阅读说明：本技术 一种适合规模化生产的高浓度纳米级氢氧化铝佐剂配制方法 (Preparation method of high-concentration nano-scale aluminum hydroxide adjuvant suitable for large-scale production ) 是由 姚雷 周振发 洪禹 李米杰 杨飞鸽 杜琳 朱卫华 于 2021-09-23 设计创作，主要内容包括：本发明是一种适合规模化配制高浓、纳米级粒径氢氧化铝佐剂的方法。使用氯化铝与氢氧化钠反应,准确控制反应速度,监控体系pH值及反应产物粒径大小,生成粒径小于1微米氢氧化铝胶体粒径,将氢氧化铝胶体在80～90℃环境陈化稳定后无菌分装保存,并取样检测理化指标。该方法简单易操作,适用于规模化生产氢氧化铝佐剂,所生产佐剂粒径小于1微米,同时佐剂铝离子浓度可达4.0mg/ml以上,并可依据实际需要适当调整。(The invention relates to a method suitable for preparing an aluminum hydroxide adjuvant with high concentration and nano-scale particle size in a large scale. The method comprises the steps of reacting aluminum chloride with sodium hydroxide, accurately controlling the reaction speed, monitoring the pH value of a system and the particle size of a reaction product to generate an aluminum hydroxide colloid with the particle size of less than 1 micron, aging and stabilizing the aluminum hydroxide colloid at 80-90 ℃, then performing aseptic subpackage storage, and sampling to detect physical and chemical indexes. The method is simple and easy to operate, is suitable for large-scale production of the aluminum hydroxide adjuvant, the particle size of the produced adjuvant is less than 1 micron, and the concentration of aluminum ions of the adjuvant can reach more than 4.0mg/ml, and can be properly adjusted according to actual requirements.)