阅读说明：本技术 抗cd47抗体及其应用 (anti-CD 47 antibodies and uses thereof ) 是由 王勇 赵立文 宋其峰 朱永强 张亚楠 韩璐薇 金亮 吴文明 于 2019-08-30 设计创作，主要内容包括：涉及抗体药物技术领域,尤其涉及一种抗CD47抗体或其抗原结合片段,包含抗CD47抗体或其抗原结合片段的药物组合物以及它们的应用。本发明的抗CD47抗体或其抗原结合片段具有显著的抗肿瘤活性,与人CD47蛋白的亲和力较高,可阻断SIRPa结合到细胞表面CD47的能力,且不具有显著的红细胞凝集活性,可在制备抗肿瘤的药物中应用。(Relates to the technical field of antibody medicines, in particular to an anti-CD 47 antibody or an antigen binding fragment thereof, a pharmaceutical composition containing the anti-CD 47 antibody or the antigen binding fragment thereof and application of the pharmaceutical composition. The anti-CD 47 antibody or the antigen binding fragment thereof has obvious anti-tumor activity, has higher affinity with human CD47 protein, can block the capacity of combining SIRPa to cell surface CD47, does not have obvious erythrocyte agglutination activity, and can be applied to the preparation of anti-tumor drugs.)