components thereof with water may initiate the release of hydrogen peroxide. For example, contacting a source of hydrogen peroxide with water may initiate the release of hydrogen peroxide. In another example, the hydrogen peroxide source may be maintained in a hydrophobic phase, and combining, mixing, or contacting the hydrophobic and hydrophilic phases with each other may initiate the release of hydrogen peroxide from the hydrogen peroxide source.
Hydrogen peroxide source
The one or more sources of hydrogen peroxide may be any compound or material capable of or configured to synergistically interact or react with the whitening potentiator to enhance or increase the whitening efficacy of the oral care product or whitening composition thereof. For example, the one or more sources of hydrogen peroxide may be or include any compound or material capable of or configured to provide or release hydrogen peroxide that synergistically interacts or reacts with the whitening potentiator to enhance or augment the oral care product or its whiteningThe composition has skin whitening effect. As discussed above, the hydrogen peroxide source may be configured to release hydrogen peroxide upon contact with water. Exemplary hydrogen peroxide sources may be or include, but are not limited to, hydrogen peroxide, urea peroxide, sodium perborate, calcium peroxide, crosslinked polyvinylpyrrolidone (PVP) hydrogen peroxide complex, sodium percarbonate, and the like, and combinations thereof. The source of hydrogen peroxide may also be or include, but is not limited to, PEROXYDONE commercially available from AshlandInc, Covington, KYIMXL 10F complex. In a typical embodiment, the source of hydrogen peroxide is hydrogen peroxide.
The amount or concentration of the hydrogen peroxide source may vary widely and may depend on the amount of hydrogen peroxide provided or delivered by the hydrogen peroxide source. In at least one embodiment, the hydrogen peroxide source may be present in an amount such that: the amount provides from greater than 0.0 wt% to less than or equal to 35.0 wt% of free hydrogen peroxide based on the total weight of the oral care product or whitening composition thereof. For example, the hydrogen peroxide source may be present in an amount such that: the amount provides from greater than 0.0 wt%, about 0.5 wt%, about 1.0 wt%, about 1.5 wt%, about 2.0 wt%, about 2.5 wt%, about 3.0 wt%, about 3.5 wt%, about 4.0 wt%, about 4.5 wt%, about 5.5 wt%, about 6.0 wt%, about 6.5 wt%, about 7.0 wt%, about 7.5 wt%, about 8.0 wt%, about 8.5 wt%, about 9.0 wt%, about 9.5 wt%, or about 10.0 wt% to about 12.0 wt%, about 14.0 wt%, about 16.0 wt%, about 18.0 wt%, about 20.0 wt%, about 22.0 wt%, about 24.0 wt%, about 26.0 wt%, about 28.0 wt%, about 30.0 wt%, about 32.0 wt%, or about 34 wt% of hydrogen peroxide, based on the total weight of the oral care product or whitening composition thereof (e.g., free hydrogen peroxide is less than about 34 wt%).
In another embodiment, the source of hydrogen peroxide may be present in an amount such that: the amount provides from greater than 0.0 wt% to less than or equal to 10.0 wt% of free hydrogen peroxide based on the total weight of the oral care product or whitening composition thereof. For example, the hydrogen peroxide source may be present in an amount such that: the amount provides hydrogen peroxide (e.g., free hydrogen peroxide) in an amount of from greater than 0.0 wt%, about 0.5 wt%, about 1.0 wt%, about 1.5 wt%, about 2.0 wt%, about 2.5 wt%, about 3.0 wt%, about 3.5 wt%, about 4.0 wt%, or about 4.5 wt% to about 5.5 wt%, about 6.0 wt%, about 6.5 wt%, about 7.0 wt%, about 7.5 wt%, about 8.0 wt%, about 8.5 wt%, about 9.0 wt%, about 9.5 wt%, or about 10.0 wt%, based on the total weight of the oral care product or whitening composition thereof. In another example, the hydrogen peroxide source may be present in an amount such that: the amount provides hydrogen peroxide in an amount from greater than 0.0 wt% to less than or equal to 10.0 wt%, about 0.5 wt% to about 9.5 wt%, about 1.0 wt% to about 9.0 wt%, about 1.5 wt% to about 8.5 wt%, about 2.0 wt% to about 8.0 wt%, about 2.5 wt% to about 7.5 wt%, about 3.0 wt% to about 7.0 wt%, about 3.5 wt% to about 6.5 wt%, about 4.0 wt% to about 6.0 wt%, or about 4.5 wt% to about 5.5 wt%.
