阅读说明：本技术 一种治疗慢性支气管炎的中药组合物及其制备方法 (Traditional Chinese medicine composition for treating chronic bronchitis and preparation method thereof ) 是由 吕向东 于 2021-09-28 设计创作，主要内容包括：本发明提出了一种治疗慢性支气管炎的中药组合物及其制备方法,涉及中药领域。一种治疗慢性支气管炎的中药组合物,其包括以下中药材：九味一枝蒿、云芝、松橄榄、下田菊、木香、水曲柳、照山白、百眼藤、羌活、麻黄、雪胆、胆木、红头翁、甘草和桑白皮。本发明采用九味一枝蒿、云芝、松橄榄、田菊、木香和水曲柳发挥其清热解毒和燥湿化痰的效果,采用照山白、百眼藤、羌活和麻黄发挥祛风散寒的作用,从侧面增强其清热解毒的效果,同时采用雪胆、胆木和红头翁消炎止痛,诸药合用,对慢性支气管炎达到标本根治的效果。(The invention provides a traditional Chinese medicine composition for treating chronic bronchitis and a preparation method thereof, and relates to the field of traditional Chinese medicines. A traditional Chinese medicine composition for treating chronic bronchitis comprises the following traditional Chinese medicinal materials: herba Achilleae, Coriolus versicolor, fructus Canarii albi, flos Chrysanthemi Segeti, radix aucklandiae, ramulus et folium Fraxini, cortex Illici, caulis Aristolochiae, Notopterygii rhizoma, herba Ephedrae, radix Hemsleyae Macrospermae, lignum naucleae, radix Pulsatillae, Glycyrrhrizae radix and cortex Mori. The invention adopts the nine-ingredient artemisia rupestris, corious versicolor, olive, chrysanthemum, elecampane and Chinese tamarisk to exert the effects of clearing away heat and toxic materials, eliminating dampness and reducing phlegm, adopts the rhododendron micranthum, the caulis periplocae, the notopterygium root and the ephedra to exert the effects of dispelling wind and cold, enhances the effects of clearing away heat and toxic materials from the side, adopts the hemsleya amabilis, the nauclea officinalis and the Chinese pulsatilla root to diminish inflammation and relieve pain, combines the medicines, and achieves the effect of radically treating the symptoms and root of chronic bronchitis.)

1. A traditional Chinese medicine composition for treating chronic bronchitis is characterized by comprising the following traditional Chinese medicinal materials: herba Achilleae, Coriolus versicolor, fructus Canarii albi, flos Chrysanthemi Segeti, radix aucklandiae, ramulus et folium Fraxini, cortex Illici, caulis Aristolochiae, Notopterygii rhizoma, herba Ephedrae, radix Hemsleyae Macrospermae, lignum naucleae, radix Pulsatillae, Glycyrrhrizae radix and cortex Mori.

2. The traditional Chinese medicine composition for treating chronic bronchitis according to claim 1, which is prepared from the following raw materials in parts by weight: 20-40 parts of artemisia rupestris, 25-35 parts of coriolus versicolor, 20-30 parts of pine olive, 15-25 parts of chrysanthemum indicum, 10-20 parts of elecampane, 15-20 parts of fraxinus rhynchophylla, 5-10 parts of rhododendron, 10-20 parts of caulis perillae, 8-15 parts of notopterygium root, 10-20 parts of ephedra, 3-8 parts of hemsleya amabilis, 8-18 parts of nauclea officinalis, 5-12 parts of radix pulsatillae, 2-5 parts of liquorice and 3-5 parts of cortex mori radicis.

3. The traditional Chinese medicine composition for treating chronic bronchitis according to claim 1, which is prepared from the following raw materials in parts by weight: 30 parts of radix aconiti brachypodi, 28 parts of coriolus versicolor, 25 parts of pine olive, 20 parts of chrysanthemum indicum, 16 parts of elecampane, 18 parts of fraxinus rhynchophylla, 7 parts of rhododendron micranthum, 15 parts of caulis periplocae, 12 parts of notopterygium root, 15 parts of ephedra, 5 parts of hemsleya amabilis, 12 parts of nauclea officinalis, 7 parts of radix pulsatillae, 3 parts of liquorice and 4 parts of cortex mori.

