阅读说明：本技术 一种促进伤口愈合的水凝胶医用敷料及其制备方法 (Hydrogel medical dressing for promoting wound healing and preparation method thereof ) 是由 周丽 于 2021-09-22 设计创作，主要内容包括：本发明属于医用敷料的技术领域,具体涉及一种促进伤口愈合的水凝胶医用敷料及其制备方法。制备方法包括：将聚异丁烯溶解,制备聚异丁烯溶液；将羧甲基纤维素钠和海藻酸钠混合,得到混合溶液；将混合溶液加入到聚异丁烯溶液中,混合均匀,静置过夜,得水凝胶；配制角蛋白溶液,用移液枪吸取角蛋白溶液于水凝胶表面,而后置于空气恒温振荡器中振荡,之后模压成型,转移至真空干燥箱中烘烤,即得水凝胶医用敷料,该水凝胶医用敷料的含水量为50％-80％。本发明的水凝胶医用敷料具有更好的修复能力和更好的舒适度,能够促进伤口愈合。(The invention belongs to the technical field of medical dressings, and particularly relates to a hydrogel medical dressing for promoting wound healing and a preparation method thereof. The preparation method comprises the following steps: dissolving polyisobutylene to prepare a polyisobutylene solution; mixing sodium carboxymethylcellulose and sodium alginate to obtain a mixed solution; adding the mixed solution into the polyisobutylene solution, uniformly mixing, and standing overnight to obtain hydrogel; preparing a keratin solution, sucking the keratin solution on the surface of the hydrogel by using a pipette gun, then placing the hydrogel in an air constant-temperature oscillator for oscillation, then carrying out compression molding, transferring the hydrogel to a vacuum drying oven for baking, and obtaining the hydrogel medical dressing, wherein the water content of the hydrogel medical dressing is 50-80%. The hydrogel medical dressing has better repairing capability and better comfort, and can promote wound healing.)

1. A preparation method of a hydrogel medical dressing for promoting wound healing is characterized by comprising the following steps: dissolving polyisobutylene to prepare a polyisobutylene solution; mixing sodium carboxymethylcellulose and sodium alginate to obtain a mixed solution; slowly adding the mixed solution into the polyisobutylene solution, stirring to uniformly mix the mixed solution, and standing overnight to obtain hydrogel; preparing a keratin solution, sucking the keratin solution on the surface of the hydrogel by using a liquid-transferring gun, then placing the hydrogel in an air constant-temperature oscillator for oscillation, then carrying out compression molding, and finally transferring the hydrogel to a vacuum drying oven for baking to obtain the hydrogel medical dressing.

2. The method of preparing a hydrogel medical dressing for promoting wound healing according to claim 1, wherein the ratio of keratin: polyisobutylene: sodium carboxymethylcellulose: the adding mass ratio of the sodium alginate is 1-3: 3-5: 2-5: 1-2.

3. The method of preparing a hydrogel medical dressing for promoting wound healing according to claim 2, wherein the ratio of keratin: polyisobutylene: sodium carboxymethylcellulose: the adding mass ratio of the sodium alginate is 2: 4: 3: 1.5.

4. the method for preparing a hydrogel medical dressing for promoting wound healing as claimed in claim 1, wherein the stirring speed is 200-300r/min, and the stirring time is 15-30 min.

5. The method for preparing a hydrogel medical dressing for promoting wound healing according to claim 1, wherein the oscillation time of the air constant temperature oscillator is 10-15 min.

6. The method for preparing a hydrogel medical dressing for promoting wound healing according to claim 1, wherein the baking temperature of the vacuum drying oven is 35-40 ℃ and the baking time is 1-2 h.

7. The hydrogel medical dressing prepared by the preparation method according to claim 1, wherein the hydrogel medical dressing has a water content of 50% to 80%.

8. The hydrogel medical dressing for promoting wound healing according to claim 7, wherein the hydrogel medical dressing has a thickness of 1.5 to 3 mm.

Technical Field

The invention belongs to the technical field of medical dressings, and particularly relates to a hydrogel medical dressing for promoting wound healing and a preparation method thereof.