In yet another embodiment, the source of hydrogen peroxide may be present in an amount such that: the amount provides from about 0.1 wt% to less than or equal to 2.0 wt% of free hydrogen peroxide based on the total weight of the oral care product or whitening composition thereof. For example, the hydrogen peroxide source may be present in an amount such that: the amount provides hydrogen peroxide (e.g., free hydrogen peroxide) in an amount from about 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, or about 1.0 wt% to about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.7 wt%, about 1.8 wt%, about 1.9 wt%, or about 2.0 wt%. In another example, the hydrogen peroxide source may be present in an amount such that: the amount provides hydrogen peroxide in an amount from about 0.1 wt% to about 2.0 wt%, about 0.2 wt% to about 1.9 wt%, about 0.3 wt% to about 1.8 wt%, about 0.4 wt% to about 1.7 wt%, about 0.5 wt% to about 1.6 wt%, about 0.6 wt% to about 1.5 wt%, about 0.7 wt% to about 1.4 wt%, about 0.8 wt% to about 1.3 wt%, about 0.9 wt% to about 1.2 wt%, or about 1.0 wt% to about 1.1 wt%. In yet another example, the source of hydrogen peroxide may be present in an amount such that: the amount provides hydrogen peroxide in an amount less than or equal to 2.0 wt.%, less than or equal to 1.8 wt.%, less than or equal to 1.6 wt.%, less than or equal to 1.4 wt.%, less than or equal to 1.2 wt.%, less than or equal to 1.0 wt.%, less than or equal to 0.8 wt.%, less than or equal to 0.6 wt.%, or less than or equal to 0.4 wt.%. In a typical embodiment, the hydrogen peroxide source may be present in an amount such that: the amount provides hydrogen peroxide in an amount of about 35.0 wt.% or less, or about 2.5 wt.% or less, or about 2.0 wt.% or less.
Whitening synergist
The whitening potentiator can be or include any compound or material that is capable of or configured to synergistically interact or react with a source of hydrogen peroxide or hydrogen peroxide thereof to enhance the whitening efficacy of the oral care product or whitening composition thereof. In at least one embodiment, the whitening potentiator can be or include one or more non-peroxide bleaching agents. The whitening potentiator or non-peroxygen bleach may be water soluble. Exemplary non-peroxide bleaching agents can be or include, but are not limited to, peroxymonosulfate or Monopersulfate (MPS). For example, the whitening potentiator can be or include, but is not limited to, an alkali metal salt of MPS, such as MPS potassium, MPS sodium, or MPS ammonium. MPS can be provided as a single molecule, a compound (such as a monopersulfate or MPS compound), or a complex (such as a monopersulfate complex). For example, the MPS compound may be a mixed or triple salt (2 KHSO)5·KHSO4·K2SO4) It can be prepared from
In at least one embodiment, the whitening potentiator may be provided in a solid form. For example, the whitening synergist may be provided in a powder, a tablet, a granule, etc., and the whitening synergist may be combined with the remaining components to form a whitening composition. It is to be understood that the solids may be free or substantially free of water. The solid may be provided in a variety of forms including, but not limited to, free-flowing granulating agents, tablets (e.g., effervescent tablets), caplets, granules, pellets, wafers, films, beads, and the like. In another embodiment, the whitening potentiator may be provided as a liquid, mixture, or solution (such as a liquid dispersion of solids).
