阅读说明：本技术 一种治疗ⅱ型糖尿病的中药组合物及其制备方法 (A kind of Chinese medicine composition and preparation method thereof for treating type II diabetes ) 是由 许汉杰 于 2019-08-13 设计创作，主要内容包括：本发明公开了一种治疗Ⅱ型糖尿病的中药组合物及其制备方法,所含组分及各组分的质量份数为：莲子粉1～10份,西洋参1～10份,甘草1～5份,蒲公英1～5份,黄芪1～5份,蜗牛粉50～100份,动物油脂10～100份。本发明立足中药标本兼治的原则,用七味药配伍,降低血糖,修复胰脏,各味药分工明确,主次突出,相辅相成,在治疗主症的同时兼顾并发症,治疗全面,疗效确切,经过临床验证效果显著,无毒副作用,可以长期服用。对糖尿病及由糖尿病导致的并发症效果明显；结合中药组方中特定组分的性质；成本低,相对于现有产品疗效快,十个月即有明显治疗效果,制作方便。(The invention discloses a kind of Chinese medicine compositions and preparation method thereof for treating type II diabetes, the mass fraction of contained component and each component are as follows: 1~10 part of lotus nut starch, 1~10 part of American Ginseng, 1~5 part of Radix Glycyrrhizae, 1~5 part of dandelion, 1~5 part of Radix Astragali, 50~100 parts of snail powder, 10~100 parts of animal fat.The present invention bases oneself upon the simultaneous principle controlled of Chinese herbal medicine specimen, with seven flavor medicine compatibility, reduces blood glucose, repair pancreas, each taste medicine division of labor is clear, and primary and secondary is prominent, complements each other, complication is taken into account while treating primary symptom, treatment is comprehensively, curative for effect, by clinical verification significant effect, it has no toxic side effect, can take for a long time.To diabetes and the complication effect as caused by diabetes is obvious；In conjunction with the property of specific components in Chinese prescription；It is at low cost, it is fast relative to existing product curative effect, there is obvious therapeutic effect within ten months, it is easy to make.)

1. a kind of Chinese medicine composition for treating type II diabetes, which is characterized in that the mass fraction of contained component and each component are as follows: 1~10 part of lotus nut starch, 1~10 part of American Ginseng, 1~5 part of Radix Glycyrrhizae, 1~5 part of dandelion, 1~5 part of Radix Astragali, snail powder 50~100 Part, 10~100 parts of animal fat.

2. a kind of Chinese medicine composition for treating type II diabetes according to claim 1, which is characterized in that contained component and The mass fraction of each component are as follows: 2~5 parts of lotus nut starch, 2~5 parts of American Ginseng, Radix Glycyrrhizae: 1~3 part, 1~3 part of dandelion, Radix Astragali 1~ 3 parts, 60~80 parts of snail powder, 10~100 parts of animal fat.

3. a kind of Chinese medicine composition for treating type II diabetes according to claim 1, which is characterized in that contained component and The mass fraction of each component are as follows: 4 parts of lotus nut starch, 4 parts of American Ginseng, 2 parts of Radix Glycyrrhizae, 2 parts of dandelion, 2 parts of Radix Astragali, 80 parts of snail powder, 20 parts of animal fat.

4. a kind of Chinese medicine composition for treating type II diabetes according to claim 1, which is characterized in that the animal oil Rouge is lard or butter, and acid value range is 0.1~1 KOH mg/g, and peroxide value is between 2~8meq/kg.

5. a kind of Chinese medicine composition for treating type II diabetes according to claim 1, which is characterized in that the snail powder Raw material be white jade snail.

6. a kind of Chinese medicine composition for treating type II diabetes according to claim 1, which is characterized in that the snail powder For at least one of snail shell powder, snail visceral meal and snail digested tankage or two or more mixtures.

7. a kind of Chinese medicine composition for treating type II diabetes according to claim 6, which is characterized in that the snail powder Include 0~10 part of snail shell powder, 0~10 part of snail visceral meal and 60~80 parts of snail digested tankage.

8. a kind of Chinese medicine composition for treating type II diabetes according to claim 1, which is characterized in that the snail powder The preparation method comprises the following steps:

Step 1: taking the healthy snail of 20~40 grams of weight, the monthly age 3 months to 4 months；

Step 2: the snail chosen is supported two days only, the collection of mucus protein is carried out to above-mentioned snail using extraction element；

Step 3: the snail for extracting mucus protein is removed shell, removes internal organ, shell, internal organ are separated with Carnis Limax；

Step 4: carrying out drying and processing to snail shell, internal organ and the Carnis Limax after separation respectively；

Step 5: carry out powder processed to snail shell, internal organ and the Carnis Limax after drying respectively, snail shell powder is formed, in snail Dirty powder and snail digested tankage；

Step 6: weighing snail shell powder, snail visceral meal and snail digested tankage respectively according to mass ratio, being mixed with to form snail Niu Fen, so far, preparation are completed.

