阅读说明：本技术 一种咪达唑仑糖果的制作方法 (Preparation method of midazolam candy ) 是由 林敏� 于 2021-08-18 设计创作，主要内容包括：一种咪达唑仑糖果的制作方法,包括以下步骤：a、采用蔗糖糖浆、白砂糖、食用胶和复合糖配置第一配料,蔗糖糖浆、白砂糖、食用胶和复合糖的质量组分比为：4:1:1:(1-1.1)；b、将第一配料熔化混合后并加热到100-150℃,冷却至80-90℃后进入步骤c；c、采用色素配置第二配料,将第二配料加入第一配料,得到第一混合物,冷却至60-70℃后进入步骤d,蔗糖糖浆、白砂糖、色素、食用胶、复合糖质量组分比为：4:1:(0.8-0.9):1:(1-1.1)；d、采用咪达唑仑配置第三配料,将第三配料加入第一混合物,冷却成固态,蔗糖糖浆、白砂糖、色素、食用胶、复合糖和咪达唑仑的质量组分比为：4:1:(0.8-0.9):1:(1-1.1)：0.001；e、切割成粒,制备成成品。减小儿童服用过后出现反流现象,药效更加平稳。(A preparation method of midazolam candy comprises the following steps: a. the first ingredient is prepared from sucrose syrup, white granulated sugar, edible gum and compound sugar, and the mass component ratio of the sucrose syrup, the white granulated sugar, the edible gum and the compound sugar is as follows: 4:1:1 (1-1.1); b. melting and mixing the first ingredients, heating to 100-150 ℃, cooling to 80-90 ℃, and then entering the step c; c. preparing a second ingredient by adopting a pigment, adding the second ingredient into the first ingredient to obtain a first mixture, cooling to 60-70 ℃, and then entering the step d, wherein the mass component ratios of the sucrose syrup, the white granulated sugar, the pigment, the edible gum and the compound sugar are as follows: 4:1 (0.8-0.9) and 1: 1-1.1); d. preparing a third ingredient by adopting midazolam, adding the third ingredient into the first mixture, cooling to form a solid state, wherein the mass component ratio of the sucrose syrup, the white granulated sugar, the pigment, the edible gum, the compound sugar and the midazolam is as follows: 4:1:(0.8-0.9):1:(1-1.1): 0.001; e. cutting into granules to prepare finished products. Reduce the phenomenon of regurgitation after children take the medicine, and the medicine effect is more stable.)

1. The preparation method of the midazolam candy is characterized by comprising the following steps of:

a. preparing a first ingredient by adopting sucrose syrup, white granulated sugar, edible gum and compound sugar, wherein the mass component ratio of the sucrose syrup, the white granulated sugar, the edible gum and the compound sugar is as follows: 4:1:1 (1-1.1);

b. melting and mixing the first ingredients, heating to 100-150 ℃, cooling to 80-90 ℃, and then entering the step c;

c. preparing a second ingredient by adopting a pigment, adding the second ingredient into the first ingredient to obtain a first mixture, cooling to 60-70 ℃, and then entering the step d, wherein the mass component ratio of the sucrose syrup, the white granulated sugar, the pigment, the edible gum and the compound sugar is as follows: 4:1 (0.8-0.9) and 1: 1-1.1);

d. preparing a third ingredient by adopting midazolam, adding the third ingredient into the first mixture, and cooling to form a solid state, wherein the mass component ratio of the sucrose syrup, the white granulated sugar, the pigment, the edible gum, the compound sugar and the midazolam is as follows: 4:1:(0.8-0.9):1:(1-1.1): 0.001;

e. cutting into granules to prepare finished products.

2. The method for preparing midazolam candy according to claim 1, wherein step b further comprises the following steps:

b, placing the sucrose syrup, the white granulated sugar, the edible gum and the compound sugar in the step a into a container, heating to the high temperature of 100-150 ℃, and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out through a stirring device, and 1-2L of water is added in the stirring process.