Background

The skin can isolate germs to prevent the human body from being damaged by the germs, but the skin of the human body can be damaged due to accidents such as burning, bumping and the like. Although the human body has certain self-repairing capacity, the wound healing period is long, and the human body cannot isolate germs without the skin barrier, so that the germs invade the human body to cause wound infection. In addition, wounds can produce large amounts of wound exudate during healing. In order to ensure that the wound is not infected by germs during the healing period and absorb a large amount of wound exudates, the medical dressing is produced at the same time.

Traditional dressings cover the wound with gauze, but the gauze needs to be replaced every few hours before the wound becomes scabby. The yarn has no moisture retention function, is easy to adhere with the wound, is easy to cause adhesion and unsmooth connection during replacement, causes secondary damage, forms a chronic wound and delays healing. Foam dressings, hydrocolloid dressings and the like are also available on the market. The foam dressing is mainly suitable for the affected parts of a plurality of liquid-permeable wounds and chronic wounds, but the foam dressing needs to be fixed by two layers of dressings or adhesive tapes, and is troublesome to use; when the exudate is too much, if the exudate is not replaced in time, the skin around the wound can be soaked; inability to use for eschar or dry wounds; some foam dressings cannot be used for certain types of wounds, such as infected wounds or sinus wounds; the higher price of imported products also limits the popularization of the imported products. Hydrocolloid dressings are mainly suitable for a small amount of liquid seepage wound surfaces such as chronic ulcers, bedsores and phlebitis, but residues can be left on a wound bed and are mistakenly considered as infection; the edge of the dressing at the position which is easy to rub is easy to curl; not available in the presence of infection; the adhesive properties are high and if removed in a short period of time, skin damage may occur if the dressing remains very adhesive.

The hydrogel dressing is a novel biomaterial with performance superior to that of the traditional dressing and the biological dressing, and has wide research and application in the field of biomedical engineering. The hydrogel dressing has strong absorption performance, a moist environment which is beneficial to tissue regeneration can be created for the wound surface, the gel state has a slippery and elastic characteristic, secondary damage caused by wound adhesion is effectively avoided, and the key point of the current hydrogel dressing research is how to maximally improve the use feeling and the use effect of the hydrogel dressing.

Disclosure of Invention

In order to solve the problem that the existing dressing is poor in repairing capability or comfort, the invention provides a hydrogel medical dressing for promoting wound healing, which has better repairing capability and better comfort.

A preparation method of a hydrogel medical dressing for promoting wound healing comprises the following steps: dissolving polyisobutylene to prepare a polyisobutylene solution; mixing sodium carboxymethylcellulose and sodium alginate to obtain a mixed solution; slowly adding the mixed solution into the polyisobutylene solution, stirring to uniformly mix the mixed solution, and standing overnight to obtain hydrogel; preparing a keratin solution, sucking the keratin solution on the surface of the hydrogel by using a liquid-transferring gun, then placing the hydrogel in an air constant-temperature oscillator for oscillation, then carrying out compression molding, and finally transferring the hydrogel to a vacuum drying oven for baking to obtain the hydrogel medical dressing.

Further, keratin: polyisobutylene: sodium carboxymethylcellulose: the adding mass ratio of the sodium alginate is 1-3: 3-5: 2-5: 1-2.

Further, keratin: polyisobutylene: sodium carboxymethylcellulose: the adding mass ratio of the sodium alginate is 2: 4: 3: 1.5.

keratin is a natural active substance, is rich in amide, carboxyl, hydroxyl, sulfenyl and other active groups, and has the functions of stopping bleeding, adhering, promoting wound repair and the like.

The composite dressing has the advantages of lasting bacteriostatic effect, no toxicity, no harm, stable property, softness, high elasticity, high tensile strength and the like.

Further, the stirring speed is 200-300r/min, and the stirring time is 15-30 min.

Further, the oscillation time of the air constant temperature oscillator is 10-15 min.

Further, the baking temperature of the vacuum drying oven is 35-40 ℃, and the baking time is 1-2 hours.

The hydrogel medical dressing prepared by the preparation method has the water content of 50-80%.

Further, the thickness of the hydrogel medical dressing is 1.5-3 mm.

Further, the hydrogel medical dressing has a thickness of 2 mm.

The invention has the beneficial effects that:

according to the hydrogel medical dressing for promoting wound healing, provided by the invention, the hydrogel dressing with good adhesiveness and water absorption is obtained by compounding the keratin solution with polyisobutylene, sodium carboxymethylcellulose and sodium alginate by utilizing the adhesiveness, the hemostatic property, the wound healing promotion and other properties of the keratin solution, and the hydrogel dressing has better repairing capacity and better comfort.

