阅读说明：本技术 一种破壁饮片的制粒工艺 (Granulating process of wall-broken decoction pieces ) 是由 朱海滨 崔彩霞 于 2020-12-25 设计创作，主要内容包括：本发明公开了一种破壁饮片的制粒工艺,包括以下步骤：S1：制备破壁软材,将药材经过间歇式杀菌,得到符合能够直接服用的饮片微生物限度药材粗粉；S2：将药材粗粉进行破壁,得到超细粉体,分级机转速在20～40r/s,破壁粉碎至300目以上,所述超细粉体的制备温度在18～26℃。该种破壁饮片的制粒工艺,通过采用边加软材边加破壁干粉的方法制粒,所得的颗粒粒型较好,松紧度适中,而且制备的颗粒较易干燥,颗粒溶散较快,在制粒前加入少量破壁干粉,避免网筛堵塞,本发明提供的方法在制粒过程中添加破壁饮片干粉,制得的颗粒松紧度适中,对后期的干燥、整粒有力,在使用者服用时易于分散,解决目前市场上破壁饮片溶散难和微生物限度难达标的问题。(The invention discloses a granulating process of wall-broken decoction pieces, which comprises the following steps: s1: preparing a wall-broken soft material, and performing intermittent sterilization on the medicinal materials to obtain crude medicinal powder which meets the microbial limit of decoction pieces and can be directly taken; s2: breaking the wall of the crude powder of the medicinal materials to obtain superfine powder, wherein the rotating speed of a grader is 20-40 r/s, the wall is broken and the superfine powder is crushed to be more than 300 meshes, and the preparation temperature of the superfine powder is 18-26 ℃. The granulating process of the wall-broken decoction pieces adopts a method of adding soft materials and wall-broken dry powder for granulation, the obtained granules are good in particle type and moderate in tightness, the prepared granules are easy to dry, the granules are fast to dissolve, a small amount of wall-broken dry powder is added before granulation, and mesh screen blockage is avoided.)

1. The granulating process of the wall-broken decoction pieces is characterized by comprising the following steps of:

s1: preparing a wall-broken soft material, and performing intermittent sterilization on the medicinal materials to obtain crude medicinal powder which meets the microbial limit of decoction pieces and can be directly taken;

s2: breaking the wall of the crude powder of the medicinal materials to obtain superfine powder, grinding the broken wall to be more than 300 meshes at the rotating speed of a classifier of 20-40 r/s, and adding absolute ethyl alcohol into the superfine powder at the preparation temperature of 18-26 ℃ to obtain a soft broken powder material;

s3: screening the soft wall-breaking powder, mixing the soft wall-breaking powder with auxiliary materials, and adding the screened and mixed soft wall-breaking powder into a granulator to obtain prepared superfine powder soft wall-breaking powder granulation;

s4: and (3) granulating after uniformly mixing, screening by using a screen with 20-40 meshes, and drying until the water content is less than or equal to 8% after screening to obtain wall-broken decoction piece granules.

2. The granulation process of wall-broken decoction pieces as claimed in claim 1, wherein in S1, the batch sterilization process comprises:

and (3) sterilization: treating the medicinal materials, placing in a constant temperature and humidity box, and keeping a certain drying and sterilizing time;

and (3) growth of the dormant body: maintaining the sterilized medicinal materials in an environment with the temperature of 25-30 ℃ and the relative humidity of 75-80% for 10-24 hours in a constant temperature and humidity box, then adjusting the temperature of the constant temperature and humidity box to 35-40 ℃ and the relative humidity to 85-92% and maintaining for 10-24 hours;

secondary sterilization: placing the medicinal materials in a constant temperature and humidity box again, and drying and sterilizing at a certain temperature for a period of time; and detecting microorganisms in the crude medicinal powder to obtain crude medicinal powder which meets the microbial limit of decoction pieces and can be directly taken, wherein the temperature is 70-80 ℃, the time is 4-8 hours, and the thickness of the crude medicinal powder in a constant temperature and humidity box is 5-30 mm.

3. The granulating process of wall-broken decoction pieces as claimed in claim 1, wherein after the intermittent sterilization is completed, if the microbial limit in the crude powder of the medicinal materials is detected to be not in accordance with the microbial limit for direct administration, the processes of dormant body growth and sterilization are repeated for 1-4 times; until the crude powder of the medicinal materials which meets the microbial limit of the directly taken medicinal slices is prepared.

4. The granulation process of wall-broken decoction pieces as claimed in claim 1, wherein in S3, the adjuvant is one or more of starch slurry, polyvinylpyrrolidone solution, honey, syrup, maltose, xylitol, fruit juice or water, and the raw material micropowder and adjuvant are mixed at a weight ratio of 100: 15-18.