4. The preparation method of the traditional Chinese medicine composition for treating chronic bronchitis according to any one of claims 1 to 3, which is characterized by comprising the following steps:

weighing the raw materials, cleaning, drying and crushing for later use;

processing herba Camptothecae Acuminatae and radix Hemsleyae Macrospermae with vinegar to obtain vinegar material;

parching corious versicolor, herba Hyperici Japonici, ramulus et folium Tamaricis, caulis Aristolochiae Manshuriensis, lignum naucleae and cortex Mori with soil, and cooling to obtain parched materials;

soaking the rest raw materials in water;

and mixing the soaked raw materials with the stir-fried materials and the vinegar-processed materials, adding water, decocting for 2-4 times, and combining filtrates to obtain the traditional Chinese medicine composition for treating chronic bronchitis.

5. The preparation method of the traditional Chinese medicine composition for treating chronic bronchitis according to claim 4, wherein the filtrate is processed and prepared into decoction, paste, tablets or pills.

6. The method for preparing a Chinese medicinal composition for treating chronic bronchitis according to claim 4, wherein the cleaning is performed by ozone bubble cleaning or ultrasonic cleaning, and the crushed particle size is 20-60 meshes.

7. The preparation method of the traditional Chinese medicine composition for treating chronic bronchitis according to claim 4, wherein the vinegar preparation is to soak traditional Chinese medicinal materials in vinegar, and the weight ratio of the traditional Chinese medicinal materials to the vinegar is 1: (3-5), the soaking time is 10-20 days.

8. The preparation method of the traditional Chinese medicine composition for treating chronic bronchitis according to claim 4, wherein the soil frying specifically comprises the steps of heating the cooking range soil, pouring the traditional Chinese medicinal materials, stir-frying for 15-25 min, sieving, taking out the traditional Chinese medicinal materials, and cooling.

9. The preparation method of the traditional Chinese medicine composition for treating chronic bronchitis according to claim 4, wherein the soaking time in water is 20-40 min.

10. The preparation method of the traditional Chinese medicine composition for treating chronic bronchitis according to claim 4, wherein the water decoction comprises the following specific steps: adding 8-12 times of water by mass into the raw materials, boiling with strong fire, then decocting with slow fire for 1-3 h, and filtering to obtain filtrate for later use.

Technical Field

The invention relates to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chronic bronchitis and a preparation method thereof.

Background

Chronic bronchitis is a chronic nonspecific inflammation of the trachea, bronchial mucosa and surrounding tissues. Cough and expectoration are the main symptoms in clinic, and the disease lasts for 3 months every year, and is continued for 2 years or more than 2 years. The general symptoms include: (1) cough: cough usually occurs in the morning, and paroxysmal cough or sputum excretion occurs during sleep. (2) Expectoration: generally white mucus and serum foams, occasionally with blood. Phlegm is more discharged in the early morning, and the phlegm can be stimulated after getting up or the body position changes. (3) Wheezing or dyspnea: patients with significant wheezing are often referred to as asthmatic bronchitis, some of which may be associated with bronchial asthma. If it is accompanied by emphysema, it may be manifested as urgent breath after work or activity. Dry and wet rales can be heard on the back or the bottom of the two lungs in the acute attack stage, and can be reduced or disappeared after cough. Such as the combination of an audible and broad wheeze in asthma with prolonged expiration.

The general treatment of chronic bronchitis includes: (1) antibacterial treatment: antibacterial treatment is selected according to the pathogen of infection and drug sensitivity test. Before a positive result of pathogenic bacteria can not be obtained, macrolides, penicillins, cephalosporins, quinolones and other medicaments can be selected. Most patients can take the antibacterial drugs orally, and the patients with serious symptoms can use intramuscular injection or intravenous drip. (2) Symptomatic treatment: for cough without phlegm, dextromethorphan, pentoxyverine or codeine can be used. The cough with phlegm is not easy to cough, and ambroxol hydrochloride or bromhexine can be selected, and the atomization can also help to dispel phlegm. The Chinese patent drug cough-relieving and phlegm-dispelling herbs can also be selected. Bronchospasm can occur, and antiasthmatic drugs such as theophyllines or receptor agonists can be used. For fever, antipyretic and analgesic drugs can be used. (3) Controlling infection: antiviral drugs are commonly used by those caused by viruses. Infants, infirm or suspected pneumonia and other suppurative infections may be treated with sulfonamides or intramuscular injections of penicillin, or with other broad-spectrum antibiotics, and if the pathogen is mycoplasma pneumoniae, erythromycin or acetylspiramycin may be used.