Detailed Description

In order to make those skilled in the art better understand the technical solutions in the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

A preparation method of a hydrogel medical dressing for promoting wound healing comprises the following steps: dissolving 4 parts of polyisobutylene in parts by mass to prepare a polyisobutylene solution; mixing 3 parts of sodium carboxymethylcellulose and 1.5 parts of sodium alginate to obtain a mixed solution; slowly adding the mixed solution into the polyisobutylene solution, stirring to uniformly mix the mixed solution, wherein the stirring speed is 300r/min, the stirring time is 15min, and standing overnight to obtain hydrogel; weighing 2 parts of keratin, preparing a keratin solution, sucking the keratin solution on the surface of hydrogel by using a liquid-transferring gun, then placing the hydrogel in an air constant-temperature oscillator for oscillation for 10min, then carrying out compression molding, and finally transferring the hydrogel to a vacuum drying oven at 35 ℃ for baking for 2h to obtain the hydrogel medical dressing, wherein the water content of the hydrogel medical dressing is 68% and the thickness of the hydrogel medical dressing is 1.5 mm.

Comparative example 1

The hydrogel medical dressing of this comparative example was the same as example 1 except that no keratin was added.

Example 2

A preparation method of a hydrogel medical dressing for promoting wound healing comprises the following steps: dissolving 5 parts of polyisobutylene in parts by mass to prepare a polyisobutylene solution; mixing 4 parts of sodium carboxymethylcellulose and 2 parts of sodium alginate to obtain a mixed solution; slowly adding the mixed solution into the polyisobutylene solution, stirring to uniformly mix the mixed solution, wherein the stirring time is 200r/min and 30min, and standing overnight to obtain hydrogel; weighing 3 parts of the protein, preparing a keratin solution, sucking the keratin solution on the surface of the hydrogel by using a liquid-transferring gun, then placing the hydrogel in an air constant-temperature oscillator for oscillation for 15min, then carrying out compression molding, and finally transferring the hydrogel to a vacuum drying oven at 40 ℃ for baking for 1.5h to obtain the hydrogel medical dressing, wherein the water content of the hydrogel medical dressing is 74%, and the thickness of the hydrogel medical dressing is 3.0 mm.

Comparative example 2

The hydrogel medical dressing of this comparative example was the same as example 2 except that no keratin was added.

Example 3 wound repair experiment

Selecting 20 SD female rats with the age of 8 weeks, weighing about 200g, dividing the rats into five groups, each group of four rats is anesthetized, then cutting off hairs on the backs of the rats, using wet medical gauze with the temperature of more than 90 ℃ as a heat carrier, scalding the backs of the rats for 15-20s to form deep II-degree scald wounds, enabling the wounds and normal skins of the wounds to form obvious boundaries, then disinfecting the wounds with iodine, applying the medicines to the wounds of the rats of each group for the first time after one hour, adopting hydrogel medical dressings of examples 1-2 and comparative examples 1-2 for the four groups of rats respectively, and using the other group as a blank group (not treated), disinfecting the rats once every day, changing the dressings once, recording the wound area size every 4 days, calculating the wound healing rate, and carrying out statistical recording as shown in Table 1.

TABLE 1 rat wound healing Rate

Item	Day 4	Day 8	Day 12	Day 16
					Example 1	17％	59％	82％	98％
Example 2	18％	56％	80％	98％
					Comparative example 1	9％	45％	71％	91％
Comparative example 2	11％	47％	68％	90％
					Blank group	2％	32％	60％	84％

The calculation formula of the wound healing rate is as follows: the wound healing rate is (area of original wound surface-area of residual wound surface)/area of original wound surface × 100%.

As can be seen from table 1, after 5 days after wound repair, the rats of the medical dressings of examples 1 and 2 grew the fastest, and the wound healed almost completely after 16 days, which is higher than the healing rate of the comparative examples 1-2 and the blank group, so that the hydrogel medical dressing of the present application is more beneficial to healing of skin wounds.

Although the present invention has been described in detail by way of preferred embodiments, the present invention is not limited thereto. Various equivalent modifications or substitutions can be made on the embodiments of the present invention by those skilled in the art without departing from the spirit and scope of the present invention, and these modifications or substitutions are within the scope of the present invention/any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.