9. a kind of prepare the preparation method that the Chinese medicine composition of type II diabetes is treated described in claim 1-8 any one, It is characterized by comprising the following steps:

Step 1: weighing lotus nut starch, American Ginseng, Radix Glycyrrhizae, dandelion and Radix Astragali according to formulation weight；

Step 2: the raw material of step 1 are respectively dried and powder processed；

Step 3: weighing snail according to formulation weight, snail powder is prepared according to method for claim 8；

Step 4: the powder that step 2 and step 3 obtain is mixed and stirred for uniformly；

Step 5: animal fat is added, it is again stirring for uniformly；

Step 6: the Chinese medicine composition that step 5 is uniformly mixed is prepared into pulvis, capsule, tablet, pill or electuary；

Step 7: drug quality inspection and packing, completion is so far prepared.

10. treating the application method of the Chinese medicine composition of type II diabetes described in the claims 9, it is characterised in that: institute State in step 2 and step 3, the condition of drying be -78~-60 DEG C be freeze-dried 12~20 hours, moisture content 5% with Under；The particle size range of powder is 60~80 mesh.

Technical field

The present invention relates to a kind of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating type II diabetes and its preparation side Method.

Background technique

Diabetes are one of big difficult and complicated illness in the world three, and diabetes are called rich people's disease, are mutual by h and E factor Common disease caused by effect belongs to endocrine metabolism disease, characterized by hypoinsulinism or effect defect, performance For chronic hyperglycemia, blood glucose fluctuation, common sympton has more drinks, diuresis, more foods and syntexis etc..Persistent high blood sugar and long-term metabolic Disorder etc. can lead to the damage of body tissue's organ, especially eye, kidney, angiocarpy and nervous system and its dysfunction and decline It exhausts.Serious person can cause dehydration, the acute complications such as electrolyte disturbance and acid-base imbalance ketoacidosis and Hyperosmotic coma.

Diabetes are divided into Type I diabetes, type II diabetes and specific type diabetes.Wherein type II diabetes is called Diabete is the illness day after tomorrow, is nowadays well off that activity is reduced, and patients with NIDDM quantity continues to increase, and current China has 13% crowd suffers from type II diabetes, is apt to occur in adult, serious person with multiple complications, as macrovascular complications, Microvascular complication, neural complication show as diabetes combined cerebral infraction, diabetes and coronary heart disease, diabetes and merge height Blood pressure, vasculopathy of lower extremity in diabetes change, diabetes, diabetic retinopathy, diabetic cataract, diabetic dermopathy Change and diabete peripheral herve pathology, wherein diabetic nephropathy belongs to common microvascular complication, will lead to a large amount of egg Even there is end-stage renal disease in albiduria, serious person, and complication is very harmful to body, the life of people, cause many people disable or It is dead.

Current main treatment method is insulin injection treatment and oral drug therapy.

When insulin injection is treated, the drawbacks for the treatment of, daily 2-5 timing progress subcutaneous insulin injection cannot be complete Meet the physiological requirements of diabetic itself, insulin requirements are unpredictable, can not accurately deal with demand；And it cannot be primary Property largely inject, avoid forming accumulation subcutaneous, it is unstable that insulin enters blood rate, causes blood glucose larger fluctuation, cannot will be complete Its 24 hours glycemic controls are steady；Diabetic cannot block or reduce the constant absorption of insulin, once low blood occurs Sugar just must additionally be fed, unfavorable to glycemic control；Hypoglycemic speed is slower, and insulin dosage is big, and the low blood of accident easily occurs Sugar；Injection daily, patient is very painful, also very inconvenient, can not improve the quality of living.In addition, studies have shown that part pancreas islet Element can cause the multiple of diabetic complication, the attached Shanghai City Sixth People's Hospital Jia Weiping professor of Medical College, Shanghai Communication Univ. The cohort study prompt of equal developments, though the patients with NIDDM of acceptor's insulin therapy suffers from cancered overall risk It is not additional to increase, but liver cancer risk is significantly raised, and All-cause death and cancer mortality risk also increase.

