阅读说明：本技术 连黄饮 (Lihuangyin (decoction of Lian Huang) ) 是由 黄英俊 于 2020-07-22 设计创作，主要内容包括：本发明涉及一种治疗糖尿病的药物,尤其是一种专治初发2型糖尿病的中医专方连黄饮,由以下重量份数计的原料药物制成：黄连5-20份、制大黄15-30份、生黄芪15-30份和天花粉15-45份。本发明专治初发2型糖尿病的中医专方连黄饮,着眼于糖尿病的总病机,从整体上将西医辨病和中医辩证相结合；连黄饮是经过科室多年积累、参考多位名老中医经验形成的,并在临床得到初步验证确认其有效性。(The invention relates to a medicine for treating diabetes, in particular to a traditional Chinese medicine special formula lianhuangyin for specially treating early-onset type 2 diabetes, which is prepared from the following raw material medicines in parts by weight: 5-20 parts of coptis chinensis, 15-30 parts of prepared rhubarb, 15-30 parts of raw astragalus and 15-45 parts of trichosanthes root. The invention relates to a traditional Chinese medicine special prescription for treating the early-onset type 2 diabetes, which is a lianhuangyin decoction, focuses on the general pathogenesis of diabetes and integrally combines the disease differentiation of western medicine and the syndrome differentiation of traditional Chinese medicine; LIANHUANG YIN is formed by years of accumulation in the department and reference to multiple famous and old traditional Chinese medicine experiences, and is clinically verified primarily to confirm the effectiveness.)

1. The LIANHUANG drink is characterized in that: the traditional Chinese medicine special prescription for treating the incipient type 2 diabetes is prepared from the following raw material medicines in parts by weight: 5-20 parts of coptis chinensis, 15-30 parts of prepared rhubarb, 15-30 parts of raw astragalus and 15-45 parts of trichosanthes root.

2. The LIANHUANG drink according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5 parts of coptis root, 15 parts of prepared rhubarb, 15 parts of raw astragalus root and 15 parts of trichosanthes root.

3. The LIANHUANG drink according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5 parts of coptis root, 22 parts of prepared rhubarb, 22 parts of raw astragalus root and 30 parts of trichosanthes root.

4. The LIANHUANG drink according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5 parts of coptis root, 30 parts of prepared rhubarb, 30 parts of raw astragalus root and 45 parts of trichosanthes root.

5. The LIANHUANG drink according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 12 parts of coptis root, 15 parts of prepared rhubarb, 15 parts of raw astragalus root and 15 parts of trichosanthes root.

6. The LIANHUANG drink according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 12 parts of coptis root, 18 parts of prepared rhubarb, 23 parts of raw astragalus root and 30 parts of trichosanthes root.

7. The LIANHUANG drink according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 12 parts of coptis root, 30 parts of prepared rhubarb, 30 parts of raw astragalus root and 45 parts of trichosanthes root.

8. The LIANHUANG drink according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20 parts of coptis root, 15 parts of prepared rhubarb, 15 parts of raw astragalus root and 15 parts of trichosanthes root.

9. The LIANHUANG drink according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20 parts of coptis root, 23 parts of prepared rhubarb, 18 parts of raw astragalus root and 28 parts of trichosanthes root.

10. The LIANHUANG drink according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20 parts of coptis root, 30 parts of prepared rhubarb, 30 parts of raw astragalus root and 45 parts of trichosanthes root.

Technical Field

The invention relates to a medicine for treating diabetes, in particular to a traditional Chinese medicine special formula Lianhuangyin for treating early-onset type 2 diabetes.

Background

The incidence of diabetes has grown year by year: in 2010, the Chinese disease prevention and control center and the division of endocrinology of the Chinese medical society investigates the diabetes of people aged 18 years and older in China, and shows that the prevalence rate of diabetes is 9.7%; in 2013, the chronic diseases and the risk factors thereof in China are monitored and shown that the prevalence rate of diabetes of people of 18 years old and above is 10.4%; in 2017, data show that the number of people with diabetes in China reaches 1.14 hundred million, and only 36.5 percent of patients can be diagnosed.

Diabetes risk and health: newly diagnosed diabetics may have chronic complications with retinopathy of 16.6% and microalbuminuria of 21%.

Diabetes imposes an economic burden: the annual costs for treating type 2 diabetes and its complications are up to 250 billion dollars, with 80% being used to treat complications.

The current situation at home and abroad is as follows: the number of educated diabetic health educators is only 47%; less than 13% of patients receive effective glycemic control; only 25.9% of patients with glycated hemoglobin reach the standard; more than 50% of patients do not know glycated hemoglobin at all; complications are the main cause of death and disability of diabetic patients, and about 75% of diabetic patients will eventually die of cardiovascular and cerebrovascular complications.