Currently, antibiotic drugs are commonly used for treating the diseases, but the long-term use of antibiotics can generate serious drug resistance, so that the drugs of a plurality of antibiotics are finally ineffective, and the inflammatory diseases are difficult to cure.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating chronic bronchitis, and the traditional Chinese medicine composition has a good curative effect on the chronic bronchitis.

The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating chronic bronchitis, which can reduce the side effects of the traditional Chinese medicine to a greater extent.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On the one hand, the embodiment of the application provides a traditional Chinese medicine composition for treating chronic bronchitis, which comprises the following traditional Chinese medicinal materials: herba Achilleae, Coriolus versicolor, fructus Canarii albi, flos Chrysanthemi Segeti, radix aucklandiae, ramulus et folium Fraxini, cortex Illici, caulis Aristolochiae, Notopterygii rhizoma, herba Ephedrae, radix Hemsleyae Macrospermae, lignum naucleae, radix Pulsatillae, Glycyrrhrizae radix and cortex Mori.

On the other hand, the embodiment of the application provides a preparation method of a traditional Chinese medicine composition for treating chronic bronchitis, which comprises the following steps:

weighing the raw materials, cleaning, drying and crushing for later use;

processing herba Camptothecae Acuminatae and radix Hemsleyae Macrospermae with vinegar to obtain vinegar material;

parching corious versicolor, herba Hyperici Japonici, ramulus et folium Tamaricis, caulis Aristolochiae Manshuriensis, lignum naucleae and cortex Mori with soil, and cooling to obtain parched materials;

soaking the rest raw materials in water;

and mixing the soaked raw materials with the stir-fried materials and the vinegar-processed materials, adding water, decocting for 2-4 times, and combining filtrates to obtain the traditional Chinese medicine composition for treating chronic bronchitis.

Nine kinds of alpine yarrow herb: bitter and astringent taste, mild in nature. Enter heart and liver meridians. Astringe to stop bleeding, remove toxicity and relieve swelling, clear heat and remove toxicity, cool blood to stop bleeding. It is mainly used for treating common cold, bronchitis, tonsillitis, costitis, dysentery with red and white feces, and traumatic hemorrhage.

Coriolus versicolor: sweet and bland in flavor, slightly cold in nature. It enters liver, spleen and lung meridians. Invigorating spleen, promoting diuresis, relieving cough and asthma, clearing away heat and toxic material, and resisting tumor. Mainly chronic active hepatitis, cirrhosis, chronic bronchitis, infantile spastic bronchitis, sore throat, various tumors, rheumatoid arthritis and leukemia.

Loosening olive: bitter taste and mild nature. Relieve cough, relieve asthma, remove toxicity. Mainly bronchitis, asthma, hemorrhoids and toothache.

Chrysanthemum of the lower county: bitter taste and cold nature; clear heat and promote diuresis, remove toxicity and relieve swelling. Can be used for treating common cold, hyperpyrexia, bronchitis, pharyngolaryngitis, tonsillitis, and icterohepatitis; it is used externally to treat carbuncle, furuncle, sore and ulcer, and snake bite.

Costustoot: pungent and bitter with warm nature. It enters spleen, stomach, large intestine, triple energizer and gallbladder meridians. Move qi and alleviate pain, invigorate spleen and promote digestion. Can be used for treating chest and abdominal pain, dysentery, tenesmus, dyspepsia, and anorexia.

Fraxinus mandshurica: bitter taste and cold nature. It enters liver, lung and large intestine meridians. Clear heat and dry dampness, clear liver and improve vision. Can be used for treating enteritis, dysentery, menoxenia, leucorrhea, chronic bronchitis, acute conjunctivitis, and malaria.

Turning to white: sour and pungent in flavor and warm in nature. Is toxic. It enters heart, lung and large intestine meridians. Dispel wind, dredge collaterals, regulate menstruation, alleviate pain, resolve phlegm and stop cough. It can be used for treating bronchitis, dysentery, puerperal pain, and fracture.

Caulis et folium piperis: sweet taste and cool nature. Clearing away heat and toxic material, dissipating blood stasis and relieving pain, dispelling wind and eliminating dampness. It can be used for treating dyspepsia, diarrhea, constipation, common cold, cough, traumatic injury, sprain, and lumbar muscle strain.

Notopterygium root: pungent and bitter with warm nature. It enters bladder and kidney meridians. Dispel cold, expel wind, remove dampness and alleviate pain. Can be used for treating wind-cold type common cold, headache, rheumatalgia, and soreness of shoulder and back.