5. The granulation process of wall-broken decoction pieces as claimed in claim 1, wherein the preparation temperature of the wall-broken powder is 18-26 ℃, and the stirrer is a groove mixer.

6. The granulation process of the wall-broken decoction pieces according to claim 1, wherein the prepared wall-broken soft material is granulated by a granulator with a 20-23 mesh sieve, and the ultrafine powder is added into the granulator while the soft material is added until the granules are prepared; the granulator is a swing type granulator or an extrusion type granulator with a 20-23-mesh sieve, and the mass ratio of the wall-breaking powder soft material to the superfine powder is 3-6: 0.5-1.

7. The granulation process of wall-broken decoction pieces according to claim 1, wherein the drying of the wall-broken decoction piece granules is performed in a hot air circulation oven, the drying temperature is set to 50-80 ℃, and the drying is performed until the moisture content is less than or equal to 8%.

Technical Field

The invention relates to the technical field of wall-broken decoction pieces, in particular to a granulating process of wall-broken decoction pieces.

Background

The superfine grinding technology is a new technology which is rapidly developed in recent years. Most of the active ingredients in the traditional Chinese medicinal materials are distributed in cells, only part of the active ingredients can be released when the decoction pieces are decocted conventionally, and the utilization rate of the active ingredients is 10-30%; and by adopting a wall-breaking crushing technology, if the traditional Chinese medicine decoction pieces are crushed to about 300 meshes, the wall-breaking rate of cells reaches 86.7 percent, the dissolution of active ingredients in the medicinal materials is improved, the drug effect of the medicinal materials is greatly enhanced, the utilization rate of the active ingredients is over 90 percent, the purposes of reducing the use amount of the medicinal materials and protecting medicinal material resources are achieved, and meanwhile, the quality of the medicine can be improved and the drug effect is improved. Radix salviae miltiorrhizae, also named as radix salviae miltiorrhizae, red ginseng, mountain ginseng, rush, red ginseng root, nonane ginseng, red ginseng, blood ginseng, red salvia miltiorrhiza, summer salvia miltiorrhiza, purple ginseng and the like, is used as a root medicine, contains tanshinone, is a strong menstrual flow stimulating agent, has the effects of removing blood stasis, promoting tissue regeneration, promoting blood circulation, regulating menstruation and the like, is a gynecological essential medicine and is mainly used for treating metrorrhagia, irregular menstruation, blood stasis, abdominal pain, menstrual pain, amenorrhea and temple pain. Has good effect on treating coronary heart disease.

The utilization efficiency of the raw materials of the traditional Chinese medicine decoction pieces is not high, the wall breaking uniformity of the raw materials of the traditional Chinese medicine decoction pieces is not high, the stability of the traditional Chinese medicine decoction pieces is not good, and the dissolving speed is slow. Therefore, the improvement is made, and a granulating process of the wall-broken decoction pieces is provided.

Disclosure of Invention

In order to solve the technical problems, the invention provides the following technical scheme:

the invention relates to a granulating process of wall-broken decoction pieces, which comprises the following steps:

s1: preparing a wall-broken soft material, and performing intermittent sterilization on the medicinal materials to obtain crude medicinal powder which meets the microbial limit of decoction pieces and can be directly taken;

s2: breaking the wall of the crude powder of the medicinal materials to obtain superfine powder, grinding the broken wall to be more than 300 meshes at the rotating speed of a classifier of 20-40 r/s, and adding absolute ethyl alcohol into the superfine powder at the preparation temperature of 18-26 ℃ to obtain a soft broken powder material;

s3: screening the soft wall-breaking powder, mixing the soft wall-breaking powder with auxiliary materials, and adding the screened and mixed soft wall-breaking powder into a granulator to obtain prepared superfine powder soft wall-breaking powder granulation;

s4: and (3) granulating after uniformly mixing, screening by using a screen with 20-40 meshes, and drying until the water content is less than or equal to 8% after screening to obtain wall-broken decoction piece granules.

As a preferred technical solution of the present invention, in S1, the process of the intermittent sterilization includes:

and (3) sterilization: treating the medicinal materials, placing in a constant temperature and humidity box, and keeping a certain drying and sterilizing time;

and (3) growth of the dormant body: maintaining the sterilized medicinal materials in an environment with the temperature of 25-30 ℃ and the relative humidity of 75-80% for 10-24 hours in a constant temperature and humidity box, then adjusting the temperature of the constant temperature and humidity box to 35-40 ℃ and the relative humidity to 85-92% and maintaining for 10-24 hours;

secondary sterilization: placing the medicinal materials in a constant temperature and humidity box again, and drying and sterilizing at a certain temperature for a period of time; and detecting microorganisms in the crude medicinal powder to obtain crude medicinal powder which meets the microbial limit of decoction pieces and can be directly taken, wherein the temperature is 70-80 ℃, the time is 4-8 hours, and the thickness of the crude medicinal powder in a constant temperature and humidity box is 5-30 mm.

