阅读说明：本技术 一种制白术的制备方法及其应用、一种提高人体免疫力的中药组合物及其制备方法 (Preparation method and application of prepared rhizoma atractylodis macrocephalae, traditional Chinese medicine composition for improving human immunity and preparation method thereof ) 是由 廖中标 唐红军 于 2018-09-11 设计创作，主要内容包括：本发明提供一种中药组合物及其制备方法,属于中药技术领域,包括以下重量份数的原料：制白术0.5～1.5份、人参0.1～0.5份、黄芪1.5～2.5份、茯苓0.5～1.5份、甘草0.1～0.5份和陈皮0.1～0.3份；将白术在170～190℃下炒制10～15min,得到黄白术,将黄土与水混合、静置,将得到的上层清液与得到的黄白术混合,将得到的黄白术混合物在170～190℃下炒制8～12min,得到制白术。人体服用本发明提供的中药组合物的冲泡水后的白细胞数与服用前的白细胞数相比,白细胞数提高了20.7～35.5％。(The invention provides a traditional Chinese medicine composition and a preparation method thereof, belonging to the technical field of traditional Chinese medicines and comprising the following raw materials in parts by weight: 0.5 to 1.5 parts of prepared largehead atractylodes rhizome, 0.1 to 0.5 part of ginseng, 1.5 to 2.5 parts of astragalus, 0.5 to 1.5 parts of tuckahoe, 0.1 to 0.5 part of liquorice and 0.1 to 0.3 part of dried orange peel; frying the white atractylodes rhizome at 170-190 ℃ for 10-15 min to obtain yellow white atractylodes rhizome, mixing the loess with water, standing, mixing the obtained supernatant with the obtained yellow white atractylodes rhizome, and frying the obtained yellow white atractylodes rhizome mixture at 170-190 ℃ for 8-12 min to obtain the prepared white atractylodes rhizome. Compared with the number of the white blood cells before administration, the number of the white blood cells after the Chinese medicinal composition is administered to a human body and is increased by 20.7-35.5%.)

1. A preparation method of prepared rhizoma atractylodis macrocephalae is characterized by comprising the following steps:

1) frying the bighead atractylodes rhizome at 170-190 ℃ for 10-15 min to obtain yellow bighead atractylodes rhizome;

2) mixing loess with water, standing, mixing the obtained supernatant with the yellow atractylodes rhizome obtained in the step 1), and frying the obtained yellow atractylodes rhizome mixture at 170-190 ℃ for 8-12 min to obtain prepared white atractylodes rhizome;

the steps 1) and 2) are not limited in chronological order.

2. The method according to claim 1, wherein the mass ratio of the loess to water is (2-4): 5-7.

3. The method according to claim 1 or 2, wherein the mass ratio of the loess to water is 3: 6.

4. The method according to claim 1, wherein the mass ratio of the supernatant to the yellow atractylodes rhizome is (0.5-1.5): (15-25).

5. The preparation method according to claim 5, wherein the mass ratio of the supernatant to the yellow atractylodes rhizome is 1: 20.

6. The preparation method of claim 1, wherein the particle size of the traditional Chinese medicine composition is 0.5-1.5 mm.

7. The use of the prepared white atractylodes rhizome prepared by the preparation method of any one of claims 1 to 6 in the preparation of a traditional Chinese medicine composition for improving human immunity.

8. The traditional Chinese medicine composition for improving the immunity of a human body is characterized by comprising the following raw materials in parts by weight: 0.5-1.5 parts of prepared rhizoma atractylodis macrocephalae, 1.5-2.5 parts of astragalus membranaceus, 0.5-1.5 parts of poria cocos, 0.1-0.5 part of ginseng, 0.1-0.5 part of liquorice and 0.1-0.3 part of pericarpium citri reticulatae, wherein the prepared rhizoma atractylodis macrocephalae is prepared by the preparation method of any one of claims 1-6.