3. The method for preparing midazolam candy according to claim 2, wherein step b further comprises the following steps:

and (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, heating and boiling are stopped when the melt has the viscosity of 200-450 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, a sticky matter is formed, and standing is carried out for slow cooling.

4. The method for preparing midazolam candy according to claim 3, wherein step c further comprises the following steps:

uniformly dividing the pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky objects at the interval of 1-3 minutes when the sticky objects are kept stand and slowly cooled to 80-90 ℃, uniformly stirring to obtain a first mixture, and keeping stand and slowly cooling.

5. The method for preparing midazolam candy according to claim 4, wherein step d further comprises the following steps:

uniformly dividing midazolam into ten equal parts, scattering the divided ten equal parts of midazolam into the first mixture at intervals of 4 minutes when the first mixture is kept stand and slowly cooled to 60-70 ℃, uniformly stirring to obtain a second mixture, and continuously keeping stand and slowly cooling for more than 24 hours.

6. The method for preparing midazolam candy according to claim 5, wherein step d further comprises the following steps:

the resulting second mixture is cooled to form a sugar base.

7. The method for preparing midazolam candy according to claim 6, wherein step d further comprises the following steps:

the second mixture was cooled by natural air cooling.

8. The method for preparing midazolam candy according to claim 6, wherein step e further comprises the following steps:

and (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

9. The method for preparing midazolam candy according to claim 8, wherein step e further comprises the following steps:

and (5) refrigerating the obtained candy at low temperature and warehousing.

10. The method for preparing midazolam candy according to any one of claims 1 to 9, wherein said complex sugar is prepared by mixing one or more of corn syrup solids, polydextrose and polyglycitol.

Technical Field

The invention relates to the technical field of candy type medicines, in particular to a preparation method of midazolam candy.

Background

Midazolam has anxiolytic, antidepressant, sedative, hypnotic, anticonvulsant and muscle relaxant effects. The solution of the traditional Chinese medicine composition can cause a reflux phenomenon when being taken, if the traditional Chinese medicine composition is swallowed in a tablet form, the medicine has an excessively fast effect, negative self-suggestion can be brought to children when the medicine is taken, if the medicine is prepared into a candy form, the children can eat the traditional Chinese medicine composition like eating the candy at ordinary times, the process is easy, and the pleasure brought by the candy and the progressive medicine effect can also enable the children to obtain better treatment and psychological consolation.

Disclosure of Invention

Aiming at the problems, the invention provides a preparation method of midazolam candy, which can avoid the occurrence of a reflux phenomenon, enable children to obtain better treatment and psychological consolation and eliminate dysphoria and nervous emotion.

The technical scheme of the invention is as follows: a preparation method of midazolam candy comprises the following steps:

a. preparing a first ingredient by adopting sucrose syrup, white granulated sugar, edible gum and compound sugar, wherein the mass component ratio of the sucrose syrup, the white granulated sugar, the edible gum and the compound sugar is as follows: 4:1:1 (1-1.1);

b. melting and mixing the first ingredients, heating to 100-150 ℃, cooling to 80-90 ℃, and then entering the step c;

c. preparing a second ingredient by adopting a pigment, adding the second ingredient into the first ingredient to obtain a first mixture, cooling to 60-70 ℃, and then entering the step d, wherein the mass component ratio of the sucrose syrup, the white granulated sugar, the pigment, the edible gum and the compound sugar is as follows: 4:1 (0.8-0.9) and 1: 1-1.1);

d. preparing a third ingredient by adopting midazolam, adding the third ingredient into the first mixture, and cooling to form a solid state, wherein the mass component ratio of the sucrose syrup, the white granulated sugar, the pigment, the edible gum, the compound sugar and the midazolam is as follows: 4:1:(0.8-0.9):1:(1-1.1): 0.001;

e. cutting into granules to prepare finished products.