Herba ephedrae: pungent, slightly bitter and warm in nature. It enters lung and bladder meridians. Induce sweating and dispel cold, ventilate lung and relieve dyspnea, induce diuresis to alleviate edema. Can be used for treating common cold due to wind-cold, chest distress, cough, edema due to wind-cold evil, and bronchial asthma.

Snow gall: bitter taste and cold nature. Has little toxicity. Clear away heat and toxic material, invigorate stomach and alleviate pain. Can be used for treating gastralgia, ulcer, upper respiratory infection, bronchitis, pneumonia, bacillary dysentery, enteritis, urinary system infection, septicemia, and other infections.

Wood liner: bitter taste and cold nature. Clear heat and remove toxicity, relieve swelling and alleviate pain. Can be used for treating common cold, fever, acute tonsillitis, pharyngolaryngitis, bronchitis, pneumonia, urinary system infection, enteritis, dysentery, and cholecystitis.

The Chinese pulsatilla root: slightly bitter taste and mild nature. Clear heat and remove toxicity, relieve swelling and alleviate pain. Can be used for treating acute tonsillitis, parotitis, bronchitis, pneumonia and lymphoid tuberculosis.

Licorice root: sweet in flavor and neutral in nature. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal distention, limb spasm, pain, carbuncle, suppurative sore, and drug toxicity and strong toxicity.

White mulberry root-bark: sweet in flavor and cold in nature. It enters lung meridian. Purge lung, relieve dyspnea, induce diuresis to alleviate edema. Can be used for treating cough and asthma due to lung heat, edema, distention, oliguria, and edema of facial skin.

Wind cold affects the lung, the lung qi is depressed without diffusing, body fluid is gathered without distributing, so there is phlegm in chronic cough, the invention uses nine kinds of herba Achilleae, Coriolus versicolor and pine olive to clear away heat and toxic material, uses herba Hyperici Japonici, radix aucklandiae and water willow to invigorate the spleen and promote diuresis, achieve the effects of drying dampness and resolving phlegm, use radix seu caulis Opuntiae Dillenii and caulis Aristolochiae Fortunei to dispel wind, use rhizoma Et radix Notopterygii and herba Ephedrae to dispel cold, assist the monarch drug to clear away heat and disperse, use ministerial drug to dispel heat; the hemsleya amabilis, the nauclea officinalis and the pulsatilla chinensis are used as adjuvant drugs for diminishing inflammation and relieving pain, and the liquorice is used for harmonizing the drugs in the recipe and the cortex mori is used for introducing the drugs into the lung to be used as guiding drugs together.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

the invention adopts the nine-ingredient artemisia rupestris, corious versicolor, olive, chrysanthemum, elecampane and Chinese tamarisk to exert the effects of clearing away heat and toxic materials, eliminating dampness and reducing phlegm, adopts the rhododendron micranthum, the caulis periplocae, the notopterygium root and the ephedra to exert the effects of dispelling wind and cold, enhances the effects of clearing away heat and toxic materials from the side, adopts the hemsleya amabilis, the nauclea officinalis and the Chinese pulsatilla root to diminish inflammation and relieve pain, combines the medicines, and achieves the effect of radically treating the symptoms and root of chronic bronchitis.

According to the invention, rhododendron micranthum and hemsleya amabilis are processed by vinegar, so that the toxicity is reduced, the blood circulation promoting effect is increased, the channel dredging and cold dispelling effects are enhanced, the corious versicolor, the chrysanthemum indicum, the fraxinus mandshurica, the byttris, the nauclea officinalis and the white mulberry root-bark are stir-fried with soil, the cold property is inhibited without reducing the drug effect, and the side effects of a patient in the using process are reduced.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

A traditional Chinese medicine composition for treating chronic bronchitis comprises the following traditional Chinese medicinal materials: herba Achilleae, Coriolus versicolor, fructus Canarii albi, flos Chrysanthemi Segeti, radix aucklandiae, ramulus et folium Fraxini, cortex Illici, caulis Aristolochiae, Notopterygii rhizoma, herba Ephedrae, radix Hemsleyae Macrospermae, lignum naucleae, radix Pulsatillae, Glycyrrhrizae radix and cortex Mori.