9. The traditional Chinese medicine composition according to claim 8, which is characterized by comprising the following raw materials in parts by weight: 1 part of processed rhizoma atractylodis macrocephalae, 2 parts of astragalus, 1 part of tuckahoe, 0.3 part of ginseng, 0.3 part of liquorice and 0.2 part of dried orange peel.

10. A method of preparing the Chinese medicinal composition of claim 8 or 9, comprising: pulverizing the processed Atractylodis rhizoma, radix astragali, Poria, Ginseng radix, Glycyrrhrizae radix and pericarpium Citri Tangerinae respectively, and mixing.

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method and application of prepared bighead atractylodes rhizome, a traditional Chinese medicine composition for improving human immunity and a preparation method thereof.

Background

The white blood cells are colorless, spherical and nucleated blood cells, and the total number of the normal adult white blood cells is 4.0-10.0 multiplied by 10⁹the/L can be changed within a certain range due to different time of day and different functional states of the body. The leucocyte is a defender of the human body in conflict with diseases, and when the pathogen invades the human body, the leucocyte can penetrate through the capillary wall through deformation and is concentrated to the invasion part of the pathogen to surround and phagocytose the pathogen. However, when virus infection (such as influenza, etc.), long-term exposure to radiation, poisoning caused by various physicochemical factors, chemotherapy and radiotherapy of tumors, splenic hyperactivity, autoimmune diseases, certain blood diseases such as aplastic anemia, myelofibrosis and application of certain medicines, etc. all can cause the reduction of the number of leucocytes, however, no traditional Chinese medicine composition capable of increasing the number of leucocytes is found in the prior art.

Disclosure of Invention

The invention aims to provide a preparation method and application of prepared white atractylodes rhizome, a traditional Chinese medicine composition for improving human immunity and a preparation method thereof.

The invention provides a preparation method of prepared bighead atractylodes rhizome, which comprises the following steps:

1) frying the bighead atractylodes rhizome at 170-190 ℃ for 10-15 min to obtain yellow bighead atractylodes rhizome;

2) mixing loess with water, standing, mixing the obtained supernatant with the yellow atractylodes rhizome obtained in the step 1), and frying the obtained yellow atractylodes rhizome mixture at 170-190 ℃ for 8-12 min to obtain prepared white atractylodes rhizome;

the steps 1) and 2) are not limited in chronological order.

Preferably, the mass ratio of the loess to the water is (2-4) to (5-7).

Preferably, the mass ratio of the loess to the water is 3: 6.

Preferably, the mass ratio of the supernatant to the yellow atractylodes rhizome is (0.5-1.5): 15-25.

Preferably, the mass ratio of the supernatant to the yellow atractylodes is 1: 20.

Preferably, the particle size of the traditional Chinese medicine composition is 0.5-1.5 mm.

The invention provides application of prepared white atractylodes rhizome prepared by the preparation method in preparing a traditional Chinese medicine composition for improving human immunity.

The invention provides a traditional Chinese medicine composition for improving human immunity, which comprises the following raw materials in parts by weight: 0.5-1.5 parts of prepared bighead atractylodes rhizome, 1.5-2.5 parts of astragalus, 0.5-1.5 parts of poria cocos, 0.1-0.5 part of ginseng, 0.1-0.5 part of liquorice and 0.1-0.3 part of dried orange peel.

Preferably, the feed comprises the following raw materials in parts by weight: 1 part of processed rhizoma atractylodis macrocephalae, 2 parts of astragalus, 1 part of tuckahoe, 0.3 part of ginseng, 0.3 part of liquorice and 0.2 part of dried orange peel.

The invention provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: pulverizing the processed Atractylodis rhizoma, radix astragali, Poria, Ginseng radix, Glycyrrhrizae radix and pericarpium Citri Tangerinae respectively, and mixing.

