阅读说明：本技术 一种牛初乳制品及其制备方法和应用 (Bovine colostrum product and preparation method and application thereof ) 是由 刘妍妍 陈文璐 杨宝嘉 白吉敏 王宪青 王利 王青云 巩燕妮 于 2020-11-30 设计创作，主要内容包括：本发明涉及保健品制备方法领域,具体公开了一种牛初乳制品及其制备方法和应用,所述牛初乳制品由牛初乳乳清和复合添加剂组成,所述牛初乳乳清和所述复合添加剂的用量比为100-120ml:30g,所述复合添加剂由以下重量份数的组分制成：2-4份益生菌粉,6-10份黄芪当归粉,10-14份黑豆粉,4-6份维生素A粉,4-6份维生素C粉。本发明获得的牛初乳制品中各种生长因子协同作用,能促进细胞正常生长、组织修复和外伤痊愈,同时还具有助消化、增强免疫力的效果。(The invention relates to the field of preparation methods of health care products, and particularly discloses a bovine colostrum product and a preparation method and application thereof, wherein the bovine colostrum product consists of bovine colostrum whey and a composite additive, the dosage ratio of the bovine colostrum whey to the composite additive is 100-120ml:30g, and the composite additive is prepared from the following components in parts by weight: 2-4 parts of probiotic powder, 6-10 parts of astragalus mongholicus and angelica sinensis powder, 10-14 parts of black bean powder, 4-6 parts of vitamin A powder and 4-6 parts of vitamin C powder. The bovine colostrum product obtained by the invention can promote normal growth of cells, tissue repair and trauma healing under the synergistic effect of various growth factors, and has the effects of promoting digestion and enhancing immunity.)

1. The bovine colostrum product is characterized by comprising bovine colostrum whey and a composite additive, wherein the dosage ratio of the bovine colostrum whey to the composite additive is 100-120ml:30 g;

the composite additive is prepared from the following components in parts by weight: 2-4 parts of probiotic powder, 6-10 parts of astragalus mongholicus and angelica sinensis powder, 10-14 parts of black bean powder, 4-6 parts of vitamin A powder and 4-6 parts of vitamin C powder.

2. The bovine colostrum product of claim 1, wherein the complex additive is prepared from the following components in parts by weight: 3 parts of probiotic powder, 8 parts of astragalus mongholicus and angelica sinensis powder, 12 parts of black bean powder, 5 parts of vitamin A and 5 parts of vitamin C.

3. A method of preparing a bovine colostrum product according to claim 1, which comprises the steps of:

s1, preparation of bovine colostrum whey: collecting fresh bovine colostrum, performing low-temperature centrifugal degreasing, and performing microfiltration sterilization to obtain bovine colostrum whey for later use;

s2, preparing astragalus and angelica powder: selecting high-quality radix astragali and radix Angelicae sinensis, boiling in boiling water for 3-5min, taking out, oven drying, slicing to obtain radix astragali tablet and radix Angelicae sinensis tablet, mixing radix astragali tablet and radix Angelicae sinensis tablet, adding Mel, stirring, baking at 70-80 deg.C for 3-4 hr, pulverizing, and sieving to obtain radix astragali and radix Angelicae sinensis powder;

the dosage ratio of the astragalus root, the angelica and the honey is 1g to 2-4 ml;

s3, preparing black bean powder: putting high-quality black beans into an oven, baking, and crushing to obtain black bean powder for later use;

s4, weighing the astragalus and angelica sinensis powder, the black bean powder, the prepared probiotic powder, the vitamin A and the vitamin C in advance according to the weight parts, and uniformly mixing to obtain the compound additive;

s5, adding the compound additive into the bovine colostrum whey while stirring, mixing uniformly to obtain a bovine colostrum product, filling and storing at 4 ℃.

4. The method for preparing a bovine colostrum product according to claim 3, wherein in S1, the temperature of low-temperature centrifugal degreasing is 4-8 ℃, the rotation speed is 3500-4000rpm, and the centrifugation time is 35-45 min.

5. A process for the preparation of a bovine colostrum product according to claim 3, wherein in S1, a 1.4 μm ceramic membrane is used for the microfiltration sterilization.

6. The method of preparing a bovine colostrum product according to claim 3, wherein the honey is native honey in S2.

7. The method of preparing a bovine colostrum product according to claim 3, wherein the slice thickness in S2 is 1-2 cm.

8. A process for the preparation of a bovine colostrum product according to claim 3, wherein in S2, after grinding, it is passed through a 20-30 mesh sieve.