Tens of kinds are reached currently used for oral drugs used in clinical treatment, doctor trained in Western medicine mainly uses two to the treatment of diabetes Although first biguanides, Glimepiride, gliclazide, Rosiglitazone etc., these drugs play the role of relatively good reduction blood glucose, but poison Side effect is obvious, and periodic monitoring blood glucose is wanted during taking, and the damage that will lead to hepatic and renal function is used for a long time and generates tolerance, If dosage is excessive, blood glucose can be made to be reduced to normal value hereinafter, causing hypoglycemia, result even in hypoglycemic shock, stupor, sternly Severe one lethal can die.Patient takes Western medicine for a long time, can bring side effect to internal organs such as kidney, liver, the heart, spleen, stomaches, and due to glycosuria Pathology, etiological study so far there are no substantive breakthrough, treatment diabetes still in control blood glucose, glucose in urine increase the stage and The conceptual phase for preventing comprehensive complication.

Traditional Chinese medicine therapy diabetes especially emphasize the sight that organic conception, diagnosis and treatment, regulating yin and yang, too many levels improve Point, this has similarity to treating diabetes viewpoint with modern medicine, shows that Chinese medicine has centainly in terms for the treatment of diabetes Advantage, and Chinese medicine is inexpensive, toxic side effect is small, influences less, Devoting Major Efforts To Developing to be worth to be promoted the use of on organ；Though but having in recent years Chinese medicine for treating diabetes, can the effects of TCM prevention and cure diabetes for many years do not protrude, clinical trial effect is not also significant, Treatment means are also more single, so also failing to obtain good result, and are formulated complexity, some traditional Chinese medicine ingredients are rare, cost is high.

The applicant just notices the significant damage of diabetes from last century early eighties, consults a large amount of Chinese medicines of China Medicine data, such as the Compendium of Material Medica of Li Shizhen (1518-1593 A.D.), wherein there is the specific considerations to diabetes, applicant passes through more than 30 years repeatedly Test, obtains inventive formulation from countless failure formulas.

Summary of the invention

It is an object of that present invention to provide a kind of Chinese medicine compositions and preparation method thereof for treating type II diabetes, it is therefore intended that With seven taste Chinese medicine reasonable formulas, promote pancreas reparation that it is made to rejuvenate, excreting insulin achievees the purpose that treating both manifestation and root cause of disease.

To achieve the above object, the present invention adopts the following technical scheme:

A kind of Chinese medicine composition for treating type II diabetes, which is characterized in that the mass fraction of contained component and each component are as follows: lotus 1~10 part of sub- powder, 1~10 part of American Ginseng, 1~5 part of Radix Glycyrrhizae, 1~5 part of dandelion, 1~5 part of Radix Astragali, snail powder 50~100 Part, 10~100 parts of animal fat.

As the preferred technical solution of the present invention, the mass fraction of contained component and each component are as follows: 2~5 parts of lotus nut starch, west 2~5 parts of American ginseng, Radix Glycyrrhizae: 1~3 part, 1~3 part of dandelion, 1~3 part of Radix Astragali, 60~80 parts of snail powder, animal fat 10~ 100 parts.

It is further preferred that as the preferred technical solution of the present invention, the mass fraction of contained component and each component are as follows: lotus 4 parts of sub- powder, 4 parts of American Ginseng, 2 parts of Radix Glycyrrhizae, 2 parts of dandelion, 2 parts of Radix Astragali, 80 parts of snail powder, 20 parts of animal fat.

It is further preferred that the animal fat is lard or butter, acid value range is 0.1~1KOH mg/g, peroxide Change value is between 2~8meq/kg.

It is further preferred that the raw material of the snail powder are white jade snail.

It is further preferred that the snail powder is at least one of snail shell powder, snail visceral meal and snail digested tankage Or two or more mixture.

It is further preferred that the snail powder includes 0~10 part of snail shell powder, 0~10 part of snail visceral meal and snail 60~80 parts of digested tankage.

It is further preferred that the snail powder the preparation method comprises the following steps:

Step 1: taking the healthy snail of 20~40 grams of weight, the monthly age 3 months to 4 months；

Step 2: the snail chosen is supported two days only, the collection of mucus protein is carried out to above-mentioned snail using extraction element；

Step 3: the snail for extracting mucus protein is removed shell, removes internal organ, shell, internal organ are separated with Carnis Limax；

Step 4: carrying out drying and processing to snail shell, internal organ and the Carnis Limax after separation respectively；

Step 5: carry out powder processed to snail shell, internal organ and the Carnis Limax after drying respectively, snail shell powder is formed, in snail Dirty powder and snail digested tankage；

Step 6: weighing snail shell powder, snail visceral meal and snail digested tankage respectively according to mass ratio, being mixed with to form snail Niu Fen, so far, preparation are completed.

