阅读说明：本技术 一种抗体偶联药物、其中间体、制备方法及应用 (Antibody coupling drug, intermediate thereof, preparation method and application ) 是由 鲍彬 郭青松 高贝 张一帆 邱雪飞 杨彤 沈毅珺 张文伯 吕伟 王磊 于 2020-06-05 设计创作，主要内容包括：本发明公开了一种抗体偶联药物、其中间体、制备方法及应用。本发明提供了抗体偶联药物,其结构通式为Ab-(L-(3)-L-(2)-L-(1)-D)-(m)。该抗体偶联药物具有更好的生物学活性、稳定性和均一性,具有降低的毒副作用,且在肿瘤细胞内有更快的酶切释放速率。采用这种新型的抗体偶联药物可以实现细胞毒性药物,特别是喜树碱在ADC领域的广泛应用,治疗对于微管类ADC耐药的肿瘤病人。(The invention discloses an antibody conjugate drug, an intermediate thereof, a preparation method and application. The invention provides an antibody coupling drug with a structural general formula of Ab- (L) 3 ‑L 2 ‑L 1 ‑D) m . The antibody conjugate drug has better biological activity, stability and uniformity, reduced toxic and side effects and faster enzyme digestion release rate in tumor cells. The novel antibody conjugate drug can realize the wide application of cytotoxic drugs, particularly camptothecin in the field of ADC, and treat microtubular ADC-resistant tumor patients.)