阅读说明：本技术 作为p2x3抑制剂的氨基喹唑啉衍生物 (As P2X3Aminoquinazoline derivatives as inhibitors ) 是由 P·布鲁诺 M·比亚杰蒂 C·费奥莱里 D·皮齐拉尼 D·帕拉 P·龙奇 C·贝克-格伦 于 2020-05-28 设计创作，主要内容包括：本发明涉及抑制P2X嘌呤受体3的式I的化合物；特别地,本发明涉及为氨基喹唑啉衍生物的化合物,制备此类化合物的方法,包含它们的药物组合物及其治疗用途。本发明的化合物可用于治疗许多与P2X-(3)受体机制相关的疾病,例如呼吸系统疾病,包括咳嗽,哮喘,特发性肺纤维化(IPF)和慢性阻塞性肺疾病(COPD)。(The present invention relates to compounds of formula I that inhibit P2X purinoceptor 3; in particular, the present invention relates to compounds which are aminoquinazoline derivatives, to processes for preparing such compounds, to pharmaceutical compositions containing them and to their therapeutic use. The compounds of the invention are useful in the treatment of a variety of diseases related to P2X 3 Diseases associated with receptor mechanisms, such as respiratory diseases including cough, asthma, Idiopathic Pulmonary Fibrosis (IPF) and Chronic Obstructive Pulmonary Disease (COPD).)