阅读说明：本技术 一种肿瘤病人专用型营养配方粉及其制备方法 (Special nutritional formula powder for tumor patients and preparation method thereof ) 是由 张文杰 于 2021-05-20 设计创作，主要内容包括：本发明公开了一种肿瘤病人专用型营养配方粉及其制备方法,所述营养配方粉包括重量比例为15～45份的碳水化合物、10～50份的优质蛋白、5～30份的脂肪、1～6份的鱼油粉、1～6份的膳食纤维、0～2份的增稠剂、1～3份的食用香精、0～2份的甜味剂、1～3份的酸度调节剂、0～1份的低钠盐、0～2份的维生素预混合粉以及0～2份的矿物质预混合粉。本发明的肿瘤病人专用型营养配方粉富含多种免疫营养素,帮助机体快速补充蛋白,能够激活免疫细胞应答,维持正常适度的免疫反应；针对性的能够改善肿瘤患者营养状况、减轻有害的或过度的炎症反应,调控细胞因子的产生和释放,减少感染的发生；并且保证患者的营养需求,从而实现缩短住院时间、提高治疗效果的作用。(The invention discloses a special nutritional formula powder for tumor patients and a preparation method thereof, wherein the nutritional formula powder comprises 15-45 parts by weight of carbohydrate, 10-50 parts by weight of high-quality protein, 5-30 parts by weight of fat, 1-6 parts by weight of fish oil powder, 1-6 parts by weight of dietary fiber, 0-2 parts by weight of thickening agent, 1-3 parts by weight of edible essence, 0-2 parts by weight of sweetening agent, 1-3 parts by weight of acidity regulator, 0-1 part by weight of low sodium salt, 0-2 parts by weight of vitamin premix powder and 0-2 parts by weight of mineral premix powder. The special nutritional formula powder for tumor patients is rich in various immune nutrients, helps organisms quickly supplement protein, can activate immune cell response, and maintains normal and appropriate immune reaction; the medicine can improve the nutritional status of tumor patients, reduce harmful or excessive inflammatory reaction, regulate the generation and release of cytokines and reduce the occurrence of infection; and the nutritional requirements of patients are ensured, thereby realizing the effects of shortening the hospitalization time and improving the treatment effect.)

1. The nutritional formula powder special for tumor patients is characterized by comprising the following components in parts by weight: the weight ratio of the carbohydrate to the high-quality protein is 15-45 parts, 10-50 parts, 5-30 parts of fat, 1-6 parts of fish oil powder, 1-6 parts of dietary fiber, 0-2 parts of thickening agent, 1-3 parts of edible essence, 0-2 parts of sweetening agent, 1-3 parts of acidity regulator, 0-1 part of low sodium salt, 0-2 parts of vitamin premixed powder and 0-2 parts of mineral premixed powder.

2. The nutritional formula powder special for tumor patients according to claim 1, wherein the high-quality protein is one or a mixture of two of whey protein isolate and soy protein isolate.

3. The nutritional formula powder for tumor patients according to claim 1, wherein the fat is one or a mixture of medium-chain fat and long-chain fat.

4. The nutritional formula powder special for tumor patients according to claim 1, wherein the dietary fiber is one or a mixture of several of resistant dextrin, inulin and fructo-oligosaccharide.

5. The nutritional formula powder for tumor patients according to claim 1, wherein the thickener is one or a mixture of xanthan gum and guar gum.

6. The nutritional formula powder special for tumor patients as claimed in claim 1, wherein the vitamin premix powder comprises, by weight, 690-1050 parts of vitamin A, 16-26 parts of vitamin D, 30000-55000 parts of vitamin E, 17000-11000 parts of vitamin B, 22000-5200 parts of vitamin B, 63467-5200 parts of vitamin B, 127.227-10.84 parts of vitamin B, 184000-276000 parts of vitamin C, 18000-27000 parts of nicotinic acid, 11000-18000 parts of pantothenic acid, 115600-174400 parts of taurine and 88.67-130 parts of folic acid.