In some embodiments of the present invention, the traditional Chinese medicine composition comprises the following raw materials by weight: 20-40 parts of artemisia rupestris, 25-35 parts of coriolus versicolor, 20-30 parts of pine olive, 15-25 parts of chrysanthemum indicum, 10-20 parts of elecampane, 15-20 parts of fraxinus rhynchophylla, 5-10 parts of rhododendron, 10-20 parts of caulis perillae, 8-15 parts of notopterygium root, 10-20 parts of ephedra, 3-8 parts of hemsleya amabilis, 8-18 parts of nauclea officinalis, 5-12 parts of radix pulsatillae, 2-5 parts of liquorice and 3-5 parts of cortex mori radicis.

In some embodiments of the present invention, the traditional Chinese medicine composition comprises the following raw materials by weight: 30 parts of radix aconiti brachypodi, 28 parts of coriolus versicolor, 25 parts of pine olive, 20 parts of chrysanthemum indicum, 16 parts of elecampane, 18 parts of fraxinus rhynchophylla, 7 parts of rhododendron micranthum, 15 parts of caulis periplocae, 12 parts of notopterygium root, 15 parts of ephedra, 5 parts of hemsleya amabilis, 12 parts of nauclea officinalis, 7 parts of radix pulsatillae, 3 parts of liquorice and 4 parts of cortex mori.

A preparation method of a traditional Chinese medicine composition for treating chronic bronchitis comprises the following steps:

weighing the raw materials, cleaning, drying and crushing for later use;

processing herba Camptothecae Acuminatae and radix Hemsleyae Macrospermae with vinegar to obtain vinegar material;

parching corious versicolor, herba Hyperici Japonici, ramulus et folium Tamaricis, caulis Aristolochiae Manshuriensis, lignum naucleae and cortex Mori with soil, and cooling to obtain parched materials;

soaking the rest raw materials in water;

mixing the soaked raw materials with the stir-fried materials and the vinegar-processed materials, adding water, decocting for 2-4 times, and combining filtrates to obtain the traditional Chinese medicine composition for treating chronic bronchitis

In some embodiments of the present invention, the filtrate is processed to make decoction, spray, tablet or pill.

In some embodiments of the invention, the cleaning is performed by ozone bubble cleaning or ultrasonic cleaning, and the crushed particle size is 20-60 meshes, so that the raw material processing time is reduced.

In some embodiments of the present invention, the vinegar preparation is specifically to soak Chinese herbal medicines in vinegar, wherein the weight ratio of the Chinese herbal medicines to the vinegar is 1: (5-10), the soaking time is 10-20 days. On one hand, the toxicity of the medicine is reduced, on the other hand, the effect of activating blood is increased, and the medicine has the strengthening effect of dredging channels and dispelling cold.

In some embodiments of the invention, the soil frying specifically comprises the steps of heating the cooking range soil, pouring the traditional Chinese medicinal materials, stir-frying for 15-25 min, sieving, taking out the traditional Chinese medicinal materials, and cooling. The stir-baked with soil can inhibit cold property without reducing drug effect, and reduce side effects of patients in application process.

In some embodiments of the present invention, the soaking time in water is 20-40 min.

In some embodiments of the present invention, the water-adding decoction comprises the following specific steps: adding 8-12 mass of water into the raw materials, boiling with strong fire, then decocting with slow fire for 1-3 h, and filtering to obtain filtrate for later use.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

A traditional Chinese medicine composition for treating chronic bronchitis comprises the following raw materials: 30g of radix aconiti brachypodi, 28g of corious versicolor, 25g of pine olive, 20g of chrysanthemum indicum, 16g of costustoot, 18g of fraxinus rhynchophylla, 7g of rhododendron micranthum, 15g of caulis periplocae, 12g of notopterygium root, 15g of ephedra, 5g of hemsleya amabilis, 12g of nauclea officinalis, 7g of Chinese pulsatilla root, 3g of liquorice and 4g of white mulberry root-bark.

The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials according to the amount, cleaning the traditional Chinese medicinal materials by adopting ultrasonic waves, washing off impurity and dust on the traditional Chinese medicinal materials, drying in the air in a natural environment after cleaning, and then respectively crushing into 20-mesh particles for later use; soaking herba Camptothecae Acuminatae and radix Hemsleyae Macrospermae in 100g of white vinegar for 10 days, taking out, and naturally air drying to obtain vinegar material; parching corious versicolor, herba Hyperici Japonici, ramulus et folium Tamaricis, caulis Aristolochiae Manshuriensis, lignum naucleae and cortex Mori with soil to obtain parched material, soaking herba Achilleae, fructus Canarii albi, radix aucklandiae, Notopterygii rhizoma, herba Ephedrae, radix Pulsatillae and Glycyrrhrizae radix in clear water for 30 min; mixing the soaked materials with the stir-fried materials and the vinegar-processed materials, adding clear water of 10 times of the mass, boiling with strong fire, turning to slow fire for decocting for 2h, filtering to obtain filtrate for later use, adding water of 9 times of the mass into the filter residue, continuing to boil with strong fire, turning to slow fire for decocting for 3h, filtering to obtain filtrate, and combining the two filtrates to obtain decoction.