9. The method for preparing bovine colostrum product according to claim 3, wherein in S3, the baking temperature of the black beans is 180-.

10. Use of a bovine colostrum product according to claim 1 or 2 for the preparation of a health product for promoting a rapid recovery after surgery.

Technical Field

The invention relates to the field of preparation methods of health care products, in particular to a bovine colostrum product and a preparation method and application thereof.

Background

Bovine colostrum is milk obtained 3 days after calving of cows, and its nutritional components are higher in protein, and lower in fat and sugar content than ordinary milk. Bovine colostrum also contains a large amount of immune and growth factors, such as immunoglobulin, lactoferrin, lysozyme, insulin-like growth factors, epidermal growth factors, etc., and is known as "health food in the 21 st century". Newborn calves generally receive fresh colostrum from cows by sucking or otherwise within the first 2-3 days of life. During this time, most healthy cows produce colostrum in an amount that exceeds the needs of the calf. Thus a portion of the colostrum is wasted.

Colostrum is most attractive because of its unique physiological functions. Most of the colostrum proteins are immunoglobulins, which form antibodies that bind antigens such as pathogenic microorganisms and toxins and protect the newborn infant from pathogenic attack before the newborn infant's autoimmune system is mature and functioning properly.

The body function descends after the human operation, and immunity reduces, and postoperative wound healing is slow, and wound healing time can increase the infection risk for a long time, seriously influences the health, has potential secondary injury to the human body, and is many to operation crowd's nutriment on the market at present, but the composition is single, and the function is single, but the product that edible nutrition is too abundant will influence wound healing, can't bear a large amount of nutrition to the not good patient of stomach and concentrate the ingestion more.

Disclosure of Invention

In order to solve the technical problems, the invention provides a bovine colostrum product and a preparation method and application thereof, and the prepared bovine colostrum product can promote the wound to be rapidly healed, simultaneously regulate the intestines and stomach, prevent the inflammation, provide sufficient nutrient elements for the human body and improve the immunity of the human body.

The first purpose of the invention is to provide a bovine colostrum product, which consists of bovine colostrum whey and a compound additive, wherein the dosage ratio of the bovine colostrum whey to the compound additive is 100-120ml:30 g;

the composite additive is prepared from the following components in parts by weight: 2-4 parts of probiotic powder, 6-10 parts of astragalus mongholicus and angelica sinensis powder, 10-14 parts of black bean powder, 4-6 parts of vitamin A powder and 4-6 parts of vitamin C powder.

Preferably, the composite additive is prepared from the following components in parts by weight: 3 parts of probiotic powder, 8 parts of astragalus mongholicus and angelica sinensis powder, 12 parts of black bean powder, 5 parts of vitamin A and 5 parts of vitamin C.

The second purpose of the invention is to provide a preparation method of the bovine colostrum product, which comprises the following steps:

s1, preparation of bovine colostrum whey: collecting fresh bovine colostrum, carrying out low-temperature centrifugal degreasing, and carrying out microfiltration sterilization to obtain bovine colostrum whey for later use;

s2, preparing astragalus and angelica powder: selecting high-quality radix astragali and radix Angelicae sinensis, boiling in boiling water for 3-5min, taking out, oven drying, slicing to obtain radix astragali tablet and radix Angelicae sinensis tablet, mixing radix astragali tablet and radix Angelicae sinensis tablet, adding Mel, stirring, baking at 70-80 deg.C for 3-4 hr, pulverizing, and sieving to obtain radix astragali and radix Angelicae sinensis powder;

the dosage ratio of the astragalus root, the angelica and the honey is 1g to 2-4 ml;

s3, preparing black bean powder: putting high-quality black beans into an oven, baking, and crushing to obtain black bean powder for later use;

s4, weighing the astragalus and angelica sinensis powder, the black bean powder, the prepared probiotic powder, the vitamin A and the vitamin C in advance according to the weight parts, and uniformly mixing to obtain the compound additive;

s5, adding the compound additive into the bovine colostrum whey while stirring, mixing uniformly to obtain a bovine colostrum product, filling and storing at 4 ℃.

Preferably, in S1, the low-temperature centrifugal degreasing temperature is 4-8 ℃, the rotation speed is 3500-4000rpm, and the centrifugation time is 35-45 min.

Preferably, in S1, a 1.4 μm ceramic membrane is used in the microfiltration sterilization process.

Preferably, in S2, the honey is native honey.

Preferably, in S2, the slice thickness is 1-2 cm.