7. The nutrition formula powder special for tumor patients according to claim 1, wherein the mineral substance premix powder comprises 5943-8914 parts of iron, 49.49-74.23 parts of iodine, 99430-149100 parts of magnesium, 1486-2229 parts of manganese, 7429-11140 parts of zinc, 491.4-737.1 parts of copper and 39.54-59.31 parts of selenium in parts by weight.

8. The nutritional formula powder special for tumor patients according to claim 1, wherein the nutritional formula powder is specifically: 30.148 parts of carbohydrate, 30.2 parts of high-quality protein, 24.8 parts of fat, 4.2 parts of fish oil powder, 4.8 parts of dietary fiber, 0.1 part of thickening agent, 1.3 parts of edible essence, 0.062 parts of sweetening agent, 0.27 parts of vitamin premixed powder, 0.7 parts of mineral premixed powder, 2.62 parts of acidity regulator and 0.8 parts of low-sodium salt.

9. The nutritional formula powder special for tumor patients according to claim 8, wherein the nutritional formula powder comprises 30.148 parts of maltodextrin, 30.2 parts of isolated whey protein, 5.8 parts of medium-chain fatty acid, 19 parts of long-chain fatty acid, 4.2 parts of fish oil powder, 1.7 parts of inulin, 2.2 parts of resistant dextrin, 0.9 part of fructo-oligosaccharide, 0.1 part of xanthan gum, 0.3 part of milk powder essence, 1 part of vanilla flavor essence, 0.02 part of sucralose, 0.042 part of stevioside, 0.27 part of vitamin premix powder, 0.7 part of mineral premix powder, 2.62 parts of sodium citrate and 0.8 part of potassium chloride.

10. The preparation method of the nutritional formula powder special for tumor patients according to any one of claims 1 to 9, wherein the preparation method comprises the following steps:

a) weighing: respectively weighing 15-45 parts of carbohydrate, 10-50 parts of high-quality protein, 5-30 parts of fat, 1-6 parts of fish oil powder, 1-6 parts of dietary fiber, 0-2 parts of thickening agent, 1-3 parts of edible essence, 0-2 parts of sweetening agent, 1-3 parts of acidity regulator, 0-1 part of low sodium salt, 0-2 parts of vitamin premixed powder and 0-2 parts of mineral premixed powder;

b) crushing: crushing and sieving the material with the particle size larger than 60 meshes;

c) premixing: premixing sodium citrate, potassium chloride, milk powder essence, xanthan gum, sucralose, stevioside, vitamin premix, mineral premix, fructo-oligosaccharide and part of carbohydrate, and sieving;

d) total mixing: totally mixing the premix obtained in the step c) with the rest materials and sieving to obtain nutrition formula powder;

e) subpackaging: subpackaging the nutritional formula powder obtained in the step d) into products of 20-60 g/bag.

Technical Field

The invention relates to special nutritional formula powder for tumor patients and a preparation method thereof, belonging to the field of foods, in particular to the field of formula foods for special medicine.

Background

The formula food for special medical application belongs to special dietary food, is specially processed and prepared for meeting the special requirements of people with limited food intake, digestive absorption disorder, metabolic disorder or specific disease states on nutrients or diet, can be used as a nutrition supplementing way, and plays an important nutrition supporting role in the aspects of treatment, rehabilitation, body function maintenance and the like.

Tumor nutrition therapy (CNT) is another therapy that is important in combination with surgery, radiation therapy, chemotherapy, targeted therapy, immunotherapy, etc. Nutritional support is sublimed into a nutritional treatment when it is not merely a deficiency in supplemental nutrients, but rather is conferred with the erratic goals of treating malnutrition, regulating metabolism, regulating immunity, and the like. Nutrition therapy is integrated into other therapeutic methods throughout the whole process of tumor treatment.

The tumor nutrition therapy comprises three stages of planning, implementing and evaluating nutrition intervention to treat tumors and complications or physical conditions thereof so as to improve the prognosis of tumor patients, namely nutrition diagnosis (screening/evaluation), nutrition intervention and curative effect evaluation (including follow-up).

