红细胞模拟粒子、其制备方法及含其的质控物或校准物

文档序号:555346 发布日期:2021-05-14 浏览:5次 >En<

阅读说明:本技术 红细胞模拟粒子、其制备方法及含其的质控物或校准物 (Erythrocyte-simulating particle, preparation method thereof and quality control substance or calibrator containing erythrocyte-simulating particle ) 是由 宋瑞霞 谢键 于 2018-12-25 设计创作,主要内容包括:一种红细胞模拟粒子、其制备方法及含有该红细胞模拟粒子的质控物或校准物。制备红细胞模拟粒子的方法包括采用pH为5.0~9.0、渗透压为300~800Osm/kg·H-2O的红细胞处理液对红细胞进行氧化处理和固定处理,其中,该红细胞处理液含有选自卤素含氧酸盐的至少一种氧化剂和选自醛或酸的至少一种固定剂;和将经该红细胞处理液处理后的红细胞洗涤并悬浮在保存液中。该方法采用环境友好的卤素含氧酸盐作为氧化剂,获得了能够长期稳定保存的且在红细胞检测通道中与天然血液红细胞粒子性质类似的红细胞模拟粒子。(A red blood cell mimic particle, a method for preparing the same, and a quality control substance or calibrator containing the red blood cell mimic particle. The method for preparing the erythrocyte mimic particle comprises the steps of adopting pH value of 5.0-9.0 and osmotic pressure of 300-800 Osm/kg.H 2 O, wherein the erythrocyte treating solution contains at least one oxidizing agent selected from halogen oxysalts and at least one fixing agent selected from aldehydes or acids; and washing and suspending the red blood cells treated with the red blood cell treatment solution in a preservation solution. The method adopts environment-friendly halogen oxysalt as an oxidant, and obtains the erythrocyte simulated particles which can be stably stored for a long time and have the property similar to that of natural erythrocyte particles in an erythrocyte detection channel.)

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