At present, the state brings diabetes into the category of '20 major diseases'.

Western medicines with definite curative effect and quick response comprise oral hypoglycemic drugs and insulin, but patients have more and heavy adverse reactions and poor compliance, the oral hypoglycemic drugs can generate hypoglycemic reaction, gastrointestinal tract reaction, anaphylactic reaction, liver and kidney damage and the like, and the insulin can generate hypoglycemic reaction, anaphylactic reaction, lipodystrophy at injection parts, limb edema, induced tumors and the like; the traditional Chinese medicine can quickly improve the symptoms of dry mouth, polydipsia, bulimia, abdominal distension and constipation, has effective blood sugar reduction without obvious adverse reaction, but has complex traditional Chinese medicine symptoms, difficult syndrome differentiation, more prescription medicines and weak curative effect.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: western medicines have more and serious adverse reactions and poor compliance, the traditional Chinese medicine has complex syndrome type, the syndrome differentiation is difficult to be accurately grasped, and the traditional Chinese medicine has more and weak curative effect, so that the traditional Chinese medicine special formula Lianhuang drink special for treating the early-onset type 2 diabetes is provided for overcoming the defects in the prior art.

The technical scheme adopted by the invention is as follows: the LIANHUANG decoction is a traditional Chinese medicine special prescription for treating early-onset type 2 diabetes, and is prepared from the following raw material medicines in parts by weight: 5-20 parts of coptis chinensis, 15-30 parts of prepared rhubarb, 15-30 parts of raw astragalus and 15-45 parts of trichosanthes root. Wherein, the coptis root is taken as a monarch drug and directly enters the middle warmer, and has the effects of clearing heat and eliminating dampness and removing intrinsic heat in stomach; the prepared rhubarb is taken as a ministerial drug, has the effects of clearing the bowels and dampness-heat, and activating blood circulation to dissipate blood stasis; the raw astragalus root is used as an adjuvant drug for supplementing qi and strengthening the spleen, and removing dampness and eliminating stagnation; trichosanthis radix as adjuvant drug has effects of nourishing yin, promoting fluid production, relieving restlessness, and quenching thirst.

Mixing the above raw materials, adding cold water to 1-2 times of the total weight of the raw materials, soaking for 30min, decocting at 90-100 deg.C for 45-60min, and filtering to obtain filtrate A; adding cold water into the filtered residue to 1-1.5 times of the total amount of the residue, decocting at 90-100 deg.C for 30-60min, and filtering to obtain filtrate B; mixing the filtrate A and the filtrate B to obtain a dose of LIANHUANG drink. Generally, each dose of LIANHUANG decoction is decocted to 400-600ml, and is sterilized and then supplied to patients for oral administration.

According to the disease symptoms of patients, the common condition of patients with early type 2 diabetes is dampness-heat trapping in the spleen. Aiming at the specific situation of a patient, the weight parts of the raw material medicaments are increased or decreased, and the treatment is carried out by taking one week as a treatment course; after one treatment course, the weight parts of the raw material medicaments are increased or decreased again according to the diseases of the patients, and the treatment and observation are repeatedly carried out for three months.

Compared with the prior art, the invention has the following advantages: the invention relates to a traditional Chinese medicine special prescription for treating the early-onset type 2 diabetes, which is a lianhuangyin decoction, focuses on the general pathogenesis of diabetes and integrally combines the disease differentiation of western medicine and the syndrome differentiation of traditional Chinese medicine; LIANHUANG YIN is formed by years of accumulation in the department and reference to multiple famous and old traditional Chinese medicine experiences, and is clinically verified primarily to confirm the effectiveness. The concrete embodiment is as follows:

1. the early type 2 diabetes mellitus has unobvious treatment effect through simple diet exercise, and can be treated by simply using LIANHUANGYIN for patients who take western medicines with conflicting emotions, only three main symptoms of body obesity, food hunger elimination and abdominal distension and constipation are needed to be mastered, complex syndrome differentiation is not needed, and the clinical application is convenient for Chinese and western doctors to master flexibly;

2. for the patients who have been treated by western medicines and have obvious adverse reactions or have unsatisfactory blood sugar control, the coptis chinensis decoction can be added to reduce toxicity and enhance efficacy;

3. for the patients with the blood sugar control reaching the standard and the three more or one less symptoms still being obvious, the LIANHUANG drink can quickly improve the clinical symptoms and can not cause hypoglycemia.

Drawings

FIG. 1 is a technical roadmap for clinical trials of the present invention.

Detailed Description

The following examples are given for the detailed implementation and specific operation of the embodiments of the present invention, but the scope of the present invention is not limited to the following examples.