The progression of most tumor patients often manifests as irreversible loss of appetite, loss of weight, deterioration of nutritional status, and ultimately death of the patient, which is malignant tumor. In the early dyscrasia stage and dyscrasia stage, the nutritional support can not only increase the energy and the intake of various nutrients of patients and improve the nutritional status of the patients, but also regulate the abnormal metabolism of tumor patients, and is beneficial to the anti-tumor treatment. From the clinical outcome, nutritional support can improve the quality of life of patients and even prolong their life. While in refractory cachexia, while nutritional therapy may not completely reverse its weight loss and metabolic abnormalities and the risks and burdens associated with nutritional support may outweigh its potential benefits, partial nutritional intake may improve patient quality of life and provide comfort to the patient and home, and identification of refractory cachexia helps the patient to be assisted by an end-of-care team. The ultimate goal of cachexia nutrition therapy is to reverse weight loss and muscle loss; the treatment of intractable dyscrasia mainly relieves symptoms related to dyscrasia and improves the whole life quality.

The tumor immunonutrition is the application of specific nutrient substances which can improve the nutritional condition of tumor patients and regulate the immune and inflammatory reactions of organisms, thereby realizing the effects of reducing infection and non-infection complications, shortening the hospitalization time and improving the treatment effect. In the face of severe malnutrition and marked dyscrasia, nutritional treatment is of paramount importance in order to prevent further debilitating deterioration of the patient. The nutrition required by tumor patients is generally embodied in three aspects, namely enough energy is used for reducing the decomposition and consumption of tissues in the body by the intake of heat; secondly, the protein is an indispensable nutrient for maintaining the growth, the renewal and the repair of tissues, and most of tumor patients are accompanied with the problem of low protein digestion and utilization rate, and the sufficient protein is particularly important for the tumor patients; thirdly, reasonable vitamins and minerals are necessary for normal metabolism, and the reasonable vitamins and minerals have good promotion effects on the aspects of improving the utilization of protein and nutrient absorption. However, the existing nutritional formula powder without the need for tumor patients increases the burden of the patients when various nutrients are mixed for eating, and may cause the deficiency of partial nutritional elements and the excess of partial nutritional elements, so that a special nutritional formula powder for the special needs of the tumor patients is urgently needed to be designed.

Disclosure of Invention

Aiming at the problems in the prior art, the invention aims to obtain the special nutritional formula powder for the tumor patients and the preparation method thereof.

In order to realize one of the purposes of the invention, the technical scheme of the special nutritional formula powder for the tumor patients is as follows:

the nutritional formula powder special for tumor patients comprises, by weight, 15-45 parts of carbohydrate, 10-50 parts of high-quality protein, 5-30 parts of fat, 1-6 parts of fish oil powder, 1-6 parts of dietary fiber, 0-2 parts of thickening agent, 1-3 parts of edible essence, 0-2 parts of sweetening agent, 1-3 parts of acidity regulator, 0-1 part of low-sodium salt, 0-2 parts of vitamin premix powder and 0-2 parts of mineral premix powder.

Preferably, the carbohydrate is maltodextrin.

Preferably, the high-quality protein is one or a mixture of two of separated whey protein and soybean protein.

Preferably, the fat is one or a mixture of two of medium-chain fat and long-chain fat.

Preferably, the dietary fiber is one or a mixture of several of resistant dextrin, inulin and fructo-oligosaccharide.

Preferably, the thickening agent is one or a mixture of xanthan gum and guar gum.

Preferably, the flavoring essence is one or a mixture of two of vanilla essence and milk powder essence.

Preferably, the sweetener is one or a mixture of two of sucralose and stevioside.

Preferably, the acidity regulator is sodium citrate and the low sodium salt is potassium chloride.

Preferably, the vitamin premix powder comprises, by weight, 690-1050 parts of vitamin A, 16-26 parts of vitamin D, 30000-55000 parts of vitamin E, 17000-11000 parts of vitamin B, 22000-5200 parts of vitamin B, 63467-5200 parts of vitamin B, 127.227-10.84 parts of vitamin B, 184000-276000 parts of vitamin C, 18000-27000 parts of nicotinic acid, 11000-18000 parts of pantothenic acid, 115600-174400 parts of taurine and 88.67-130 parts of folic acid.