Example 2

A traditional Chinese medicine composition for treating chronic bronchitis comprises the following raw materials: 40g of radix aconiti brachypodi, 25g of corious versicolor, 28g of pine olive, 25g of chrysanthemum indicum, 12g of costustoot, 15g of fraxinus rhynchophylla, 5g of rhododendron micranthum, 20g of periwinkle stem, 8g of notopterygium root, 12g of ephedra, 3g of hemsleya amabilis, 18g of nauclea officinalis, 5g of Chinese pulsatilla root, 5g of liquorice and 3g of white mulberry root-bark.

The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials according to the amount, cleaning the traditional Chinese medicinal materials by adopting ultrasonic waves, washing off impurity and dust on the traditional Chinese medicinal materials, drying in the air in a natural environment after cleaning, and then respectively crushing into 50-mesh particles for later use; soaking herba rhodobryumi and hemsleya amabilis in 80g of white vinegar for 15 days, taking out, and naturally drying to obtain a vinegar material; parching corious versicolor, herba Hyperici Japonici, ramulus et folium Tamaricis, caulis Aristolochiae Manshuriensis, lignum naucleae and cortex Mori with soil to obtain parched material, soaking herba Achilleae, fructus Canarii albi, radix aucklandiae, Notopterygii rhizoma, herba Ephedrae, radix Pulsatillae and Glycyrrhrizae radix in clear water for 20 min; mixing the soaked materials with the stir-fried materials and the vinegar-processed materials, adding clear water 12 times the mass of the materials, boiling with strong fire, turning to slow fire for decocting for 3h, filtering to obtain filtrate for later use, adding water 11 times the mass of the materials into the filter residue, continuing to boil with strong fire, turning to slow fire for decocting for 1h, filtering to obtain filtrate, and combining the two filtrates to obtain decoction.

Example 3

A traditional Chinese medicine composition for treating chronic bronchitis comprises the following raw materials: 35g of radix aconiti brachypodi, 35g of corious versicolor, 20g of pine olive, 25g of chrysanthemum indicum, 10g of costustoot, 16g of fraxinus rhynchophylla, 6g of rhododendron micranthum, 20g of periwinkle stem, 10g of notopterygium root, 11g of ephedra, 4g of hemsleya amabilis, 18g of nauclea officinalis, 7g of Chinese pulsatilla root, 4g of liquorice and 3g of white mulberry root-bark.

The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials according to the amount, cleaning the traditional Chinese medicinal materials by adopting ultrasonic waves, washing off impurity and dust on the traditional Chinese medicinal materials, drying in the air in a natural environment after cleaning, and then respectively crushing into 60-mesh particles for later use; soaking herba rhodobryumi and hemsleya amabilis in 50g of white vinegar for 20 days, taking out, and naturally drying to obtain vinegar material; parching corious versicolor, herba Hyperici Japonici, ramulus et folium Tamaricis, caulis Aristolochiae Manshuriensis, lignum naucleae and cortex Mori with soil to obtain parched material, soaking herba Achilleae, fructus Canarii albi, radix aucklandiae, Notopterygii rhizoma, herba Ephedrae, radix Pulsatillae and Glycyrrhrizae radix in clear water for 35 min; mixing the soaked materials with the stir-fried materials and the vinegar making materials, adding clear water with the mass of 12 times, boiling with strong fire, turning to slow fire for decocting for 2.5h, filtering to obtain filtrate for later use, adding water with the mass of 9 times into filter residues, continuing to boil with strong fire, turning to slow fire for decocting for 1h, filtering to obtain filtrate, and combining the two filtrates to obtain decoction.

Example 4

A traditional Chinese medicine composition for treating chronic bronchitis comprises the following raw materials: 20g of radix aconiti brachypodi, 28g of corious versicolor, 30g of pine olive, 15g of chrysanthemum indicum, 20g of costustoot, 20g of fraxinus rhynchophylla, 10g of rhododendron micranthum, 18g of periwinkle stem, 15g of notopterygium root, 20g of ephedra, 8g of hemsleya amabilis, 16g of nauclea officinalis, 12g of Chinese pulsatilla root, 2g of liquorice and 5g of white mulberry root-bark.

