阅读说明：本技术 包含细胞因子和支架蛋白的融合蛋白 (Fusion proteins comprising a cytokine and a scaffold protein ) 是由 J·斯泰亚特 E·帕顿 A·沃尔科尼格 V·卡利恰克 W·弗兰肯 T·乌坎斯基 A·舍维 于 2019-12-20 设计创作，主要内容包括：本发明涉及结构生物学领域。更具体地,本发明涉及新型融合蛋白、它们在大分子三维结构分析中的用途和方法,如X射线晶体学和高分辨率冷冻电镜,以及它们在基于结构的药物设计和筛选中的用途。甚至更具体地,本发明涉及细胞因子和支架蛋白的功能性融合蛋白,其中支架是折叠蛋白,其打断细胞因子的拓扑结构以形成保留了其受体结合和激活能力的刚性融合蛋白。更具体地,本文公开了基于趋化因子和白介素的功能性融合蛋白及其生产和用途。(The present invention relates to the field of structural biology. More specifically, the present invention relates to novel fusion proteins, their use and methods in the analysis of the three-dimensional structure of macromolecules, such as X-ray crystallography and high resolution cryoelectron microscopy, and their use in structure-based drug design and screening. Even more particularly, the present invention relates to functional fusion proteins of a cytokine and a scaffold protein, wherein the scaffold is a folding protein that disrupts the topology of the cytokine to form a rigid fusion protein that retains its receptor binding and activation capabilities. More specifically, functional chemokine and interleukin based fusion proteins and their production and use are disclosed.)