Preferably, the mineral substance premixing powder comprises 5943-8914 parts of iron, 49.49-74.23 parts of iodine, 99430-149100 parts of magnesium, 1486-2229 parts of manganese, 7429-11140 parts of zinc, 491.4-737.1 parts of copper and 39.54-59.31 parts of selenium according to parts by weight.

As a preferred embodiment, the nutritional formula is: 30.148 parts of carbohydrate, 30.2 parts of high-quality protein, 24.8 parts of fat, 4.2 parts of fish oil powder, 4.8 parts of dietary fiber, 0.1 part of thickening agent, 1.3 parts of edible essence, 0.062 parts of sweetening agent, 0.27 parts of vitamin premixed powder, 0.7 parts of mineral premixed powder, 2.62 parts of acidity regulator and 0.8 parts of low-sodium salt.

Specifically, the nutritional formula powder comprises the following components: 30.148 parts of maltodextrin, 30.2 parts of separated whey protein, 5.8 parts of medium-chain fatty acid, 19 parts of long-chain fatty acid, 4.2 parts of fish oil powder, 1.7 parts of inulin, 2.2 parts of resistant dextrin, 0.9 part of fructo-oligosaccharide, 0.1 part of xanthan gum, 0.3 part of milk powder essence, 1 part of vanilla flavor, 0.02 part of sucralose, 0.042 part of stevioside, 0.27 part of vitamin premixed powder, 0.7 part of mineral premixed powder, 2.62 parts of sodium citrate and 0.8 part of potassium chloride.

The nutritional formula powder can also specifically comprise: 30.148 parts of maltodextrin, 30.2 parts of soybean protein isolate, 10.8 parts of medium-chain fatty acid, 14 parts of long-chain fatty acid, 4.2 parts of fish oil powder, 3.9 parts of inulin, 0.9 part of fructo-oligosaccharide, 0.1 part of xanthan gum, 1.3 parts of milk powder essence, 0.02 part of sucralose, 0.042 part of stevioside, 0.27 part of vitamin premixed powder, 0.7 part of mineral premixed powder, 2.62 parts of sodium citrate and 0.8 part of potassium chloride.

The nutritional formula powder can also specifically comprise: 30.148 parts of maltodextrin, 10 parts of soybean protein isolate, 20.2 parts of whey protein isolate, 24.8 parts of medium-chain fatty acid, 4.2 parts of fish oil powder, 1.9 parts of inulin, 1.5 parts of resistant dextrin, 1.4 parts of fructo-oligosaccharide, 0.06 parts of xanthan gum, 0.04 parts of guar gum, 0.3 parts of milk powder essence, 1 part of vanilla flavor, 0.02 parts of sucralose, 0.042 parts of stevioside, 0.27 parts of vitamin premixed powder, 0.7 parts of mineral premixed powder, 2.62 parts of sodium citrate and 0.8 parts of potassium chloride.

As a preferred embodiment, the nutritional formula may further specifically be: 30.148 parts of maltodextrin, 30.2 parts of separated whey protein, 5.8 parts of medium-chain fatty acid, 19 parts of long-chain fatty acid, 4.2 parts of fish oil powder, 1.7 parts of inulin, 2.2 parts of resistant dextrin, 0.9 part of fructo-oligosaccharide, 0.1 part of xanthan gum, 0.3 part of milk powder essence, 1 part of vanilla flavor, 0.02 part of sucralose, 0.042 part of stevioside, 0.27 part of vitamin premix powder, 0.7 part of mineral premix powder, 2.62 parts of sodium citrate and 0.8 part of potassium chloride.