In the traditional Chinese medicine composition, the prepared rhizoma atractylodis macrocephalae is a monarch drug, the astragalus root is a ministerial drug, the ginseng is a conductant drug, the poria cocos is a conductant drug, and the astragalus root has the effects of tonifying qi, strengthening the superficial resistance, arresting sweating, enhancing immunity, conditioning the body, increasing the toxicity of the liquorice, regulating the drug, and increasing the pericarpium citri reticulatae to regulate the flow of qi and strengthen the spleen, so that the number of white blood cells can be increased.

The results of the embodiments of the present invention show that: compared with the leukocyte before taking, the leukocyte after taking the Chinese medicinal composition with the brewing water provided by the invention is improved by 20.7-35.5%.

Detailed Description

The invention provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight:

0.5-1.5 parts of prepared bighead atractylodes rhizome, 1.5-2.5 parts of astragalus, 0.5-1.5 parts of poria cocos, 0.1-0.5 part of ginseng, 0.1-0.5 part of liquorice and 0.1-0.3 part of dried orange peel;

the preparation method of the prepared white atractylodes rhizome comprises the following steps:

1) frying the bighead atractylodes rhizome at 170-190 ℃ for 10-15 min to obtain yellow bighead atractylodes rhizome;

2) mixing loess with water, standing, mixing the obtained supernatant with the yellow atractylodes rhizome obtained in the step 1), and frying the obtained yellow atractylodes rhizome mixture at 170-190 ℃ for 8-12 min to obtain prepared white atractylodes rhizome;

the steps 1) and 2) are not limited in chronological order.

In the invention, the traditional Chinese medicine composition is used for treating spleen deficiency, transportation and transformation loss, poor appetite, qi deficiency, edema, viscus prolapse and body resistance weakening, the enhancement of nutrient-blood-defensive qi in the traditional Chinese medicine theory is corresponding to the strength of immunity of western medicines, the intrinsic meaning of spleen-governing blood is obtained, the spleen is enriched with white blood cells and returns to the normal value of a human body, the immunity of the human body is enhanced, and cold is not easy to occur.

The traditional Chinese medicine composition provided by the invention mainly has the effects of strengthening spleen and tonifying qi, strengthening spleen and calming heart, tonifying spleen and tonifying qi, tonifying spleen and benefiting lung, regulating qi and strengthening spleen, tonifying qi and invigorating yang, and recovering pulse and relieving depletion to regulate the main transportation and transformation of spleen, and eliminating dampness, diuresis and phlegm.

The traditional Chinese medicine composition provided by the invention comprises 0.5-1.5 parts by weight of prepared bighead atractylodes rhizome, preferably 0.8-1.2 parts by weight, and more preferably 1 part by weight. In the invention, the prepared rhizoma atractylodis macrocephalae is a monarch drug, has the effects of strengthening exterior, arresting sweating and resisting oxidation, can effectively inhibit lipid, reduce the content of lipid peroxide in tissues and enhance the capability of white blood cells for phagocytosing staphylococcus aureus, thereby achieving the effect of enhancing the immunity of organisms.

In the invention, the preparation method of the prepared white atractylodes rhizome comprises the following steps:

1) frying the bighead atractylodes rhizome at 170-190 ℃ for 10-15 min to obtain yellow bighead atractylodes rhizome;

2) mixing loess with water, standing, mixing the obtained supernatant with the yellow atractylodes rhizome obtained in the step 1)), and frying the obtained yellow atractylodes rhizome mixture at 170-190 ℃ for 8-12 min to obtain prepared white atractylodes rhizome;

the steps 1) and 2) are not limited in chronological order.

The invention fries the white atractylodes rhizome at 170-190 ℃ for 10-15 min to obtain yellow white atractylodes rhizome, preferably fries the white atractylodes rhizome at 175-185 ℃ for 11-14 min, and more preferably fries the white atractylodes rhizome at 180 ℃ for 12-13 min.