Further, the present invention also provides the preparation method of the Chinese medicine composition of above-mentioned treatment type II diabetes, features It is, includes the following steps:

Step 1: weighing lotus nut starch, American Ginseng, Radix Glycyrrhizae, dandelion and Radix Astragali according to formulation weight；

Step 2: the raw material of step 1 are respectively dried and powder processed；

Step 3: weighing snail according to formulation weight, snail powder is prepared according to method for claim 8；

Step 4: the powder that step 2 and step 3 obtain is mixed and stirred for uniformly；

Step 5: animal fat is added, it is again stirring for uniformly；

Step 6: the Chinese medicine composition that step 5 is uniformly mixed is prepared into pulvis, capsule, tablet, pill or electuary；

Step 7: drug quality inspection and packing, completion is so far prepared.

Further, in the step 2 and step 3, the condition of drying is that -78~-60 DEG C of freeze-dryings 12~20 are small When, moisture content is below 5%；The particle size range of powder is 60~80 mesh.

In said medicine, amorphous crystal alkaloid N -9 contained by lotus seeds are had antihypertensive effect.The tool of alkaloid contained by Lotus Plumule There is significant antihypertensive effect, there are also the effects of stronger arrhythmia, relieving mental strain and helping sleep, are beneficial to diabetes and merge insomnia trouble Person；The a variety of ginsenosides of American Ginseng, a variety of volatile components, resin, starch, carbohydrate and amino acid, inorganic salts etc., have resist it is molten Blood, hemostasis reduce blood coagulability, inhibit platelet aggregation, Adjust-blood lipid, the hardening of anti-artery congee, reduce the effects of blood glucose, are applicable in In the diseases such as hyperlipemia artery sclerosis, senile disease, diabetes, boosting qi and nourishing yin, clearing heat and promoting fluid the effect of, impairment of both QI and YIN card, lung are cured mainly The deficiency of vital energy and syndrome of deficiency of lung yin, pyreticosis deficiency of vital energy injury thirst and diabetes.

Radix Glycyrrhizae has clearing heat and detoxicating, expelling phlegm and arresting coughing and prevention and treatment tumor function.Radix Glycyrrhizae has anti-inflammatory, anti-allergic effects, can protect The throat and tunica mucosa tracheae of inflammation, extract of licorice root and glycyrrhizic acid have the detoxication of similar glucuronic acid to certain poisonous substances.Moral State Marx Planck molecule genetics research institute researcher has found from licorice can reduce the object that blood glucose inhibits inflammation Matter-amorfrutin.These wholesome effects have directly been moored in nucleus based on amorfrutin molecule On receptor PPAR γ, morfrutin molecule is integrated on PPAR γ, activate various participation reduce in blood plasma certain fatty acid with The gene of concentration of glucose, blood glucose level reduction can prevent from forming the main cause of disease of insulin resistant-maturity-onset diabetes.But by The content of material is too low in Radix Glycyrrhizae, so individually edible Radix Glycyrrhizae can not achieve the effect that treat diabetes.

Dandelion has clearing heat and detoxicating, dispersing swelling and dissipating binds, effect that dampness removing is treating stranguria.Cure mainly carbuncle, swelling and furuncle, acute mastitis internal carbuncle, heat gonorrhea is puckery Bitterly, jaundice with damp-heat pathogen clears liver and improve vision.In addition, can also prevent anaemia, can help to supplement irony containing ferro element more abundant, There is hypoferric anemia in prevention body；Alleviate dermatitis, containing can help the problems such as inhibiting eczema, dermatitis anti-inflammatory it is antibacterial at Point, external application can help to inhibit fungi, improve skin problem caused by fungal infection；Antibacterial, dandelion contains more plant Acid and taraxacin, there is good bacteriostasis, have apparent inhibition to make staphylococcus aureus, hemolytic streptococcus With in addition there is certain inhibiting effect for Diplococcus pneumopniae, proteus, shigella dysenteriae, micrococcus catarrhalis etc..