The working principle of the technical scheme is as follows:

through the treatment of the steps a to e, the midazolam is prepared into the candy, so that the phenomenon of reflux after the children take the midazolam is avoided, the children can obtain better treatment and psychological consolation, and the dysphoria and the nervous mood are eliminated. The sugar syrup, white granulated sugar, pigment, edible gum, compound sugar and midazolam are prepared from the following components in percentage by mass: 4:1:(0.8-0.9):1:(1-1.1): the candy is prepared by the design of 0.001, and according to the actual clinical application of 100 children, the absorption and acting time of the candy prepared from midazolam in children is more stable than that of the candy prepared by directly taking midazolam orally in the formula.

In a further technical scheme, the step b further comprises the following steps: b, placing the sucrose syrup, the white granulated sugar, the edible gum and the compound sugar in the step a into a container, heating to the high temperature of 100-150 ℃, and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out through a stirring device, and 1-2L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

In a further technical scheme, the step b further comprises the following steps: and (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, heating and boiling are stopped when the melt has the viscosity of 200-450 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, a sticky matter is formed, and standing is carried out for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

In a further technical scheme, the method also comprises the following steps: uniformly dividing the pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky objects at the interval of 1-3 minutes when the sticky objects are kept stand and slowly cooled to 80-90 ℃, uniformly stirring to obtain a first mixture, and keeping stand and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

In a further technical scheme, the midazolam is uniformly divided into ten equal parts, when the first mixture is kept stand and slowly cooled to 60-70 ℃, the divided ten equal parts of midazolam are scattered into the first mixture at intervals of 4 minutes and are uniformly stirred to obtain a second mixture, and the second mixture is kept stand and slowly cooled for more than 24 hours. Ensuring the even drug effect of the candy.

In a further technical scheme, the method also comprises the following steps: the resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

In a further technical scheme, the step d further comprises the following steps: the second mixture was cooled by natural air cooling. To reduce manufacturing costs.

In a further technical scheme, the step e further comprises the following steps: and (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

In a further technical scheme, the step e further comprises the following steps: and (5) refrigerating the obtained candy at low temperature and warehousing. So as to ensure the efficacy and safety of the medicine.

In a further technical scheme, the compound sugar is prepared by mixing one or more of corn syrup solid, polydextrose and polyalditol.

The invention has the beneficial effects that:

1. through the treatment of the steps a to e, the midazolam is prepared into the candy, so that the phenomenon of reflux after the children take the midazolam is avoided, the children can obtain better treatment and psychological consolation, and the dysphoria and the nervous mood are eliminated. The sugar syrup, white granulated sugar, pigment, edible gum, compound sugar and midazolam are prepared from the following components in percentage by mass: 4:1:(0.8-0.9):1:(1-1.1): the candy is prepared by the design of 0.001, and according to the actual clinical application of 100 children, the absorption and acting time of the candy prepared from midazolam in children is more stable than that of the candy prepared by directly taking midazolam orally in the formula.

2. The method comprises the following steps: b, placing the sucrose syrup, the white granulated sugar, the edible gum and the compound sugar in the step a into a container, heating to the high temperature of 100-150 ℃, and melting to obtain a melt; wherein, at the in-process of carrying out high-temperature melting, stir through agitating unit, add the design of 1 ~ 2L water at stirring in-process to guarantee the steady of whole high-temperature melting process, and the even of mixing.

3. The method comprises the following steps: and (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, heating and boiling are stopped when the melt has the viscosity of 200-450 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, a sticky substance is formed, and the design of standing and slow cooling is adopted, so that a foundation is provided for adding pigment and midazolam subsequently.

4. The method further comprises the following steps: uniformly dividing the pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky objects at an interval of 1-3 minutes when the sticky objects are kept stand and slowly cooled to 80-90 ℃, uniformly stirring to obtain a first mixture, and keeping stand and slowly cooling to ensure the coloring uniformity of the candy in the manufacturing process of the candy.