The preparation method comprises the steps of mixing loess with water, standing, mixing the obtained supernatant with the obtained yellow largehead atractylodes rhizome, and frying the obtained yellow largehead atractylodes rhizome mixture at 170-190 ℃ for 8-12 min to obtain the prepared largehead atractylodes rhizome. In the present invention, the supernatant contains water-soluble components of loess. In the invention, the yellow atractylodes mixture is preferably fried at 175-185 ℃ for 9-11 min, and more preferably fried at 180 ℃ for 10 min. The source of the bighead atractylodes rhizome is not particularly limited, and a commercially available product is adopted. In the invention, the loess is preferably pollution-free clay with viscosity, and the clay is preferably clay on the upper layer of kaolin below 3m of the ground surface; the loess is preferably loess from Sichuan.

The standing is not specially limited, and the natural standing layering does not change any more.

In the invention, the mass ratio of the loess to the water is preferably (2-4): 5-7), more preferably (2.5-3.5): 5.5-6.5), and most preferably 3: 6.

In the invention, the mass ratio of the supernatant to the yellow atractylodes rhizome is preferably (0.5-1.5): 15-25), more preferably (0.8-1.2): 18-22, and most preferably 1: 20. In the invention, the prepared white atractylodes rhizome prepared by mixing the supernatant with the yellow white atractylodes rhizome has the functions of relieving dryness, strengthening spleen and checking diarrhea and has the functions of strengthening mutual reinforcement of qi tonifying, spleen strengthening, dampness drying, diuresis inducing and sweating stopping.

The traditional Chinese medicine composition provided by the invention comprises 1.5-2.5 parts by weight of astragalus, preferably 1.8-2.2 parts by weight, and more preferably 2 parts by weight. In the invention, the astragalus is a ministerial drug, has the functions of tonifying qi, strengthening exterior, enhancing the hypoxia tolerance and stress resistance of organisms, resisting bacteria and inhibiting viruses, promoting the metabolism of the organisms, improving the cardiac function and enhancing the immunity of the organisms. The source of the astragalus is not particularly limited, and the astragalus can be obtained by adopting a conventional commercial product.

The traditional Chinese medicine composition provided by the invention comprises 0.5-1.5 parts of poria cocos by weight, preferably 0.8-1.2 parts of poria cocos by weight, and more preferably 1 part of poria cocos by weight. In the invention, the poria cocos is a messenger drug, contains abundant pachymaran, has the function of enhancing the immunity of a human body, and has the effect of inhibiting the production of tumors. The source of the poria cocos is not particularly limited, and the poria cocos can be obtained by adopting a conventional commercial product.

The traditional Chinese medicine composition provided by the invention comprises 0.1-0.5 part of ginseng, preferably 0.2-0.4 part, and more preferably 0.3 part by weight. In the invention, the ginseng is used as a guiding drug, the ginseng plays a role of guiding drugs in the combined medicine, the ginseng has the effect of tonifying primordial qi, and the ginseng has the effects of reinforcing qi and strengthening spleen, calming spirit and calming soul and tonifying qi and relieving depletion after being combined with the bighead atractylodes rhizome and the poria cocos. The source of the ginseng is not particularly limited, and the ginseng can be obtained by adopting a conventional commercial product.

The traditional Chinese medicine composition provided by the invention comprises 0.1-0.5 part by weight of liquorice, preferably 0.2-0.4 part by weight, and more preferably 0.3 part by weight. In the present invention, the licorice mediates toxicity of the various drugs. The source of the liquorice is not particularly limited, and the liquorice can be prepared from conventional commercial products.

The traditional Chinese medicine composition provided by the invention comprises 0.1-0.3 part of dried orange peel by weight, preferably 0.15-0.25 part of dried orange peel by weight, and more preferably 0.2 part of dried orange peel by weight. In the present invention, the dried orange peel is preferably dried orange peel produced in Sichuan. In the invention, the dried orange peel has the functions of regulating qi, strengthening spleen, eliminating dampness and phlegm.

