阅读说明：本技术 一种包被胍基乙酸的制备方法 (Preparation method of coated guanidinoacetic acid ) 是由 杨立彬 沈承琪 刘伟国 于 2019-10-16 设计创作，主要内容包括：一种包被胍基乙酸的制备方法,以胍基乙酸及包材为原料,通过包衣机底喷系统将包材喷涂于颗粒胍基乙酸表面,其制备步骤如下：(1)前处理；(2)丸芯制备；(3)初包被；(4)二次包被；本发明对包被胍基乙酸的工艺进行了优化,包括辅料的选择及制备过程中所有参数的选择,通过本发明的方法能制备出稳定性好、生物利用率高的包被胍基乙酸,尤其是对于反刍动物,降低了产品存在瘤胃中降解率,且通过瘤胃后达到了缓释的效果,生物利用率较高。本发明适用于饲料添加剂制备领域。(A preparation method of coated glycocyamine takes glycocyamine and a coating material as raw materials, the coating material is sprayed on the surface of granular glycocyamine through a bottom spraying system of a coating machine, and the preparation method comprises the following steps: (1) pre-treating; (2) preparing a pill core; (3) primary coating; (4) secondary coating; the method optimizes the process of coating glycocyamine, comprises the selection of auxiliary materials and the selection of all parameters in the preparation process, can prepare the coated glycocyamine with good stability and high bioavailability by the method, particularly for ruminants, reduces the degradation rate of the product in rumen, achieves the effect of slow release after passing through the rumen, and has high bioavailability. The invention is suitable for the field of preparation of feed additives.)

1. A preparation method of coated guanidinoacetic acid is characterized in that: the preparation steps are as follows:

(1) pretreatment of

Carrying out superfine grinding and screening on the guanidinoacetic acid to obtain guanidinoacetic acid powder;

(2) preparation of pellet core

Placing guanidinoacetic acid powder and gelatinized starch solution into hydroxypropyl methyl cellulose solution, uniformly mixing, then preparing into spherical particles, screening the spherical particles, and then putting into a dryer for drying to obtain pill cores;

(3) primary coating

Putting the pellet cores into a particle coating machine, primarily coating by adopting a bottom spraying mode and ethyl cellulose alcohol solution or polyacrylic resin IV alcohol solution as a coating material to obtain primarily coated pellet cores, and screening the primarily coated pellet cores;

(4) secondary coating

Placing the screened primary coated pellet core particles in a fluidized bed coating machine, melting the food-grade hydrogenated vegetable oil through a bottom spraying system of the fluidized bed coating machine, and then using the melted food-grade hydrogenated vegetable oil as a coating material to carry out secondary coating on the primary coated pellet core, thereby obtaining the coated glycocyamine.

2. The preparation method of coated guanidinoacetic acid according to claim 1, characterized in that: selecting guanidinoacetic acid powder from the guanidinoacetic acid in the step (1); and carrying out swing arrangement and grading screening on the glycocyamine through a sieve of 80 meshes, and taking glycocyamine powder of 80 meshes.

3. The preparation method of coated glycocyamine according to claim 1, wherein the starch in step (2) is any plant starch, preferably corn starch or potato starch, and the starch accounts for 0.4% ~ 0.6.6% of the mass of the pellet core.

4. The preparation method of the coated guanidinoacetic acid as claimed in claim 1, characterized in that in the step (2), the hydroxypropyl methylcellulose accounts for 0.4 percent ~ 0.6.6 percent, preferably 0.4 percent of the mass of the pellet core;

the concentration of the hydroxypropyl methylcellulose solution is 10% ~ 15%, preferably 10%.

5. The preparation method of coated guanidinoacetic acid as claimed in claim 1, characterized in that the spherical particles formed in step (2) are subjected to swing finishing and classified screening by a 20-mesh ~ 60-mesh screen;

the parameters in the dryer in the step (2) are that the air inlet speed is 80 ~ 85 ℃, the air outlet speed is 60 ~ 80 ℃, and the drying time is 15 ~ 30 minutes.