The invention also aims to provide a preparation method of the special nutritional formula powder for the tumor patients, which comprises the following steps:

a) weighing: 15-45 parts of carbohydrate, 10-50 parts of high-quality protein, 5-30 parts of fat, 1-6 parts of fish oil powder, 1-6 parts of dietary fiber, 0-2 parts of thickening agent, 1-3 parts of edible essence, 0-2 parts of sweetening agent, 1-3 parts of acidity regulator, 0-1 part of low sodium salt, 0-2 parts of vitamin premixed powder and 0-2 parts of mineral premixed powder;

b) crushing: crushing and sieving the material with larger granularity;

c) premixing: pre-mixing and sieving materials with a small addition amount and part of carbohydrate;

d) total mixing: mixing all the materials and sieving;

e) subpackaging: and (4) subpackaging the totally mixed materials into products of 20-60 g/bag.

Preferably, in the step b), the material with relatively large granularity is crushed to 30-60 meshes.

Preferably, the part of carbohydrate is 2-5 times of the total amount of other materials in the step c).

Patients with gastrointestinal tumors that retain intestinal function are recommended to first apply immunonutrition by the enteral route (evidence grade: medium; recommended grade: strong). The use of complex immunonutritional formulas is suggested, and the use of single immunonutrients (evidence grade: low; recommended grade: strong) is not recommended for the time being.

The nutrition formula powder of the invention must ensure uniform mixing, and ensure that the Coefficient of Variation (CV) of mixing is less than 8%.

The high-quality carbohydrate added in the invention can supplement the basic energy requirement daily required by other tumor people, and the dosage is accurately adjusted, thereby ensuring sufficient and not excessive energy.

The protein source of the invention is high-quality protein such as whey protein and soybean protein, the content of essential amino acid is rich, the amino acid mode is close to the human body, and the protein is easy to absorb and utilize. And the whey protein has the functions of promoting fat utilization and converting energy, so that the ingestion of the whey protein is helpful for reducing the formation of excessive fat and effectively controlling the body weight.

The medium chain triglyceride powder added in the invention can be completely hydrolyzed into fatty acid and glycerol under the action of the pancreatic lipase, is quickly absorbed, is not easy to synthesize triglyceride after being absorbed by small intestine, is suitable for people with fat malabsorption, is easy to digest, and can be absorbed even under the condition of lacking the pancreatic lipase and bile salt.

The fish oil powder is added, wherein the fish oil belongs to polyunsaturated fatty acid, not only can provide nutrition support for organisms, but also can promote the synthesis of eicosane by inhibiting the synthesis of arachidonic acid to reduce the inflammatory reaction of the organisms, can also increase the phagocytic function of macrophages to reduce the release of inflammatory factors and promote the release of the inflammatory factors to play an anti-inflammatory function, and the occurrence of infectious complications of the organisms can be obviously reduced when the inflammatory reaction is reduced.

The dietary fiber is added, and the inulin is a natural fat substitute, can keep good taste and texture, can help maintain normal intestinal function, relax bowel and improve constipation.

The invention adds calcium which participates in lactation and restores the mineral density of bones. The abundant supply of calcium and magnesium elements is beneficial to eliminating nervous tension state, helping the lying-in women keep smooth mood, relieving insomnia and recovering the body of the lying-in women.

The invention adds proper amount of iron, iodine, magnesium, manganese, zinc, copper and selenium minerals to meet the mineral demand of tumor patients. The iron is emulsified and embedded ferric pyrophosphate which is stable and has little iron fishy smell, can be transferred to each part of a body, has an iron gradual release effect, can achieve the average iron absorption rate equal to that of ferrous sulfate, has higher safety than ferrous sulfate and has little stimulation to the stomach and intestine.

The vitamin C, the vitamin A, the vitamin D, the vitamin E, the vitamin B1, the vitamin B2, the vitamin B6, the vitamin B12, the vitamin K, the folic acid, the pantothenic acid, the taurine and the biotin are added to the feed, so that the requirement of a tumor patient on the vitamins can be met. Vitamins A and C have the effects of preventing cell degeneration and diffusion, and increasing epithelial cell stability, and vitamin C can also prevent common symptoms of tumor chemotherapy injury, and can increase leukocyte level; vitamin B1 can stimulate appetite and relieve symptoms caused by radiotherapy. Vitamin E blocks the ability of carcinogenic nitroso compounds to synthesize, is a natural antioxidant that limits the production of peroxides and reoxides in vivo, maintains the stability of cell membranes, and prevents certain enzymes and intracellular punishment from being destroyed. Vitamin E has certain effect in preventing breast cancer.