The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: pulverizing the processed Atractylodis rhizoma, radix astragali, Poria, Ginseng radix, Glycyrrhrizae radix, and pericarpium Citri Tangerinae respectively, and mixing.

In the present invention, the conditions for the pulverization preferably include: cleaning, cleaning and drying the raw materials of the traditional Chinese medicine composition until the moisture content of the raw material medicines is not more than 13%, preferably crushing each raw material medicine for 3 times, crushing the raw material medicines into large particles (with the diameter within 0.8 cm) for the first time, crushing the raw material medicines for the second time to be less than 0.5cm in diameter, crushing the raw material medicines for the third time to be more than 0.5cm in diameter to be within 0.3-0.5 cm in diameter, pouring the crushed materials into a stirrer according to a proportion to mix after obtaining qualified crushed materials, and mixing for 15 minutes.

In the invention, the granularity of the traditional Chinese medicine composition is preferably 0.5-1.5 mm, more preferably 0.8-1.2 mm, and most preferably 1 mm.

In the invention, the using method of the traditional Chinese medicine composition is preferably as follows: soaking the traditional Chinese medicine composition with water at 90-100 ℃, wherein when the tea is drunk, the daily dosage of the traditional Chinese medicine composition is preferably 5-15 g, more preferably 6-12 g, and most preferably 8 g; the mass ratio of the traditional Chinese medicine composition to water is preferably 5-12: 250-350, more preferably 7-10: 280-320, and most preferably 8: 300.

The preparation method and application of the prepared rhizoma atractylodis macrocephalae, the traditional Chinese medicine composition for improving human immunity and the preparation method thereof are further described in detail with reference to specific examples, and the technical scheme of the invention includes but is not limited to the following examples.

Example 1

Preparation of processed rhizoma atractylodis macrocephalae: parching Atractylodis rhizoma at 180 deg.C for 10min to obtain yellow Atractylodis rhizoma; mixing 3kg loess with 6kg water, standing, mixing the obtained supernatant 1kg with yellow Atractylodis rhizoma 20kg, and parching at 180 deg.C for 10min to obtain processed Atractylodis rhizoma; the loess is obtained from Sichuan, and is pollution-free loess with surface area below 3m and above Kaolinitum layer;

mixing 1kg processed Atractylodis rhizoma, 2kg radix astragali, 1kg Poria, 0.3kg Ginseng radix, 0.3kg Glycyrrhrizae radix and 0.2kg pericarpium Citri Tangerinae, and pulverizing to obtain Chinese medicinal composition with particle size of 1mm and production area of pericarpium Citri Tangerinae of Sichuan province.

Example 2

Preparation of processed rhizoma atractylodis macrocephalae: parching Atractylodis rhizoma at 180 deg.C for 10min to obtain yellow Atractylodis rhizoma; mixing 2kg loess with 5kg water, standing, mixing the obtained supernatant 0.5kg with 15kg yellow Atractylodis rhizoma, and parching at 180 deg.C for 10min to obtain processed Atractylodis rhizoma; the loess is obtained from Sichuan, and is pollution-free loess with surface area below 3m and above Kaolinitum layer;

mixing 0.5kg processed Atractylodis rhizoma, 1.5kg radix astragali, 1kg Poria, 0.5kg Ginseng radix, 0.1kg Glycyrrhrizae radix and 0.1kg pericarpium Citri Tangerinae, and pulverizing to obtain Chinese medicinal composition with particle size of 1mm and production area of pericarpium Citri Tangerinae of Sichuan province.