As a preferred technical scheme, after the intermittent sterilization is finished, if the microbial limit in the crude powder of the medicinal materials is detected in a conventional manner and does not conform to the microbial limit of direct taking, the growth and sterilization processes of the dormant body are repeated for 1-4 times; until the crude powder of the medicinal materials which meets the microbial limit of the directly taken medicinal slices is prepared.

In a preferable technical scheme of the invention, in the step S3, the auxiliary material is any one or more of starch slurry, polyvinylpyrrolidone solution, honey, syrup, maltose, xylitol, fruit juice or water, and the raw material ultrafine powder and the auxiliary material are mixed according to a weight ratio of 100: 15-18.

As a preferred technical scheme of the invention, the preparation temperature of the wall-broken powder is 18-26 ℃, and the stirrer is a groove-type mixer.

As a preferred technical scheme of the invention, the prepared wall-breaking powder soft material is granulated by a granulator with a 20-23-mesh sieve, and superfine powder is added into the granulator while the soft material is added until the granule preparation is finished; the granulator is a swing type granulator or an extrusion type granulator with a 20-23-mesh sieve, and the mass ratio of the wall-breaking powder soft material to the superfine powder is 3-6: 0.5-1.

According to a preferable technical scheme, the wall-broken decoction piece particles are dried in a hot air circulation oven, the drying temperature is set to be 50-80 ℃, and the wall-broken decoction piece particles are dried until the moisture content is less than or equal to 8%.

The invention has the beneficial effects that: according to the granulating process of the wall-broken decoction pieces, the wall-broken dry powder is added while the soft material is added for granulation, the obtained granules are good in particle type and moderate in tightness, the prepared granules are easy to dry, the granules are fast to dissolve, a small amount of wall-broken dry powder is added before granulation, and the mesh screen is prevented from being blocked;

adding a small amount of wall-breaking dry powder before granulating to avoid mesh screen blockage, allowing the dormant body to grow in a high-humidity environment, killing after the dormant body grows into a propagule, having obvious killing effect, facilitating the preparation of subsequent wall-breaking decoction pieces, meeting the requirement of microorganism limit of directly taking decoction pieces, keeping dry environment, hardly damaging the components of the medicinal materials, and hardly influencing the content of the medicinal materials through the processes of killing propagules, growing dormant bodies and killing propagules, thereby ensuring the drug effect and sterilization; the situation that the medicinal materials are oxidized and denatured can not occur; the method has short time and low energy consumption. In addition, the constant temperature and humidity box is adopted, the growth environment of dormant bodies in the crude medicinal powder is effectively ensured, the situation that foreign matters and dust enter the crude medicinal powder due to movement of the crude medicinal powder during intermittent sterilization can be effectively prevented, secondary pollution is effectively prevented, and the wall-broken decoction pieces have the advantages of time saving, convenience in application and the like;

the method has the advantages that the raw materials of the traditional Chinese medicine decoction pieces are treated by adopting the processes of intermittent sterilization and secondary wall breaking and crushing, so that the sterilization quality of the raw materials of the traditional Chinese medicine decoction pieces is improved, the secondary wall breaking and crushing can improve the precipitation rate of active ingredients in the raw materials of the traditional Chinese medicine decoction pieces, the utilization rate of the raw materials of the traditional Chinese medicine decoction pieces is improved, the raw materials after superfine crushing and auxiliary materials are mixed and then granulated, so that the traditional Chinese medicine decoction pieces are good in stability, fast in dissolution and high in nutrient substance precipitation speed, the problems of difficult dissolution, low absorption rate and poor stability of the traditional Chinese medicine decoction pieces with the.

Drawings

Fig. 1 is a flow chart of a granulation process of a wall-broken decoction piece of the invention;

fig. 2 is a flow chart of the intermittent sterilization process of the granulation process of the wall-broken decoction pieces.

Detailed Description

The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.

Example one

The invention relates to a granulating process of wall-broken decoction pieces, which comprises the following steps:

s1: preparing a wall-broken soft material, and performing intermittent sterilization on the medicinal materials to obtain crude medicinal powder which meets the microbial limit of decoction pieces and can be directly taken;

s2: breaking the wall of the crude powder to obtain superfine powder, pulverizing the wall broken powder to 300 meshes above at a classifier rotation speed of 20r/s, and adding absolute ethanol into the superfine powder at a preparation temperature of 18 ℃ to obtain a soft wall-broken powder;

s3: screening the soft wall-breaking powder, mixing the soft wall-breaking powder with auxiliary materials, and adding the screened and mixed soft wall-breaking powder into a granulator to obtain prepared superfine powder soft wall-breaking powder granulation;

s4: mixing, granulating, sieving with 20 mesh sieve, and oven drying until water content is less than 8% to obtain wall-broken decoction pieces granule.

