阅读说明：本技术 一种具有抗糖基化功效的组合物及其应用 (Composition with anti-glycosylation effect and application thereof ) 是由 汪晓凌 朱华伟 罗珍 唐健 于 2019-10-15 设计创作，主要内容包括：本发明公开了一种具有抗糖基化功效的组合物及其应用。该抗糖基化组合物由如下质量份数的组分组成：桂花提取物0.1～5份、石榴提取物0.1～5份、石榴提取物0.01～0.1份,其中所述桂花提取物中多酚质量含量为≥10％,且毛蕊花糖苷质量含量≥10％；所述石榴提取物中多酚质量含量为≥30％,且安石榴苷质量含量≥8％；所述橄榄果提取物中多酚质量含量为≥10％,且羟基酪醇质量含量≥3％。通过本发明的特定配伍的特定品质的桂花提取物、石榴提取物和橄榄果提取物协同作用,显著降低了成纤维细胞糖基化反应终产物CML的产生、降低了AGEs的产生和增加SOD表达三个维度实现皮肤的抗糖化能力提升。(The invention discloses a composition with an anti-glycosylation effect and application thereof. The anti-glycosylation composition comprises the following components in parts by weight: 0.1-5 parts of osmanthus fragrans extract, 0.1-5 parts of pomegranate extract and 0.01-0.1 part of pomegranate extract, wherein the mass content of polyphenol in the osmanthus fragrans extract is more than or equal to 10%, and the mass content of verbascoside is more than or equal to 10%; the mass content of polyphenol in the pomegranate extract is more than or equal to 30 percent, and the mass content of punicalagin is more than or equal to 8 percent; the olive fruit extract contains more than or equal to 10% of polyphenol by mass and more than or equal to 3% of hydroxytyrosol by mass. By the synergistic effect of the specially-matched osmanthus fragrans extract, the pomegranate extract and the olive fruit extract with specific quality, the generation of a fibroblast glycosylation reaction end product CML is obviously reduced, the generation of AGEs is reduced, and three dimensions of SOD expression are increased, so that the anti-saccharification capacity of the skin is improved.)

1. The composition with the anti-glycosylation effect is characterized by comprising the following components in parts by mass: 0.1 to 5 parts of osmanthus extract, 0.1 to 5 parts of pomegranate extract, 0.1 to 2 parts of olive extract,

wherein the mass content of polyphenol in the sweet osmanthus flower extract is more than or equal to 10 percent, and the mass content of verbascoside is more than or equal to 10 percent;

the mass content of polyphenol in the pomegranate extract is more than or equal to 30 percent, and the mass content of punicalagin is more than or equal to 8 percent;

the olive fruit extract contains more than or equal to 10% of polyphenol by mass and more than or equal to 3% of hydroxytyrosol by mass.

2. The composition with the anti-glycosylation efficacy according to claim 1, wherein the composition consists of the following components in parts by mass: 0.5-3 parts of osmanthus fragrans extract, 0.5-5 parts of pomegranate extract and 0.1-2 parts of olive fruit extract.

3. The composition with the anti-glycosylation efficacy according to claim 2, wherein the composition consists of the following components in parts by mass: 1-3 parts of osmanthus fragrans extract, 1-2 parts of pomegranate extract and 0.1-2 parts of olive fruit extract.

4. The composition with the anti-glycosylation efficacy according to claim 3, wherein the composition consists of the following components in parts by mass: 3 parts of osmanthus fragrans extract, 1 part of pomegranate extract and 0.1 part of olive fruit extract.

5. The composition with anti-glycosylation efficacy of claim 4, wherein in said composition:

the mass content of polyphenol in the sweet osmanthus extract is 10 percent, and the mass content of verbascoside is 10 percent;

the pomegranate extract contains 30% of polyphenol by mass and 10% of punicalagin by mass;

the olive fruit extract contains 10% of polyphenol by mass and 3% of hydroxytyrosol by mass.

6. Use of the composition with anti-glycosylation effect according to any one of claims 1 to 5 in the preparation of an anti-skin-glycosylation product.

7. An anti-glycation preparation, which is characterized by consisting of the anti-glycation composition as claimed in any one of claims 1 to 4 and other acceptable auxiliary materials.

8. The preparation having an anti-glycation effect according to claim 7, wherein the preparation comprises drinks, skin care products, foods and health products.

Technical Field

The invention relates to the technical field of anti-glycosylation, and more particularly relates to a composition with an anti-glycosylation effect and application thereof.