Example 3

Preparation of processed rhizoma atractylodis macrocephalae: parching Atractylodis rhizoma at 180 deg.C for 10min to obtain yellow Atractylodis rhizoma; mixing 4kg loess with 7kg water, standing, mixing the obtained supernatant 1.5kg with yellow Atractylodis rhizoma 25kg, and parching at 180 deg.C for 10min to obtain processed Atractylodis rhizoma; the loess is obtained from Sichuan, and is pollution-free loess with surface area below 3m and above Kaolinitum layer;

mixing and pulverizing 1.5kg processed Atractylodis rhizoma, 2.5kg radix astragali, 1.5kg Poria, 0.5kg Ginseng radix, 0.5kg Glycyrrhrizae radix and 0.3kg pericarpium Citri Tangerinae to obtain Chinese medicinal composition with particle size of 1mm and production area of pericarpium Citri Tangerinae of Sichuan province.

Example 4

Liao Yang Hua, male, 75 years old, suffered from gastric cancer in 2016, had 2.9% of white blood cells before taking the Chinese medicinal composition, 8g of the Chinese medicinal composition prepared in example 1 was soaked in 100 ℃ water, when the tea was drunk, 1500ml of the water with which the Chinese medicinal composition was brewed was drunk at most one day, and after 60 days of continuous taking, the white blood cells were 3.5% and increased by 20.7%.

Example 5

Li Guo Rong, male, age 75, had bladder cancer in 2016, the number of leukocytes before taking the Chinese medicinal composition was 3.5%, 8g of the Chinese medicinal composition prepared in example 1 was soaked in 100 ℃ water, 1500ml of the water with which the Chinese medicinal composition was soaked was drunk the most a day when the tea was drunk, and after 60 days of continuous administration, the number of leukocytes was 4.5% and increased by 28.6%.

Example 6

Wuqi, women and 42 years old are frequently cold and have low immunity, the number of white blood cells before taking the traditional Chinese medicine composition is 3.1%, 8g of the traditional Chinese medicine composition prepared in the example 1 is soaked in water with the temperature of 100 ℃, when the tea is drunk, 1500ml of water for brewing the traditional Chinese medicine composition is drunk at most one day, after 60 days of continuous taking, the number of white blood cells is 4.2%, and the number of white blood cells is increased by 35.5%.

Example 7

Plum, female, 37 years old, often cold and low in immunity, the number of white blood cells before taking the Chinese medicinal composition is 3.7%, 8g of the Chinese medicinal composition prepared in example 1 is soaked in water of 100 ℃, when the tea is drunk, 1500ml of water for brewing the Chinese medicinal composition is drunk at most one day, after 60 days of continuous taking, the number of white blood cells is 4.7%, and the white blood cells are improved by 27%.

Example 8

The people taking the traditional Chinese medicine composition are 10 people with the age of 45-60 years, 8g of the traditional Chinese medicine composition prepared in the embodiment 1 is brewed by water with the temperature of 100 ℃ every day, when the tea is drunk, 1500ml of the water for brewing the traditional Chinese medicine composition is drunk at most every day, and the tea is continuously taken for 30 days. The control group is 10 persons, the age is 45-60 years old, the person taking the traditional Chinese medicine composition drinks boiled water with the same dosage while drinking brewing water, the person continuously drinks the boiled water for 30 days, the first comparison check is carried out, the leucocytes of the person taking the traditional Chinese medicine composition and the person taking the boiled water are respectively detected after the person continues to take the boiled water for 30 days, and the result is shown in table 1.

TABLE 1 examination of the results of the administration of the Chinese medicinal composition and the administration of boiled water for the leukocytes of the people

As can be seen from Table 1, the number of neutrophilic rod-shaped nuclear granulocytes and neutrophilic lobular nuclear granulocytes is increased after the traditional Chinese medicine composition provided by the invention is taken.

The above examples show that the number of leukocytes after the traditional Chinese medicine composition provided by the invention is taken with the infusion water is increased by 20.7-35.5% compared with the number of leukocytes before the traditional Chinese medicine composition is taken with the infusion water.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.