Compared with the prior art, the special nutritional formula powder for the tumor patients integrates the physical characteristics and clinical nutritional requirements of the tumor patients, integrates the current advanced physiology, medicine, nutrition, clinical application and other research results according to the requirements of the general rule of formula food for special medical uses, and is added with whey protein powder, inulin, L-leucine (8%), vitamin C, taurine, vitamin B1, vitamin B2 and other nutrients, wherein the special nutritional formula powder for the tumor patients is rich in various immune nutrients, helps the organism to quickly supplement protein, can activate immune cell response and maintain normal and proper immune response; the nutritional status of a tumor patient can be improved in a targeted manner, harmful or excessive inflammatory reaction can be relieved, the generation and release of cytokines can be regulated, and the occurrence of infection can be reduced; and the nutritional requirements of patients are ensured, so that the effects of reducing infection and non-infection complications, shortening hospitalization time and improving treatment effect are realized. The medium-chain fat in the formula has good gastrointestinal tolerance and stronger pertinence, can improve the tolerance of the enteral nutrition preparation, ensures that a patient is not easy to have diarrhea while providing nutrients, improves the nutritional status of the patient and improves the life quality of the patient. In addition, the formula contains energy, vitamins and minerals required by the patient every day, and can effectively ensure the nutrition supply of the patient during the treatment period.

Detailed Description

The specific nutritional formula powder for tumor patients and the preparation method thereof provided by the invention are further described in detail and completely by combining the examples. The following examples are illustrative only and are not to be construed as limiting the invention.

The experimental procedures in the following examples are conventional unless otherwise specified. The experimental materials used in the following examples were all commercially available unless otherwise specified.

Example 1

30.148 parts of maltodextrin, 30.2 parts of isolated soy protein, 10.8 parts of medium-chain fatty acid, 14 parts of long-chain fatty acid, 4.2 parts of fish oil powder, 3.9 parts of inulin, 0.9 part of fructo-oligosaccharide, 0.1 part of xanthan gum, 1.3 parts of milk powder essence, 0.02 part of sucralose, 0.042 part of stevioside, 0.27 part of vitamin premixed powder, 0.7 part of mineral premixed powder, 2.62 parts of sodium citrate and 0.8 part of potassium chloride are accurately weighed according to the weight ratio.

Each part of mineral matter premixing powder is composed of 690-1050 parts of vitamin A, 16-26 parts of vitamin D, 30000-55000 parts of vitamin E, 17000-11000 parts of vitamin B, 22000-5200 parts of vitamin B, 63467-5200 parts of vitamin B, 127.227-10.84 parts of vitamin B, 184000-276000 parts of vitamin C, 18000-27000 parts of nicotinic acid, 11000-18000 parts of pantothenic acid, 115600-174400 parts of taurine and 88.67-130 parts of folic acid.

Each part of mineral premixed powder comprises 5943-8914 parts of iron, 49.49-74.23 parts of iodine, 99430-149100 parts of magnesium, 1486-2229 parts of manganese, 7429-11140 parts of zinc, 491.4-737.1 parts of copper and 39.54-59.31 parts of selenium in parts by weight.

The preparation method of the nutritional formula powder comprises the following steps:

a) weighing and crushing: weighing the components in the weight ratio respectively, crushing the sodium citrate and the potassium chloride into 40 meshes, and sieving;

b) pre-mixing and sieving: pre-mixing sodium citrate, potassium chloride, milk powder essence, xanthan gum, sucralose, stevioside, vitamin premix, mineral premix and fructo-oligosaccharide with part (2 times of the total amount of other materials) of maltodextrin, and sieving with a 60-mesh sieve;

d) total mixing and screening: mixing all the materials together and sieving the mixture with a 40-mesh sieve;

e) subpackaging: and packaging the total mixed materials into products of 30 g/bag.