The whitening potentiator can be provided separately from one or more of the remaining components or ingredients of the whitening composition, and at the point-of-use, the whitening potentiator can be combined, mixed, dispersed, or contacted with one or more of the remaining components to form an oral care product or whitening composition thereof. For example, as discussed above, the whitening potentiator can be provided as a solid and can be contacted with one or more of the remaining components to form or provide an oral care product or whitening composition thereof.
In at least one embodiment, the whitening potentiator can be provided in an air-tight, moisture-proof container, package, vessel, or the like. Exemplary packages may be or include, but are not limited to, sealed metal foil pouches, blister packs, lidded tubes containing desiccant, and the like. The package may be made of a polymeric material (such as polyethylene, polypropylene, and the like, or copolymers thereof), a metallic material (e.g., aluminum), or both a polymeric material and a metallic material. The whitening potentiator may be packaged in single or multiple doses.
The amount or concentration of the whitening synergist may vary widely. In at least one embodiment, the whitening potentiator may be provided in an amount of greater than 0.0 to about 10 weight% based on the total weight of the oral care product or whitening composition thereof. For example, the whitening potentiator may be provided in an amount from greater than 0.0, about 0.5, about 1, about 1.5, about 2, about 2.5, about 3, about 3.5, about 4, or about 4.5 to about 5, about 5.5, about 6, about 6.5, about 7, about 7.5, about 8, about 8.5, about 9, about 9.5, or about 10 weight percent. In another example, the whitening potentiator may be provided in an amount from greater than 0.0, about 0.1, about 0.2, about 0.3, about 0.4, about 0.5, about 0.6, about 0.7, about 0.8, about 0.9, or about 1.0 to about 1.1, about 1.2, about 1.3, about 1.4, about 1.5, about 1.6, about 1.7, about 1.8, about 1.9, or about 2.0 weight percent. In yet another example, the whitening potentiator may be provided in an amount from greater than 0.0% to about 2.0%, about 0.1% to about 1.9%, about 0.2% to about 1.8%, about 0.3% to about 1.7%, about 0.4% to about 1.6%, about 0.5% to about 1.5%, about 0.6% to about 1.4%, about 0.7% to about 1.3%, about 0.8% to about 1.2%, or about 0.9% to about 1.1% by weight.
In at least one embodiment, the amount of whitening synergist present in the whitening composition may be determined at least in part by or in accordance with the amount of hydrogen peroxide provided or delivered by the hydrogen peroxide source. For example, the whitening potentiator may be provided in an amount such that: the amount is such that the ratio of the amount of whitening synergist to the amount of hydrogen peroxide provided by the source of hydrogen peroxide may be from about 0.1: 1 to about 5: 1, or from about 0.1: 1 to about 10: 1, or from about 0.1: 1 to about 15: 1. For example, the ratio of the amount of hydrogen peroxide provided by the whitening potentiator to the source of hydrogen peroxide can be from about 0.01: 1, about 0.1: 1, about 0.5: 1, about 1: 1, about 1.5: 1, or about 2: 1 to about 2.5: 1, about 3: 1, about 3.5: 1, about 4: 1, about 4.5: 1, about 5: 1, about 10: 1, or about 15: 1. In another example, the ratio of the amount of hydrogen peroxide provided by the whitening potentiator to the source of hydrogen peroxide can be from about 0.1: 1 to about 5: 1, about 0.5: 1 to about 4.5: 1, about 1: 1 to about 4: 1, about 1.5: 1 to about 3.5: 1, or about 2: 1 to about 3: 1.
Polymer and method of making same
The oral care product or whitening composition thereof may comprise one or more polymers. Exemplary polymers that may be included in the oral care products or whitening compositions thereof may include polyvinyl methyl ether maleic acid copolymers and/or polysaccharides (such as cellulose derivatives, polysaccharide gums, and the like), and combinations thereof. The cellulose derivative may comprise carboxymethyl cellulose and the polysaccharide gum may comprise xanthan gum or carrageenan.