6. The preparation method of the coated guanidinoacetic acid as claimed in claim 1, wherein the adding mass ratio of the pellet core and the ethyl cellulose or polyacrylic resin IV in the step (3) is 21.5 ~ 28: 1;

the concentration of the ethyl cellulose alcohol solution is 20% ~ 40%, preferably 20%, and the concentration of the polyacrylic resin IV alcohol solution is 5% ~ 8%, preferably 5%;

the parameters of the particle coating machine are that the air inlet temperature is less than 85 ℃, the material temperature is less than 80 ℃, the atomization pressure is 0.80 MPa ~ 0.90.90 MPa, and the pump flow rate is 15 ~ 30 L.h^-1Treatment time of 30 ~ 45 minutes;

in the step (3), the primarily coated pellet cores are subjected to swinging, granulating and grading screening by a sieve with 20 meshes and ~ 60 meshes.

7. The preparation method of coated guanidinoacetic acid as claimed in claim 1, wherein the melting temperature of the food grade hydrogenated vegetable oil in the step (4) is 65 ℃ ~ 100 ℃;

the addition mass ratio of the sieved primary coating pellet core particles to the food-grade hydrogenated vegetable oil is 2.5 ~ 12.5.5: 1;

the parameters of the fluidized bed coating machine are that the air inlet temperature is less than 65 ℃, the material temperature is less than 45 ℃, the atomization pressure is 0.20 MPa ~ 0.25.25 MPa, and the pump flow rate is 15 ~ 30 L.h^-1The treatment time was 30 ~ 45 minutes.

8. The preparation method of coated guanidinoacetic acid according to claim 1, characterized in that: after the secondary coating in the step (4) is finished, performing swing finishing and grading screening by using a 40-mesh screen, and taking oversize products to obtain coated guanidinoacetic acid.

9. The preparation method of coated guanidinoacetic acid as claimed in claims 1-8, characterized in that the final product has round or oval appearance and the effective component content of guanidinoacetic acid after secondary coating is up to 60% ~ 90%.

Technical Field

The invention belongs to the field of preparation of feed additives, and particularly relates to a preparation method of coated guanidinoacetic acid.

Background

The glycocyamine belongs to amino acid and derivatives thereof, is a functional feed additive, and is suitable for livestock and poultry mainly based on plant daily ration. The glycocyamine has important effects of improving the production performance of livestock and poultry, improving the meat quality, promoting energy metabolism, improving the resource value of protein feed and the like. Most guanidinoacetic acid obtained by the existing preparation method is in a powder crystal shape, the flowability is poor in practical use, particularly, the product has high degradation rate in rumen in the aspect of ruminant utilization, the sustained-release effect cannot be achieved after the product passes through the rumen, and the bioavailability is low.

Disclosure of Invention

The invention aims to provide a preparation method of coated glycocyamine, which protects glycocyamine through technical treatment, prevents glycocyamine from being fermented and degraded in a rumen to directly enter a small intestine and then be digested and absorbed, and thus achieves the purpose of improving the utilization rate of glycocyamine.

A preparation method of coated guanidinoacetic acid comprises the following preparation steps:

(1) pretreatment of

Carrying out superfine grinding and screening on the guanidinoacetic acid to obtain guanidinoacetic acid powder;

(2) preparation of pellet core

Placing guanidinoacetic acid powder and gelatinized starch solution into hydroxypropyl methyl cellulose solution, uniformly mixing, then preparing into spherical particles, screening the spherical particles, and then putting into a dryer for drying to obtain pill cores;

(3) primary coating

Putting the pellet cores into a particle coating machine, primarily coating by adopting a bottom spraying mode and ethyl cellulose alcohol solution or polyacrylic resin IV alcohol solution as a coating material to obtain primarily coated pellet cores, and screening the primarily coated pellet cores;

(4) secondary coating

Placing the screened primary coated pellet core particles in a fluidized bed coating machine, melting the food-grade hydrogenated vegetable oil through a bottom spraying system of the fluidized bed coating machine, and then using the melted food-grade hydrogenated vegetable oil as a coating material to carry out secondary coating on the primary coated pellet core, thereby obtaining the coated glycocyamine.