5. The preparation method comprises the steps of uniformly dividing midazolam into ten equal parts, scattering the divided ten equal parts of midazolam into the first mixture at intervals of 4 minutes when the first mixture is kept stand and slowly cooled to 60-70 ℃, uniformly stirring to obtain a second mixture, and continuously keeping stand and slowly cooling for more than 24 hours to ensure that the drug effect of the candy is uniform.

6. The method further comprises the following steps: the resulting second mixture is cooled to form a sugar-based design for forming different shaped confectioneries.

7. In the step d, the method further comprises the following steps: the second mixture is cooled by natural air cooling, so that the manufacturing cost is reduced.

8. In the step e, the method further comprises the following steps: the obtained candy is refrigerated at low temperature and put in storage to ensure the drug effect and safety.

Drawings

Fig. 1 is a flow chart of a method for making midazolam confectionery according to example 1 of the present invention.

Detailed Description

The embodiments of the present invention will be further described with reference to the accompanying drawings.

Example 1:

the technical scheme of the invention is as follows: a preparation method of midazolam candy comprises the following steps:

a. preparing a first ingredient by adopting sucrose syrup, white granulated sugar, edible gum and compound sugar, wherein the mass component ratio of the sucrose syrup, the white granulated sugar, the edible gum and the compound sugar is as follows: 4:1:1 (1-1.1);

b. melting and mixing the first ingredients, heating to 100-150 ℃, cooling to 80-90 ℃, and then entering the step c;

c. preparing a second ingredient by adopting a pigment, adding the second ingredient into the first ingredient to obtain a first mixture, cooling to 60-70 ℃, and then entering the step d, wherein the mass component ratio of the sucrose syrup, the white granulated sugar, the pigment, the edible gum and the compound sugar is as follows: 4:1 (0.8-0.9) and 1: 1-1.1);

d. preparing a third ingredient by adopting midazolam, adding the third ingredient into the first mixture, and cooling to form a solid state, wherein the mass component ratio of the sucrose syrup, the white granulated sugar, the pigment, the edible gum, the compound sugar and the midazolam is as follows: 4:1:(0.8-0.9):1:(1-1.1): 0.001;

e. cutting into granules to prepare finished products.

The working principle of the technical scheme is as follows:

through the treatment of the steps a to e, the midazolam is prepared into the candy, so that the phenomenon of reflux after the children take the midazolam is avoided, the children can obtain better treatment and psychological consolation, and the dysphoria and the nervous mood are eliminated. The sugar syrup, white granulated sugar, pigment, edible gum, compound sugar and midazolam are prepared from the following components in percentage by mass: 4:1:(0.8-0.9):1:(1-1.1): the candy is prepared by the design of 0.001, and according to the actual clinical application of 100 children, the absorption and acting time of the candy prepared from midazolam in children is more stable than that of the candy prepared by directly taking midazolam orally in the formula.

In a further technical scheme, the step b further comprises the following steps: b, placing the sucrose syrup, the white granulated sugar, the edible gum and the compound sugar in the step a into a container, heating to the high temperature of 100-150 ℃, and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out through a stirring device, and 1-2L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

In a further technical scheme, the step b further comprises the following steps: and (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, heating and boiling are stopped when the melt has the viscosity of 200-450 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, a sticky matter is formed, and standing is carried out for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

In a further technical scheme, the method also comprises the following steps: uniformly dividing the pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky objects at the interval of 1-3 minutes when the sticky objects are kept stand and slowly cooled to 80-90 ℃, uniformly stirring to obtain a first mixture, and keeping stand and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

In a further technical scheme, the midazolam is uniformly divided into ten equal parts, when the first mixture is kept stand and slowly cooled to 60-70 ℃, the divided ten equal parts of midazolam are scattered into the first mixture at intervals of 4 minutes and are uniformly stirred to obtain a second mixture, and the second mixture is kept stand and slowly cooled for more than 24 hours. Ensuring the even drug effect of the candy.