In at least one embodiment, the whitening composition may include one or more copolymers, such as polyvinyl methyl ether/maleic anhydride (PVM/MA) copolymer, polymaleic anhydride, polystyrene/maleic anhydride (PS/MA) copolymer, polyethylene/maleic anhydride (PE/MA) copolymer, polypropylene/maleic anhydride (PP/MA) copolymer, polypropylene grafted maleic anhydride, polyethylene grafted maleic anhydride and polyisoprene grafted maleic anhydride, phosphate/acrylate copolymers, and the like, and combinations thereof. Exemplary PVM/MA copolymers can include
Fluoride ion source
The oral care product and/or whitening composition thereof may further comprise one or more fluoride ion sources (e.g., soluble fluoride salts). A variety of fluoride ion-generating materials may be employed as the soluble fluoride source. Examples of suitable fluoride ion-generating materials can be found in U.S. Pat. No. 3,535,421 to Briner et al, U.S. Pat. No. 4,885,155 to Parran, Jr. et al, and U.S. Pat. No. 3,678,154 to Widder et al, the disclosures of which are incorporated herein by reference. Exemplary fluoride ion sources include, but are not limited to, stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof. In one exemplary embodiment, the fluoride ion source comprises sodium fluoride. The amount of fluoride ion source in the oral care composition may be less than 0.08 wt.%, less than 0.07 wt.%, less than 0.06 wt.%, less than 0.05 wt.%, or less than 0.04 wt.%. For example, the amount of fluoride ion source may be about 0.05 wt%. In another embodiment, the fluoride ion source is present in an amount such that: the amount provides a total of about 100 to about 20,000ppm, about 200 to about 5,000ppm, or about 500 to about 2,500ppm of fluoride ions.
Surface active agent
The oral care product or whitening composition thereof may comprise one or more surfactants. For example, the whitening composition may comprise one or more anionic surfactants, one or more cationic surfactants, one or more zwitterionic surfactants, one or more nonionic surfactants, and mixtures thereof. Examples of suitable surfactants can be found in U.S. Pat. No. 3,959,458 to Agricola et al, U.S. Pat. No. 3,937,807 to Haefele, and U.S. Pat. No. 4,051,234 to Gieske et al, the disclosures of which are incorporated herein by reference in their entirety to the extent they are consistent with the present disclosure.
In at least one embodiment, the oral care product or whitening composition thereof comprises at least one anionic surfactant. Exemplary anionic surfactants can include, but are not limited to, water soluble salts of higher fatty acid monoglyceride monosulfates, such as the sodium salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids, such as sodium N-methyl N-cocoyl taurate, sodium cocoate monoglyceride sulfate. Examples of the inventionThe anionic surfactants may also include higher alkyl sulfates. As used herein, "higher alkyl" refers to C6-30An alkyl group. For example, in a preferred embodiment, the anionic surfactant is sodium lauryl sulfate. Anionic surfactants may also include higher alkyl ether sulfates. For example, the anionic surfactant may have the formula CH3(CH2)mCH2(OCH2CH2)nOSO3X, wherein m is 6-16, n is 1-6, and X is Na or K. In an exemplary embodiment, m is 10, and n is 2, 3 or 4, and X is Na or K. For example, the anionic surfactant may be sodium dodecyl polyoxyethylene ether-2 sulfate (CH)3(CH2)10CH2(OCH2CH2)2OSO3Na). In another embodiment, the anionic surfactant may include higher alkyl aryl sulfonates such as sodium dodecylbenzene sulfonate (sodium dodecylbenzene sulfonate) and higher alkyl sulfoacetates such as sodium lauryl sulfoacetate (sodium dodecyl sulfoacetate), higher fatty acid esters of 1,2 dihydroxypropane sulfonic acid, sulfolaurate (potassium N-2-ethyl laurate sulfoacetamide), and sodium lauryl sarcosinate. In one exemplary embodiment, the anionic surfactant is a water soluble salt of an alkyl sulfate having 10 to 18 carbon atoms in the alkyl group and a water soluble salt of a sulfonated monoglyceride of a fatty acid having 10 to 18 carbon atoms. For example, the anionic surfactant can be or include sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl monoglyceride sulfonate, and the like, and mixtures thereof.
