阅读说明：本技术 女贞子提取物、含该提取物的颗粒剂及其制备工艺 (Glossy privet fruit extract, granules containing extract and preparation process of granules ) 是由 高亮亮 于 2020-07-28 设计创作，主要内容包括：本发明公开了一种女贞子提取物、含该提取物的颗粒剂及其制备工艺。所述女贞子提取物是将女贞子果实粉碎成女贞子粉末,加水煎煮所述女贞子粉末,过滤后取滤液,得到待浓缩滤液,将所述待浓缩滤液浓缩得到所述女贞子提取物。女贞子提取物的颗粒剂的制备工艺,其包括以下步骤：按照比例取所述女贞子提取物、乳糖粉和糊精混合均匀得到混合物,向所述混合物中加入乙醇湿润剂后,干燥,得到所述颗粒剂。女贞子的水提物中的主要成分提取出来制备成颗粒剂,有利于服用,可更高效的利用吸收其营养成分,可提高人体免疫力。(The invention discloses a glossy privet fruit extract, granules containing the extract and a preparation process thereof. The fructus Ligustri Lucidi extract is prepared by pulverizing fructus Ligustri Lucidi into powder, decocting with water, filtering, collecting filtrate to obtain filtrate, and concentrating the filtrate to obtain the fructus Ligustri Lucidi extract. The preparation process of the glossy privet fruit extract granule comprises the following steps: and uniformly mixing the glossy privet fruit extract, lactose powder and dextrin according to a proportion to obtain a mixture, adding an ethanol wetting agent into the mixture, and drying to obtain the granules. The main component in the aqueous extract of glossy privet fruit is extracted and prepared into granules, which are beneficial to taking, can more efficiently utilize and absorb the nutrient components and can improve the immunity of human bodies.)

1. A glossy privet fruit extract is characterized in that glossy privet fruit extract is prepared by crushing glossy privet fruit into glossy privet fruit powder, adding water for decocting the glossy privet fruit powder, filtering, taking filtrate to obtain filtrate to be concentrated, and concentrating the filtrate to be concentrated to obtain the glossy privet fruit extract.

2. The extract of Ligustrum lucidum ait of claim 1,

the preparation process of the filtrate to be concentrated comprises the following steps: taking 50g of powder, adding 500ml of water, decocting for 2.5h, filtering and separating to obtain filtrate and filter residue; adding 400ml of water into the filter residue, decocting for 1.5h, filtering and separating to obtain filtrate and filter residue; and combining the obtained filtrates to obtain the filtrate to be concentrated.

3. Granules containing the glossy privet fruit extract of claim 1.

4. The granule of fructus Ligustri Lucidi extract of claim 2, wherein the granule further comprises lactose powder and dextrin.

5. The process for preparing the glossy privet fruit extract granules as claimed in claim 4, which comprises the steps of:

and uniformly mixing the glossy privet fruit extract, lactose powder and dextrin according to a proportion to obtain a mixture, adding an ethanol wetting agent into the mixture, and drying to obtain the granules.

6. The process for preparing the fructus Ligustri Lucidi extract granule as claimed in claim 5,

the mass ratio of the glossy privet fruit extract to the lactose powder to the dextrin is 1:2: 1.

7. The process for preparing the fructus Ligustri Lucidi extract granule as claimed in claim 5,

the mass fraction of the ethanol wetting agent is 70%.

8. The process for preparing the fructus Ligustri Lucidi extract granule as claimed in claim 5,

the drying temperature was 60 ℃.

9. The process for preparing the fructus Ligustri Lucidi extract granule as claimed in claim 5,

the glossy privet fruit extract, the lactose powder, the dextrin proportion, the mass concentration of the ethanol wetting agent and the drying temperature value are obtained by orthogonal tests.

Technical Field

The invention relates to the technical field of medicine preparation, in particular to a glossy privet fruit extract, granules containing the extract and a preparation process of the granules.

Background

Fructus Ligustri Lucidi is mature fruit of Ligustrum lucidum Ait (Ligustrum lucidum Ait) belonging to Ligustrum of Oleaceae, has effects of consolidating body constitution, strengthening primordial qi, and protecting hair and eyes, and can be used for treating diseases such as liver and kidney asthenia, dizziness, tinnitus, body fatigue, and early hair whitening. Many components in the aqueous extract of glossy privet fruit, such as polysaccharide, have the advantages of enhancing the autoimmunity of human bodies, preventing excessive oxidation, delaying senescence and the like. A plurality of reports are made on the glossy privet fruit related polysaccharide research in China. The polysaccharide component in the aqueous extract of glossy privet fruit is one of plant substances with multiple efficacies of glossy privet fruit, and the latest pharmacological research shows that the polysaccharide component of glossy privet fruit has the advantages of enhancing the autoimmunity of a human body, preventing excessive oxidation, delaying senescence and the like. Through the use history of China for nearly one thousand years, the Chinese medicinal composition is determined to be a nontoxic Chinese medicament. The glossy privet fruit is hard in texture and is not beneficial to taking, and related granules and a preparation method thereof are not available in the market at present, so that further improvement is urgently needed.