Preferably, in S2, after being crushed, the mixture is sieved by a sieve with 20 to 30 meshes.

Preferably, in S3, the baking temperature of the black beans is 180-.

The third purpose of the invention is to provide the application of the bovine colostrum product in preparing health care products for promoting the quick recovery after operation.

Compared with the prior art, the invention has the beneficial effects that:

1. the bovine colostrum whey in the bovine colostrum product prepared by the invention contains a large amount of immune and growth factors, such as immunoglobulin, lactoferrin, lysozyme, insulin-like growth factor, epidermal growth factor and the like, and can improve the immune function of a human body, prevent infection and promote wound healing;

2. the astragalus and angelica powder in the bovine colostrum product prepared by the invention is prepared by adding honey into astragalus and angelica, wherein the astragalus has the functions of benefiting vital qi, strengthening spleen and stomach, expelling pus and relieving pain, activating blood and promoting tissue regeneration, can effectively promote wound healing and can prevent inflammation;

the angelica has the functions of enriching the blood and invigorating the blood circulation, the mouth feel of the angelica and the astragalus is improved by combining the angelica and the astragalus through honey, and meanwhile, the honey can combine the angelica to have the function of lubricating the intestines, so that the constipation caused by insufficient exercise after the operation is prevented;

3. the probiotic powder in the bovine colostrum product can regulate the balance of intestinal flora, promote digestion and absorption of nutrient substances, and promote propagation in intestinal tracts through bovine colostrum;

4. the bovine colostrum product prepared by the method is very beneficial to postoperative patients, can promote the postoperative wound to heal quickly, and when the wound is infected a little, the hepcidin in the organism is increased due to inflammatory reaction, and the excessive activity of the hepcidin can reduce the iron content in blood excessively, so that the synthesis of red blood cells is limited, and anemia is caused;

5. the bovine colostrum product prepared by the invention contains a large amount of growth factors, immunoglobulin, bioactive peptide binding protein, vitamins and trace elements required by human body, thereby improving the system immunity, regulating the intestinal flora, and promoting the growth and development of gastrointestinal tracts or the healing of intestinal tissue wounds;

6. the bovine colostrum product is prepared from bovine colostrum whey, probiotic powder, radix astragali and angelica powder, black bean powder, vitamin A powder and vitamin C powder, and the components cooperate with each other to promote the wound to heal quickly, regulate intestines and stomach, prevent inflammation, provide sufficient nutrient elements for human bodies and improve the immunity of the human bodies.

Detailed Description

The following detailed description of specific embodiments of the invention is provided, but it should be understood that the scope of the invention is not limited to the specific embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. The experimental methods described in the examples of the present invention are all conventional methods unless otherwise specified.

Example 1:

this example provides a bovine colostrum product, which is made up of 110ml of bovine colostrum whey and 33g of a complex additive;

the composite additive is prepared from the following components in parts by mass: 3g of probiotic powder, 8g of astragalus mongholicus and angelica sinensis powder, 12g of black bean powder, 5g of vitamin A and 5g of vitamin C.

The preparation method of the colostrum product comprises the following steps:

s1, preparation of bovine colostrum whey: collecting milk (bovine colostrum) of healthy cow after farrowing for 2 days, placing fresh bovine colostrum in a low-speed freezing centrifuge, centrifuging at 6 deg.C and 3700rpm for 40min for degreasing, removing fat layer to obtain low-fat bovine colostrum, and performing microfiltration sterilization by 1.4 μm ceramic membrane to obtain bovine colostrum whey for use;

s2, preparing astragalus and angelica powder: purchasing high-quality radix astragali and radix Angelicae sinensis from Gansu area with abundant traditional Chinese medicines, decocting in boiling water for 4min, taking out, drying in a microwave dryer under microwave power of 60 kilowatts for 20min, slicing to obtain slices with thickness of 1-2cm to obtain radix astragali slices and radix Angelicae sinensis slices, mixing the radix astragali slices and radix Angelicae sinensis slices, adding Mel, stirring, baking at 75 deg.C for 3.5h, pulverizing, and sieving with 20 mesh sieve to obtain radix astragali and radix Angelicae sinensis powder;

the dosage ratio of the astragalus root, the angelica and the honey is 1g to 3 ml;

s3, preparing black bean powder: baking high-quality semen Sojae Atricolor in oven at 180 deg.C for 18min, pulverizing, and sieving with 20 mesh sieve to obtain semen Sojae Atricolor powder;

s4, weighing the astragalus and angelica sinensis powder, the black bean powder, the prepared probiotic powder, the vitamin A and the vitamin C in advance according to the weight parts, and uniformly mixing to obtain the compound additive;

s5, adding the compound additive into the bovine colostrum whey while stirring, uniformly mixing to obtain a bovine colostrum product, filling according to a 150 ml/tank, and storing at 4 ℃.