In at least one embodiment, the oral care product or whitening composition thereof may comprise at least one nonionic surfactant. Thus, the oral care product or whitening composition thereof may comprise at least one anionic surfactant, at least one nonionic surfactant, or both anionic and nonionic surfactants. Nonionic surfactants may be used as emulsifiers. Exemplary nonionic surfactants can include, but are not limited to, poloxamers and the like. For example, the nonionic surfactant can include polysorbate 20, poloxamer 407, poloxamer 338, and the like, and mixtures thereof. Nonionic surfactants can also include, but are not limited to, ethoxylated castor oil and hydrogenated ethoxylated castor oil, such as those commonly referred to as PEG NN castor oil or PEG NN hydrogenated castor oil, where "NN" denotes the number of ethylene oxide units polymerized onto the castor oil to form the nonionic surfactant. For example, the nonionic surfactant can be or include PEG 16, 20, 25, 30, 40, 50, 60, 80, 100, 200, and combinations thereof. In a preferred embodiment, the nonionic surfactant is polysorbate 20.
The amount of any one or more surfactants in the oral care product or whitening composition thereof can be from about 0.010, about 0.020, about 0.030, about 0.040, about 0.045, about 0.049, or about 0.050 to about 0.051, about 0.055, about 0.060, about 0.065, about 0.070, about 0.075, about 0.080, or more. In another example, the amount of any one or more surfactants in the oral care product or whitening composition thereof can be from about 0.010 to about 0.090 weight%, from about 0.020 to about 0.080 weight%, from about 0.030 to about 0.070 weight%, from about 0.040 to about 0.060 weight%, from about 0.045 to about 0.055 weight%, or from about 0.050 to about 0.051 weight%. In yet another example, the amount of any one or more surfactants in the oral care product or whitening composition thereof can be greater than 0.010 weight%, greater than 0.020 weight%, greater than 0.030 weight%, greater than 0.040 weight%, greater than 0.045 weight%, greater than 0.049 weight%, or greater than 0.050 weight%. The amount of any one or more surfactants in the oral care product or whitening composition thereof can also be from about 0.10 wt%, about 0.20 wt%, about 0.30 wt%, about 0.40 wt%, about 0.45 wt%, about 0.49 wt%, or about 0.50 wt% to about 0.51 wt%, about 0.55 wt%, about 0.60 wt%, about 0.65 wt%, about 0.70 wt%, about 0.75 wt%, about 0.80 wt%, or more. In another example, the amount of any one or more surfactants in the oral care product or whitening composition thereof can be from about 0.10% to about 0.90%, from about 0.20% to about 0.80%, from about 0.30% to about 0.70%, from about 0.40% to about 0.60%, from about 0.45% to about 0.55%, or from about 0.50% to about 0.51% by weight. In yet another example, the amount of any one or more surfactants in the oral care product or whitening composition thereof can be greater than 0.10 wt%, greater than 0.20 wt%, greater than 0.30 wt%, greater than 0.40 wt%, greater than 0.45 wt%, greater than 0.49 wt%, or greater than 0.50 wt%.
Flavoring agent
The oral care product or whitening composition thereof may further comprise one or more flavoring agents. Exemplary flavoring agents may include, but are not limited to, essential oils and various flavoring aldehydes, esters, alcohols, and the like. Flavoring agents may also include, but are not limited to, sweeteners, sucralose, dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup (including high fructose corn syrup and corn syrup solids), partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and salts thereof (e.g., sodium saccharin), dipeptide-based intense sweeteners, cyclamate, dihydrochalcone, and mixtures thereof. Examples of the essential oils include oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange. In another example, the flavoring agents may include menthol, carvone, and anethole. In a preferred embodiment, the flavoring agents include peppermint and spearmint. In another preferred embodiment, the flavoring agent comprises a Firmenich Newman flavor.
