阅读说明：本技术 氟化胆汁酸衍生物 (Fluorinated bile acid derivatives ) 是由 A·C·韦茅斯-威尔逊 G·帕克 B·J·P·林克劳 D·基德-辛克莱 K·A·沃森 于 2019-07-30 设计创作，主要内容包括：通式(I)的化合物：其中R～(2a)、R～(2b)、R～(3a)、R～(3b)、R～5、Y和R～7如本文所定义,该化合物为FXR受体的选择性激动剂,并且用于治疗或预防疾病和病症,包括非酒精性脂肪性肝炎(NASH)；原发性胆汁性肝硬化；原发性硬化性胆管炎；胆道闭锁；胆汁郁积性肝病；丙型肝炎感染；酒精性肝病；纤维化；或因纤维化导致的肝损伤。(A compound of the general formula (I): wherein R is 2a 、R 2b 、R 3a 、R 3b 、R 5 Y and R 7 As herein describedAs defined, which are selective agonists of the FXR receptor and are useful for the treatment or prevention of diseases and disorders, including nonalcoholic steatohepatitis (NASH); primary biliary cirrhosis; primary sclerosing cholangitis; closing the biliary tract; cholestatic liver disease; hepatitis c infection; alcoholic liver disease; fiberizing; or liver damage due to fibrosis.)