阅读说明：本技术 与延伸起始因子4e结合的肽和化合物 (Peptides and compounds that bind to elongation initiation factor 4E ) 是由 S·吴 C·J·布朗 于 2020-03-30 设计创作，主要内容包括：本发明涉及与延伸起始因子4E(eIF4E)结合的肽,其包含氨基酸序列CEX--(1)GX-(2)X-(3)X-(4)X-(5)C(SEQ ID NO:1),其中X--(1)是选自由苏氨酸(T)、甲硫氨酸(M)或亮氨酸(L)组成的组的氨基酸,X-(2)和X-(3)是选自由苯丙氨酸(F)、经修饰的苯丙氨酸和酪氨酸(Y)组成的组的氨基酸,X-(4)和X-(5)是任何氨基酸,其中两个半胱氨酸残基通过二硫键连接。本文限定的肽可以用于治疗与帽依赖性翻译失调有关的疾病状况,例如癌症、传染病、孤独症或脆性X染色体综合征。(The present invention relates to peptides which bind to elongation initiation factor 4E (eIF4E) comprising the amino acid sequence CEX- 1 GX 2 X 3 X 4 X 5 C (SEQ ID NO:1), wherein X- 1 Is an amino acid selected from the group consisting of threonine (T), methionine (M) or leucine (L), X 2 And X 3 Is selected from benzeneAmino acids of the group consisting of alanine (F), modified phenylalanine and tyrosine (Y), X 4 And X 5 Is any amino acid in which two cysteine residues are linked by a disulfide bond. The peptides defined herein may be used to treat disease conditions associated with cap-dependent translational disorders, such as cancer, infectious disease, autism, or fragile X syndrome.)