The amount of flavoring agent in the oral care product or whitening composition thereof may be less than 1.0 wt%, less than 0.9 wt%, less than 0.8 wt%, or less than 0.7 wt%. For example, the flavoring agent may be present in the oral care product or whitening composition thereof in an amount of from about 0.0% to about 1.0%, from about 0.5% to about 0.9%, from about 0.7% to about 0.8% by weight. In a preferred embodiment, the amount of flavoring agent in the oral care product or whitening composition thereof is from about 0.01% to about 0.4% by weight, preferably from about 0.1% to about 0.3% by weight, or about 0.2% by weight.
Moisture-retaining agent
The oral care product or whitening composition thereof may comprise one or more humectants. The humectant may be capable of or configured to reduce evaporation and reduce water activity. It is to be understood that the humectant may also be capable of imparting a desired sweetener or flavoring agent to the oral care product or whitening composition thereof. Exemplary humectants can include, but are not limited to, polyols (such as glycerol, sorbitol, xylitol, propylene glycol, and other polyols) and mixtures thereof. In at least one embodiment, the one or more humectants are present in an amount of from about 10% to about 20% by weight based on the total weight of the oral care product or whitening composition thereof.
Water (W)
The oral care product or whitening composition thereof may comprise water. The water of the oral care product or whitening composition thereof may be deionized water and free of organic impurities. Water may constitute the balance of the oral care product or whitening composition thereof. For example, the amount of water in the oral care product or whitening composition thereof may be from about 10% to 90%, from about 40% to about 85%, or from about 60% to about 80% by weight. In another example, the amount of water in the oral care product or whitening composition thereof may be at least 60 wt.%, at least 65 wt.%, at least 70 wt.%, at least 78 wt.%, or at least 79 wt.%. The amount of water in the oral care product or whitening composition thereof may include added free water and water introduced by other components or materials of the oral care product or whitening composition thereof. For example, the amount of water in the oral care product or whitening composition thereof may include free water and water with a humectant, flavoring agent, or oral care product or whitening composition thereof
pH adjusting/buffering agent
The oral care product or whitening composition thereof may optionally comprise one or more pH adjusting agents. For example, the oral care product or whitening composition thereof may comprise one or more acidulants and/or one or more alkalizers for reducing and/or increasing pH, respectively. The oral care product or whitening composition thereof may also include one or more buffering agents to control or adjust the pH within a predetermined or desired range. Exemplary buffering agents can include, but are not limited to, anhydrous carbonates, sesquicarbonates, sodium bicarbonate, sodium phosphate, sodium hydroxide, sodium carbonate, sodium acid pyrophosphate, citric acid, sodium citrate, phosphoric acid, sorbitol, polysorbates, and the like, and combinations thereof. Sodium phosphate can include sodium dihydrogen phosphate (NaH2 PO)4) Disodium hydrogen phosphate (Na2 HPO)4) Trisodium phosphate (Na)3PO4) And mixtures thereof. In a preferred embodiment, the buffer is anhydrous disodium phosphate (sodium phosphate dibasic or sodium phosphate).
In at least one embodiment, acidulants, alkalizers, and/or buffers may be included in the oral care product or whitening composition thereof to provide the oral care composition with a pH of between 2 to 10, 2 to 8, 3 to 9,4 to 8, 6 to 10, or 7 to 9. Additional orally acceptable pH adjusting agents can be used, such as carboxylic, phosphoric and sulfonic acids, acid salts (e.g., monosodium citrate, disodium citrate, monosodium malate, etc.), alkali metal hydroxides (such as sodium hydroxide), carbonates (such as sodium carbonate, bicarbonate, sesquicarbonate), borates, silicates, phosphates (e.g., monosodium phosphate, trisodium phosphate, pyrophosphate salts, etc.), imidazoles, and mixtures thereof. The one or more pH adjusting agents may be present in an amount effective to maintain the oral care product or whitening composition thereof within an orally acceptable pH range. In a preferred embodiment, the pH adjusting agent comprises any one or more of sodium bicarbonate, citric acid, phosphoric acid, sorbitol, polysorbate, and combinations and mixtures thereof.