Radix Astragali slightly warm in nature sweet in flavor, return lung, spleen, liver and kidney channel.Polishing consolidates table, and torr sore myogenic can reduce blood viscosity, subtract Few thrombosis, reduce blood pressure, cardioprotection, bidirectional modulation blood glucose, free radical resisting damage, anti-aging, anti anoxia, it is antitumor, Enhance immunity of organisms effect, can be used to treat the diseases such as heart disease, hypertension, diabetes；Raw Radix Astragali has invigorating qi for consolidating superficies, benefit The effect of water detumescence, detoxification, myogenic, suitable for spontaneous perspiration, night sweat, blood-arthralgia, edema, un-festering of ulcer or bursts and does not hold back etc. diseases long；Radix Astragali Blood vessel can also be expanded, skin blood circulation and nutrition condition are improved, thus it is effective to the long disunion person of chronic ulcer；Radix Astragali can be mended Spleen QI invigorating is effected a permanent cure, and energy inducing diuresis to remove edema temporary solution, is one of the important drugs for treating qi and blood oedema；Radix Astragali itself has the function of blood-nourishing Effect, and green blood is facilitated by the effect of tonifying Qi again, therefore Radix Astragali is also commonly used for treating blood deficiency chlorosis and syndrome of deficiency of both qi and blood； Effective component astragalus polyose and anti-tumor drug have shared the function of Synergy and attenuation in Radix Astragali, i.e. enhancing anticancer effect, mitigate secondary make With.

Snail smell is salty, cold, slightly poisonous, is that the present invention matches containing a large amount of amino acid and enzyme needed by human in Carnis Limax The core of side, such as the content data table that table 1 is white jade snail aminoacid ingredient.

The content data table of 1. white jade snail aminoacid ingredient of table

As shown in Table 1, in human body 22 in necessary amino acid, white jade snail meat contains 20 kinds.In addition, can containing other in Carnis Limax Feeding habits animal is difficult to the valuable plain object having, and applicant passes through research in 15 years, browses 26 countries and grind to snail The paper report studied carefully, counted the type of contained enzyme and plain object in snail: cellulase, hemicellulase, pectase, sweet dew are poly- Carbohydrase, lactase, galactase, invertase, proteolytic enzyme, protein kinase, propionyl based cholinesterase, aromatic sulfuric acid esterase, Phosphatase, galactogen synzyme, alpha-amylase, alkaline phosphatase, poly galactase, beta-glucuronidase, digestive ferment, fruit Sugar-phosphate aldolase, half tartaric acid dehydrogenase, lactase dehydrogenase, pyruvate kinase, poly- deoxythymidine enzyme, fibrinolysis Enzyme, sulphur hydrolyze sour enzyme, neutral protease, total 29 kinds of enzymes such as acyl group cholinesterase and arginase, in addition, also containing deoxidation Ribonucleic acid, thuja acid are cyclized acid, hemocyanin, α-hemocyanin, β_CHemocyanin, lectins and A haemoglutinin etc., In some substances can the cell to lesion carried out affine destruction, have inhibiting effect to the special lesion of the mankind, such as snail polypeptide There is hypoglycemic effect.

Compared with prior art, the present invention has following technical advantage:

1, the present invention bases oneself upon the simultaneous principle controlled of Chinese herbal medicine specimen, with seven flavor medicine compatibility, reduces blood glucose, repairs pancreas, each taste medicine division of labor Clear, primary and secondary is prominent, complements each other, and complication is taken into account while treating primary symptom, treatment is comprehensively, curative for effect, by clinic Verification the verifying results are significant, have no toxic side effect, and can take for a long time.

2, in conjunction with the property of specific components in Chinese prescription, pharmacology Synergy advantage in performance, to diabetes and by sugar Complication effect caused by urine disease is obvious, is proved by 102 clinical tests, there is 100% curative effect to type II diabetes, success Rate is up to 96%, fast relative to existing product curative effect, makes rehabilitation in patients with NIDDM 10 months, not only can effectively cure II Patients with type Ⅰ DM, and the system of patient can be enhanced, there is fabulous health-care effect.

3, inventive formulation is simple, easy to make, at low cost, securely and reliably, without any side effects.

Specific embodiment

Hereinafter, it will be explained in detail a kind of Chinese medicine composition and preparation method thereof for treating type II diabetes of the invention Embodiment.The embodiment recorded herein is specific specific embodiment of the invention, for illustrating design of the invention, Be it is explanatory and illustrative, should not be construed as the limitation to embodiment of the present invention and the scope of the invention.Except what is recorded herein Outside embodiment, those skilled in the art can also based on the claim of this application book and specification disclosure of that using aobvious and The other technical solutions being clear to, these technical solutions include using any obvious to making for the embodiment recorded herein The technical solution of substitutions and modifications.

The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit Determine the scope of the present invention.