In a further technical scheme, the method also comprises the following steps: the resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

In a further technical scheme, the step d further comprises the following steps: the second mixture was cooled by natural air cooling. To reduce manufacturing costs.

In a further technical scheme, the step e further comprises the following steps: and (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

In a further technical scheme, the step e further comprises the following steps: and (5) refrigerating the obtained candy at low temperature and warehousing. So as to ensure the efficacy and safety of the medicine.

In a further technical scheme, the compound sugar is prepared by mixing one or more of corn syrup solid, polydextrose and polyalditol.

The specific implementation is as follows:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared by mixing corn syrup solid and polydextrose.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out by a stirring device, and 1L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, when the melt has the viscosity of 200 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, stopping heating and boiling to form a viscous substance, and standing for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between each part when the sticky object is kept standing and is slowly cooled to 80 ℃, uniformly stirring to obtain a first mixture, and keeping standing and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

0.001 part of midazolam is uniformly divided into ten equal parts, when the first mixture is kept stand and slowly cooled to 70 ℃, the divided ten equal parts of midazolam are scattered into the first mixture at intervals of 4 minutes and are uniformly stirred to obtain a second mixture, and the second mixture is kept stand and slowly cooled for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

Example 2:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared by mixing one or more of corn syrup solid and polysugar alcohol.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out by a stirring device, and 1L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, when the melt has the viscosity of 300 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, stopping heating and boiling to form a viscous substance, and standing for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between each part when the sticky object is kept standing and is slowly cooled to 85 ℃, uniformly stirring to obtain a first mixture, and keeping standing and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

0.001 part of midazolam is uniformly divided into ten equal parts, when the first mixture is kept stand and slowly cooled to 70 ℃, the divided ten equal parts of midazolam are scattered into the first mixture at intervals of 4 minutes and are uniformly stirred to obtain a second mixture, and the second mixture is kept stand and slowly cooled for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

Example 3:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared by mixing corn syrup solid, polydextrose and polyglycitol.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out by a stirring device, and 2L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, when the melt has the viscosity of 450 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, stopping heating and boiling to form a viscous substance, and standing for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between each part when the sticky object is kept standing and is slowly cooled to 90 ℃, uniformly stirring to obtain a first mixture, and keeping standing and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

0.001 part of midazolam is uniformly divided into ten equal parts, when the first mixture is kept stand and slowly cooled to 70 ℃, the divided ten equal parts of midazolam are scattered into the first mixture at intervals of 4 minutes and are uniformly stirred to obtain a second mixture, and the second mixture is kept stand and slowly cooled for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

Example 4:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared from corn syrup solids.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out by a stirring device, and 1.5L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, heating and boiling are stopped when the melt has the viscosity of 200-300 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, a sticky material is formed, and standing is carried out for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between every two parts when the sticky object is kept stand and slowly cooled to 80-85 ℃, uniformly stirring to obtain a first mixture, and keeping stand and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

Uniformly dividing 0.001 part of midazolam into ten equal parts, scattering the divided ten equal parts of midazolam into the first mixture at intervals of 4 minutes when the first mixture is kept stand and slowly cooled to 60-65 ℃, uniformly stirring to obtain a second mixture, and continuously keeping stand and slowly cooling for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

Example 5:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared from polydextrose.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out through a stirring device, and 1.5-2L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, heating and boiling are stopped when the melt has the viscosity of 300-450 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, a sticky matter is formed, and standing is carried out for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between each part when the sticky object is kept standing and is slowly cooled to 85-90 ℃, uniformly stirring to obtain a first mixture, and keeping standing and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