Additional ingredients
It will be appreciated by those of ordinary skill in the art that the oral care product and/or its whitening composition may comprise other additional ingredients/components. For example, the oral care product and/or whitening composition thereof can comprise anticaries agents, desensitizing agents, viscosity modifiers, diluents, mouth feel agents, colorants, preservatives, and the like, as well as combinations and mixtures thereof. It will also be appreciated by those of ordinary skill in the art that while the general attributes of each of the above categories of materials may differ, there may be some common attributes and any given material may serve multiple purposes within two or more of these categories of materials.
In at least one embodiment, the additional ingredients/components can include one or more active materials configured to prevent and/or treat one or more diseases and/or conditions of the oral cavity. For example, the one or more active materials can be configured to prevent and/or treat one or more diseases and/or conditions of the hard and/or soft tissues of the oral cavity. The active material can also be configured to prevent and/or treat one or more physiological conditions and/or diseases, and/or provide aesthetic benefits to the oral cavity.
In at least one embodiment, the oral care product and/or whitening composition thereof may comprise an anticalculus agent. In general, the anticalculus agent may not be compatible with some whitening compositions, however, embodiments of the present disclosure may incorporate the anticalculus agent and the whitening composition into a single phase oral care product. Exemplary anticalculus agents may include, but are not limited to, phosphates and polyphosphates (e.g., pyrophosphates), polyaminopropanesulfonic Acid (AMPS), hexametaphosphates, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, bisphosphonates. In a typical embodiment, the anticalculus agent comprises tetrasodium pyrophosphate (TSPP), Sodium Tripolyphosphate (STPP), or a combination thereof.
The oral care product and/or whitening composition thereof may optionally comprise one or more antimicrobial agents and/or one or more preservatives, such as Methylisothiazolinone (MIT), sodium benzoate, potassium sorbate, benzyl alcohol, and combinations thereof. In another example, the oral care composition may comprise one or more antibacterial agents selected from halogenated diphenyl ethers (e.g., triclosan), herbal extracts and essential oils (e.g., rosemary extract, tea extract, magnolia extract, thymol, menthol, eucalyptol, geraniol, carvacrol, citral, hinokitiol, catechol, methyl salicylate, epigallocatechin gallate, epigallocatechin, gallic acid, miswak (miswak) extract, sea buckthorn extract), biguanide preservatives (e.g., chlorhexidine, alexidine, or octenidine), quaternary ammonium compounds (e.g., cetylpyridinium chloride (CPC), benzalkonium chloride, tetradecylpyridine chloride (TPC), N-tetradecyl-4-ethylpyridinium chloride (TDEPC)), phenolic preservatives, hexetidine (hexetidine), and mixtures thereof, Octenidine (octenidine), sanguinarine, povidone iodine, delmopinol (delmopinol), salifluor, other metal ions (e.g., stannous salts, copper salts, iron salts), sanguinarine, propolis (propolis) and oxidizing agents (e.g., hydrogen peroxide, buffered sodium perborate or sodium percarbonate), phthalic acid and its salts, monoperoxyphthalic acid and its salts and esters, ascorbyl stearate, oleoylsarcosine, alkyl sulfates, dioctyl sulfosuccinate, salicylanilide, domiphen bromide, delmopinol (delmopinol), octapinol and other piperidino derivatives, nicotinic acid (nicotine) preparations, chlorite salts; and mixtures of any of the foregoing. In a typical embodiment, the antibacterial agent comprises cetylpyridinium chloride (CPC). For example, all dual phase mouthwash compositions disclosed herein can comprise CPC as an antibacterial agent.