Example 2:

this example provides a bovine colostrum product, which is composed of 95ml of bovine colostrum whey and 26g of a complex additive;

the composite additive is prepared from the following components in parts by mass: 2g of probiotic powder, 6g of astragalus mongholicus and angelica sinensis powder, 10g of black bean powder, 4g of vitamin A and 4g of vitamin C.

The preparation method of the colostrum product comprises the following steps:

s1, preparation of bovine colostrum whey: collecting milk (bovine colostrum) of healthy cows after farrowing for 2 days, placing fresh bovine colostrum in a low-speed freezing centrifuge, centrifuging at 4 deg.C and 3500rpm for 35min for degreasing, removing fat layer to obtain low-fat bovine colostrum, and performing microfiltration sterilization by using 1.4 μm ceramic membrane to obtain bovine colostrum whey for use;

s2, preparing astragalus and angelica powder: purchasing high-quality radix astragali and radix Angelicae sinensis from Gansu area with abundant traditional Chinese medicines, decocting in boiling water for 3min, taking out, drying in a microwave dryer under microwave power of 60 kilowatts for 18min, slicing to obtain slices with thickness of 1-2cm to obtain radix astragali slices and radix Angelicae sinensis slices, mixing the radix astragali slices and radix Angelicae sinensis slices, adding Mel, stirring, baking at 70 deg.C for 3 hr, pulverizing, and sieving with 20 mesh sieve to obtain radix astragali and radix Angelicae sinensis powder;

the dosage ratio of the astragalus root, the angelica and the honey is 1g to 2 ml;

s3, preparing black bean powder: baking high-quality semen Sojae Atricolor in oven at 200 deg.C for 15min, pulverizing, and sieving with 20 mesh sieve to obtain semen Sojae Atricolor powder;

s4, weighing the astragalus and angelica sinensis powder, the black bean powder, the prepared probiotic powder, the vitamin A and the vitamin C in advance according to the weight parts, and uniformly mixing to obtain the compound additive;

s5, adding the compound additive into the bovine colostrum whey while stirring, uniformly mixing to obtain a bovine colostrum product, filling according to a 150 ml/tank, and storing at 4 ℃.

Example 3:

this example provides a bovine colostrum product, which is made up of 160ml of bovine colostrum whey and 40g of a complex additive;

the composite additive is prepared from the following components in parts by mass: 4g of probiotic powder, 10g of astragalus mongholicus and angelica sinensis powder, 14g of black bean powder, 6g of vitamin A and 6g of vitamin C.

The preparation method of the colostrum product comprises the following steps:

s1, preparation of bovine colostrum whey: collecting milk (bovine colostrum) of healthy cows on day 3 after farrowing, placing fresh bovine colostrum in a low-speed freezing centrifuge, centrifuging at 8 deg.C and 4000rpm for 45min for degreasing, removing fat layer to obtain low-fat bovine colostrum, and performing microfiltration sterilization by using 1.4 μm ceramic membrane to obtain bovine colostrum whey for later use;

s2, preparing astragalus and angelica powder: purchasing high-quality radix astragali and radix Angelicae sinensis from Gansu area with abundant traditional Chinese medicines, decocting in boiling water for 5min, taking out, drying in a microwave dryer under microwave power of 60 kilowatts for 22min, slicing to obtain slices with thickness of 1-2cm to obtain radix astragali slices and radix Angelicae sinensis slices, mixing the radix astragali slices and radix Angelicae sinensis slices, adding Mel, stirring, baking at 80 deg.C for 4 hr, pulverizing, and sieving with 20 mesh sieve to obtain radix astragali and radix Angelicae sinensis powder;

the dosage ratio of the astragalus root, the angelica and the honey is 1g to 4 ml;

s3, preparing black bean powder: baking high-quality semen Sojae Atricolor in oven at 200 deg.C for 20min, pulverizing, and sieving with 20 mesh sieve to obtain semen Sojae Atricolor powder;

s4, weighing the astragalus and angelica sinensis powder, the black bean powder, the prepared probiotic powder, the vitamin A and the vitamin C in advance according to the weight parts, and uniformly mixing to obtain the compound additive;

s5, adding the compound additive into the bovine colostrum whey while stirring, uniformly mixing to obtain a bovine colostrum product, filling according to a 150 ml/tank, and storing at 4 ℃.