Example 2

30.148 parts of maltodextrin, 10 parts of soybean protein isolate, 20.2 parts of whey protein isolate, 24.8 parts of medium-chain fatty acid, 4.2 parts of fish oil powder, 1.9 parts of inulin, 1.5 parts of resistant dextrin, 1.4 parts of fructo-oligosaccharide, 0.06 parts of xanthan gum, 0.04 parts of guar gum, 0.3 parts of milk powder essence, 1 part of vanilla essence, 0.02 parts of sucralose, 0.042 parts of stevioside, 0.27 parts of vitamin premix powder, 0.7 parts of mineral premix powder, 2.62 parts of sodium citrate and 0.8 parts of potassium chloride are accurately weighed. The vitamin premixed powder and the mineral premixed powder were mixed in the same ratio as in example 1.

The preparation prevention of this example is different from that of example 1 in that sodium citrate and potassium chloride having a relatively large particle size are pulverized to 40 mesh and then sieved. Premixing and sieving sodium citrate, potassium chloride, milk powder essence, vanilla-flavored essence, xanthan gum, guar gum, sucralose, stevioside, vitamin premix, mineral premix, fructo-oligosaccharide, resistant dextrin and a proper amount of maltodextrin with relatively small addition amount. And (4) totally mixing the premixed material with the rest materials and sieving. And packaging the total mixed materials into products of 30 g/bag.

Example 3

30.148 parts of maltodextrin, 30.2 parts of separated whey protein, 5.8 parts of medium-chain fatty acid, 19 parts of long-chain fatty acid, 4.2 parts of fish oil powder, 1.7 parts of inulin, 2.2 parts of resistant dextrin, 0.9 part of fructo-oligosaccharide, 0.1 part of xanthan gum, 0.3 part of milk powder essence, 1 part of vanilla flavor, 0.02 part of sucralose, 0.042 part of stevioside, 0.27 part of vitamin premixed powder, 0.7 part of mineral premixed powder, 2.62 parts of sodium citrate and 0.8 part of potassium chloride are accurately weighed according to the weight ratio. The vitamin premixed powder and the mineral premixed powder were mixed in the same ratio as in example 1.

The preparation prevention of this example is different from that of example 1 in that sodium citrate and potassium chloride having a relatively large particle size are pulverized to 40 mesh and then sieved. Premixing and sieving sodium citrate, potassium chloride, milk powder essence, vanilla-flavored essence, xanthan gum, sucralose, stevioside, vitamin premix, mineral premix, fructo-oligosaccharide, resistant dextrin and a proper amount of maltodextrin with small addition amount. And (4) totally mixing the premixed material with the rest materials and sieving. And packaging the total mixed materials into products of 60 g/bag.

Example 4

The preparation method comprises the following steps of accurately weighing 15 parts of maltodextrin, 10 parts of separated whey protein, 5 parts of medium-chain fatty acid, 5 parts of long-chain fatty acid, 1.5 parts of fish oil powder, 1.3 parts of chrysanthemum powder, 0.5 part of fructo-oligosaccharide, 0.5 part of milk powder essence, 0.5 part of vanilla flavor essence, 0.5 part of vitamin premixed powder, 0.2 part of mineral premixed powder, 1 part of sodium citrate and 0.2 part of potassium chloride in weight ratio. The vitamin premixed powder and the mineral premixed powder were mixed in the same ratio as in example 1.

The preparation prevention of this example is different from that of example 1 in that sodium citrate and potassium chloride having a relatively large particle size are pulverized to 40 mesh and then sieved. Sodium citrate, potassium chloride, milk powder essence, vanilla essence, vitamin premix, mineral matter premix, fructo-oligosaccharide and proper amount of maltodextrin with small addition amount are premixed and sieved. And (4) totally mixing the premixed material with the rest materials and sieving. And packaging the total mixed materials into products of 60 g/bag.