The oral care product and/or whitening composition thereof may comprise an antioxidant. Any orally acceptable antioxidant can be used, including, but not limited to, Butylated Hydroxyanisole (BHA), Butylated Hydroxytoluene (BHT), vitamin a, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, and the like, and combinations and mixtures thereof.
Carrier
The whitening composition may form at least a part of or be used in one or more oral care products. Exemplary oral care products can include, but are not limited to, mouthwashes, toothpastes (dentifrices), prophylactic pastes, tooth powders, tooth polishes, tooth gels (e.g., whitening gels), chewing gums, lozenges, whitening strips, paint-on gels, paints, veneers, and tubes containing gels or pastes, dental syringes or trays, or gels or pastes coated on an application support, such as dental floss or a toothbrush (e.g., a manual toothbrush, an electric toothbrush, a sonic toothbrush, combinations thereof, or an ultrasonic toothbrush)). In a typical embodiment, the whitening composition may form at least a portion of a mouthwash or be used in a mouthwash. For example, the whitening composition may generally be a mouthwash, such as a dual phase mouthwash or a single phase mouthwash. In another example, the whitening composition or components thereof can be a solid (e.g., a powder) in combination with a mouthwash. The whitening composition can be mixed, dispersed, dissolved, combined, or contacted with an orally acceptable carrier to form an oral care product (e.g., a mouthwash). In an exemplary embodiment, the orally acceptable carrier can include glycerin and/or water. In at least one embodiment, the orally acceptable carrier can include one or more humectants.
All ingredients for use in the compositions described herein should be orally acceptable. As used herein, the term "orally acceptable" means that the ingredients are present in the composition in amounts and in a form that do not render the composition unsafe for use in the oral cavity.
Method of producing a composite material
The present disclosure may provide methods for whitening teeth in a human or animal subject using an oral care product and/or a whitening composition thereof. For example, the present disclosure may provide methods for whitening the surface of teeth and/or dentin in a human or animal subject using an oral care product and/or whitening composition thereof. As used herein, "animal subject" may include higher non-human mammals (such as dogs, cats, and horses).
The method may comprise storing and/or including the whitening composition or components thereof in a stable form until the time of use or point of use. For example, the method may comprise storing and/or including the whitening potentiator (e.g., MPS) and/or source of hydrogen peroxide in a stable form until use. The method may further include blending, stirring, combining, mixing, or contacting the components of the whitening composition with each other to form the whitening composition, and contacting the whitening composition with the surface of the teeth. In at least one embodiment, contacting the components of the whitening composition with each other to form the whitening composition may include blending, stirring, combining, mixing, or contacting the first phase (e.g., the hydrophilic phase) with the second phase (e.g., the hydrophobic phase). The method may further comprise combining, mixing or contacting a source of hydrogen peroxide with water to produce hydrogen peroxide, and contacting the hydrogen peroxide with a whitening synergist.
The method can further include rinsing the mouth with an oral care product, brushing the teeth with an oral care product, or placing an oral care product in a dental tray and placing the dental tray in the oral cavity so that their contents contact the surfaces of the teeth. In some embodiments, an oral care product (e.g., mouthwash) or whitening composition thereof can be applied directly to the teeth using a delivery device, such as a pen (e.g.,
The oral care product and/or its whitening composition may be applied and/or contacted to the surface of the teeth at predetermined intervals. For example, the oral care product and/or its whitening composition may be applied and/or contacted with the surface of the teeth daily, at least once daily for a continuous number of days, at least twice daily for a continuous number of days, or every other day. The oral care product and/or whitening composition thereof may be used for a period of up to 1 day, up to 2 days, up to 7 days, up to 10 days, up to 2 weeks, up to 3 weeks, up to 4 weeks, up to 6 weeks, up to 8 weeks, or more.