As a limitation of step (1), selecting powder guanidinoacetic acid from guanidinoacetic acid in the step (1); and carrying out swing arrangement and grading screening on the glycocyamine through a sieve of 80 meshes, and taking glycocyamine powder of 80 meshes.

As the limitation of the step (2), the starch in the step (2) is any plant starch, preferably corn starch or potato starch, and the starch accounts for 0.4 percent ~ 0.6.6 percent of the mass of the pellet core.

As a second limitation of step (2), hydroxypropyl methylcellulose constitutes 0.4% ~ 0.6.6%, preferably 0.4%, of the mass of the pellet core in step (2);

the concentration of the hydroxypropyl methylcellulose solution is 10% ~ 15%, preferably 10%.

As a third limitation of the step (2), the spherical particles formed in the step (2) are subjected to swing finishing and classification screening by a 20-mesh ~ 60-mesh screen;

the parameters in the dryer in the step (2) are that the air inlet speed is 80 ~ 85 ℃, the air outlet speed is 60 ~ 80 ℃, and the drying time is 15 ~ 30 minutes.

As a limitation of the step (3), the adding mass ratio of the pellet core to the ethyl cellulose or polyacrylic resin IV in the step (3) is 21.5 ~ 28: 1;

the concentration of the ethyl cellulose alcohol solution is 20 percent ~ 40 percent, preferably 20 percent, and the concentration of the polyacrylic resin IV alcohol solution is 5 percent ~ 8 percent, preferably 5 percent

The parameters of the particle coating machine are that the air inlet temperature is less than 85 ℃, the material temperature is less than 80 ℃, the atomization pressure is 0.80 MPa ~ 0.90.90 MPa, and the pump flow rate is 15 ~ 30 L.h^-1Treatment time of 30 ~ 45 minutes;

in the step (3), the primarily coated pellet cores are subjected to swinging, granulating and grading screening by a sieve with 20 meshes and ~ 60 meshes.

As a limitation of step (4), the food grade hydrogenated vegetable oil in step (4) has a melting temperature of 65 ℃ ~ 100 ℃;

the addition mass ratio of the sieved primary coating pellet core particles to the food-grade hydrogenated vegetable oil is 2.5 ~ 12.5.5: 1;

the parameters of the fluidized bed coating machine are that the air inlet temperature is less than 65 ℃, the material temperature is less than 45 ℃, the atomization pressure is 0.20 MPa ~ 0.25.25 MPa, and the pump flow rate is 15 ~ 30 L.h^-1The treatment time was 30 ~ 45 minutes.

And (3) as a second limitation of the step (4), after the secondary coating of the step (4) is finished, carrying out swing arrangement and classification screening by using a 40-mesh screen to obtain the coated guanidinoacetic acid on oversize products.

By way of limitation, the appearance of the finally obtained product is in a strip shape or an oval shape, and the effective component of glycocyamine after secondary coating reaches 60 percent ~ 90 percent.

Due to the adoption of the technical scheme, compared with the prior art, the invention has the technical progress that:

(1) after the glycocyamine is coated, the glycocyamine has good free-running property and is easy to process feed;

(2) the glycocyamine is protected by multiple coatings, the rumen bypass rate of glycocyamine active ingredients is improved, the glycocyamine is prevented from being fermented and degraded in rumen and directly entering small intestine and then being digested and absorbed, and the utilization rate of glycocyamine is improved;

(3) the degradation rate of the guanidinoacetic acid in rumen is reduced, the slow release effect of the product is realized, and the bioavailability of the product is improved;

(4) after being coated for many times, the product has better stability, is beneficial to storage, and resists abrasion in the processing process and high temperature in the feed granulating process.

Drawings

The invention is described in further detail below with reference to the figures and the embodiments.

FIG. 1 is a process flow diagram of the preparation method of the present invention.

Detailed Description

The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.