Example 5

Accurately weighing 25 parts of maltodextrin, 14 parts of soybean protein isolate, 13 parts of whey protein isolate, 10 parts of medium-chain fatty acid, 5 parts of long-chain fatty acid, 3 parts of fish oil powder, 0.8 part of inulin, 0.5 part of resistant dextrin, 2.5 parts of fructo-oligosaccharide, 0.1 part of xanthan gum, 0.1 part of guar gum, 1 part of milk powder essence, 1 part of fragrant grass flavor, 0.2 part of sucralose, 0.3 part of stevioside, 1 part of vitamin premixed powder, 1 part of mineral premixed powder, 1.5 parts of sodium citrate and 0.5 part of potassium chloride. The vitamin premixed powder and the mineral premixed powder were mixed in the same ratio as in example 1.

The preparation prevention of this example is different from that of example 1 in that sodium citrate and potassium chloride having a relatively large particle size are pulverized to 40 mesh and then sieved. Premixing and sieving sodium citrate, potassium chloride, milk powder essence, vanilla-flavored essence, xanthan gum, guar gum, sucralose, stevioside, vitamin premix, mineral premix, fructo-oligosaccharide, resistant dextrin and a proper amount of maltodextrin with relatively small addition amount. And (4) totally mixing the premixed material with the rest materials and sieving. And packaging the total mixed materials into products of 60 g/bag.

Example 6

The preparation method comprises the following steps of accurately weighing 42 parts of maltodextrin, 48 parts of separated whey protein, 14.5 parts of medium-chain fatty acid, 14.5 parts of long-chain fatty acid, 5.8 parts of fish oil powder, 0.5 part of inulin, 3 parts of resistant dextrin, 1.7 parts of fructo-oligosaccharide, 1.5 parts of xanthan gum, 0.3 part of guar gum, 1.4 parts of milk powder essence, 1.5 parts of vanilla flavor, 0.8 part of sucralose, 0.9 part of stevioside, 1.8 parts of vitamin premixed powder, 1.7 parts of mineral premixed powder, 2 parts of sodium citrate and 1 part of potassium chloride in weight ratio. The vitamin premixed powder and the mineral premixed powder were mixed in the same ratio as in example 1.

The preparation prevention of this example is different from that of example 1 in that sodium citrate and potassium chloride having a relatively large particle size are pulverized to 40 mesh and then sieved. Premixing and sieving sodium citrate, potassium chloride, milk powder essence, vanilla-flavored essence, xanthan gum, guar gum, sucralose, stevioside, vitamin premix, mineral premix, fructo-oligosaccharide, resistant dextrin and a proper amount of maltodextrin with relatively small addition amount. And (4) totally mixing the premixed material with the rest materials and sieving. And packaging the total mixed materials into products of 60 g/bag.

The nutritional formula powder of the 6 embodiments is respectively dissolved in 300ml of warm water for user experience evaluation, and the evaluation is considered from three aspects of taste, nutrition and cost, wherein each 0 point is the lowest, 5 points are full, and the lower the cost, the higher the point is. The evaluation results are shown in the following table:

as can be seen from the table, the thickener, the essence and the sweetener have large influence on the taste, and the components are also required to be added in a proper amount in order to enhance the user experience. The content of carbohydrates, high-quality proteins, whole milk powder, fat, microorganisms and minerals has a great influence on nutrition and cost, but when the adding amount is too high, the taste is excessively sticky, and absorption is possibly influenced by too much intake at one time. In the examples 1 and 2, the packaging amount is half of that of the other examples, so the whole taste is thin, the nutrient components are not good, and the tumor patients can be advised to increase the intake times properly under the condition of reducing the packaging.

The eating method comprises the following steps: eating 3 bags daily; when in brewing, 120mL warm boiled water with the temperature lower than 50 ℃ is poured into the cup, and then 1 bag of the product is added and stirred to be dissolved, thus 160mL solution with standard concentration can be obtained. The product should be drunk immediately after being mixed with water.

Finally, it must be said here that: the above embodiments are only for further detailed description of the technical scheme of the present invention, and should not be understood as limiting the scope of the present invention, and the insubstantial modifications and adjustments made by those skilled in the art based on the above description of the present invention are included in the scope of the present invention.