Background

The skin is a covered organ composed of dermis, dermis-epidermis junction, and epidermis. As with all other organs, the skin undergoes a complex physiological aging process that gradually leads to atrophy, dryness, reduction in elasticity and appearance of fine lines and wrinkles of the dermis and epidermis. The protein is a life foundation, is present in all parts of the whole body such as skin, muscle, blood vessels and the like, 60% of the body of a normal adult is water, 17-18% of the body of the adult is formed by the protein, the compact skin is formed by collagen and elastin in a dermis layer, once sugar retained in the body is combined with the protein, inferior protein is formed, advanced glycosylation end products (AGEs) are formed, and the skin is saccharified. Skin saccharification mainly refers to that collagen fibers of skin are broken to cause skin relaxation, darkness, yellowing and the like, and the collagen easily causes inflammatory reaction on the skin and gradually inactivates the collagen, so that the saccharified collagen and elastin cannot normally act, and facial relaxation and wrinkles are caused. In addition, the glycation of the dermis causes the skin to turn yellow gradually, and after the stratum corneum is glycated, one of the main causes of skin aging.

For example, CN107080726A discloses a skin whitening scheme, wherein the beauty food-anti-glycation food comprises olive extract, sweet osmanthus extract and astragalus extract, but the skin whitening scheme only explores the influence of the beauty food on the comprehensive skin of the skin, does not specifically study the deep glycosylation mechanism of the skin, and cannot solve the problem of skin glycation well from the inherent influences of the expression of the deep glycation product and the like.

Disclosure of Invention

The invention aims to overcome the defect and the defect that the existing skin anti-glycation product can not deeply solve the skin glycation from the gene expression level and provide a composition with the anti-glycation effect.

The invention aims to provide application of the composition with the anti-glycosylation effect in preparing an anti-skin-glycosylation product.

Still another object of the present invention is to provide a preparation having anti-glycation efficacy, which consists of the composition having anti-glycation efficacy and other acceptable excipients.

The above purpose of the invention is realized by the following technical scheme:

the composition with the anti-glycosylation effect comprises the following components in parts by mass: 0.1 to 5 parts of osmanthus extract, 0.1 to 2 parts of pomegranate extract, 0.01 to 0.1 part of olive extract,

wherein the mass content of polyphenol in the sweet osmanthus flower extract is more than or equal to 10 percent, and the mass content of verbascoside is more than or equal to 10 percent;

the mass content of polyphenol in the pomegranate extract is more than or equal to 30 percent, and the mass content of punicalagin is more than or equal to 10 percent;

the olive fruit extract contains more than or equal to 10% of polyphenol by mass and more than or equal to 3% of hydroxytyrosol by mass.

In the anti-glycosylation composition, the mullein glucoside in the sweet osmanthus extract can inhibit the generation of AGEs (glycosylation end products), particularly the content of the mullein glucoside is more than 10%, the inhibition effect is better, and the dull and transparent feeling of the skin and the skin luster can be obviously improved.

The sweet osmanthus extract, the pomegranate extract and the olive extract all contain polyphenol, the mass content of the polyphenol is more than 10%, and the polyphenol has the effects of resisting oxidation, removing free radicals, resisting inflammation and the like, can effectively accelerate the sugar metabolism speed, and strengthens and purifies the skin.

Punicalagin in the pomegranate extract can also inhibit AGEs from generating, has the functions of preventing a protein structure from being damaged by saccharification, reducing damage of MGO (pre-glycosylation object) to skin activity and oxidation, and can effectively accelerate sugar metabolism, capture free oxygen free radicals, effectively resist various oxidative damages, eliminate turbidity and yellow, and brighten, fresh and tender skin when the content of punicalagin is more than 10%.

The hydroxytyrosol in the olive fruit extract can improve the oxidation resistance, the content of hydroxytyrosol is more than 10 percent, the antioxidation effect can be obviously enhanced, the oxidation of primary saccharified products to form AGEs is inhibited, the dark and uneven skin color is improved, and the skin is bright.

Drawings

FIG. 1 shows CML expression in saccharification-induced fibroblasts.

FIG. 2 shows the expression of AGEs in a mouse model of aging.

FIG. 3 shows the expression of SOD in aged mice model.

Detailed Description

The present invention will be further described with reference to specific embodiments, but the present invention is not limited to the examples in any way. The starting reagents employed in the examples of the present invention are, unless otherwise specified, those that are conventionally purchased.