Disclosure of Invention

Therefore, the invention provides a glossy privet fruit extract, granules containing the extract and a preparation process thereof.

In order to achieve the above purpose, the invention provides the following technical scheme:

a fructus Ligustri Lucidi extract is prepared by pulverizing fructus Ligustri Lucidi into powder, decocting with water, filtering, collecting filtrate to obtain filtrate, and concentrating the filtrate to obtain the fructus Ligustri Lucidi extract.

In one embodiment of the present invention, the preparation process of the filtrate to be concentrated is as follows: taking 50g of powder, adding 500ml of water, decocting for 2.5h, filtering and separating to obtain filtrate and filter residue; adding 400ml of water into the filter residue, decocting for 1.5h, filtering and separating to obtain filtrate and filter residue; and combining the obtained filtrates to obtain the filtrate to be concentrated.

The granules containing the glossy privet fruit extract also belong to the protection scope of the invention.

In one embodiment of the invention, the granules further comprise lactose powder and dextrin.

The invention also provides a preparation process of the glossy privet fruit extract granules, which comprises the following steps:

and uniformly mixing the glossy privet fruit extract, lactose powder and dextrin according to a proportion to obtain a mixture, adding an ethanol wetting agent into the mixture, and drying to obtain the granules.

In one embodiment of the invention, the mass ratio of the glossy privet fruit extract to the lactose powder to the dextrin is 1:2: 1.

In one embodiment of the invention, the ethanol humectant is 70% by weight.

In one embodiment of the present invention, the drying temperature is 60 ℃.

In an embodiment of the present invention, the ratio of the fructus ligustri lucidi extract, lactose powder and dextrin, the mass concentration of the ethanol humectant and the drying temperature value are all obtained by orthogonal tests.

The invention has the following advantages:

the invention determines the optimal proportioning prescription preparation conditions of the glossy privet fruit aqueous extract granules by an orthogonal method, takes the comprehensive evaluation of the qualified rate of the granules as an index, and discusses the influence of the proportion of the extract and auxiliary materials (lactose powder and dextrin), the ethanol dosage and the drying temperature on the quality of the glossy privet fruit granules. The mathematical model established by the orthogonal test method is consistent with experimental observation data, the optimized preparation process method of the glossy privet fruit aqueous extract granules is simple and convenient, and the preparation quality is enhanced.

The test of the invention proves that: in the process method, the optimal proportioning prescription is as follows: mixing dextrin at a ratio of 1:2:1, making into soft material with 70% ethanol solution as humectant, sieving, drying at 60 deg.C, and grading to obtain fructus Ligustri Lucidi granule. The main component in the aqueous extract of glossy privet fruit is extracted and prepared into granules, which are beneficial to taking, can more efficiently utilize and absorb the nutrient components and can improve the immunity of human bodies.

The invention obtains an item (No.1908085MH290) on the basis of the natural science fund in 2019 of Anhui province, and a talent introduction item (No. SPYJ201602) of the Excellent youth backbone talent foreign visitors research and repair item (No.1704f0704062) and Anhui science institute of academic and technology in 2018 of the Anhui province.

Detailed Description

The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Test materials of the present invention: fructus Ligustri Lucidi (purchased from Baicaotang Qinling).

The test instrument of the embodiment of the invention: an electric heating constant temperature drying oven (Jiangsu Tiancheng scientific instruments Co., Ltd.); electronic analytical balance (Jiangsu Tiancheng scientific instruments, Inc.); electric heating jackets (Jiangsu Tiancheng scientific instruments, ltd); screens (16 meshes, 40 meshes, I and V), mortar, evaporating dish, measuring cylinder (10ml), rubber-tipped dropper, glass rod and a plurality of beakers (obtained in laboratory).

Test reagents of the present invention: the test substance used in the experiment is polysaccharide extract extracted from glossy privet fruit, namely glossy privet fruit extract. Other reagents: lactose powder (Shanghai Wucheng Chemicals Co.); dextrin (Jiangsu Tiancheng chemical reagents, Inc.); absolute ethanol (Nanjing Biochemical Reversant Co.); and (4) distilled water.

The measurement items and methods of the present invention: single factor test: selecting 3 factors of the proportion of the extract and the auxiliary materials (lactose powder and dextrin), the ethanol concentration and the drying temperature during preparation, carrying out single-factor test, preparing the granules, and judging the influence of each factor on the forming effect of the granules by taking the granule qualification rate as an index. The percent of pass of the granules is equal to the mass of qualified granules/the total mass of the granules is equal to 100 percent.