The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials according to the amount, cleaning the traditional Chinese medicinal materials by adopting ultrasonic waves, washing off impurity and dust on the traditional Chinese medicinal materials, drying in the air in a natural environment after cleaning, and then respectively crushing into 60-mesh particles for later use; soaking herba rhodobryumi and hemsleya amabilis in 90g of white vinegar for 20 days, taking out, and naturally drying to obtain vinegar material; parching corious versicolor, herba Hyperici Japonici, ramulus et folium Tamaricis, caulis Aristolochiae Manshuriensis, lignum naucleae and cortex Mori with soil to obtain parched material, soaking herba Achilleae, fructus Canarii albi, radix aucklandiae, Notopterygii rhizoma, herba Ephedrae, radix Pulsatillae and Glycyrrhrizae radix in clear water for 40 min; mixing the soaked materials with the stir-fried materials and the vinegar-processed materials, adding clean water 11 times the mass of the materials, boiling with strong fire, turning to slow fire for decocting for 2h, filtering to obtain filtrate for later use, adding water 8 times the mass of the materials into the filter residue, continuing to boil with strong fire, turning to slow fire for decocting for 1h, filtering to obtain filtrate, and combining the two filtrates to obtain decoction.

Example 5

A traditional Chinese medicine composition for treating chronic bronchitis comprises the following raw materials: 50g of artemisia rupestris, 18g of corious versicolor, 20g of pine olive, 25g of chrysanthemum indicum, 23g of costustoot, 15g of fraxinus rhynchophylla, 3g of rhododendron micranthum, 22g of periwinkle stem, 12g of notopterygium root, 16g of ephedra, 4g of hemsleya amabilis, 12g of nauclea officinalis, 10g of Chinese pulsatilla root, 5g of liquorice and 8g of white mulberry root-bark.

The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials according to the amount, cleaning the traditional Chinese medicinal materials by adopting ultrasonic waves, washing off impurity and dust on the traditional Chinese medicinal materials, drying in the air in a natural environment after cleaning, and then respectively crushing into 40-mesh particles for later use; soaking herba Camptothecae Acuminatae and radix Hemsleyae Macrospermae in 100g of white vinegar for 12 days, taking out, and naturally air drying to obtain vinegar material; parching corious versicolor, herba Hyperici Japonici, ramulus et folium Tamaricis, caulis Aristolochiae Manshuriensis, lignum naucleae and cortex Mori with soil to obtain parched material, soaking herba Achilleae, fructus Canarii albi, radix aucklandiae, Notopterygii rhizoma, herba Ephedrae, radix Pulsatillae and Glycyrrhrizae radix in clear water for 20 min; mixing the soaked materials with the stir-fried materials and the vinegar-processed materials, adding clear water 12 times the mass of the materials, boiling with strong fire, turning to slow fire for decocting for 2h, filtering to obtain filtrate for later use, adding water 9 times the mass of the materials into the filter residue, continuing to boil with strong fire, turning to slow fire for decocting for 1h, filtering to obtain filtrate, and combining the two filtrates to obtain decoction.

Comparative example 1

The difference between this comparative example and example 1 is that the raw material which was originally stir-fried with soil was soaked in water without stir-frying with soil.

Comparative example 2

The comparative example differs from example 1 in that the raw material originally vinegar-processed was soaked in water without vinegar-processing.

Experimental example 1

Animal phlegm elimination experiment: taking 80 mice, each half of male and female, randomly dividing the mice into 8 experimental groups, 10 mice in each group and 5 mice in each group, continuously performing intragastric administration on the mice 3 days before the experiment, wherein the decoction prepared in the experimental groups 1-7 in the examples 1-5 and the decoction prepared in the comparative examples 1-2 are respectively subjected to intragastric administration, and the physiological saline with the same dosage is administered to the experimental group 8 1 time per day. After 6 o' clock in the evening before the experiment, no food is taken any more, only purified water is provided, 10ml/kg of phenol red is injected into the abdominal cavity of the mouse 30min after the gavage on the experiment day, the cervical vertebra is dislocated and killed 30min later, a section of trachea from the thyroid cartilage to the position 1-2 cm above the trachea is detected, the trachea is put into physiological saline for room temperature oscillation, then the solution is sucked into a test tube and added with 1mol/l of sodium hydroxide with the concentration of 0.1ml, the color is measured at the position with the wavelength of 546nm, the phenol red excretion of the mouse is calculated according to the obtained absorbance, the phenol red excretion increase rate compared with a control group (experiment group 8) is calculated, the higher the red excretion rate proves that the phlegm eliminating effect is better, and the result is shown in table 1.