Example two

The invention relates to a granulating process of wall-broken decoction pieces, which comprises the following steps:

s1: preparing a wall-broken soft material, and performing intermittent sterilization on the medicinal materials to obtain crude medicinal powder which meets the microbial limit of decoction pieces and can be directly taken;

s2: breaking the wall of the crude powder to obtain superfine powder, pulverizing the wall broken powder to 300 meshes above at a classifier rotation speed of 30r/s, and adding absolute ethanol into the superfine powder at a preparation temperature of 22 ℃ to obtain a soft wall-broken powder;

s3: screening the soft wall-breaking powder, mixing the soft wall-breaking powder with auxiliary materials, and adding the screened and mixed soft wall-breaking powder into a granulator to obtain prepared superfine powder soft wall-breaking powder granulation;

s4: mixing, granulating, sieving with 30 mesh sieve, and oven drying until water content is less than 8% to obtain wall-broken decoction pieces granule.

EXAMPLE III

The invention relates to a granulating process of wall-broken decoction pieces, which comprises the following steps:

s1: preparing a wall-broken soft material, and performing intermittent sterilization on the medicinal materials to obtain crude medicinal powder which meets the microbial limit of decoction pieces and can be directly taken;

s2: breaking the wall of the crude powder to obtain superfine powder, pulverizing the wall broken powder to 300 meshes above at a classifier rotation speed of 40r/s, and adding absolute ethanol into the superfine powder at a preparation temperature of 26 ℃ to obtain a soft wall-broken powder;

s3: screening the soft wall-breaking powder, mixing the soft wall-breaking powder with auxiliary materials, and adding the screened and mixed soft wall-breaking powder into a granulator to obtain prepared superfine powder soft wall-breaking powder granulation;

s4: mixing, granulating, sieving with 40 mesh sieve, and oven drying until water content is less than 8% to obtain wall-broken decoction pieces granule.

Compared with the conventional granulation method, the auxiliary material adding granulation method provided by the invention has better effect, and compared with the conventional granulation method, the auxiliary material adding granulation method can obtain granules with higher content of basic substances and better stability;

adding a small amount of wall-breaking dry powder before granulating to avoid mesh screen blockage, allowing the dormant body to grow in a high-humidity environment, killing after the dormant body grows into a propagule, having obvious killing effect, facilitating the preparation of subsequent wall-breaking decoction pieces, meeting the requirement of microorganism limit of directly taking decoction pieces, keeping dry environment, hardly damaging the components of the medicinal materials, and hardly influencing the content of the medicinal materials through the processes of killing propagules, growing dormant bodies and killing propagules, thereby ensuring the drug effect and sterilization; the situation that the medicinal materials are oxidized and denatured can not occur; the method has short time and low energy consumption. In addition, the constant temperature and humidity box is adopted, the growth environment of dormant bodies in the crude medicinal powder is effectively ensured, the situation that foreign matters and dust enter the crude medicinal powder due to movement of the crude medicinal powder during intermittent sterilization can be effectively prevented, secondary pollution is effectively prevented, and the wall-broken decoction pieces have the advantages of time saving, convenience in application and the like;

the granules are granulated by adopting a method of adding soft materials and wall-breaking dry powder, the obtained granules have good granule type and moderate tightness, and the prepared granules are easy to dry and quick to dissolve. A small amount of wall-breaking dry powder is added before granulation, so that the mesh screen is prevented from being blocked. According to the method provided by the invention, the wall-broken decoction piece dry powder is added in the granulation process, the prepared granules are moderate in tightness, powerful in later-stage drying and granule finishing, easy to disperse when taken by a user, and capable of solving the problems that the wall-broken decoction pieces are difficult to dissolve and the microbial limit is difficult to reach the standard in the current market;

the method has the advantages that the raw materials of the traditional Chinese medicine decoction pieces are treated by adopting the processes of intermittent sterilization and secondary wall breaking and crushing, so that the sterilization quality of the raw materials of the traditional Chinese medicine decoction pieces is improved, the secondary wall breaking and crushing can improve the precipitation rate of active ingredients in the raw materials of the traditional Chinese medicine decoction pieces, the utilization rate of the raw materials of the traditional Chinese medicine decoction pieces is improved, the raw materials after superfine crushing and auxiliary materials are mixed and then granulated, so that the traditional Chinese medicine decoction pieces are good in stability, fast in dissolution and high in nutrient substance precipitation speed, the problems of difficult dissolution, low absorption rate and poor stability of the traditional Chinese medicine decoction pieces with the.

Finally, it should be noted that: in the description of the present invention, it should be noted that the terms "vertical", "upper", "lower", "horizontal", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.