0.001 part of midazolam is uniformly divided into ten equal parts, when the first mixture is kept stand and slowly cooled to 65-70 ℃, the divided ten equal parts of midazolam are scattered into the first mixture at intervals of 4 minutes and uniformly stirred to obtain a second mixture, and the second mixture is kept stand and slowly cooled for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

Example 6:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared from polyglycitol.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out by a stirring device, and 1.5L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, when the melt has the viscosity of 300 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, stopping heating and boiling to form a viscous substance, and standing for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between each part when the sticky object is kept standing and is slowly cooled to 90 ℃, uniformly stirring to obtain a first mixture, and keeping standing and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

0.001 part of midazolam is uniformly divided into ten equal parts, when the first mixture is kept stand and slowly cooled to 65 ℃, the divided ten equal parts of midazolam are scattered into the first mixture at intervals of 4 minutes and are uniformly stirred to obtain a second mixture, and the second mixture is kept stand and slowly cooled for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

Example 7:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared by mixing one or more of corn syrup solid and polysugar alcohol.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out through a stirring device, and 1-2L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, when the melt has the viscosity of 200 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, stopping heating and boiling to form a viscous substance, and standing for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between every two parts when the sticky object is kept stand and slowly cooled to 80-85 ℃, uniformly stirring to obtain a first mixture, and keeping stand and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

Uniformly dividing 0.001 part of midazolam into ten equal parts, scattering the divided ten equal parts of midazolam into the first mixture at intervals of 4 minutes when the first mixture is kept stand and slowly cooled to 60-65 ℃, uniformly stirring to obtain a second mixture, and continuously keeping stand and slowly cooling for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

Example 8:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared by mixing one or more of polydextrose and polysugar alcohol.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out through a stirring device, and 1-2L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, when the melt has the viscosity of 250 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, stopping heating and boiling to form a viscous substance, and standing for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between each part when the sticky object is kept standing and is slowly cooled to 85 ℃, uniformly stirring to obtain a first mixture, and keeping standing and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

0.001 part of midazolam is uniformly divided into ten equal parts, when the first mixture is kept stand and slowly cooled to 75 ℃, the divided ten equal parts of midazolam are scattered into the first mixture at intervals of 4 minutes and are uniformly stirred to obtain a second mixture, and the second mixture is kept stand and slowly cooled for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

Example 9:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared by mixing one or more of corn syrup solid and polydextrose.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out through a stirring device, and 1-2L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, heating and boiling are stopped when the melt has the viscosity of 200-450 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, a sticky matter is formed, and standing is carried out for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between each part when the sticky object is kept standing and is slowly cooled to 90 ℃, uniformly stirring to obtain a first mixture, and keeping standing and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

Uniformly dividing 0.001 part of midazolam into ten equal parts, scattering the divided ten equal parts of midazolam into the first mixture at intervals of 4 minutes when the first mixture is kept stand and slowly cooled to 60 ℃, uniformly stirring to obtain a second mixture, and continuously keeping stand and slowly cooling for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy. When the prepared candy is in a spherical shape with the diameter of 8-10mm and is swallowed, a plurality of uniform small holes (with the diameter of 0.5-2mm) can be formed in the peripheral wall surface, and the interior of the candy is hollowed into a hollow shape (the hollowed mode can be realized by adopting the existing mature traditional hollowed-out process) on the premise of ensuring the administration dosage. After the child swallows the candy, the candy can be decomposed from the interior of the candy through the exterior of the candy and the small holes, so that the decomposition area is increased. Controlling the number of orifices controls the rate of dissolution from the interior of the confectionery while further avoiding the occurrence of regurgitation.

