阅读说明：本技术 具有改变的糖基化和降低的效应物功能的包含fc的多肽 (FC-containing polypeptides with altered glycosylation and reduced effector function ) 是由 C·潘 H·邱 于 2013-09-12 设计创作，主要内容包括：本发明涉及具有改变的糖基化和降低的效应物功能的包含FC的多肽,具体提供了结合多肽(例如,抗体)及其药物偶联物,其包含具有改变的糖基化概貌和降低的效应物功能的Fc结构域。在具体的实施方案中,所述Fc结构域包含：根据EU编号在氨基酸位点298的天冬酰胺残基；和根据EU编号在氨基酸位点300的丝氨酸或苏氨酸残基。还提供了编码抗原结合多肽的核酸、用于制造这种抗原-结合多肽的重组表达载体和宿主细胞。还提供了使用本文公开的抗原-结合多肽来治疗疾病的方法。(The present invention relates to FC-containing polypeptides with altered glycosylation and reduced effector function, and specifically provides binding polypeptides (e.g., antibodies) and drug conjugates thereof comprising an FC domain with altered glycosylation profile and reduced effector function. In particular embodiments, the Fc domain comprises: an asparagine residue at amino acid position 298 according to EU numbering; and a serine or threonine residue at amino acid position 300 according to EU numbering. Nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides are also provided. Also provided are methods of treating diseases using the antigen-binding polypeptides disclosed herein.)