The above examples 1-3 are specific examples of the preparation of bovine colostrum product according to the present invention, and sensory evaluation of the taste, color and flavor of the bovine colostrum product prepared in examples 1-3 is described, and the evaluation results are shown in table 1, and the partial nutrients of the bovine colostrum product are measured in example 1 and shown in table 2;

TABLE 1 organoleptic evaluation table of bovine colostrum product prepared according to the present invention

As can be seen from Table 1, the bovine colostrum product prepared by the method has good mouthfeel, is not sticky to teeth, has faint scent and slightly sweet taste, and the light mouthfeel is suitable for popular tastes of the public.

TABLE 2 partial nutrient composition table of bovine colostrum product prepared according to example 1 of the present invention

Index (I)	The colostrum is prepared from cow colostrumArticle (A)	Mass percent (%)
			Protein	48g	51.6％
Fat	2.7g	2.9％
			Vitamin A	6.8g	7.3％
Vitamin C	5.2g	5.6％
			Vitamin E	0.9g	0.97％
Vitamin B12	0.5g	0.54％

As can be seen from Table 2, the bovine colostrum product prepared in example 1 of the present invention contains a high content of protein (51.6%) and several important vitamins, and has a low fat content.

The edible method of the bovine colostrum product prepared by the invention comprises the following steps: the product can be eaten instantly after opening the can, or drunk after heating in water bath, and can be drunk by healthy people without operation every day, and by patients after operation every morning and evening.

The invention specially selects 50 patients with appendicitis excision surgery as volunteers to be investigated, wherein 50 patients are divided into two groups, each group is 25 and is respectively marked as A group and B group, the A group is divided into five groups according to the ages and is marked as A1, A2, A3, A4 and A5, wherein the A1 group is between 10 and 16 years old, the A2 group is between 20 and 16 years old, the A3 group is between 28 and 36 years old, the A4 group is between 38 and 45 years old, and the A5 group is between 50 and 60 years old;

group B is divided into five groups according to the ages and is marked as group B1, group B2, group B3, group B4 and group B5, wherein the group B1 is between 10 and 16 years old, the group B2 is between 20 and 16 years old, the group B3 is between 28 and 36 years old, the group B4 is between 38 and 45 years old, and the group B5 is between 50 and 60 years old;

taking the group A as a control group, carrying out normal repair and recovery after surgery according to medical advice, drinking the bovine colostrum product prepared in the embodiment 1 every day by the group B on the basis of the medical advice, respectively recording the postoperative wound healing time and the recovery time of the group A and the group B, calculating the average value of each group, and recording the result in the table 3;

TABLE 3 promotion of wound healing by bovine colostrum product prepared according to the present invention

Note: healing time refers to complete wound healing; recovery time refers to the recovery of the body without affecting the activity of the body at all.

As can be seen from Table 3, the bovine colostrum product prepared by the invention has the effect of healing wounds quickly, provides multiple immunoglobulins for human bodies, improves the immunity, prevents infection of no one patient in group B, and meanwhile, as can be seen from Table 3, the bovine colostrum product prepared by the invention is beneficial to postoperative body recovery after being taken after operation, greatly shortens the time of postoperative symptoms such as weak body, short breath and the like, and enables the patients to recover health early.

It should be noted that four of five persons in A1 healed for 3 days, the fifth person had wound infection, and the healing time was 13 days, so the average value of group A1 was 5 days; two persons in group A4 suffered from wound infection, the wound healing time was 14 days and 15 days, respectively, the other three persons did not suffer from infection, and the wound healing time was 6 days, and 9 days, respectively; none of the remaining patients had wound infections.

It should be noted that the probiotic powder of the present invention is purchased from Jilin Qingchen pharmaceutical industry Co., Ltd, and the product is named as whale force multi-solid beverage, and the ingredients are inulin, lactobacillus plantarum, lactobacillus acidophilus, lactobacillus casei, bifidobacterium bifidum, bifidobacterium lactis, bifidobacterium longum, lactobacillus paracasei, rhamnosus, fructo-oligosaccharide, isomalto-oligosaccharide, xylo-oligosaccharide and stachyose.

To sum up, the bovine colostrum product obtained by the application is very beneficial to the postoperative patient, provides a large amount of immunoglobulin for the organism, enhances the immunity, promotes the quick healing of the postoperative wound, and prevents infection.

While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.