Example 10:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared by mixing one or more of polydextrose and polysugar alcohol.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out through a stirring device, and 1-2L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, heating and boiling are stopped when the melt has the viscosity of 200-450 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, a sticky matter is formed, and standing is carried out for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between every two parts when the sticky object is kept standing and is slowly cooled to 80 ℃, uniformly stirring to obtain a first mixture, and keeping standing and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

0.001 part of midazolam is uniformly divided into ten equal parts, when the first mixture is kept stand and slowly cooled to 65 ℃, the divided ten equal parts of midazolam are scattered into the first mixture at intervals of 4 minutes and are uniformly stirred to obtain a second mixture, and the second mixture is kept stand and slowly cooled for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

Example 11:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared by mixing corn syrup solid, polydextrose and polyglycitol.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out through a stirring device, and 1-2L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, when the melt has the viscosity of 350 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, stopping heating and boiling to form a viscous substance, and standing for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between each part when the sticky object is kept standing and is slowly cooled to 90 ℃, uniformly stirring to obtain a first mixture, and keeping standing and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

0.001 part of midazolam is uniformly divided into ten equal parts, when the first mixture is kept stand and slowly cooled to 70 ℃, the divided ten equal parts of midazolam are scattered into the first mixture at intervals of 4 minutes and are uniformly stirred to obtain a second mixture, and the second mixture is kept stand and slowly cooled for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

Example 12:

4 parts of sucrose syrup, 1 part of white granulated sugar, 1 part of edible gum and 1-1.1 parts of compound sugar, wherein the compound sugar is prepared by mixing corn syrup solid, polydextrose and polyglycitol.

Placing sucrose syrup, white granulated sugar, edible gum and compound sugar into a container, heating to the high temperature of 100-150 ℃ and melting to obtain a melt; wherein, in the process of high-temperature melting, stirring is carried out through a stirring device, and 1-2L of water is added in the stirring process. So as to ensure the stability of the whole high-temperature melting process and the uniformity of mixing.

And (2) placing the melt after high-temperature melting into a container, boiling, wherein the temperature is higher than or equal to 100 ℃, so that the moisture of the melt is evaporated, the viscosity is increased, when the melt has the viscosity of 250 poise at the shear rate of 2-8 sec < -1 > in the temperature range of 100 ℃ to 150 ℃, stopping heating and boiling to form a viscous substance, and standing for slow cooling. Provides a basis for the subsequent addition of pigment and midazolam.

Uniformly dividing 0.8-0.9 part of pigment into five equal parts, scattering the divided five equal parts of pigment into the sticky object in a mode of spacing 1-3 minutes between each part when the sticky object is kept standing and is slowly cooled to 85 ℃, uniformly stirring to obtain a first mixture, and keeping standing and slowly cooling. The coloring uniformity of the candy is ensured in the manufacturing process of the candy.

Uniformly dividing 0.001 part of midazolam into ten equal parts, scattering the divided ten equal parts of midazolam into the first mixture at intervals of 4 minutes when the first mixture is kept stand and slowly cooled to 60-70 ℃, uniformly stirring to obtain a second mixture, and continuously keeping stand and slowly cooling for more than 24 hours. Ensuring the even drug effect of the candy.

The resulting second mixture is cooled to form a sugar base. So as to be made into candies with different shapes.

And (3) compressing the obtained sugar base material into a bar-shaped block, and placing the bar-shaped block-shaped sugar base material into a forming machine for granulation to prepare the candy.

In the above embodiment, the following are satisfied: the mass component ratio of the sucrose syrup, the white granulated sugar, the pigment, the edible gum, the compound sugar and the midazolam is as follows: 4:1:(0.8-0.9):1:(1-1.1): under the precondition of 0.001, the method can be realized.

Through the 12 above embodiments and further embodiments, it is found that when the melt has a viscosity of 200 to 450 poises at a shear rate of 2 to 8 sec-1 at a temperature range of 100 ℃ and 150 ℃ for cooking, the product has the highest qualification rate after subsequent cooling and the finished product is produced, and the product has good taste and stable melting rate when orally taken.

Wherein the candy in the above embodiment has a mass deviation of + -0.1 g, and the content deviation of midazolam in the candy is + -0.1 g.

The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.