TABLE 1

As can be seen from Table 1, the excretion of mouse tracheal phenol red can be significantly increased in experimental groups 1 to 7, which shows that the traditional Chinese medicine compositions prepared in examples 1 to 5 and comparative examples 1 to 2 have the effect of eliminating phlegm, and especially the effect of example 1 is the best.

Experimental example 2

258 chronic bronchitis patients collected from 8 months in 2017 to 11 months in 2020 are selected as study objects and randomly divided into 8 experimental groups, and the 8 experimental groups are respectively treated by the traditional Chinese medicine compositions prepared in examples 1-5 and comparative examples 1-2 and by the mode of inputting physiological saline.

Inclusion criteria were: firstly, the age is 20-70 years old; ② the clinical symptoms are manifested as continuous cough for more than 1 month; and the diagnosis is confirmed by chest X-ray or chest CT. Exclusion criteria: firstly, the history of malignant tumor is accompanied in the past; ② serious diseases of liver, cardiovascular and cerebrovascular and kidney system; ③ mental disorders.

And (3) curative effect evaluation: clinical symptoms completely disappear after treatment, the lung signs are improved, and the pulmonary damp is reduced by 70 to 100 percent to show effect; after treatment, clinical symptoms and lung signs are improved to a certain extent, and the effect of reducing the pulmonary damp-zero by 40-69 percent is achieved; no obvious change or even deterioration after treatment, and no effect of reducing < 40% of pulmonary damp.

After 3 treatment courses (1 course of 1 month), the results were counted as shown in table 2.

TABLE 2

Grouping

Medicine taking

Total number of people

Number of effective people

Number of effective persons

Number of invalid persons

High efficiency

Experimental group 1

Example 1

33 persons

27 persons

4 persons

2 persons

93.9％

Experimental group 2

Example 2

33 persons

20 persons

12 persons

1 person

97.0％

Experimental group 3

Example 3

32 persons

17 persons

12 persons

3 persons

90.6％

Experimental group 4

Example 4

32 persons

19 persons

10 persons

3 persons

90.6％

Experimental group 5

Example 5

32 persons

12 persons

14 persons

7 persons

81.3％

Experimental group 6

Comparative example 1

32 persons

9 persons

18 persons

5 persons

84.4％

Experimental group 7

Comparative example 2

32 persons

11 persons

17 persons

4 persons

87.5％

Experimental group 8

Physiological saline

32 persons

3 persons

4 persons

25 persons

21.9％

As can be seen from Table 2, the traditional Chinese medicine compositions prepared in the embodiments 1-5 and the comparative examples 1-2 of the invention have better treatment effect on patients with clinical bronchitis. Wherein the effect of the comparative example 1 and the comparative example 2 is slightly poor, and after the feedback of the patients of the experimental group 6 and the experimental group 7, the patients who take the traditional Chinese medicines of the examples 1 to 5 have side effects such as dizziness and vomit, and the patients who take the traditional Chinese medicines of the examples 1 to 5 have no feedback of the patients to have the relevant side effects.

The invention adopts the nine-ingredient artemisia rupestris, corious versicolor, olive, chrysanthemum, elecampane and Chinese tamarisk to exert the effects of clearing away heat and toxic materials, eliminating dampness and reducing phlegm, adopts the rhododendron micranthum, the caulis periplocae, the notopterygium root and the ephedra to exert the effects of dispelling wind and cold, enhances the effects of clearing away heat and toxic materials from the side, adopts the hemsleya amabilis, the nauclea officinalis and the Chinese pulsatilla root to diminish inflammation and relieve pain, combines the medicines, and achieves the effect of radically treating the symptoms and root of chronic bronchitis.

According to the invention, rhododendron micranthum and hemsleya amabilis are processed by vinegar, so that the toxicity is reduced, the blood circulation promoting effect is increased, the channel dredging and cold dispelling effects are enhanced, the corious versicolor, the chrysanthemum indicum, the fraxinus mandshurica, the byttris, the nauclea officinalis and the white mulberry root-bark are stir-fried with soil, the cold property is inhibited without reducing the drug effect, and the side effects of a patient in the using process are reduced.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.